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Liver Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"7824","DOI":"10.3748\/wjg.v22.i34.7824","article-title":"Global epidemiology of hepatitis C virus infection: An up-date of the distribution and circulation of hepatitis C virus genotypes","volume":"22","author":"A Petruzziello","year":"2016","journal-title":"World J Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"47","DOI":"10.7150\/ijms.3.47","article-title":"The natural history of hepatitis C virus (HCV) infection","volume":"3","author":"SL Chen","year":"2006","journal-title":"Int J Med Sci"},{"key":"ref4","first-page":"20","article-title":"Global burden of disease (GBD) for hepatitis C","volume":"44","year":"2004","journal-title":"Global burden of disease (GBD) for hepatitis C"},{"key":"ref5","unstructured":"European Centre for Disease Prevention and Control. Hepatitis B and C in the EU neighbourhood: prevalence, burden of disease and screening policies. Stockholm: European Centre for Disease Prevention and Control; 2010. Available at <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/ecdc.europa.eu\/sites\/portal\/files\/media\/en\/publications\/Publications\/TER_100914_Hep_B_C%20_EU_neighbourhood.pdf\" xlink:type=\"simple\">https:\/\/ecdc.europa.eu\/sites\/portal\/files\/media\/en\/publications\/Publications\/TER_100914_Hep_B_C%20_EU_neighbourhood.pdf<\/ext-link>. Accessed July 4, 2018."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1053\/j.gastro.2015.09.007","article-title":"Hepatitis C virus infection is associated with increased cardiovascular mortality: A meta-analysis of observational studies","volume":"150","author":"S Petta","year":"2016","journal-title":"Gastroenterology"},{"issue":"Suppl 5","key":"ref7","doi-asserted-by":"crossref","first-page":"S165","DOI":"10.1016\/j.dld.2014.10.005","article-title":"Extrahepatic manifestations of chronic hepatitis C virus infection","volume":"46","author":"P Cacoub","year":"2014","journal-title":"Dig Liver Dis"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.jhep.2008.08.006","article-title":"Hepatitis C infection and risk of diabetes: a systematic review and meta-analysis","volume":"49","author":"DL White","year":"2008","journal-title":"J Hepatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"343","DOI":"10.14218\/JCTH.2017.00021","article-title":"Risk of cardiovascular disease due to chronic hepatitis C infection: A review","volume":"5","author":"A Babiker","year":"2017","journal-title":"J Clin Transl Hepatol"},{"key":"ref10","first-page":"258","article-title":"Hepatitis C virus as a multifaceted disease: a simple and updated approach for extrahepatic manifestations of hepatitis C virus infection, Hepat","volume":"10","author":"MA Khattab","year":"2010","journal-title":"Mon"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/00004836-200411000-00014","article-title":"Silent celiac disease in chronic hepatitis C: impact of interferon treatment on the disease onset and clinical outcome","volume":"38","author":"E Durante-Mangoni","year":"2004","journal-title":"J. Clin. Gastroenterol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1365-2893.2010.01290.x","article-title":"Total and cause-specific mortality rates in a prospective study of community-acquired hepatitis C virus infection in northern Norway","volume":"18","author":"MG Kristiansen","year":"2011","journal-title":"J Viral Hepat"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1093\/aje\/kwm370","article-title":"Increased all-cause, liver, and cardiac mortality among hepatitis C virus-seropositive blood donors","volume":"167","author":"AM Guiltinan","year":"2008","journal-title":"Am J Epidemiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"2894","DOI":"10.1161\/STROKEAHA.110.598136","article-title":"Hepatitis C virus infection and increased risk of cerebrovascular disease","volume":"41","author":"MH Lee","year":"2010","journal-title":"Stroke"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/infdis\/jis385","article-title":"Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study","volume":"206","author":"MH Lee","year":"2012","journal-title":"J Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.drugalcdep.2015.03.026","article-title":"The impact of bloodborne viruses on cause-specific mortality among opioid dependent people: an Australian population-based cohort study","volume":"152","author":"CM Vajdic","year":"2015","journal-title":"Drug Alcohol Depend"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1086\/599371","article-title":"Hepatitis C virus infection and the risk of coronary disease","volume":"49","author":"AA Butt","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1111\/j.1475-097X.2012.01152.x","article-title":"Hepatitis C virus infection and risk of coronary artery disease: a systematic review of the literature","volume":"32","author":"T Roed","year":"2012","journal-title":"Clin Physiol Funct Imaging"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.amjcard.2015.06.035","article-title":"Comparison of angiographic burden of coronary artery disease in patients with versus without hepatitis C infection","volume":"116","author":"NV Pothineni","year":"2015","journal-title":"Am J Cardiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1007\/s10620-014-3222-3","article-title":"Hepatitis C virus infection and coronary artery disease risk: a systematic review of the literature","volume":"59","author":"RJ Wong","year":"2014","journal-title":"Dig Dis Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"S69","DOI":"10.1016\/j.jhep.2014.08.003","article-title":"Facts and fictions of HCV and comorbidities: steatosis, diabetes mellitus, and cardiovascular diseases","volume":"61","author":"F Negro","year":"2014","journal-title":"J Hepatol"},{"key":"ref22","unstructured":"World Health Organization. The top 10 causes of death.2018. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death\" xlink:type=\"simple\">http:\/\/www.who.int\/news-room\/fact-sheets\/detail\/the-top-10-causes-of-death<\/ext-link>. Accessed July 4, 2018."},{"key":"ref23","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1161\/CIRCULATIONAHA.107.699579","article-title":"General cardiovascular risk profile for use in primary care: the Framingham Heart Study","volume":"117","author":"R.B. D'Agostino","year":"2008","journal-title":"Circulation"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project","volume":"24","author":"RM Conroy","year":"2003","journal-title":"Eur Heart J"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/hc0302.102575","article-title":"Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow up of the Prospective Cardiovascular M\u00fcnster (PROCAM) study","volume":"105","author":"G Assmann","year":"2002","journal-title":"Circulation"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1136\/bmj.39261.471806.55","article-title":"Derivation and validation of QRISK, a new cardiovascular disease risk score for the United Kingdom: prospective open cohort study","volume":"335","author":"J Hippisley-Cox","year":"2007","journal-title":"BMJ"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1001\/jama.297.6.611","article-title":"Development and validation of improved algorithms for the assessment of global cardiovascular risk in women: the Reynolds Risk Score","volume":"297","author":"PM Ridker","year":"2007","journal-title":"JAMA"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2243","DOI":"10.1161\/CIRCULATIONAHA.108.814251","article-title":"C-reactive protein and parental history improve global cardiovascular risk prediction: the Reynolds Risk Score for men","volume":"118","author":"PM Ridker","year":"2008","journal-title":"Circulation"},{"key":"ref29","first-page":"417","article-title":"Practical use of the Framingham risk score in primary prevention Canadian perspective","volume":"57","author":"NJ Bosomworth","year":"2011","journal-title":"Can Fam Physician"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"PW Wilson","year":"1998","journal-title":"Circulation"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF03405437","article-title":"Canadian Health Measures Survey: Brief overview","volume":"98","author":"MS Tremblay","year":"2007","journal-title":"Can J Public Heal"},{"key":"ref32","first-page":"7","article-title":"Canadian Health Measures Survey: rationale, background and overview","volume":"18","author":"M Tremblay","year":"2007","journal-title":"Heal Rep"},{"key":"ref33","first-page":"31","article-title":"Canadian Health Measures Survey: sampling strategy overview","volume":"18","author":"S Giroux","year":"2007","journal-title":"Heal Rep"},{"key":"ref34","first-page":"37","article-title":"Canadian Health Measures Survey: Ethical, legal and social issues","volume":"18","author":"B Day","year":"2007","journal-title":"Health Rep"},{"article-title":"National Health and Nutrition Examination Survey III: weighting and examination methodology","year":"1996","author":"LMJ Mohadjer","key":"ref35"},{"key":"ref36","first-page":"1","article-title":"National Health and Nutrition Examination Survey: Sample Design, 2007\u20132010","volume":"160","author":"LR Curtin","year":"2010","journal-title":"Vital Heal Stat"},{"key":"ref37","first-page":"1","article-title":"National Health and Nutrition Examination Survey: Sample Design, 2011\u20132014","volume":"2","author":"CL Johnson","year":"2014","journal-title":"Vital Heal Stat"},{"key":"ref38","first-page":"347","article-title":"The association between obesity, cardiometabolic disease biomarkers, and innate immunity-related inflammation in Canadian adults","volume":"5","author":"LA Da Costa","year":"2012","journal-title":"Diabetes Metab Syndr Obes"},{"issue":"Suppl 1","key":"ref39","first-page":"S62","article-title":"Diagnosis and classification of diabetes mellitus","volume":"33","year":"2010","journal-title":"Diabetes Care"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1161\/CIRCULATIONAHA.105.169404","article-title":"Diagnosis and management of the metabolic syndrome: An American Heart Association\/National Heart, Lung, and Blood Institute scientific statement","volume":"112","author":"SM Grundy","year":"2005","journal-title":"Circulation"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"E377","DOI":"10.25011\/cim.v34i6.15899","article-title":"Plasma vitamin D and risk of the metabolic syndrome in Canadians","volume":"34","author":"DR Brenner","year":"2011","journal-title":"Clin. Invest. Med"},{"key":"ref42","article-title":"Prevalence of 10-year risk of cardiovascular diseases and associated risks in Canadian adults: The contribution of cardiometabolic risk assessment introduction","author":"S Setayeshgar","year":"2013","journal-title":"Int J Hyper"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1007\/BF00280883","article-title":"Homeostasis model assessment: insulin resistance and \u03b2-cell function from fasting plasma glucose and insulin concentrations in man","volume":"28","author":"DR Matthews","year":"1985","journal-title":"Diabetologia"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"297","DOI":"10.2147\/DMSO.S60569","article-title":"Relationship between insulin resistance and plasma vitamin D in adults","volume":"7","author":"A Badawi","year":"2014","journal-title":"Diabet. Metab. Synd. Obe"},{"key":"ref45","first-page":"1","article-title":"National health and nutrition examination survey. Analytic guidelines, 1999\u20132010","volume":"161","author":"CL Johnson","year":"2013","journal-title":"Vital Health Stat 2"},{"key":"ref46","article-title":"Instructions for combining multiple cycles of Canadian Health Measures Survey (CHMS) data","author":"Statistics Canada","year":"2017","journal-title":"Instructions for combining multiple cycles of Canadian Health Measures Survey (CHMS) data"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1161\/circ.106.25.3143","article-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) &quot;final report.&quot;","volume":"106","year":"2002","journal-title":"Circulation"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.ijcard.2016.06.337","article-title":"The risk of coronary artery disease and cerebrovascular disease in patients with hepatitis C: A systematic review and meta-analysis","volume":"221","author":"P Ambrosino","year":"2016","journal-title":"Int J Cardiolo"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1161\/CIRCOUTCOMES.108.847202","article-title":"Trends in 10-year predicted risk of cardiovascular disease in the United States, 1976\u20132004","volume":"2","author":"F Lopez-Jimenez","year":"2009","journal-title":"Circ Cardiovasc Qual Outcomes"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/j.1742-1241.2012.02953.x","article-title":"Risk of cardiovascular disease in HIV, hepatitis C, or HIV\/hepatitis C patients compared to the general population","volume":"67","author":"L Kakinami","year":"2013","journal-title":"Int J Clin Pract"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"309","DOI":"10.3851\/IMP2724","article-title":"Risk of cardiovascular disease associated with HCV and HBV coinfection among antiretroviral-treated HIV-infected individuals","volume":"19","author":"J Gillis","year":"2014","journal-title":"Antivir Ther"},{"key":"ref52","first-page":"116","article-title":"Prevalence, sociodemographic characteristics and risk factors for hepatitis C infection among pregnant women in Calabar municipality, Nigeria","volume":"10","author":"CI Mboto","year":"2010","journal-title":"Hepat Mon"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s10903-014-0015-x","article-title":"Sociodemographic characteristics, knowledge and prevalence of viral hepatitis infection among Vietnamese Americans at community screenings","volume":"17","author":"C Strong","year":"2015","journal-title":"J Immigr Minor Health"},{"key":"ref54","first-page":"2","article-title":"Socio-demographic characteristics as risk factors for hepatitis C virus infection among pregnant women in Iraq","volume":"2","author":"WA Al-Kubaisy","year":"2013","journal-title":"J Women Heal Issues Care"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"147","DOI":"10.4269\/ajtmh.2001.64.147","article-title":"Hepatitis c and cirrhotic liver disease in the Nile delta of Egypt: a community-based study","volume":"64","author":"MA Darwish","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1053\/jhep.2001.24432","article-title":"Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity","volume":"33","author":"LE Adinolfi","year":"2001","journal-title":"Hepatology"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/hep.510250340","article-title":"Analysis of histopathological manifestations of chronic hepatitis C virus infection with respect to virus genotype","volume":"25","author":"S Mihm","year":"1997","journal-title":"Hepatology"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"2880","DOI":"10.1111\/j.1572-0241.2002.07056.x","article-title":"Hepatocellular fat accumulation and low serum cholesterol in patients infected with HCV-3a","volume":"97","author":"H Hofer","year":"2002","journal-title":"Am J Gastroenterol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"e17309","DOI":"10.1371\/journal.pone.0017309","article-title":"Decreases in the serum VLDL-TG\/non-VLDL-TG ratio from early stages of chronic hepatitis C: alterations in TG-rich lipoprotein levels","volume":"6","author":"M Nishimura","year":"2011","journal-title":"PLoS One"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S1386-6346(02)00309-1","article-title":"Serum lipid profile of patients with genotype 1b hepatitis C viral infection in Japan","volume":"25","author":"K Moriya","year":"2003","journal-title":"Hepatol Res"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"10299","DOI":"10.3748\/wjg.v21.i36.10299","article-title":"Chronic hepatitis C virus infection and lipoprotein metabolism","volume":"21","author":"Y Aizawa","year":"2015","journal-title":"World J Gastroenterol"},{"key":"ref62","article-title":"Lipoprotein(a) in Cardiovascular Diseases","author":"M Malaguarnera","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"e106376","DOI":"10.1371\/journal.pone.0106376","article-title":"Is hepatitis C associated with atherosclerotic burden? A systematic review and meta-analysis","volume":"9","author":"H Huang","year":"2014","journal-title":"PLoS One"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/cpf.12229","article-title":"Hepatitis C as a risk factor for carotid atherosclerosis\u2014a systematic review","volume":"36","author":"OO Olubamwo","year":"2016","journal-title":"Clin Physiol Funct Imaging"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jhep.2015.08.027","article-title":"Dysregulation of distal cholesterol biosynthesis in association with relapse and advanced disease in CHC genotype 2 and 3 treated with sofosbuvir and ribavirin","volume":"64","author":"ZM Younossi","year":"2016","journal-title":"J Hepatol"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1089\/apc.2006.0150","article-title":"Hepatitis C infection is associated with lower lipids and high-sensitivity C-reactive protein in HIV-infected men","volume":"21","author":"M Floris-Moore","year":"2007","journal-title":"AIDS Patient Care STDS"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1620\/tjem.178.287","article-title":"Comparative study of C-reactive protein in chronic hepatitis B and chronic hepatitis C","volume":"178","author":"M Shima","year":"1996","journal-title":"Tohoku J Exp Med"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1097\/QAD.0000000000000654","article-title":"Association of HIV, hepatitis C virus and liver fibrosis severity with interleukin-6 and C-reactive protein levels","volume":"29","author":"S Shah","year":"2015","journal-title":"AIDS"},{"key":"ref69","first-page":"468596","article-title":"Association between plasma fibrinogen levels and mortality in acute-on-chronic hepatitis B liver failure","author":"Z Shao","year":"2015","journal-title":"Dis Markers"},{"key":"ref70","first-page":"163","article-title":"Detection of plasma fibrinogen level and function in patients with carcinoma, hepatic-nephrotic disease, diabetes mellitus and its clinical significance","volume":"7","author":"LH Zhou","year":"2001","journal-title":"Ch J Thromb Hemost"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1038\/nrcardio.2016.185","article-title":"Inflammatory processes in cardiovascular disease: a route to targeted therapies","volume":"14","author":"N Ruparelia","year":"2017","journal-title":"Nat Rev Cardiol"},{"key":"ref72","first-page":"953461","article-title":"Acute phase reactants as novel predictors of cardiovascular disease","volume":"6","author":"MS Ahmed","year":"2012","journal-title":"ISRN Inflamm"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.jhep.2008.05.024","article-title":"Clinical and pathologic risk factors for atherosclerosis in cirrhosis: a comparison between NASH related cirrhosis and cirrhosis due to other aetiologies","volume":"49","author":"A Kadayifci","year":"2008","journal-title":"J. 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Sci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1097\/MCG.0000000000000251","article-title":"ST elevation myocardial infarction mortality among patients with liver cirrhosis: a nationwide analysis across a decade","volume":"49","author":"MS Abougergi","year":"2015","journal-title":"J. Clin. Gastroenterol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"528","DOI":"10.4254\/wjh.v5.i10.528","article-title":"Chronic HCV infection and inflammation: clinical impact on hepatic and extra-hepatic manifestations","volume":"5","author":"R Zampino","year":"2013","journal-title":"World J. Hepatol"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"2634","DOI":"10.1111\/j.1572-0241.2002.06041.x","article-title":"Serum and liver micronutrient antioxidants and serum oxidative stress in patients with chronic hepatitis C","volume":"97","author":"D Yadav","year":"2002","journal-title":"Am. J. Gastroenterol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S0009-9120(01)00210-7","article-title":"Immunopathogenesis of hepatitis C viral infection: Th1\/Th2 responses and the role of cytokines","volume":"34","author":"PM Jacobson Brown","year":"2001","journal-title":"Clin. Biochem"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1258\/095646207779949880","article-title":"High hepatitis C virus prevalence and incidence among Canadian intravenous drug users","volume":"18","author":"E Roy","year":"2007","journal-title":"Int J STD AIDS"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.jhep.2013.11.014","article-title":"The changing epidemiology of hepatitis C virus infection in the United States: National Health and Nutrition Examination Survey 2001 through 2010","volume":"60","author":"I Ditah","year":"2014","journal-title":"J Hepatol"},{"key":"ref83","first-page":"3","article-title":"Seroprevalence of hepatitis B and C virus infections: Results from the 2007 to 2009 and 2009 to 2011 Canadian Health Measures Survey","volume":"24","author":"M Rotermann","year":"2013","journal-title":"Heal Rep."},{"key":"ref84","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1155\/2014\/317623","article-title":"Burden of disease and cost of chronic hepatitis C virus infection in Canada","volume":"28","author":"RP Myers","year":"2014","journal-title":"Can J Gastroenterol Hepatol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0208839","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:49:32Z","timestamp":1588970972000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0208839"}},"subtitle":[],"editor":[{"given":"Hans","family":"Tillmann","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,12]]},"references-count":84,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0208839","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,12,12]]}}}