{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:43:00Z","timestamp":1789576980677,"version":"build-2803163510"},"reference-count":59,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T00:00:00Z","timestamp":1541030400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AG055401"],"award-info":[{"award-number":["R01AG055401"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["RC4AG039036-01"],"award-info":[{"award-number":["RC4AG039036-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P30AG043073-01"],"award-info":[{"award-number":["P30AG043073-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01AG042498"],"award-info":[{"award-number":["K01AG042498"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL126804"],"award-info":[{"award-number":["R01HL126804"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL130462"],"award-info":[{"award-number":["R01HL130462"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"University of Southern California Zumberge Research Fund","award":["1R34AG049652"],"award-info":[{"award-number":["1R34AG049652"]}]},{"name":"Schaeffer-Amgen Fellowship Program"},{"name":"Sigmund Gestetner Foundation"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0206705","type":"journal-article","created":{"date-parts":[[2018,11,1]],"date-time":"2018-11-01T13:50:36Z","timestamp":1541080236000},"page":"e0206705","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":80,"title":["The association of multiple anti-hypertensive medication classes with Alzheimer\u2019s disease incidence across sex, race, and ethnicity"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0511-5520","authenticated-orcid":true,"given":"Douglas","family":"Barthold","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geoffrey","family":"Joyce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Whitney","family":"Wharton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Kehoe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie","family":"Zissimopoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,1]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.jalz.2017.02.001","article-title":"2017 Alzheimer\u2019s disease facts and figures","volume":"13","year":"2017","journal-title":"Alzheimer\u2019s & Dementia"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1515\/fhep-2014-0013","article-title":"The Value of Delaying Alzheimer\u2019s Disease Onset","volume":"18","author":"J. Zissimopoulos","year":"2015","journal-title":"Forum for Health Economics and Policy"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s40263-015-0230-6","article-title":"Antihypertensive drugs, prevention of cognitive decline and dementia: a systematic review of observational studies, randomized controlled trials and meta-analyses, with discussion of potential mechanisms","volume":"29","author":"L. Rouch","year":"2015","journal-title":"CNS drugs"},{"key":"ref4","article-title":"CDC grand rounds: a public health approach to detect and control hypertension. MMWR","volume":"65","author":"R. Merai","year":"2016","journal-title":"Morbidity and mortality weekly report"},{"issue":"3","key":"ref5","first-page":"e28","article-title":"Heart disease and stroke statistics\u20142014 update: a report from the American Heart Association","volume":"129","author":"A.S. Go","year":"2014","journal-title":"circulation"},{"key":"ref6","article-title":"<italic>Health, United States, 2016: With Chartbook on Long-term Trends in Health<\/italic>","year":"2017"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1097\/HJH.0b013e3283603f53","article-title":"Antihypertensive classes, cognitive decline and incidence of dementia: a network meta-analysis","volume":"31","author":"N.L. Marpillat","year":"2013","journal-title":"Journal of hypertension"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1474-4422(08)70143-1","article-title":"Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial","volume":"7","author":"R. Peters","year":"2008","journal-title":"The Lancet Neurology"},{"key":"ref9","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD004034.pub2","article-title":"Blood pressure lowering in patients without prior cerebrovascular disease for prevention of cognitive impairment and dementia","volume":"2","author":"B. McGuinness","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"issue":"18","key":"ref10","doi-asserted-by":"crossref","first-page":"2046","DOI":"10.1001\/archinte.162.18.2046","article-title":"The prevention of dementia with antihypertensive treatment: new evidence from the Systolic Hypertension in Europe (Syst-Eur) study","volume":"162","author":"F. Forette","year":"2002","journal-title":"Archives of internal medicine"},{"issue":"10046","key":"ref11","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0140-6736(16)30950-3","article-title":"Effectiveness of a 6-year multidomain vascular care intervention to prevent dementia (preDIVA): a cluster-randomised controlled trial","volume":"388","author":"E.P.M. Van Charante","year":"2016","journal-title":"The Lancet"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1111\/jgs.13627","article-title":"Modulation of Renin-Angiotensin System May Slow Conversion from Mild Cognitive Impairment to Alzheimer\u2019s Disease","volume":"63","author":"W. Wharton","year":"2015","journal-title":"Journal of the American Geriatrics Society"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1054\/npep.2000.0845","article-title":"Comparative studies on the memory-enhancing actions of captopril and losartan in mice using inhibitory shock avoidance paradigm","volume":"35","author":"V. Raghavendra","year":"2001","journal-title":"Neuropeptides"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0143-4179(98)90065-8","article-title":"Involvement of cholinergic system in losartan-induced facilitation of spatial and short-term working memory","volume":"32","author":"V. Raghavendra","year":"1998","journal-title":"Neuropeptides"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1038\/sj.jhh.1001613","article-title":"Influence of losartan and atenolol on memory function in very elderly hypertensive patients","volume":"17","author":"R. Fogari","year":"2003","journal-title":"Journal of human hypertension"},{"issue":"11","key":"ref16","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0895-7061(99)00156-9","article-title":"Comparison of losartan and hydrochlorothiazide on cognitive function and quality of life in hypertensive patients","volume":"12","author":"M.A. Tedesco","year":"1999","journal-title":"American journal of hypertension"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1592\/phco.28.3.366","article-title":"Effects of antihypertensive drug treatment on the risk of dementia and cognitive impairment","volume":"28","author":"I.O. Poon","year":"2008","journal-title":"Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","DOI":"10.3233\/JAD-171119","article-title":"The coming of age of the angiotensin hypothesis in Alzheimer\u2019s disease\u2014progress towards disease prevention and treatment?","volume":"62","author":"P.G. Kehoe","year":"2018","journal-title":"Journal of Alzheimer\u2019s Disease"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"b5465","DOI":"10.1136\/bmj.b5465","article-title":"Use of angiotensin receptor blockers and risk of dementia in a predominantly male population: prospective cohort analysis","volume":"340","author":"N. Li","year":"2010","journal-title":"Bmj"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S1474-4422(10)70250-7","article-title":"Renin-angiotensin system blockade and cognitive function in patients at high risk of cardiovascular disease: analysis of data from the ONTARGET and TRANSCEND studies","volume":"10","author":"C. Anderson","year":"2011","journal-title":"The Lancet Neurology"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1016\/S1474-4422(08)70198-4","article-title":"Effects of aspirin plus extended-release dipyridamole versus clopidogrel and telmisartan on disability and cognitive function after recurrent stroke in patients with ischaemic stroke in the Prevention Regimen for Effectively Avoiding Second Strokes (PRoFESS) trial: a double-blind, active and placebo-controlled study","volume":"7","author":"H. Diener","year":"2008","journal-title":"The Lancet Neurology"},{"key":"ref22","doi-asserted-by":"crossref","unstructured":"Wharton, W., Zhao, L., Steenland, K., Gearing, M., and Goldstein, F.C., <italic>Less Conversion to AD and Fewer Neurofibrillary Tangles in MCI Patients Taking Certain Antihypertensives<\/italic>, in <italic>Alzheimer\u2019s Association International Conference<\/italic>. 2017: London, UK.","DOI":"10.1016\/j.jalz.2017.06.1906"},{"key":"ref23","unstructured":"Wharton, W., Zhao, L., Steenland, K., Gearing, M., and Goldstein, F., <italic>Fewer Neurofibrillary Tangles and Slower Conversion to AD in MCI Patients Taking RAS Acting Antihypertensives<\/italic>. in <italic>Americans Neurological Association Conference<\/italic>. 2016. Baltimore, MD."},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1001\/archneurol.2012.1010","article-title":"Impact of Angiotensin receptor blockers on Alzheimer disease neuropathology in a large brain autopsy series","volume":"69","author":"I. Hajjar","year":"2012","journal-title":"Archives of neurology"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/jgs.12100","article-title":"Antihypertensive therapy and cerebral hemodynamics in executive mild cognitive impairment: results of a pilot randomized clinical trial","volume":"61","author":"I. Hajjar","year":"2013","journal-title":"Journal of the American Geriatrics Society"},{"issue":"51","key":"ref26","doi-asserted-by":"crossref","first-page":"47863","DOI":"10.1074\/jbc.M104068200","article-title":"Angiotensin-converting enzyme degrades Alzheimer amyloid \u03b2-peptide (A\u03b2); retards A\u03b2 aggregation, deposition, fibril formation; and inhibits cytotoxicity","volume":"276","author":"J. Hu","year":"2001","journal-title":"Journal of Biological Chemistry"},{"issue":"45","key":"ref27","doi-asserted-by":"crossref","first-page":"37644","DOI":"10.1074\/jbc.M508460200","article-title":"Amyloid \u03b2-protein is degraded by cellular angiotensin-converting enzyme (ACE) and elevated by an ACE inhibitor","volume":"280","author":"M.L. Hemming","year":"2005","journal-title":"Journal of Biological Chemistry"},{"issue":"32","key":"ref28","doi-asserted-by":"crossref","first-page":"8628","DOI":"10.1523\/JNEUROSCI.1549-07.2007","article-title":"Angiotensin-converting enzyme converts amyloid \u03b2-protein 1\u201342 (A\u03b21\u201342) to A\u03b21\u201340, and its inhibition enhances brain A\u03b2 deposition","volume":"27","author":"K. Zou","year":"2007","journal-title":"Journal of Neuroscience"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1474-4422(07)70077-7","article-title":"Is inhibition of the renin\u2013angiotensin system a new treatment option for Alzheimer\u2019s disease?","volume":"6","author":"P.G. Kehoe","year":"2007","journal-title":"The Lancet Neurology"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.tins.2009.07.006","article-title":"Angiotensins in Alzheimer\u2019s disease\u2013friend or foe?","volume":"32","author":"P.G. Kehoe","year":"2009","journal-title":"Trends in neurosciences"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/sj.tpj.6500384","article-title":"Clinical implications of pharmacogenomics of statin treatment","volume":"6","author":"L. Mangravite","year":"2006","journal-title":"The pharmacogenomics journal"},{"issue":"3","key":"ref32","first-page":"266","article-title":"Interactions between oestrogen and the renin angiotensin system-potential mechanisms for gender differences in Alzheimer\u2019s disease","volume":"1","author":"T.S. O\u2019Hagan","year":"2012","journal-title":"American journal of neurodegenerative disease"},{"key":"ref33","article-title":"Sex and Race Differences in the Association Between Statin Use and the Incidence of Alzheimer Disease","author":"J.M. Zissimopoulos","year":"2016","journal-title":"JAMA Neurology"},{"issue":"7404","key":"ref34","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1136\/bmj.326.7404.1427","article-title":"Value of low dose combination treatment with blood pressure lowering drugs: analysis of 354 randomised trials","volume":"326","author":"M.R. Law","year":"2003","journal-title":"Bmj"},{"key":"ref35","article-title":"Prevention, detection, evaluation, and management of high blood pressure in adults","author":"A.S. Cifu","year":"2017","journal-title":"JAMA"},{"issue":"1","key":"ref36","first-page":"1","article-title":"Comparison of the performance of the CMS Hierarchical Condition Category (CMS-HCC) risk adjuster with the Charlson and Elixhauser comorbidity measures in predicting mortality","volume":"10","author":"P. Li","year":"2010","journal-title":"BMC health services research"},{"key":"ref37","article-title":"<italic>Creation of new race-ethnicity codes and socioeconomic status (SES) indicators for Medicare beneficiaries<\/italic>","author":"A. Bonito","year":"2008"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.jalz.2018.02.001","article-title":"2018 Alzheimer\u2019s disease facts and figures","volume":"14","year":"2018","journal-title":"Alzheimer\u2019s & Dementia"},{"key":"ref39","article-title":"<italic>Projected Age Groups and Sex Composition of the Population<\/italic>: <italic>Main Projection Series for the United States<\/italic>, <italic>2017\u20132060<\/italic>","year":"2017"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3233\/JAD-161198","article-title":"Rationale and Design of the Mechanistic Potential of Antihypertensives in Preclinical Alzheimer\u2019s (HEART) Trial","volume":"61","author":"W. Wharton","year":"2018","journal-title":"Journal of Alzheimer\u2019s disease: JAD"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"803","DOI":"10.3233\/JAD-170101","article-title":"The Rationale and Design of the Reducing Pathology in Alzheimer\u2019s Disease through Angiotensin TaRgeting (RADAR) Trial","volume":"61","author":"P.G. Kehoe","year":"2018","journal-title":"Journal of Alzheimer\u2019s disease: JAD"},{"issue":"5\u20136","key":"ref42","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000447585","article-title":"Associations of Blood Pressure with Functional and Cognitive Changes in Patients with Alzheimer\u2019s Disease","volume":"41","author":"F.F. de Oliveira","year":"2016","journal-title":"Dementia and geriatric cognitive disorders"},{"key":"ref43","article-title":"Pharmacogenetics of angiotensin-converting enzyme inhibitors in patients with Alzheimer\u2019s disease dementia","author":"F.F. de Oliveira","year":"2017","journal-title":"Current Alzheimer research"},{"issue":"22","key":"ref44","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1097\/00029330-200811020-00019","article-title":"Altered angiotensin-converting enzyme and its effects on the brain in a rat model of Alzheimer disease","volume":"121","author":"D. Hou","year":"2008","journal-title":"Chinese medical journal"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1007\/s12035-015-9260-9","article-title":"Angiotensin-(1\u20137) is reduced and inversely correlates with Tau hyperphosphorylation in animal models of Alzheimer\u2019s disease","volume":"53","author":"T. Jiang","year":"2016","journal-title":"Molecular neurobiology"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s13195-016-0217-7","article-title":"Angiotensin-converting enzyme 2 is reduced in Alzheimer\u2019s disease in association with increasing amyloid-\u03b2 and tau pathology","volume":"8","author":"P.G. Kehoe","year":"2016","journal-title":"Alzheimer\u2019s research & therapy"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"699","DOI":"10.3233\/JAD-2011-110347","article-title":"Associations of anti-hypertensive treatments with Alzheimer\u2019s disease, vascular dementia, and other dementias","volume":"26","author":"N.M. Davies","year":"2011","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1212\/WNL.56.1.49","article-title":"Incidence of AD in African-Americans, Caribbean hispanics, and caucasians in northern Manhattan","volume":"56","author":"M. Tang","year":"2001","journal-title":"Neurology"},{"issue":"2","key":"ref49","article-title":"Aging in the United States","volume":"70","author":"M. Mather","year":"2015","journal-title":"Population Bulletin"},{"key":"ref50","first-page":"P25","article-title":"Projections on the size and composition of the U.S. population: 2014 to 2060","author":"S.L. Colby","year":"2014","journal-title":"Current Population Reports"},{"issue":"3","key":"ref51","doi-asserted-by":"crossref","first-page":"165","DOI":"10.2165\/11631520-000000000-00000","article-title":"Epidemiology and management of hypertension in the hispanic population","volume":"12","author":"N.J. Guzman","year":"2012","journal-title":"American Journal of Cardiovascular Drugs"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ajh\/hpt276","article-title":"Association of renin and aldosterone with ethnicity and blood pressure: the multi-ethnic study of atherosclerosis","volume":"27","author":"D.E. Rifkin","year":"2014","journal-title":"American journal of hypertension"},{"key":"ref53","first-page":"24430","article-title":"A guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: a report of the American College of Cardiology\/American Heart Association Task Force on Clinical Practice Guidelines","author":"P.K. Whelton","year":"2017","journal-title":"Journal of the American College of Cardiology"},{"key":"ref54","article-title":"Dementia prevention, intervention, and care","author":"G. Livingston","year":"2017","journal-title":"The Lancet"},{"issue":"8","key":"ref55","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1097\/HJH.0b013e328301a280","article-title":"Effects of hypertension therapy based on eprosartan on systolic arterial blood pressure and cognitive function: primary results of the Observational Study on Cognitive function And Systolic Blood Pressure Reduction open-label study","volume":"26","author":"O. Hanon","year":"2008","journal-title":"Journal of hypertension"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1016\/j.neuroscience.2008.06.023","article-title":"Involvement of angiotensin converting enzyme in cerebral hypoperfusion induced anterograde memory impairment and cholinergic dysfunction in rats","volume":"155","author":"D. Kumaran","year":"2008","journal-title":"Neuroscience"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1111\/cns.12802","article-title":"Candesartan ameliorates brain inflammation associated with Alzheimer\u2019s disease","volume":"24","author":"N. Torika","year":"2018","journal-title":"CNS neuroscience & therapeutics"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3233\/JAD-2012-120763","article-title":"The effects of ramipril in individuals at risk for Alzheimer\u2019s disease: results of a pilot clinical trial","volume":"32","author":"W. Wharton","year":"2012","journal-title":"Journal of Alzheimer\u2019s Disease"},{"issue":"7407","key":"ref59","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/bmj.327.7407.147","article-title":"Lesson of the week: Interaction of spironolactone with ACE inhibitors or angiotensin receptor blockers: analysis of 44 cases","volume":"327","author":"E. Wrenger","year":"2003","journal-title":"BMJ: British Medical Journal"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0206705","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T22:57:10Z","timestamp":1775257030000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0206705"}},"subtitle":[],"editor":[{"given":"Tatsuo","family":"Shimosawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,1]]},"references-count":59,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0206705","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,1]]}}}