{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T19:51:22Z","timestamp":1791921082120,"version":"4.3.4"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T00:00:00Z","timestamp":1542585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2016R1D1A1B03933345"],"award-info":[{"award-number":["NRF-2016R1D1A1B03933345"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF-2017R1A5A2015385"],"award-info":[{"award-number":["NRF-2017R1A5A2015385"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002462","name":"Chungnam National University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002462","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003718","name":"Korea Institute of Oriental Medicine","doi-asserted-by":"publisher","award":["K16402"],"award-info":[{"award-number":["K16402"]}],"id":[{"id":"10.13039\/501100003718","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0207696","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T18:35:06Z","timestamp":1542652506000},"page":"e0207696","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Protective effects of a traditional herbal extract from Stellaria dichotoma var. lanceolata against Mycobacterium abscessus infections"],"prefix":"10.1371","volume":"13","author":[{"given":"Su-Jin","family":"Bae","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Won","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byung-Joon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jina","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eun-Kyeong","family":"Jo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Ha","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung-Bae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0630-9194","authenticated-orcid":true,"given":"Jae-Min","family":"Yuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,19]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0378-8741(84)90092-8","article-title":"Pharmacognosy: the oldest modern science","volume":"11","author":"A. de Pasquale","year":"1984","journal-title":"J Ethnopharmacol"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0100-879X2000000200004","article-title":"Efficacy, safety, quality control, marketing and regulatory guidelines for herbal medicines (phytotherapeutic agents)","volume":"33","author":"JB Calixto","year":"2000","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"ref3","first-page":"15","article-title":"[Research on the originol plant <italic>Stellaria dichotoma<\/italic> var. <italic>Lanceolata<\/italic> in the ben-cao pharmaopeia]","volume":"10","author":"J. Teng","year":"1985","journal-title":"Zhong Yao Tong Bao"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1021\/np1003627","article-title":"beta-carboline alkaloids from <italic>Stellaria dichotoma<\/italic> var. <italic>lanceolata<\/italic> and their anti-inflammatory activity","volume":"73","author":"YF Chen","year":"2010","journal-title":"J Nat Prod"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"1194","DOI":"10.1248\/cpb.52.1194","article-title":"Bioactive constituents from Chinese natural medicines. XIV. New glycosides of beta-carboline-type alkaloid, neolignan, and phenylpropanoid from <italic>Stellaria dichotoma<\/italic> L. <italic>var<\/italic>. <italic>lanceolata<\/italic> and their antiallergic activities","volume":"52","author":"T Morikawa","year":"2004","journal-title":"Chem Pharm Bull (Tokyo)"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1089\/jmf.2007.0135","article-title":"Antioxidant activity of enzymatic extracts from <italic>Stellaria dichotoma<\/italic>","volume":"11","author":"BO Lim","year":"2008","journal-title":"J Med Food"},{"key":"ref7","first-page":"7597596","article-title":"Radix Bupleuri: A Review of Traditional Uses, Botany, Phytochemistry, Pharmacology, and Toxicology","volume":"2017","author":"F Yang","year":"2017","journal-title":"Biomed Res Int"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.2042-7158.2010.01170.x","article-title":"Genus Bupleurum: a review of its phytochemistry, pharmacology and modes of action","volume":"63","author":"ML Ashour","year":"2011","journal-title":"J Pharm Pharmacol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.jep.2016.09.052","article-title":"Toxic polyacetylenes in the genus <italic>Bupleurum<\/italic> (Apiaceae)\u2014Distribution, toxicity, molecular mechanism and analysis","volume":"193","author":"M Lin","year":"2016","journal-title":"J Ethnopharmacol"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1191\/0960327106het654oa","article-title":"Pharmacology and toxicology of <italic>Bupleurum<\/italic> root-containing Kampo medicines in clinical use","volume":"25","author":"F Ikegami","year":"2006","journal-title":"Hum Exp Toxicol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1016\/j.bse.2007.03.023","article-title":"Flavonoids from aerial part of <italic>Bupleurum chinense<\/italic> DC","volume":"35","author":"T Zhang","year":"2007","journal-title":"Biochemical Systematics and Ecology"},{"issue":"2","key":"ref12","first-page":"155","article-title":"Saikosaponins from <italic>Bupleurum chinense<\/italic> and inhibition of HBV DNA replication activity","volume":"3","author":"F Yin","year":"2008","journal-title":"Nat Prod Commun"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0008-6215(91)89050-P","article-title":"Partial structure of an anti-ulcer pectic polysaccharide from the roots of Bupleurum falcatum L","volume":"219","author":"H Yamada","year":"1991","journal-title":"Carbohydrate research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/0008-6215(89)84098-4","article-title":"Structural Characterization of an Anti-Complementary Pectic Polysaccharide from the Roots of <italic>Bupleurum-Falcatum<\/italic> L","volume":"189","author":"H Yamada","year":"1989","journal-title":"Carbohydrate research"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"422","DOI":"10.4014\/jmb.1110.10077","article-title":"<italic>Bupleurum falcatum<\/italic> prevents depression and anxiety-like behaviors in rats exposed to repeated restraint stress","volume":"22","author":"B Lee","year":"2012","journal-title":"Journal of microbiology and biotechnology"},{"issue":"4","key":"ref16","first-page":"200","article-title":"[Differentiation of species of <italic>Bupleurum<\/italic> and its changes]","volume":"43","author":"BL Zhao","year":"2013","journal-title":"Zhonghua Yi Shi Za Zhi"},{"key":"ref17","unstructured":"Defining Dictionary for Medicinal Herbs in Korea Institute of Oriental Medicine. Available online: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/boncho.kiom.re.kr\/codex\/\" xlink:type=\"simple\">http:\/\/boncho.kiom.re.kr\/codex\/<\/ext-link> (accessed on 4 April, 2018). (In Korean) [Internet]."},{"key":"ref18","unstructured":"The Korean Pharmacopoeia. 11th ed: Korea Food and Drug Administration; 2014. p. 64\u20135."},{"key":"ref19","unstructured":"Shanghai:Shanghai Science and Technology Press. 2nd ed: Zhong Yao Da Ci Dian. Nanjing University of Chinese Medicine; 2006. Encyclopedia of Chinese Materia Medica; p. 3029."},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.micinf.2015.01.004","article-title":"How bacterial pathogens colonize their hosts and invade deeper tissues","volume":"17","author":"D Ribet","year":"2015","journal-title":"Microbes Infect"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.cell.2006.01.034","article-title":"Anti-immunology: evasion of the host immune system by bacterial and viral pathogens","volume":"124","author":"BB Finlay","year":"2006","journal-title":"Cell"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1128\/CMR.15.4.716-746.2002","article-title":"Clinical and taxonomic status of pathogenic nonpigmented or late-pigmenting rapidly growing mycobacteria","volume":"15","author":"BA Brown-Elliott","year":"2002","journal-title":"Clinical microbiology reviews"},{"issue":"Pt 10","key":"ref23","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1099\/jmm.0.077164-0","article-title":"<italic>Mycobacterium abscessus<\/italic> infection in cystic fibrosis: molecular typing and clinical outcomes","volume":"63","author":"KA Harris","year":"2014","journal-title":"J Med Microbiol"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.tim.2009.12.007","article-title":"<italic>Mycobacterium abscessus<\/italic>: a new player in the mycobacterial field","volume":"18","author":"H Medjahed","year":"2010","journal-title":"Trends in microbiology"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1097\/QCO.0000000000000104","article-title":"<italic>Mycobacterium abscessus<\/italic>: challenges in diagnosis and treatment","volume":"27","author":"JL Benwill","year":"2014","journal-title":"Curr Opin Infect Dis"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0966-842X(97)01165-7","article-title":"Host cell invasion by <italic>Toxoplasma gondii<\/italic>","volume":"6","author":"JF Dubremetz","year":"1998","journal-title":"Trends in microbiology"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.pt.2010.01.009","article-title":"<italic>Toxoplasma gondii<\/italic>: epidemiology, feline clinical aspects, and prevention","volume":"26","author":"SA Elmore","year":"2010","journal-title":"Trends in parasitology"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"D Tang","year":"2012","journal-title":"Immunological reviews"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00281-012-0339-3","article-title":"Immune response and immunopathology during toxoplasmosis","volume":"34","author":"CD Dupont","year":"2012","journal-title":"Seminars in immunopathology"},{"issue":"9","key":"ref30","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1038\/nri3495","article-title":"Mitogen-activated protein kinases in innate immunity","volume":"13","author":"JS Arthur","year":"2013","journal-title":"Nature reviews Immunology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1146\/annurev-biophys-083012-130338","article-title":"Molecular basis of NF-kappaB signaling","volume":"42","author":"J Napetschnig","year":"2013","journal-title":"Annu Rev Biophys"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1111\/j.1462-5822.2008.01151.x","article-title":"<italic>Mycobacterium abscessus<\/italic> activates the macrophage innate immune response via a physical and functional interaction between TLR2 and dectin-1","volume":"10","author":"DM Shin","year":"2008","journal-title":"Cellular microbiology"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1165\/rcmb.2007-0413OC","article-title":"<italic>Mycobacterium abscessus<\/italic> and <italic>M<\/italic>. <italic>avium<\/italic> trigger Toll-like receptor 2 and distinct cytokine response in human cells","volume":"39","author":"EP Sampaio","year":"2008","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"e0141550","DOI":"10.1371\/journal.pone.0141550","article-title":"Intracellular Networks of the PI3K\/AKT and MAPK Pathways for Regulating <italic>Toxoplasma gondii<\/italic>-Induced IL-23 and IL-12 Production in Human THP-1 Cells","volume":"10","author":"JH Quan","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"6361","DOI":"10.1038\/s41598-017-06610-4","article-title":"NADPH oxidase 4 is required for the generation of macrophage migration inhibitory factor and host defense against <italic>Toxoplasma gondii<\/italic> infection","volume":"7","author":"JH Kim","year":"2017","journal-title":"Scientific reports"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"PD Ray","year":"2012","journal-title":"Cell Signal"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1038\/icb.2008.74","article-title":"Role of apoptosis-regulating signal kinase 1 in innate immune responses by <italic>Mycobacterium bovis<\/italic> bacillus Calmette-Guerin","volume":"87","author":"JM Yuk","year":"2009","journal-title":"Immunol Cell Biol"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1111\/j.1462-5822.2007.01081.x","article-title":"ASK1-p38 MAPK-p47phox activation is essential for inflammatory responses during tuberculosis via TLR2-ROS signalling","volume":"10","author":"CS Yang","year":"2008","journal-title":"Cellular microbiology"},{"issue":"16","key":"ref39","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1136\/vr.116.16.431","article-title":"Guidelines on the recognition of pain, distress and discomfort in experimental animals and an hypothesis for assessment","volume":"116","author":"DB Morton","year":"1985","journal-title":"Vet Rec"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.immuni.2015.07.003","article-title":"Orphan Nuclear Receptor ERRalpha Controls Macrophage Metabolic Signaling and A20 Expression to Negatively Regulate TLR-Induced Inflammation","volume":"43","author":"JM Yuk","year":"2015","journal-title":"Immunity"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1021\/np040080a","article-title":"Structures of new beta-carboline-type alkaloids with antiallergic effects from <italic>Stellaria dichotoma<\/italic>(1,2)","volume":"67","author":"B Sun","year":"2004","journal-title":"J Nat Prod"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/nri3598","article-title":"Innate immunity to <italic>Toxoplasma gondii<\/italic> infection","volume":"14","author":"F. Yarovinsky","year":"2014","journal-title":"Nature reviews Immunology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1146\/annurev.immunol.26.021607.090326","article-title":"Monocyte-mediated defense against microbial pathogens","volume":"26","author":"NV Serbina","year":"2008","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"O Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"225","DOI":"10.4167\/jbv.2011.41.4.225","article-title":"Toll-like Receptors and Innate Immunity. journal of","volume":"41","author":"JM Yuk","year":"2011","journal-title":"Bacteriology and Virology"},{"issue":"1","key":"ref46","first-page":"1","article-title":"Pathophysiological roles of ASK1-MAP kinase signaling pathways","volume":"40","author":"H Nagai","year":"2007","journal-title":"J Biochem Mol Biol"},{"issue":"7","key":"ref47","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1002\/stem.2353","article-title":"A Novel Therapeutic Approach Using Mesenchymal Stem Cells to Protect Against <italic>Mycobacterium abscessus<\/italic>","volume":"34","author":"JS Kim","year":"2016","journal-title":"Stem Cells"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.micinf.2016.09.001","article-title":"<italic>Mycobacterium abscessus<\/italic> ESX-3 plays an important role in host inflammatory and pathological responses during infection","volume":"19","author":"YS Kim","year":"2017","journal-title":"Microbes Infect"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijbiomac.2013.03.043","article-title":"An anti-complementary polysaccharide from the roots of Bupleurum chinense","volume":"58","author":"H Di","year":"2013","journal-title":"Int J Biol Macromol"},{"issue":"S48","key":"ref50","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1002\/ppul.23825","article-title":"Nontuberculous mycobacteria in cystic fibrosis: Updates and the path forward","volume":"52","author":"SL Martiniano","year":"2017","journal-title":"Pediatr Pulmonol"},{"issue":"2S","key":"ref51","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1016\/j.jcf.2017.10.004","article-title":"Inflammation and host-pathogen interaction: Cause and consequence in cystic fibrosis lung disease","volume":"17","author":"A Bragonzi","year":"2018","journal-title":"J Cyst Fibros"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1128\/IAI.00014-07","article-title":"Importance of T cells, gamma interferon, and tumor necrosis factor in immune control of the rapid grower <italic>Mycobacterium abscessus<\/italic> in C57BL\/6 mice","volume":"75","author":"M Rottman","year":"2007","journal-title":"Infection and immunity"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/1074-7613(95)90001-2","article-title":"Tumor necrosis factor-alpha is required in the protective immune response against <italic>Mycobacterium tuberculosis<\/italic> in mice","volume":"2","author":"JL Flynn","year":"1995","journal-title":"Immunity"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"6954","DOI":"10.1128\/IAI.68.12.6954-6961.2000","article-title":"Immunopathologic effects of tumor necrosis factor alpha in murine mycobacterial infection are dose dependent","volume":"68","author":"LG Bekker","year":"2000","journal-title":"Infection and immunity"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"405310","DOI":"10.1155\/2011\/405310","article-title":"Innate immune recognition of <italic>Mycobacterium tuberculosis<\/italic>","volume":"2011","author":"J Kleinnijenhuis","year":"2011","journal-title":"Clin Dev Immunol"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1007\/s10875-013-9978-y","article-title":"<italic>Mycobacterium massiliense<\/italic> induces inflammatory responses in macrophages through Toll-like receptor 2 and c-Jun N-terminal kinase","volume":"34","author":"TS Kim","year":"2014","journal-title":"J Clin Immunol"},{"issue":"8","key":"ref57","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.4049\/jimmunol.167.8.4574","article-title":"Acute toxoplasmosis leads to lethal overproduction of Th1 cytokines","volume":"167","author":"DG Mordue","year":"2001","journal-title":"J Immunol"},{"issue":"4","key":"ref58","doi-asserted-by":"crossref","first-page":"2584","DOI":"10.4049\/jimmunol.177.4.2584","article-title":"<italic>Toxoplasma gondii<\/italic> genotype determines MyD88-dependent signaling in infected macrophages","volume":"177","author":"L Kim","year":"2006","journal-title":"J Immunol"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1111\/j.1462-5822.2007.00914.x","article-title":"Intracellular signalling cascades regulating innate immune responses to Mycobacteria: branching out from Toll-like receptors","volume":"9","author":"EK Jo","year":"2007","journal-title":"Cellular microbiology"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/bs.ircmb.2015.07.004","article-title":"New Insight into the Role of Reactive Oxygen Species (ROS) in Cellular Signal-Transduction Processes","volume":"319","author":"EG Russell","year":"2015","journal-title":"International review of cell and molecular biology"},{"issue":"6","key":"ref61","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1038\/ni1200","article-title":"ROS-dependent activation of the TRAF6-ASK1-p38 pathway is selectively required for TLR4-mediated innate immunity","volume":"6","author":"A Matsuzawa","year":"2005","journal-title":"Nature immunology"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1128\/IAI.72.4.2123-2130.2004","article-title":"Reactive oxygen and nitrogen species differentially regulate Toll-like receptor 4-mediated activation of NF-kappa B and interleukin-8 expression","volume":"72","author":"KA Ryan","year":"2004","journal-title":"Infection and immunity"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0207696","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:59:04Z","timestamp":1589011144000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0207696"}},"subtitle":[],"editor":[{"given":"Thomas A.","family":"Kufer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,19]]},"references-count":62,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0207696","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,19]]}}}