{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T01:54:10Z","timestamp":1790214850711,"version":"4.1.0"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T00:00:00Z","timestamp":1543795200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008672","name":"Wilhelm Sander-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008672","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KFO-262 P10"],"award-info":[{"award-number":["KFO-262 P10"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0207858","type":"journal-article","created":{"date-parts":[[2018,12,3]],"date-time":"2018-12-03T18:24:35Z","timestamp":1543861475000},"page":"e0207858","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Use of statins or NSAIDs and survival of patients with high-grade glioma"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4923-4495","authenticated-orcid":true,"given":"Corinna","family":"Seliger","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Schaertl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gerken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Luber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Proescholdt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus J.","family":"Riemenschneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael F.","family":"Leitzmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Hau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Klinkhammer-Schalke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,3]]},"reference":[{"issue":"10","key":"ref1","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1056\/NEJMoa043330","article-title":"Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma","volume":"352","author":"R Stupp","year":"2005","journal-title":"The New England journal of medicine"},{"key":"ref2","article-title":"WHO Classification of Tumours of the Central Nervous System","author":"OH Louis DN","year":"2016"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1056\/NEJMoa043331","article-title":"MGMT gene silencing and benefit from temozolomide in glioblastoma","volume":"352","author":"ME Hegi","year":"2005","journal-title":"The New England journal of medicine"},{"issue":"6 Suppl 19","key":"ref4","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1053\/j.seminoncol.2003.11.031","article-title":"Factors influencing survival in high-grade gliomas","volume":"30","author":"JC Buckner","year":"2003","journal-title":"Seminars in oncology"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11060-011-0676-4","article-title":"Type 2 diabetes mellitus and obesity are independent risk factors for poor outcome in patients with high-grade glioma","volume":"106","author":"LB Chambless","year":"2012","journal-title":"Journal of neuro-oncology"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tips.2013.06.005","article-title":"Cancer drug discovery by repurposing: teaching new tricks to old dogs","volume":"34","author":"SC Gupta","year":"2013","journal-title":"Trends in pharmacological sciences"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.phrs.2014.11.006","article-title":"Lovastatin and perillyl alcohol inhibit glioma cell invasion, migration, and proliferation\u2014impact of Ras-\/Rho-prenylation","volume":"91","author":"S Afshordel","year":"2015","journal-title":"Pharmacol Res"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s11060-007-9475-3","article-title":"Lovastatin sensitized human glioblastoma cells to TRAIL-induced apoptosis","volume":"86","author":"DY Chan","year":"2008","journal-title":"Journal of neuro-oncology"},{"issue":"2\u20133","key":"ref9","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.neulet.2004.08.020","article-title":"Simvastatin induces proliferation inhibition and apoptosis in C6 glioma cells via c-jun N-terminal kinase","volume":"370","author":"M Koyuturk","year":"2004","journal-title":"Neuroscience letters"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0304-3835(02)00278-1","article-title":"Inhibition of migration of human glioblastoma cells by cerivastatin in association with focal adhesion kinase (FAK)","volume":"185","author":"S Obara","year":"2002","journal-title":"Cancer letters"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/s004010000254","article-title":"Lovastatin and phenylacetate induce apoptosis, but not differentiation, in human malignant glioma cells","volume":"101","author":"F Schmidt","year":"2001","journal-title":"Acta neuropathologica"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1756-9966-30-74","article-title":"Statin-induced apoptosis via the suppression of ERK1\/2 and Akt activation by inhibition of the geranylgeranyl-pyrophosphate biosynthesis in glioblastoma","volume":"30","author":"M Yanae","year":"2011","journal-title":"J Exp Clin Cancer Res"},{"issue":"4","key":"ref13","first-page":"2761","article-title":"Inhibition of Ras farnesylation by lovastatin leads to downregulation of proliferation and migration in primary cultured human glioblastoma cells","volume":"20","author":"HL Bouterfa","year":"2000","journal-title":"Anticancer research"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1006\/bbrc.1994.2861","article-title":"Lovastatin induces growth inhibition and apoptosis in human malignant glioma cells","volume":"205","author":"KD Jones","year":"1994","journal-title":"Biochemical and biophysical research communications"},{"issue":"4B","key":"ref15","first-page":"2547","article-title":"Celecoxib increased expression of 14-3-3sigma and induced apoptosis of glioma cells","volume":"27","author":"JC Chen","year":"2007","journal-title":"Anticancer research"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neulet.2008.07.014","article-title":"TRAIL-mediated apoptosis in malignant glioma cells is augmented by celecoxib through proteasomal degradation of survivin","volume":"442","author":"T Gaiser","year":"2008","journal-title":"Neuroscience letters"},{"issue":"1","key":"ref17","first-page":"7","article-title":"Combination celecoxib and temozolomide in C6 rat glioma orthotopic model","volume":"15","author":"SG Kang","year":"2006","journal-title":"Oncology reports"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.4161\/cbt.3.1.571","article-title":"Differential effects of selective COX-2 inhibitors on cell cycle regulation and proliferation of glioblastoma cell lines","volume":"3","author":"A Kardosh","year":"2004","journal-title":"Cancer biology & therapy"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"651","DOI":"10.3171\/2009.11.JNS091396","article-title":"Celecoxib and radioresistant glioblastoma-derived CD133+ cells: improvement in radiotherapeutic effects. Laboratory investigation","volume":"114","author":"HI Ma","year":"2013","journal-title":"Journal of neurosurgery"},{"issue":"2","key":"ref20","first-page":"263","article-title":"Intracranial inhibition of glioma cell growth by cyclooxygenase-2 inhibitor celecoxib","volume":"11","author":"DH Nam","year":"2004","journal-title":"Oncology reports"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/s11060-011-0662-x","article-title":"The nonsteroidal anti-inflammatory drug celecoxib suppresses the growth and induces apoptosis of human glioblastoma cells via the NF-kappaB pathway","volume":"106","author":"GR Sareddy","year":"2012","journal-title":"Journal of neuro-oncology"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.neuint.2011.06.018","article-title":"COX-2 regulates the proliferation of glioma stem like cells","volume":"59","author":"V Sharma","year":"2011","journal-title":"Neurochemistry international"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1093\/neuonc\/not062","article-title":"Celecoxib enhances radiosensitivity of hypoxic glioblastoma cells through endoplasmic reticulum stress","volume":"15","author":"K Suzuki","year":"2013","journal-title":"Neuro-oncology"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1002\/ijc.27712","article-title":"Diclofenac inhibits lactate formation and efficiently counteracts local immune suppression in a murine glioma model","volume":"132","author":"SR Chirasani","year":"2013","journal-title":"International journal of cancer"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"e66987","DOI":"10.1371\/journal.pone.0066987","article-title":"New aspects of an old drug\u2014diclofenac targets MYC and glucose metabolism in tumor cells","volume":"8","author":"E Gottfried","year":"2013","journal-title":"PloS one"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"e0140613","DOI":"10.1371\/journal.pone.0140613","article-title":"Ibuprofen and Diclofenac Restrict Migration and Proliferation of Human Glioma Cells by Distinct Molecular Mechanisms","volume":"10","author":"V Leidgens","year":"2015","journal-title":"PloS one"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.canep.2014.09.010","article-title":"Statin use and survival following glioblastoma multiforme","volume":"38","author":"D Gaist","year":"2014","journal-title":"Cancer epidemiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.jocn.2016.03.010","article-title":"Preoperative statin use is not associated with improvement in survival after glioblastoma surgery","volume":"31","author":"S Bhavsar","year":"2016","journal-title":"J Clin Neurosci"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s11060-018-2786-8","article-title":"Do statins, ACE inhibitors or sartans improve outcome in primary glioblastoma?","volume":"138","author":"C Happold","year":"2018","journal-title":"Journal of neuro-oncology"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s11060-015-1834-x","article-title":"Metronomic chemotherapy with daily low-dose temozolomide and celecoxib in elderly patients with newly diagnosed glioblastoma multiforme: a retrospective analysis","volume":"124","author":"G Welzel","year":"2015","journal-title":"Journal of neuro-oncology"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1002\/pbc.25045","article-title":"Radiation therapy and concurrent topotecan followed by maintenance triple anti-angiogenic therapy with thalidomide, etoposide, and celecoxib for pediatric diffuse intrinsic pontine glioma","volume":"61","author":"M Porkholm","year":"2014","journal-title":"Pediatric blood & cancer"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1007\/s11060-010-0192-y","article-title":"Continuous low-dose temozolomide and celecoxib in recurrent glioblastoma","volume":"100","author":"F Stockhammer","year":"2010","journal-title":"Journal of neuro-oncology"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1002\/cncr.20776","article-title":"Phase II trial of irinotecan plus celecoxib in adults with recurrent malignant glioma","volume":"103","author":"DA Reardon","year":"2005","journal-title":"Cancer"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1093\/neuonc\/nou155","article-title":"Randomized phase II adjuvant factorial study of dose-dense temozolomide alone and in combination with isotretinoin, celecoxib, and\/or thalidomide for glioblastoma","volume":"17","author":"M Penas-Prado","year":"2015","journal-title":"Neuro-oncology"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1215\/15228517-2008-005","article-title":"Phase II study of temozolomide, thalidomide, and celecoxib for newly diagnosed glioblastoma in adults","volume":"10","author":"S Kesari","year":"2008","journal-title":"Neuro-oncology"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1215\/15228517-2007-006","article-title":"Phase II study of metronomic chemotherapy for recurrent malignant gliomas in adults","volume":"9","author":"S Kesari","year":"2007","journal-title":"Neuro-oncology"},{"key":"ref37","unstructured":"Krebs in Deutschland 2011\/ 12. 10. Ausgabe. Robert Koch-Institut (Hrsg) und die Gesellschaft der epidemiologischen Krebsregister in Deutschland e.V. (Hrsg). Berlin, 2015."},{"issue":"13","key":"ref38","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1080\/15384101.2016.1186316","article-title":"Metformin inhibits proliferation and migration of glioblastoma cells independently of TGF-beta2","volume":"15","author":"C Seliger","year":"2016","journal-title":"Cell cycle"},{"issue":"19","key":"ref39","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1056\/NEJMoa1201735","article-title":"Statin use and reduced cancer-related mortality","volume":"367","author":"SF Nielsen","year":"2012","journal-title":"The New England journal of medicine"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1227\/01.NEU.0000360130.52812.1D","article-title":"Effect of simvastatin on glioma cell proliferation, migration, and apoptosis","volume":"65","author":"H Wu","year":"2009","journal-title":"Neurosurgery"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10143-003-0258-9","article-title":"Migration, proliferation, and invasion of human glioma cells following treatment with simvastatin","volume":"26","author":"J Gliemroth","year":"2003","journal-title":"Neurosurgical review"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1006\/bbrc.1994.1570","article-title":"PKC activity in rat C6 glioma cells: changes associated with cell cycle and simvastatin treatment","volume":"200","author":"MR Soma","year":"1994","journal-title":"Biochemical and biophysical research communications"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1471-4159.2004.02319.x","article-title":"Lovastatin-induced up-regulation of the BH3-only protein, Bim, and cell death in glioblastoma cells","volume":"89","author":"Z Jiang","year":"2004","journal-title":"Journal of neurochemistry"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s40256-015-0139-y","article-title":"Meta-Analyses of Statin Therapy for Primary Prevention Do Not Answer Key Questions: An Empirical Appraisal of 5 Years of Statin Meta-Analyses","volume":"15","author":"C Huded","year":"2015","journal-title":"Am J Cardiovasc Drugs"},{"issue":"11","key":"ref45","first-page":"4375","article-title":"Cyclooxygenase-2 expression in human gliomas: prognostic significance and molecular correlations","volume":"61","author":"T Shono","year":"2001","journal-title":"Cancer research"},{"issue":"7","key":"ref46","doi-asserted-by":"crossref","first-page":"4352","DOI":"10.4049\/jimmunol.173.7.4352","article-title":"Induction of a CD4+ T regulatory type 1 response by cyclooxygenase-2-overexpressing glioma","volume":"173","author":"Y Akasaki","year":"2004","journal-title":"J Immunol"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1073\/pnas.1612920114","article-title":"COX2\/mPGES1\/PGE2 pathway regulates PD-L1 expression in tumor-associated macrophages and myeloid-derived suppressor cells","volume":"114","author":"V Prima","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref48","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1158\/1055-9965.EPI-07-2621","article-title":"Long-term anti-inflammatory and antihistamine medication use and adult glioma risk","volume":"17","author":"ME Scheurer","year":"2008","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1093\/aje\/kwh153","article-title":"Case-control study of use of nonsteroidal antiinflammatory drugs and glioblastoma multiforme","volume":"159","author":"NR Sivak-Sears","year":"2004","journal-title":"American journal of epidemiology"},{"issue":"12","key":"ref50","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1158\/1940-6207.CAPR-11-0274","article-title":"Nonsteroidal anti-inflammatory drugs and glioma in the NIH-AARP Diet and Health Study cohort","volume":"4","author":"SE Daugherty","year":"2011","journal-title":"Cancer Prev Res (Phila)"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"e0149293","DOI":"10.1371\/journal.pone.0149293","article-title":"Use of Selective Cyclooxygenase-2 Inhibitors, Other Analgesics, and Risk of Glioma","volume":"11","author":"C Seliger","year":"2016","journal-title":"PloS one"},{"issue":"6","key":"ref52","doi-asserted-by":"crossref","first-page":"E1031","DOI":"10.1002\/ijc.27536","article-title":"HMG CoA reductase inhibitors, NSAIDs and risk of glioma","volume":"131","author":"JS Ferris","year":"2012","journal-title":"International journal of cancer"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"1189","DOI":"10.1038\/bjc.2013.87","article-title":"Use of low-dose aspirin and non-aspirin nonsteroidal anti-inflammatory drugs and risk of glioma: a case-control study","volume":"108","author":"D Gaist","year":"2013","journal-title":"British journal of cancer"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.jmgm.2012.12.013","article-title":"Mechanism of the irreversible inhibition of human cyclooxygenase-1 by aspirin as predicted by QM\/MM calculations","volume":"40","author":"L Toth","year":"2013","journal-title":"J Mol Graph Model"},{"issue":"9759","key":"ref55","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0140-6736(10)62110-1","article-title":"Effect of daily aspirin on long-term risk of death due to cancer: analysis of individual patient data from randomised trials","volume":"377","author":"PM Rothwell","year":"2011","journal-title":"Lancet"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.ejca.2018.06.029","article-title":"Associations of anticoagulant use with outcome in newly diagnosed glioblastoma","volume":"101","author":"E Le Rhun","year":"2018","journal-title":"Eur J Cancer"},{"issue":"8","key":"ref57","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1055\/s-0036-1592334","article-title":"Venous Thromboembolism in Patients with High-Grade Glioma","volume":"42","author":"DJ Cote","year":"2016","journal-title":"Seminars in thrombosis and hemostasis"},{"issue":"7","key":"ref58","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1080\/14737175.2016.1181542","article-title":"A critical balance: managing coagulation in patients with glioma","volume":"16","author":"ER Morgan","year":"2016","journal-title":"Expert review of neurotherapeutics"},{"issue":"8","key":"ref59","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7326\/0003-4819-147-8-200710160-00004","article-title":"Effect of low-dose aspirin on the occurrence of venous thromboembolism: a randomized trial","volume":"147","author":"RJ Glynn","year":"2007","journal-title":"Annals of internal medicine"},{"issue":"7","key":"ref60","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1161\/STR.0000000000000024","article-title":"Guidelines for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline for healthcare professionals from the American Heart Association\/American Stroke Association","volume":"45","author":"WN Kernan","year":"2014","journal-title":"Stroke"},{"issue":"7","key":"ref61","doi-asserted-by":"crossref","DOI":"10.3390\/cancers9070094","article-title":"Targeting Platelets for the Treatment of Cancer","volume":"9","author":"O Elaskalani","year":"2017","journal-title":"Cancers"},{"issue":"1","key":"ref62","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/cam4.46","article-title":"Preventive effects of low-dose aspirin on colorectal adenoma growth in patients with familial adenomatous polyposis: double-blind, randomized clinical trial","volume":"2","author":"H Ishikawa","year":"2013","journal-title":"Cancer medicine"},{"issue":"6","key":"ref63","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1001\/jama.2009.1112","article-title":"Aspirin use and survival after diagnosis of colorectal cancer","volume":"302","author":"AT Chan","year":"2009","journal-title":"Jama"},{"issue":"9809","key":"ref64","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/S0140-6736(11)61049-0","article-title":"Long-term effect of aspirin on cancer risk in carriers of hereditary colorectal cancer: an analysis from the CAPP2 randomised controlled trial","volume":"378","author":"J Burn","year":"2011","journal-title":"Lancet"},{"issue":"11","key":"ref65","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1158\/1055-9965.EPI-15-0452","article-title":"Aspirin use and risk of breast cancer: systematic review and meta-analysis of observational studies","volume":"24","author":"S Zhong","year":"2015","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s13045-014-0065-5","article-title":"Lower circulating platelet counts and antiplatelet therapy independently predict better outcomes in patients with head and neck squamous cell carcinoma","volume":"7","author":"S Rachidi","year":"2014","journal-title":"Journal of hematology & oncology"},{"issue":"2","key":"ref67","doi-asserted-by":"crossref","first-page":"R34","DOI":"10.1186\/bcr3638","article-title":"Post-diagnostic prescriptions for low-dose aspirin and breast cancer-specific survival: a nested case-control study in a breast cancer cohort from the UK Clinical Practice Research Datalink","volume":"16","author":"LJ Murray","year":"2014","journal-title":"Breast Cancer Res"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1471-2407-14-391","article-title":"Aspirin intake and breast cancer survival\u2014a nation-wide study using prospectively recorded data in Sweden","volume":"14","author":"MD Holmes","year":"2014","journal-title":"BMC cancer"},{"issue":"3","key":"ref69","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1215\/15228517-2007-013","article-title":"Preoperative thrombocytosis predicts poor survival in patients with glioblastoma","volume":"9","author":"MA Brockmann","year":"2007","journal-title":"Neuro-oncology"},{"issue":"Pt 5","key":"ref70","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1093\/brain\/aww046","article-title":"Corticosteroids compromise survival in glioblastoma","volume":"139","author":"KL Pitter","year":"2016","journal-title":"Brain"},{"issue":"5","key":"ref71","doi-asserted-by":"crossref","first-page":"338","DOI":"10.47102\/annals-acadmedsg.V36N5p338","article-title":"Improved median survival for glioblastoma multiforme following introduction of adjuvant temozolomide chemotherapy","volume":"36","author":"MF Back","year":"2007","journal-title":"Ann Acad Med Singapore"},{"issue":"11","key":"ref72","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1038\/bjc.2015.404","article-title":"Dexamethasone exerts profound immunologic interference on treatment efficacy for recurrent glioblastoma","volume":"113","author":"ET Wong","year":"2015","journal-title":"British journal of cancer"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0207858","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T23:50:33Z","timestamp":1720828233000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0207858"}},"subtitle":[],"editor":[{"given":"Helen","family":"Fillmore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,3]]},"references-count":72,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0207858","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,3]]}}}