{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T19:41:57Z","timestamp":1790710917927,"version":"4.1.0"},"reference-count":46,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T00:00:00Z","timestamp":1544054400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0207950","type":"journal-article","created":{"date-parts":[[2018,12,6]],"date-time":"2018-12-06T22:27:24Z","timestamp":1544135244000},"page":"e0207950","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Human bone marrow contains high levels of extracellular vesicles with a tissue-specific subtype distribution"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5636-0043","authenticated-orcid":true,"given":"Andreas","family":"Rank","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rienk","family":"Nieuwland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anton","family":"K\u00f6hler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cordula","family":"Franz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Waidhauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bettina","family":"Toth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/S0021-9258(17)34997-9","article-title":"The biological significance of the thromboplastic protein of blood","volume":"166","author":"E Chargaff","year":"1946","journal-title":"J Biol Chem"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0008-6363(03)00367-5","article-title":"Microparticles in cardiovascular diseases","volume":"59","author":"MJ VanWijk","year":"2003","journal-title":"Cardiovasc Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3791","DOI":"10.1182\/blood.V94.11.3791","article-title":"Activated platelets release two types of membrane vesicles: microvesicles by surface shedding and exosomes derived from exocytosis of multivesicular bodies and alpha-granules","volume":"94","author":"HF Heijnen","year":"1999","journal-title":"Blood"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1067\/mob.2002.124279","article-title":"Microparticle subpopulations are increased in pre-eclampsia: possible involvement in vascular dysfunction?","volume":"187","author":"JM Van Wijk","year":"2002","journal-title":"Am J Obstet Gynecol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.exer.2018.07.003","article-title":"Molecular and functional characterization of circulating extracellular vesicles from diabetic patients with and without retinopathy and healthy subjects","volume":"176","author":"A Mazzeo","year":"2018","journal-title":"Exp Eye Res"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1161\/01.HYP.0000049760.15764.2D","article-title":"Effects of severe hypertension on endothelial and platelet microparticles","volume":"41","author":"RA Preston","year":"2003","journal-title":"Hypertension"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1080\/09537104.2016.1254174","article-title":"Platelet extracellular vesicles as biomarkers for arterial thrombosis","volume":"28","author":"A Gasecka","year":"2017","journal-title":"Platelets"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1055\/s-0037-1615753","article-title":"Microparticles from patients with multiple organ dysfunction syndrome and sepsis support coagulation through multiple mechanisms","volume":"85","author":"K Joop","year":"2001","journal-title":"Thromb Haemost"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"17279","DOI":"10.18632\/oncotarget.13973","article-title":"Tumour-derived exosomes as a signature of pancreatic cancer\u2014liquid biopsies as indicators of tumour progression","volume":"8","author":"Z Nuzhat","year":"2017","journal-title":"Oncotarget"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/ncb3169","article-title":"Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver","author":"B Costa-Silva","year":"2015","journal-title":"Nat Cell Biol"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1056\/NEJMra1704286","article-title":"Circulating Extracellular Vesicles in Human Disease","volume":"379","author":"R Shah","year":"2018","journal-title":"NEJM"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1002\/hep.29291","article-title":"Serum extracellular vesicles contain protein biomarkers for primary sclerosing cholangitis and cholangiocarcinoma","volume":"66","author":"A Arbelaiz","year":"2017","journal-title":"Hepatology"},{"issue":"46","key":"ref13","doi-asserted-by":"crossref","first-page":"80666","DOI":"10.18632\/oncotarget.20881","article-title":"Exosomal miR-665 as a novel minimally invasive biomarker for hepatocellular carcinoma diagnosis and prognosis","volume":"8","author":"Z Qu","year":"2017","journal-title":"Oncotarget"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1016\/j.jtho.2016.05.034","article-title":"Exosomal Proteins as Diagnostic Biomarkers in Lung Cancer","volume":"11","author":"B Sandfeld-Paulsen","year":"2016","journal-title":"J Thorac Oncol"},{"issue":"31","key":"ref15","doi-asserted-by":"crossref","first-page":"50365","DOI":"10.18632\/oncotarget.10395","article-title":"Microvesicle removal of anticancer drugs contributes to drug resistance in human pancreatic cancer cells","volume":"7","author":"V Muralidharan-Chari","year":"2016","journal-title":"Oncotarget"},{"issue":"14","key":"ref16","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1089\/neu.2012.2596","article-title":"More than cell dust: microparticles isolated from cerebrospinal fluid of brain injured patients are messengers carrying mRNAs, miRNAs, and proteins","volume":"30","author":"S Patz","year":"2013","journal-title":"J Neurotrauma"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"e49726","DOI":"10.1371\/journal.pone.0049726","article-title":"Improved flow cytometric assessment reveals distinct microvesicle (cell-derived microparticle) signatures in joint diseases","volume":"7","author":"B Gy\u00f6rgy","year":"2012","journal-title":"PLoS One"},{"key":"ref18","first-page":"639","article-title":"Romijn FPHTM, Hack CE, Sturk A. Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation","volume":"83","author":"RJ Berckmans","year":"2001","journal-title":"Thromb Haemost"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1161\/01.CIR.96.10.3534","article-title":"Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant","volume":"96","author":"R Nieuwland","year":"1997","journal-title":"Circulation"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/nar\/gkp857","article-title":"Mesenchymal stem cell secretes microparticles enriched in pre-microRNAs","volume":"38","author":"TS Chen","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"96","key":"ref21","doi-asserted-by":"crossref","first-page":"3534","DOI":"10.1161\/01.CIR.96.10.3534","article-title":"Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant","author":"R Nieuwland","year":"1997","journal-title":"Circulation"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"2561","DOI":"10.1046\/j.1538-7836.2003.00456.x","article-title":"Human cell-derived microparticles promote thrombus formation in vivo in a tissue factor-dependent manner","author":"E Biro","year":"2003","journal-title":"J Thromb Haemost"},{"issue":"29","key":"ref23","doi-asserted-by":"crossref","first-page":"17049","DOI":"10.1016\/S0021-9258(18)71457-9","article-title":"Assembly of the platelet prothrombinase complex is linked to vesiculation of the platelet plasma membrane. Studies in Scott syndrome: an isolated defect in platelet procoagulant activity","volume":"264","author":"PJ Sims","year":"1989","journal-title":"J Biol Chem"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0741-5214(03)01033-4","article-title":"P-selectin and leu- kocyte microparticles are associated with ve- nous thrombogenesis","volume":"38","author":"DD Myers","year":"2003","journal-title":"J Vasc Surg"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1182\/blood-2007-10-117051","article-title":"The incidence of and risk factors for venous thromboembolism (VTE) and bleeding among 1514 patients undergoing hematopoietic stem cell transplantation: implications for VTE prevention","volume":"112","author":"DE Gerber","year":"2008","journal-title":"Blood"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1097\/00007890-200211150-00018","article-title":"Hemostatic complications in bone marrow transplantation: a retrospective analysis of 447 patients","volume":"74","author":"R Pihusch","year":"2002","journal-title":"Transplantation"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bcmd.2005.04.008","article-title":"Exosome release by reticulocytes\u2014an integral part of the red cell differentiation system","volume":"35","author":"L. Blanc","year":"2005","journal-title":"Blood Cells Mol. Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1537-2995.2006.00692.x","article-title":"The how and why of exocytic vesicles","volume":"46","author":"T.J. Greenwalt","year":"2006","journal-title":"Transfusion"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.3324\/haematol.2009.008938","article-title":"CURAMA study group. Circulating erythrocyte-derived microparticles are associated with coagulation activation in sickle cell disease","volume":"94","author":"EJ van Beers","year":"2009","journal-title":"Haematologica"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1080\/10641950801955733","article-title":"Changes in microparticle numbers and cellular origin during pregnancy and preeclampsia","volume":"27","author":"CA Lok","year":"2008","journal-title":"Hypertens Pregnancy"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1097\/TP.0b013e318221d3e9","article-title":"Microparticles for diagnosis of graft-versus-host disease after allogeneic stem transplantation","volume":"92","author":"A Rank","year":"2011","journal-title":"Transplantation"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1080\/01926230600939856","article-title":"Normal Structure, Function, and Histology of the Bone Marrow","volume":"34","author":"GS Travlos","year":"2006","journal-title":"Toxicol Pathol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1182\/blood.V89.7.2336","article-title":"Ultrastructure of platelet formation by human megakaryocytes cultured with the Mpl ligand","volume":"89","author":"EM Cramer","year":"1997","journal-title":"Blood"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1016\/j.yexcr.2008.09.020","article-title":"Trafficking and function of the tetraspanin CD63","volume":"315","author":"MS Pols","year":"2009","journal-title":"Exp Cell Res"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/j.1600-0854.2006.00515.x","article-title":"Tetraspanins as regulators of protein trafficking","volume":"8","author":"F Berditchevski","year":"2007","journal-title":"Traffic"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.1161\/01.ATV.0000249639.36915.04","article-title":"Circulating leukocyte-derived microparticles predict subclinical atherosclerosis burden in asymptomatic subjects","volume":"26","author":"G Chironi","year":"2006","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1093\/ndt\/gfr748","article-title":"Microparticle generation and leucocyte death in Shiga toxin-mediated HUS","volume":"27","author":"S Ge","year":"2012","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/S0049-3848(03)00064-1","article-title":"Endothelial cells release phenotypically and quantitatively distinct microparticles in activation and apoptosis","volume":"109","author":"JJ Jimenez","year":"2003","journal-title":"Thromb Res"},{"issue":"42","key":"ref39","doi-asserted-by":"crossref","first-page":"2972","DOI":"10.1093\/eurheartj\/ehu153","article-title":"Association of circulating endothelial microparticles with cardiometabolic risk factors in the Framingham Heart Study","volume":"35","author":"N Amabile","year":"2014","journal-title":"Eur Heart J"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1093\/rheumatology\/ken373","article-title":"Diagnostic role of endothelial microparticles in vasculitis","volume":"47","author":"U Erdbruegger","year":"2008","journal-title":"Rheumatology (Oxford)"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12933-016-0367-8","article-title":"Vascular endothelial microparticles-incorporated microRNAs are altered in patients with diabetes mellitus","volume":"15","author":"F Jansen","year":"2016","journal-title":"Cardiovasc Diabetol"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1177\/0003319714546183","article-title":"Circulating Endothelial Cells and Platelet Microparticles in Mitral Valve Disease With and Without Atrial Fibrillation","volume":"66","author":"NK Idriss","year":"2015","journal-title":"Angiology"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1046\/j.1365-2141.2001.02516.x","article-title":"Elevated endothelial microparticles in thrombotic thrombocytopenic purpura: findings from brain and renal microvascular cell culture and patients with active disease","volume":"112","author":"JJ Jimenez","year":"2001","journal-title":"Br J Haematol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1477-9560-7-11","article-title":"Plasma TF activity predicts cardiovascular mortality in patients with acute myocardial infarction","volume":"7","author":"BA Steppich","year":"2009","journal-title":"Thromb J"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.arcmed.2012.01.006","article-title":"Number of microparticles generated during acute myocardial infarction and stable angina correlates with platelet activation","volume":"43","author":"E Stepien","year":"2012","journal-title":"Arch Med Res"},{"issue":"6","key":"ref46","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1111\/jth.14009","article-title":"Standardization of extracellular vesicle measurements by flow cytometry through vesicle diameter approximation","volume":"16","author":"E van der Pol","year":"2018","journal-title":"J Thromb Haemost"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0207950","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,7]],"date-time":"2022-09-07T20:20:53Z","timestamp":1662582053000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0207950"}},"subtitle":[],"editor":[{"given":"Graca D.","family":"Almeida-Porada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,6]]},"references-count":46,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0207950","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,6]]}}}