{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:13:58Z","timestamp":1790021638858,"version":"4.0.1"},"reference-count":93,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T00:00:00Z","timestamp":1543968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM077402"],"award-info":[{"award-number":["GM077402"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0208151","type":"journal-article","created":{"date-parts":[[2018,12,5]],"date-time":"2018-12-05T13:41:53Z","timestamp":1544017313000},"page":"e0208151","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Comparative genomics of transport proteins in seven Bacteroides species"],"prefix":"10.1371","volume":"13","author":[{"given":"Hassan","family":"Zafar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5530-0017","authenticated-orcid":true,"given":"Milton H.","family":"Saier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,5]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1128\/CMR.00008-07","article-title":"Bacteroides: the good, the bad, and the nitty-gritty","volume":"20","author":"HM Wexler","year":"2007","journal-title":"Clin Microbiol Rev"},{"issue":"5728","key":"ref2","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.1126\/science.1110591","article-title":"Diversity of the human intestinal microbial flora","volume":"308","author":"PB Eckburg","year":"2005","journal-title":"Science"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1099\/0022-1317-49-9-827","article-title":"Aerobic and anaerobic microbiology in intra-abdominal infections associated with diverticulitis","volume":"49","author":"I Brook","year":"2000","journal-title":"J Med Microbiol"},{"issue":"6053","key":"ref4","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1126\/science.1209791","article-title":"The antibacterial lectin RegIIIgamma promotes the spatial segregation of microbiota and host in the intestine","volume":"334","author":"S Vaishnava","year":"2011","journal-title":"Science"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s10534-013-9650-2","article-title":"Ferritin-like family proteins in the anaerobe Bacteroides fragilis: when an oxygen storm is coming, take your iron to the shelter","volume":"26","author":"ER Rocha","year":"2013","journal-title":"Biometals"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"17026","DOI":"10.1038\/nmicrobiol.2017.26","article-title":"An insider's perspective: Bacteroides as a window into the microbiome","volume":"2","author":"AG Wexler","year":"2017","journal-title":"Nat Microbiol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1146\/annurev.nutr.22.011602.092259","article-title":"How host-microbial interactions shape the nutrient environment of the mammalian intestine","volume":"22","author":"LV Hooper","year":"2002","journal-title":"Annu Rev Nutr"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1016\/j.chom.2008.09.007","article-title":"Mucosal glycan foraging enhances fitness and transmission of a saccharolytic human gut bacterial symbiont","volume":"4","author":"EC Martens","year":"2008","journal-title":"Cell Host Microbe"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1128\/MMBR.69.4.608-634.2005","article-title":"Comparative genomic analyses of the bacterial phosphotransferase system","volume":"69","author":"RD Barabote","year":"2005","journal-title":"Microbiol Mol Biol Rev"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1128\/JB.187.3.890-901.2005","article-title":"Characterization of the RokA and HexA broad-substrate-specificity hexokinases from Bacteroides fragilis and their role in hexose and N-acetylglucosamine utilization","volume":"187","author":"CJ Brigham","year":"2005","journal-title":"J Bacteriol"},{"key":"ref11","first-page":"71","article-title":"Transport proteins promoting Escherichia coli pathogenesis","author":"F Tang","year":"2014","journal-title":"Microb Pathog"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.micpath.2017.03.022","article-title":"Comparative genomics of transport proteins in probiotic and pathogenic Escherichia coli and Salmonella enterica strains","volume":"107","author":"J Do","year":"2017","journal-title":"Microb Pathog"},{"issue":"6256","key":"ref13","doi-asserted-by":"crossref","first-page":"aac5992","DOI":"10.1126\/science.aac5992","article-title":"Genetic determinants of in vivo fitness and diet responsiveness in multiple human gut Bacteroides","volume":"350","author":"M Wu","year":"2015","journal-title":"Science"},{"issue":"41","key":"ref14","doi-asserted-by":"crossref","first-page":"14919","DOI":"10.1073\/pnas.0404172101","article-title":"Genomic analysis of Bacteroides fragilis reveals extensive DNA inversions regulating cell surface adaptation","volume":"101","author":"T Kuwahara","year":"2004","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"191","DOI":"10.4056\/sigs.1704212","article-title":"Complete genome sequence of Bacteroides salanitronis type strain (BL78)","volume":"4","author":"S Gronow","year":"2011","journal-title":"Stand Genomic Sci"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"e156","DOI":"10.1371\/journal.pbio.0050156","article-title":"Evolution of symbiotic bacteria in the distal human intestine","volume":"5","author":"J Xu","year":"2007","journal-title":"PLoS Biol"},{"issue":"11","key":"ref17","doi-asserted-by":"crossref","first-page":"2036","DOI":"10.1111\/j.1742-4658.2012.08590.x","article-title":"BioV Suite\u2014a collection of programs for the study of transport protein evolution","volume":"279","author":"VS Reddy","year":"2012","journal-title":"FEBS J"},{"issue":"1","key":"ref18","first-page":"19","article-title":"Transmembrane topology prediction methods: a re-assessment and improvement by a consensus method using a dataset of experimentally-characterized transmembrane topologies","volume":"2","author":"M Ikeda","year":"2002","journal-title":"In Silico Biol"},{"issue":"4","key":"ref19","first-page":"501","article-title":"A web-based program (WHAT) for the simultaneous prediction of hydropathy, amphipathicity, secondary structure and transmembrane topology for a single protein sequence","volume":"3","author":"Y Zhai","year":"2001","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17040599","article-title":"In Silico Structure and Sequence Analysis of Bacterial Porins and Specific Diffusion Channels for Hydrophilic Molecules: Conservation, Multimericity and Multifunctionality","volume":"17","author":"HS Vollan","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"e0152733","DOI":"10.1371\/journal.pone.0152733","article-title":"Properties and Phylogeny of 76 Families of Bacterial and Eukaryotic Organellar Outer Membrane Pore-Forming Proteins","volume":"11","author":"BL Reddy","year":"2016","journal-title":"PLoS One"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/JB.02046-14","article-title":"Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications","volume":"197","author":"MH Saier Jr.","year":"2015","journal-title":"J Bacteriol"},{"issue":"2\u20134","key":"ref23","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1159\/000091558","article-title":"Sodium ion pumps and hydrogen production in glutamate fermenting anaerobic bacteria","volume":"10","author":"CD Boiangiu","year":"2005","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"e10935","DOI":"10.1371\/journal.pone.0010935","article-title":"Structure-function relations in oxaloacetate decarboxylase complex. Fluorescence and infrared approaches to monitor oxomalonate and Na(+) binding effect","volume":"5","author":"T Granjon","year":"2010","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.micpath.2015.07.019","article-title":"Comparative genomic analyses of transport proteins encoded within the genomes of Leptospira species","volume":"88","author":"B Buyuktimkin","year":"2015","journal-title":"Microb Pathog"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/9780470985571.ch11","article-title":"Vectorial acylation: linking fatty acid transport and activation to metabolic trafficking","volume":"286","author":"PN Black","year":"2007","journal-title":"Novartis Found Symp"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"8041","DOI":"10.1074\/jbc.M113.545384","article-title":"Structures of complexes of a metal-independent glycosyltransferase GT6 from Bacteroides ovatus with UDP-N-acetylgalactosamine (UDP-GalNAc) and its hydrolysis products","volume":"289","author":"TT Pham","year":"2014","journal-title":"J Biol Chem"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1042\/BJ20130388","article-title":"Channel-mediated lactic acid transport: a novel function for aquaglyceroporins in bacteria","volume":"454","author":"GP Bienert","year":"2013","journal-title":"Biochem J"},{"issue":"21","key":"ref29","doi-asserted-by":"crossref","first-page":"7791","DOI":"10.1128\/JB.00404-07","article-title":"The NtcA-regulated amtB gene is necessary for full methylammonium uptake activity in the cyanobacterium Synechococcus elongatus","volume":"189","author":"J Paz-Yepes","year":"2007","journal-title":"J Bacteriol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1134\/S0006297916010041","article-title":"Proteomic Analysis of Escherichia coli Protein Fractions Resistant to Solubilization by Ionic Detergents","volume":"81","author":"KS Antonets","year":"2016","journal-title":"Biochemistry (Mosc)"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1096\/fj.10-170878","article-title":"An in vivo screen reveals protein-lipid interactions crucial for gating a mechanosensitive channel","volume":"25","author":"I Iscla","year":"2011","journal-title":"FASEB J"},{"issue":"8","key":"ref32","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1128\/AEM.01573-07","article-title":"Responses of Bacillus subtilis to hypotonic challenges: physiological contributions of mechanosensitive channels to cellular survival","volume":"74","author":"T Hoffmann","year":"2008","journal-title":"Appl Environ Microbiol"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"R183","DOI":"10.1016\/S0960-9822(03)00119-2","article-title":"Mechanosensitive channels: stress relief","volume":"13","author":"PC Biggin","year":"2003","journal-title":"Curr Biol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"31526","DOI":"10.1038\/srep31526","article-title":"The tetrameric MotA complex as the core of the flagellar motor stator from hyperthermophilic bacterium","volume":"6","author":"N Takekawa","year":"2016","journal-title":"Sci Rep"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"317","DOI":"10.5114\/ceji.2016.63133","article-title":"Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs)","volume":"41","author":"T Kolinski","year":"2016","journal-title":"Cent Eur J Immunol"},{"issue":"3","key":"ref36","first-page":"BE01","article-title":"Bacterial Heat Shock Protein Activity","volume":"10","author":"F Maleki","year":"2016","journal-title":"J Clin Diagn Res"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"e01084","DOI":"10.7554\/eLife.01084","article-title":"A family of fluoride-specific ion channels with dual-topology architecture","volume":"2","author":"RB Stockbridge","year":"2013","journal-title":"Elife"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s00232-011-9364-8","article-title":"Bioinformatic characterization of the trimeric intracellular cation-specific channel protein family","volume":"241","author":"AL Silverio","year":"2011","journal-title":"J Membr Biol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"e0117732","DOI":"10.1371\/journal.pone.0117732","article-title":"Analysis of the outer membrane proteome and secretome of Bacteroides fragilis reveals a multiplicity of secretion mechanisms","volume":"10","author":"MM Wilson","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/ni1079","article-title":"Getting a grip on things: how do communities of bacterial symbionts become established in our intestine?","volume":"5","author":"JL Sonnenburg","year":"2004","journal-title":"Nat Immunol"},{"issue":"7236","key":"ref41","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nature07678","article-title":"Transmembrane passage of hydrophobic compounds through a protein channel wall","volume":"458","author":"EM Hearn","year":"2009","journal-title":"Nature"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1093\/ajcn\/87.5.1324","article-title":"Identification and quantitation of cobalamin and cobalamin analogues in human feces","volume":"87","author":"RH Allen","year":"2008","journal-title":"Am J Clin Nutr"},{"issue":"1679","key":"ref43","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2015.0029","article-title":"Lipopolysaccharide transport to the cell surface: biosynthesis and extraction from the inner membrane","volume":"370","author":"BW Simpson","year":"2015","journal-title":"Philos Trans R Soc Lond B Biol Sci"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.3390\/md12021023","article-title":"The lipopolysaccharide export pathway in Escherichia coli: structure, organization and regulated assembly of the Lpt machinery","volume":"12","author":"A Polissi","year":"2014","journal-title":"Mar Drugs"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nrmicro.2015.3","article-title":"Pore-forming toxins: ancient, but never really out of fashion","volume":"14","author":"M Dal Peraro","year":"2016","journal-title":"Nat Rev Microbiol"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1159\/000481286","article-title":"The Membrane Attack Complex\/Perforin Superfamily","volume":"27","author":"G Moreno-Hagelsieb","year":"2017","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1574-6976.2000.tb00534.x","article-title":"Class IIa bacteriocins: biosynthesis, structure and activity","volume":"24","author":"S Ennahar","year":"2000","journal-title":"FEMS Microbiol Rev"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1007\/BF00271205","article-title":"The R gene product of bacteriophage lambda is the murein transglycosylase","volume":"184","author":"K Bienkowska-Szewczyk","year":"1981","journal-title":"Mol Gen Genet"},{"issue":"1","key":"ref49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1128\/JB.02046-14","article-title":"Holins in bacteria, eukaryotes, and archaea: multifunctional xenologues with potential biotechnological and biomedical applications","volume":"197","author":"MH Saier Jr.","year":"2015","journal-title":"J Bacteriol"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"2468","DOI":"10.1128\/JB.01545-10","article-title":"Staphylococcus aureus CidA and LrgA proteins exhibit holin-like properties","volume":"193","author":"DK Ranjit","year":"2011","journal-title":"J Bacteriol"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"3516","DOI":"10.1128\/AAC.01756-09","article-title":"Human antimicrobial peptide LL-37 induces MefE\/Mel-mediated macrolide resistance in Streptococcus pneumoniae","volume":"54","author":"D Zahner","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"1\u20132","key":"ref52","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0378-1119(96)00128-X","article-title":"Cloning of a gene from Escherichia coli that confers resistance to fosmidomycin as a consequence of amplification","volume":"175","author":"S Fujisaki","year":"1996","journal-title":"Gene"},{"issue":"8","key":"ref53","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nrmicro1464","article-title":"Multidrug-resistance efflux pumps\u2014not just for resistance","volume":"4","author":"LJ Piddock","year":"2006","journal-title":"Nat Rev Microbiol"},{"issue":"22","key":"ref54","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1128\/JB.187.22.7815-7825.2005","article-title":"Cell division defects in Escherichia coli deficient in the multidrug efflux transporter AcrEF-TolC","volume":"187","author":"SY Lau","year":"2005","journal-title":"J Bacteriol"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1186\/s13104-017-2504-1","article-title":"Identification of potential Campylobacter jejuni genes involved in biofilm formation by EZ-Tn5 Transposome mutagenesis","volume":"10","author":"AHT Teh","year":"2017","journal-title":"BMC Res Notes"},{"issue":"13","key":"ref56","doi-asserted-by":"crossref","first-page":"3620","DOI":"10.1046\/j.1432-1327.2001.02265.x","article-title":"The drug\/metabolite transporter superfamily","volume":"268","author":"DL Jack","year":"2001","journal-title":"Eur J Biochem"},{"issue":"6","key":"ref57","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00203-002-0408-4","article-title":"Sequence and phylogenetic analyses of the twin-arginine targeting (Tat) protein export system","volume":"177","author":"MR Yen","year":"2002","journal-title":"Arch Microbiol"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/PL00006442","article-title":"Getting in or out: early segregation between importers and exporters in the evolution of ATP-binding cassette (ABC) transporters","volume":"48","author":"W Saurin","year":"1999","journal-title":"J Mol Evol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1007\/978-0-387-72124-8_9","article-title":"Polyamines in bacteria: pleiotropic effects yet specific mechanisms","volume":"603","author":"BW Wortham","year":"2007","journal-title":"Adv Exp Med Biol"},{"issue":"49","key":"ref60","doi-asserted-by":"crossref","first-page":"37861","DOI":"10.1074\/jbc.M607453200","article-title":"Cross-linking between helices within subunit a of Escherichia coli ATP synthase defines the transmembrane packing of a four-helix bundle","volume":"281","author":"BE Schwem","year":"2006","journal-title":"J Biol Chem"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1365-2958.2012.08014.x","article-title":"The PTS(Ntr) system globally regulates ATP-dependent transporters in Rhizobium leguminosarum","volume":"84","author":"J Prell","year":"2012","journal-title":"Mol Microbiol"},{"issue":"1\u20132","key":"ref62","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1159\/000319588","article-title":"The p-type ATPase superfamily","volume":"19","author":"H Chan","year":"2010","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"3\u20134","key":"ref63","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1159\/000099638","article-title":"Active transport in communication, protection and nutrition","volume":"12","author":"MH Saier Jr","year":"2007","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0378-1119(96)00804-9","article-title":"Binding and transport of transforming DNA by Bacillus subtilis: the role of type-IV pilin-like proteins\u2014a review","volume":"192","author":"D Dubnau","year":"1997","journal-title":"Gene"},{"issue":"4","key":"ref65","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1073\/pnas.1217816110","article-title":"Membrane-integral pyrophosphatase subfamily capable of translocating both Na+ and H+","volume":"110","author":"HH Luoto","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref66","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.chom.2011.10.002","article-title":"Eating for two: how metabolism establishes interspecies interactions in the gut","volume":"10","author":"MA Fischbach","year":"2011","journal-title":"Cell Host Microbe"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1128\/JB.187.6.2020-2029.2005","article-title":"Cytochrome bd oxidase, oxidative stress, and dioxygen tolerance of the strictly anaerobic bacterium Moorella thermoacetica","volume":"187","author":"A Das","year":"2005","journal-title":"J Bacteriol"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0005-2728(00)00276-0","article-title":"Na(+) translocation by bacterial NADH:quinone oxidoreductases: an extension to the complex-I family of primary redox pumps","volume":"1505","author":"J Steuber","year":"2001","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"ref69","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.tig.2005.05.011","article-title":"Identification of a bacterial regulatory system for ribonucleotide reductases by phylogenetic profiling","volume":"21","author":"DA Rodionov","year":"2005","journal-title":"Trends Genet"},{"issue":"24","key":"ref70","doi-asserted-by":"crossref","first-page":"7224","DOI":"10.1128\/JB.183.24.7224-7230.2001","article-title":"Biochemical analysis of interactions between outer membrane proteins that contribute to starch utilization by Bacteroides thetaiotaomicron","volume":"183","author":"KH Cho","year":"2001","journal-title":"J Bacteriol"},{"issue":"19","key":"ref71","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.1128\/JB.182.19.5365-5372.2000","article-title":"Characterization of four outer membrane proteins involved in binding starch to the cell surface of Bacteroides thetaiotaomicron","volume":"182","author":"JA Shipman","year":"2000","journal-title":"J Bacteriol"},{"issue":"3","key":"ref72","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1042\/BJ20131415","article-title":"Structural and functional characterization of NanU, a novel high-affinity sialic acid-inducible binding protein of oral and gut-dwelling Bacteroidetes species","volume":"458","author":"C Phansopa","year":"2014","journal-title":"Biochem J"},{"issue":"3","key":"ref73","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/dnares\/3.3.109","article-title":"Sequence analysis of the genome of the unicellular cyanobacterium Synechocystis sp. strain PCC6803. II. Sequence determination of the entire genome and assignment of potential protein-coding regions","volume":"3","author":"T Kaneko","year":"1996","journal-title":"DNA Res"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.pep.2014.06.002","article-title":"Biophysical characterization of the outer membrane polysaccharide export protein and the polysaccharide co-polymerase protein from Xanthomonas campestris","volume":"101","author":"MI Bianco","year":"2014","journal-title":"Protein Expr Purif"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.3389\/fmicb.2017.01454","article-title":"The Type VI Secretion System: A Dynamic System for Bacterial Communication?","volume":"8","author":"M Gallique","year":"2017","journal-title":"Front Microbiol"},{"issue":"9","key":"ref76","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/j.1462-5822.2010.01499.x","article-title":"Type IV secretion systems: versatility and diversity in function","volume":"12","author":"K Wallden","year":"2010","journal-title":"Cell Microbiol"},{"issue":"5717","key":"ref77","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1126\/science.1104816","article-title":"Host-bacterial mutualism in the human intestine","volume":"307","author":"F Backhed","year":"2005","journal-title":"Science"},{"issue":"3","key":"ref78","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.cell.2016.01.013","article-title":"Are We Really Vastly Outnumbered? Revisiting the Ratio of Bacterial to Host Cells in Humans","volume":"164","author":"R Sender","year":"2016","journal-title":"Cell"},{"issue":"5778","key":"ref79","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"SR Gill","year":"2006","journal-title":"Science"},{"issue":"18","key":"ref80","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1128\/AEM.00563-12","article-title":"Discerning the role of Bacteroides fragilis in celiac disease pathogenesis","volume":"78","author":"E Sanchez","year":"2012","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"ref81","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1093\/jac\/dki443","article-title":"Molecular investigation of genetic elements contributing to metronidazole resistance in Bacteroides strains","volume":"57","author":"J Soki","year":"2006","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 4","key":"ref82","doi-asserted-by":"crossref","first-page":"S390","DOI":"10.1093\/clinids\/16.Supplement_4.S390","article-title":"Antimicrobial resistance in Bacteroides","volume":"16","author":"BA Rasmussen","year":"1993","journal-title":"Clin Infect Dis"},{"issue":"6","key":"ref83","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1111\/mmi.12839","article-title":"An antimicrobial protein of the gut symbiont Bacteroides fragilis with a MACPF domain of host immune proteins","volume":"94","author":"M Chatzidaki-Livanis","year":"2014","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref84","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1016\/j.bbrc.2004.11.085","article-title":"Bacteroides fragilis interferes with iNOS activity and leads to pore formation in macrophage surface","volume":"326","author":"JM Vieira","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"ref85","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1128\/IAI.74.4.2304-2316.2006","article-title":"Characterization of Bacteroides fragilis hemolysins and regulation and synergistic interactions of HlyA and HlyB","volume":"74","author":"KP Robertson","year":"2006","journal-title":"Infect Immun"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrmicro3185","article-title":"Type VI secretion system effectors: poisons with a purpose","volume":"12","author":"AB Russell","year":"2014","journal-title":"Nat Rev Microbiol"},{"issue":"9","key":"ref87","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.15252\/embr.201642282","article-title":"Strain competition restricts colonization of an enteric pathogen and prevents colitis","volume":"17","author":"AL Hecht","year":"2016","journal-title":"EMBO Rep"},{"issue":"1","key":"ref88","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1574-6968.1991.tb04567.x","article-title":"Effect of ferric and ferrous iron chelators on growth of Bacteroides fragilis under anaerobic conditions","volume":"68","author":"ER Rocha","year":"1991","journal-title":"FEMS Microbiol Lett"},{"issue":"4","key":"ref89","doi-asserted-by":"crossref","DOI":"10.1002\/mbo3.479","article-title":"Anaerobic utilization of Fe(III)-xenosiderophores among Bacteroides species and the distinct assimilation of Fe(III)-ferrichrome by Bacteroides fragilis within the genus","volume":"6","author":"ER Rocha","year":"2017","journal-title":"Microbiologyopen"},{"issue":"11","key":"ref90","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1093\/molbev\/msw164","article-title":"Membrane Proteins Are Dramatically Less Conserved than Water-Soluble Proteins across the Tree of Life","volume":"33","author":"V Sojo","year":"2016","journal-title":"Mol Biol Evol"},{"issue":"7","key":"ref91","doi-asserted-by":"crossref","first-page":"e1000867","DOI":"10.1371\/journal.pcbi.1000867","article-title":"More than 1,001 problems with protein domain databases: transmembrane regions, signal peptides and the issue of sequence homology","volume":"6","author":"WC Wong","year":"2010","journal-title":"PLoS Comput Biol"},{"issue":"6","key":"ref92","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1016\/j.chom.2014.11.005","article-title":"The gut commensal Bacteroides thetaiotaomicron exacerbates enteric infection through modification of the metabolic landscape","volume":"16","author":"MM Curtis","year":"2014","journal-title":"Cell Host Microbe"},{"issue":"2","key":"ref93","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1128\/AEM.67.2.561-568.2001","article-title":"Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon","volume":"67","author":"NB Shoemaker","year":"2001","journal-title":"Appl Environ Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0208151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:52:32Z","timestamp":1588963952000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0208151"}},"subtitle":[],"editor":[{"given":"Luis Caetano Martha","family":"Antunes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,5]]},"references-count":93,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0208151","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,5]]}}}