{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T20:19:08Z","timestamp":1778876348852,"version":"3.51.4"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T00:00:00Z","timestamp":1542240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Grant-in-Aid for Scientific Research from the Japan Society for the promotion of Science","award":["16K20666"],"award-info":[{"award-number":["16K20666"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0207201","type":"journal-article","created":{"date-parts":[[2018,11,15]],"date-time":"2018-11-15T19:21:56Z","timestamp":1542309716000},"page":"e0207201","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Periodontal regenerative effect of enamel matrix derivative in diabetes"],"prefix":"10.1371","volume":"13","author":[{"given":"Kohei","family":"Takeda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1610-7430","authenticated-orcid":true,"given":"Koji","family":"Mizutani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daisuke","family":"Kido","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risako","family":"Mikami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masahiro","family":"Noda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prima","family":"Buranasin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5400-3958","authenticated-orcid":true,"given":"Yoshiyuki","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,11,15]]},"reference":[{"issue":"8 Suppl","key":"ref1","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1902\/jop.2008.080246","article-title":"The role of inflammatory cytokines in diabetes and its complications","volume":"79","author":"GL King","year":"2008","journal-title":"J Periodontol"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1038\/nrendo.2011.106","article-title":"Diabetes mellitus and periodontitis: a tale of two common interrelated diseases","volume":"7","author":"E Lalla","year":"2011","journal-title":"Nat Rev Endocrinol"},{"issue":"4 Suppl","key":"ref3","first-page":"S135","article-title":"Effect of periodontal disease on diabetes: systematic review of epidemiologic observational evidence","volume":"84","author":"WS Borgnakke","year":"2013","journal-title":"J Periodontol"},{"issue":"11","key":"ref4","article-title":"Treatment of periodontal disease for glycaemic control in people with diabetes mellitus","author":"TC Simpson","year":"2015","journal-title":"Cochrane Database Syst Rev"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/jcpe.12837","article-title":"A systematic review and meta-analysis of epidemiologic observational evidence on the effect of periodontitis on diabetes An update of the EFP-AAP review","volume":"45","author":"F Graziani","year":"2018","journal-title":"J Clin Periodontol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ijos.2015.2","article-title":"Diabetes mellitus related bone metabolism and periodontal disease","volume":"7","author":"YY Wu","year":"2015","journal-title":"Int J Oral Sci"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0002-9440(10)63821-7","article-title":"Cellular dysfunction in the diabetic fibroblast: impairment in migration, vascular endothelial growth factor production, and response to hypoxia","volume":"162","author":"OZ Lerman","year":"2003","journal-title":"Am J Pathol"},{"issue":"9498","key":"ref8","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/S0140-6736(05)67700-8","article-title":"Wound healing and its impairment in the diabetic foot","volume":"366","author":"V. Falanga","year":"2005","journal-title":"Lancet"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1111\/j.1600-051X.1998.tb02417.x","article-title":"Healing response to non-surgical periodontal therapy in patients with diabetes mellitus: clinical, microbiological, and immunologic results","volume":"25","author":"M Christgau","year":"1998","journal-title":"J Clin Periodontol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00011-010-0248-7","article-title":"Gingival crevicular fluid IL-6, tPA, PAI-2, albumin levels following initial periodontal treatment in chronic periodontitis patients with or without type 2 diabetes","volume":"60","author":"L Karde\u015fler","year":"2011","journal-title":"Inflamm Res"},{"issue":"6","key":"ref11","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1177\/0022034514532102","article-title":"Obesity-associated Gingival Vascular Inflammation and Insulin Resistance","volume":"93","author":"K Mizutani","year":"2014","journal-title":"J Dent Res"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"e0189601","DOI":"10.1371\/journal.pone.0189601","article-title":"Impact of diabetes on gingival wound healing via oxidative stress","volume":"12","author":"D Kido","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1177\/154405910408300210","article-title":"In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts","volume":"83","author":"S Keila","year":"2004","journal-title":"J Dent Res"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1034\/j.1600-0722.2002.21340.x","article-title":"Possible involvement of extracellular signal-regulated kinases 1\/2 in mitogenic response of periodontal ligament cells to enamel matrix derivative","volume":"110","author":"N Matsuda","year":"2002","journal-title":"Eur J Oral Sci"},{"issue":"9 Pt 2","key":"ref15","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1111\/j.1600-051X.1997.tb00250.x","article-title":"In vitro studies on periodontal ligament cells and enamel matrix derivative","volume":"24","author":"S Gestrelius","year":"1997","journal-title":"J Clin Periodontol"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1034\/j.1600-0765.2001.360604.x","article-title":"Enamel matrix derivative (EMDOGAIN) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells","volume":"36","author":"T Kawase","year":"2001","journal-title":"J Periodontal Res"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1089\/ten.teb.2011.0365","article-title":"Enamel matrix derivative: a review of cellular effects in vitro and a model of molecular arrangement and functioning","volume":"18","author":"HM Grandin","year":"2012","journal-title":"Tissue Eng Part B Rev"},{"issue":"4","key":"ref18","article-title":"Enamel matrix derivative (Emdogain(R)) for periodontal tissue regeneration in intrabony defects","author":"M Esposito","year":"2009","journal-title":"Cochrane Database Syst Rev"},{"issue":"9 Pt 2","key":"ref19","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.1600-051X.1997.tb00253.x","article-title":"Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects","volume":"24","author":"L Heijl","year":"1997","journal-title":"J Clin Periodontol"},{"issue":"2 Suppl","key":"ref20","first-page":"S77","article-title":"Periodontal regeneration\u2014intrabony defects: a systematic review from the AAP Regeneration Workshop","volume":"86","author":"RT Kao","year":"2015","journal-title":"J Periodontol"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.2337\/diab.25.7.595","article-title":"Studies on streptozotocin diabetes","volume":"25","author":"OP Ganda","year":"1976","journal-title":"Diabetes"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/jre.12084","article-title":"Periodontal healing after application of enamel matrix derivative in surgical supra\/infrabony periodontal defects in rats with streptozotocin-induced diabetes","volume":"49","author":"Y Shirakata","year":"2014","journal-title":"J Periodontal Res"},{"key":"ref23","first-page":"743798","article-title":"Tracing fasting glucose fluxes with unstressed catheter approach in streptozotocin induced diabetic rats","volume":"2014","author":"S Du","year":"2014","journal-title":"J Diabetes Res"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1007\/s001250051335","article-title":"Learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: interaction of diabetes and ageing","volume":"43","author":"A Kamal","year":"2000","journal-title":"Diabetologia"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1038\/2012","article-title":"Suppression of accelerated diabetic atherosclerosis by the soluble receptor for advanced glycation endproducts","volume":"4","author":"L Park","year":"1998","journal-title":"Nat Med"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"e0201855","DOI":"10.1371\/journal.pone.0201855","article-title":"High glucose-induced oxidative stress impairs proliferation and migration of human gingival fibroblasts","volume":"13","author":"P Buranasin","year":"2018","journal-title":"PLoS One"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1600-0722.2012.00999.x","article-title":"Enamel matrix derivative induces production of vascular endothelial cell growth factor in human gingival fibroblasts","volume":"120","author":"K Sakoda","year":"2012","journal-title":"Eur J Oral Sci"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1902\/jop.2009.090127","article-title":"Enamel matrix derivative protein stimulated wound healing via phosphoinositide 3-kinase","volume":"80","author":"S Goda","year":"2009","journal-title":"J Periodontol"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1111\/j.1600-051X.2007.01127.x","article-title":"Effect of non-surgical periodontal therapy on clinical and immunological response and glycaemic control in type 2 diabetic patients with moderate periodontitis","volume":"34","author":"AB Navarro-Sanchez","year":"2007","journal-title":"J Clin Periodontol"},{"issue":"7","key":"ref30","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1600-051X.1997.tb00219.x","article-title":"Periodontal disease related to diabetic status. A pilot study of the response to periodontal therapy in type 1 diabetes","volume":"24","author":"T Tervonen","year":"1997","journal-title":"J Clin Periodontol"},{"issue":"12","key":"ref31","first-page":"1135","article-title":"Complications associated with diabetes mellitus after guided tissue regeneration\u2014a case report revisited","volume":"23","author":"JS Mattson","year":"2002","journal-title":"Compend Contin Educ Dent"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1172\/JCI8942","article-title":"Blockade of RAGE suppresses periodontitis-associated bone loss in diabetic mice","volume":"105","author":"E Lalla","year":"2000","journal-title":"J Clin Invest"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1600-0757.2006.00168.x","article-title":"Diabetic periodontitis: a model for activated innate immunity and impaired resolution of inflammation","volume":"43","author":"H Nassar","year":"2007","journal-title":"Periodontol 2000"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1549-8719.2001.tb00174.x","article-title":"Vascular dysfunction induced by AGE is mediated by VEGF via mechanisms involving reactive oxygen species, guanylate cyclase, and protein kinase C","volume":"8","author":"Y Ido","year":"2001","journal-title":"Microcirculation"},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1902\/jop.2011.110325","article-title":"Patterns of diabetic periodontal wound repair: a study using micro-computed tomography and immunohistochemistry","volume":"83","author":"PC Chang","year":"2012","journal-title":"J Periodontol"},{"key":"ref36","first-page":"6170352","article-title":"Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats","volume":"2018","author":"LSB Amaral","year":"2018","journal-title":"J Diabetes Res"},{"issue":"4998","key":"ref37","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1126\/science.2006409","article-title":"Diabetic hyperglycemia: link to impaired glucose transport in pancreatic beta cells","volume":"251","author":"RH Unger","year":"1991","journal-title":"Science"},{"issue":"4","key":"ref38","first-page":"751","article-title":"Insulitis and islet microvasculature in type 1 diabetes","volume":"8","author":"G Papaccio","year":"1993","journal-title":"Histol Histopathol"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1002\/jcp.20198","article-title":"Interleukin (IL)-1beta toxicity to islet beta cells: Efaroxan exerts a complete protection","volume":"203","author":"G Papaccio","year":"2005","journal-title":"J Cell Physiol"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/prd.12089","article-title":"Local inflammatory reactions in patients with diabetes and periodontitis","volume":"69","author":"SK Sonnenschein","year":"2015","journal-title":"Periodontol 2000"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1902\/jop.2012.120354","article-title":"Histometric analysis of the effect of enamel matrix derivative on the healing of periodontal defects in rats with diabetes","volume":"84","author":"MG Corr\u00eaa","year":"2013","journal-title":"J Periodontol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1111\/jcpe.12324","article-title":"Fibroblast growth factor-2 promotes healing of surgically created periodontal defects in rats with early, streptozotocin-induced diabetes via increasing cell proliferation and regulating angiogenesis","volume":"42","author":"T Bizenjima","year":"2015","journal-title":"J Clin Periodontol"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1177\/154405910708600106","article-title":"Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK","volume":"86","author":"E Zeldich","year":"2007","journal-title":"J Dent Res"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.2337\/diabetes.52.6.1502","article-title":"A role for advanced glycation end products in diminished bone healing in type 1 diabetes","volume":"52","author":"RB Santana","year":"2003","journal-title":"Diabetes"},{"issue":"9 Pt 2","key":"ref45","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/j.1600-051X.1997.tb00247.x","article-title":"Enamel matrix, cementum development and regeneration","volume":"24","author":"L. Hammarstr\u00f6m","year":"1997","journal-title":"J Clin Periodontol"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1902\/jop.2006.050317","article-title":"Effect of enamel matrix protein derivative on healing of surgical supra-infrabony periodontal defects in the rat molar: a histomorphometric study","volume":"77","author":"CE Nemcovsky","year":"2006","journal-title":"J Periodontol"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1902\/jop.2007.060111","article-title":"In vitro effects of enamel matrix derivative on microvascular cells","volume":"78","author":"SR Schlueter","year":"2007","journal-title":"J Periodontol"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/j.1600-051X.1991.tb01132.x","article-title":"Influence of high glucose concentrations on glycosaminoglycan and collagen synthesis in cultured human gingival fibroblasts","volume":"18","author":"B Willershausen-Z\u00f6nnchen","year":"1991","journal-title":"J Clin Periodontol"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0218798","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,6,18]],"date-time":"2019-06-18T00:00:00Z","timestamp":1560816000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0207201","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:28:19Z","timestamp":1589012899000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0207201"}},"subtitle":[],"editor":[{"given":"Gianpaolo","family":"Papaccio","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,15]]},"references-count":48,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0207201","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0218798","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,15]]}}}