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Kampala, Uganda: 2003."},{"key":"ref16","unstructured":"UNAIDS. Uganda HIV and AIDS estimates 2015 [10.07.2017]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unaids.org\/en\/regionscountries\/countries\/uganda\/\" xlink:type=\"simple\">http:\/\/www.unaids.org\/en\/regionscountries\/countries\/uganda\/<\/ext-link>."},{"key":"ref17","unstructured":"World Health Organisation. Health statistics and information systems. Estimates for 2000\u20132015. Cause-specific mortality [18.07.2017]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/healthinfo\/global_burden_disease\/estimates\/en\/index1.html\" xlink:type=\"simple\">http:\/\/www.who.int\/healthinfo\/global_burden_disease\/estimates\/en\/index1.html<\/ext-link>."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12879-015-0927-7","article-title":"Trends in prevalence of selected opportunistic infections associated with HIV\/AIDS in Uganda","volume":"15","author":"J Rubaihayo","year":"2015","journal-title":"BMC Infect Dis"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1365-3156.2008.02078.x","article-title":"Antiretroviral therapy in resource-limited settings 1996 to 2006: patient characteristics, treatment regimens and monitoring in sub-Saharan Africa, Asia and Latin America","volume":"13","author":"O Keiser","year":"2008","journal-title":"Trop Med Int 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