{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T03:39:44Z","timestamp":1793763584163,"version":"4.6.1"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"11","license":[{"start":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T00:00:00Z","timestamp":1543449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005339","name":"American Academy of Neurology","doi-asserted-by":"publisher","award":["P0519279"],"award-info":[{"award-number":["P0519279"]}],"id":[{"id":"10.13039\/100005339","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Gottfried and Julia Bangerter-Rhyner Foundation, Basel, Switzerland"},{"name":"Freiwillige Akademische Gesellschaft, Basel, Switzerland"},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01 AG045390"],"award-info":[{"award-number":["U01 AG045390"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P01 AG019724-09"],"award-info":[{"award-number":["P01 AG019724-09"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0208255","type":"journal-article","created":{"date-parts":[[2018,11,29]],"date-time":"2018-11-29T18:45:32Z","timestamp":1543517132000},"page":"e0208255","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Measurement of spinal cord atrophy using phase sensitive inversion recovery (PSIR) imaging in motor neuron disease"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3114-6638","authenticated-orcid":true,"given":"Nicholas T.","family":"Olney","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3862-5738","authenticated-orcid":true,"given":"Antje","family":"Bischof","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Howard","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Caverzasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1236-7654","authenticated-orcid":true,"given":"William A.","family":"Stern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Lomen-Hoerth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland G.","family":"Henry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nico","family":"Papinutto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,11,29]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3121\/cmr.2009.883","article-title":"Jean-Martin Charcot: the father of neurology","volume":"9","author":"DR Kumar","year":"2011","journal-title":"Clin Med Res"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.ncl.2015.07.012","article-title":"Neuropathology of Amyotrophic Lateral Sclerosis and Its Variants","volume":"33","author":"S Saberi","year":"2015","journal-title":"Neurol Clin"},{"issue":"Suppl 1","key":"ref3","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3109\/21678421.2013.778548","article-title":"Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis","volume":"14","author":"J Ravits","year":"2013","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1212\/WNL.0b013e31825dce13","article-title":"FOSMN syndrome: novel insight into disease pathophysiology","volume":"79","author":"S Vucic","year":"2012","journal-title":"Neurology"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000381944","article-title":"Facial Onset Sensory and Motor Neuronopathy: Further Evidence for a TDP-43 Proteinopathy","volume":"7","author":"B Ziso","year":"2015","journal-title":"Case Rep Neurol"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1080\/146608200300079536","article-title":"World Federation of Neurology Research Group on Motor Neuron D. El Escorial revisited: revised criteria for the diagnosis of amyotrophic lateral sclerosis","volume":"1","author":"BR Brooks","year":"2000","journal-title":"Amyotroph Lateral Scler Other Motor Neuron Disord"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.clinph.2007.09.143","article-title":"Electrodiagnostic criteria for diagnosis of ALS","volume":"119","author":"M de Carvalho","year":"2008","journal-title":"Clin Neurophysiol"},{"issue":"Pt 2","key":"ref8","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1093\/brain\/115.2.495","article-title":"Primary lateral sclerosis. Clinical features, neuropathology and diagnostic criteria","volume":"115","author":"CE Pringle","year":"1992","journal-title":"Brain"},{"issue":"3\u20134","key":"ref9","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1080\/21678421.2016.1267768","article-title":"Amyotrophic lateral sclerosis\u2014frontotemporal spectrum disorder (ALS-FTSD): Revised diagnostic criteria","volume":"18","author":"MJ Strong","year":"2017","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/mus.20728","article-title":"Primary lateral sclerosis","volume":"35","author":"MA Singer","year":"2007","journal-title":"Muscle Nerve"},{"issue":"6","key":"ref11","first-page":"751","article-title":"A long-term prospective study of the natural course of sporadic adult-onset lower motor neuron syndromes","volume":"66","author":"RM Van den Berg-Vos","year":"2009","journal-title":"Arch Neurol"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/mus.24979","article-title":"ALS biomarkers for therapy development: State of the field and future directions","volume":"53","author":"M Benatar","year":"2016","journal-title":"Muscle Nerve"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.3592","article-title":"Diffusion MRI of the spinal cord: from structural studies to pathology","volume":"30","author":"Y Cohen","year":"2017","journal-title":"NMR Biomed"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.4155\/cli.11.127","article-title":"New considerations in the design of clinical trials for amyotrophic lateral sclerosis","volume":"1","author":"JD Berry","year":"2011","journal-title":"Clin Investig (Lond)"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/jnnp-2015-311952","article-title":"A large-scale multicentre cerebral diffusion tensor imaging study in amyotrophic lateral sclerosis","volume":"87","author":"HP Muller","year":"2016","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref16","article-title":"Imaging the pathoanatomy of amyotrophic lateral sclerosis in vivo: targeting a propagation-based biological marker","author":"J Kassubek","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.nicl.2017.08.002","article-title":"Multimodal structural MRI in the diagnosis of motor neuron diseases","volume":"16","author":"PM Ferraro","year":"2017","journal-title":"Neuroimage Clin"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s12883-017-0854-x","article-title":"Survival prediction in Amyotrophic lateral sclerosis based on MRI measures and clinical characteristics","volume":"17","author":"C Schuster","year":"2017","journal-title":"BMC Neurol"},{"issue":"Pt 9","key":"ref19","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1093\/brain\/awr178","article-title":"White matter alterations differ in primary lateral sclerosis and amyotrophic lateral sclerosis","volume":"134","author":"NK Iwata","year":"2011","journal-title":"Brain"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/s12883-016-0672-6","article-title":"The value of magnetic resonance imaging as a biomarker for amyotrophic lateral sclerosis: a systematic review","volume":"16","author":"G Grolez","year":"2016","journal-title":"BMC Neurol"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1111\/j.1460-9568.2010.07445.x","article-title":"MRI predictors of long-term evolution in amyotrophic lateral sclerosis","volume":"32","author":"F Agosta","year":"2010","journal-title":"Eur J Neurosci"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1002\/hbm.22286","article-title":"Intrahemispheric and interhemispheric structural network abnormalities in PLS and ALS","volume":"35","author":"F Agosta","year":"2014","journal-title":"Hum Brain Mapp"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/S1474-4422(14)70167-X","article-title":"Neuroimaging in amyotrophic lateral sclerosis: insights into structural and functional changes","volume":"13","author":"A Chio","year":"2014","journal-title":"Lancet Neurol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/j.neuroimage.2013.07.014","article-title":"The current state-of-the-art of spinal cord imaging: applications","volume":"84","author":"CA Wheeler-Kingshott","year":"2014","journal-title":"Neuroimage"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.ejrad.2007.11.005","article-title":"Artifacts in 3-T MRI: physical background and reduction strategies","volume":"65","author":"O Dietrich","year":"2008","journal-title":"Eur J Radiol"},{"key":"ref26","article-title":"Spinal Cord Gray Matter Atrophy in Amyotrophic Lateral Sclerosis","author":"ME Paquin","year":"2017","journal-title":"AJNR Am J Neuroradiol"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","DOI":"10.1002\/nbm.3801","article-title":"Region-specific impairment of the cervical spinal cord (SC) in amyotrophic lateral sclerosis: A preliminary study using SC templates and quantitative MRI (diffusion tensor imaging\/inhomogeneous magnetization transfer)","volume":"30","author":"H Rasoanandrianina","year":"2017","journal-title":"NMR Biomed"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1002\/jmri.24819","article-title":"2D phase-sensitive inversion recovery imaging to measure in vivo spinal cord gray and white matter areas in clinically feasible acquisition times","volume":"42","author":"N Papinutto","year":"2015","journal-title":"J Magn Reson Imaging"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1002\/mrm.10051","article-title":"Phase-sensitive inversion recovery for detecting myocardial infarction using gadolinium-delayed hyperenhancement","volume":"47","author":"P Kellman","year":"2002","journal-title":"Magn Reson Med"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1177\/1352458513492245","article-title":"Magnetic resonance imaging correlates of physical disability in relapse onset multiple sclerosis of long disease duration","volume":"20","author":"H Kearney","year":"2014","journal-title":"Mult Scler"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"e0118576","DOI":"10.1371\/journal.pone.0118576","article-title":"Age, gender and normalization covariates for spinal cord gray matter and total cross-sectional areas at cervical and thoracic levels: A 2D phase sensitive inversion recovery imaging study","volume":"10","author":"N Papinutto","year":"2015","journal-title":"PLoS One"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1002\/ana.24241","article-title":"Spinal cord gray matter atrophy correlates with multiple sclerosis disability","volume":"76","author":"R Schlaeger","year":"2014","journal-title":"Ann Neurol"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1001\/jamaneurol.2015.0993","article-title":"Association Between Thoracic Spinal Cord Gray Matter Atrophy and Disability in Multiple Sclerosis","volume":"72","author":"R Schlaeger","year":"2015","journal-title":"JAMA Neurol"},{"issue":"1\u20132","key":"ref34","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0022-510X(99)00210-5","article-title":"The ALSFRS-R: a revised ALS functional rating scale that incorporates assessments of respiratory function","volume":"169","author":"JM Cedarbaum","year":"1999","journal-title":"J Neurol Sci"},{"issue":"5\u20136","key":"ref35","doi-asserted-by":"crossref","first-page":"414","DOI":"10.3109\/21678421.2016.1140786","article-title":"The ALSFRS as an outcome measure in therapeutic trials and its relationship to symptom onset","volume":"17","author":"M Proudfoot","year":"2016","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.neuroimage.2009.12.121","article-title":"Rapid semi-automatic segmentation of the spinal cord from magnetic resonance images: application in multiple sclerosis","volume":"50","author":"MA Horsfield","year":"2010","journal-title":"Neuroimage"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuroimage.2016.07.062","article-title":"Gray matter segmentation of the spinal cord with active contours in MR images","volume":"147","author":"E Datta","year":"2017","journal-title":"Neuroimage"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuroimage.2017.03.010","article-title":"Spinal cord grey matter segmentation challenge","volume":"152","author":"F Prados","year":"2017","journal-title":"Neuroimage"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1037\/0033-2909.86.2.420","article-title":"Intraclass correlations: uses in assessing rater reliability","volume":"86","author":"PE Shrout","year":"1979","journal-title":"Psychol Bull"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1080\/17482960802521126","article-title":"Awaji diagnostic algorithm increases sensitivity of El Escorial criteria for ALS diagnosis","volume":"10","author":"MD Carvalho","year":"2009","journal-title":"Amyotroph Lateral Scler"},{"issue":"Pt 9","key":"ref41","doi-asserted-by":"crossref","first-page":"2456","DOI":"10.1093\/brain\/awr179","article-title":"Sensitivity of revised diagnostic criteria for the behavioural variant of frontotemporal dementia","volume":"134","author":"K Rascovsky","year":"2011","journal-title":"Brain"},{"issue":"10","key":"ref42","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1212\/01.WNL.0000125182.17874.59","article-title":"Objective tests for upper motor neuron involvement in amyotrophic lateral sclerosis (ALS)","volume":"62","author":"P Kaufmann","year":"2004","journal-title":"Neurology"},{"issue":"22","key":"ref43","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1212\/WNL.0b013e3181a8269b","article-title":"Clinical features that distinguish PLS, upper motor neuron-dominant ALS, and typical ALS","volume":"72","author":"PH Gordon","year":"2009","journal-title":"Neurology"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1212\/01.wnl.0000341933.97883.a4","article-title":"Transcranial magnetic stimulation in ALS: utility of central motor conduction tests","volume":"72","author":"AG Floyd","year":"2009","journal-title":"Neurology"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1007\/s13311-016-0487-6","article-title":"Transcranial Magnetic Stimulation for the Assessment of Neurodegenerative Disease","volume":"14","author":"S Vucic","year":"2017","journal-title":"Neurotherapeutics"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1212\/WNL.0b013e3181b6bbbd","article-title":"ALS motor phenotype heterogeneity, focality, and spread: deconstructing motor neuron degeneration","volume":"73","author":"JM Ravits","year":"2009","journal-title":"Neurology"},{"issue":"7\u20138","key":"ref47","doi-asserted-by":"crossref","first-page":"524","DOI":"10.3109\/21678421.2015.1051989","article-title":"attendees of the 4th Ni Sm. Mind the gap: the mismatch between clinical and imaging metrics in ALS","volume":"16","author":"E Verstraete","year":"2015","journal-title":"Amyotroph Lateral Scler Frontotemporal Degener"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0208255","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T08:50:51Z","timestamp":1589014251000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0208255"}},"subtitle":[],"editor":[{"given":"Friedemann","family":"Paul","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,11,29]]},"references-count":47,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2018,11,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0208255","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,11,29]]}}}