{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T13:50:53Z","timestamp":1762005053369,"version":"3.37.3"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T00:00:00Z","timestamp":1545177600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","award":["1185918N"],"award-info":[{"award-number":["1185918N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Instituut voor Innovatie door Wetenschap en Technologie","award":["SB\/121396"],"award-info":[{"award-number":["SB\/121396"]}]},{"DOI":"10.13039\/501100003132","name":"Agentschap voor Innovatie door Wetenschap en Technologie","doi-asserted-by":"publisher","award":["IWT-SBO-HILIM-3D"],"award-info":[{"award-number":["IWT-SBO-HILIM-3D"]}],"id":[{"id":"10.13039\/501100003132","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002749","name":"Federaal Wetenschapsbeleid","doi-asserted-by":"publisher","award":["BELSPO-IUAP-BELVIR"],"award-info":[{"award-number":["BELSPO-IUAP-BELVIR"]}],"id":[{"id":"10.13039\/501100002749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002749","name":"Federaal Wetenschapsbeleid","doi-asserted-by":"publisher","award":["BELSPO-IUAP-DEVREPAIR"],"award-info":[{"award-number":["BELSPO-IUAP-DEVREPAIR"]}],"id":[{"id":"10.13039\/501100002749","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["681002"],"award-info":[{"award-number":["681002"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["734584"],"award-info":[{"award-number":["734584"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["734548"],"award-info":[{"award-number":["734548"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0209097","type":"journal-article","created":{"date-parts":[[2018,12,19]],"date-time":"2018-12-19T18:34:40Z","timestamp":1545244480000},"page":"e0209097","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Human stem cell-derived hepatocyte-like cells support Zika virus replication and provide a relevant model to assess the efficacy of potential antivirals"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6710-4838","authenticated-orcid":true,"given":"Tine","family":"Tricot","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicky","family":"Helsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne J. F.","family":"Kaptein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Neyts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine M.","family":"Verfaillie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,12,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.micinf.2016.03.003","article-title":"Zika virus\u2014an overview","volume":"18","author":"C Zanluca","year":"2016","journal-title":"Microbes Infect"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1590\/0037-8682-0220-2015","article-title":"Zika virus in Brazil and the danger of infestation by Aedes (Stegomyia) mosquitoes","volume":"49","author":"CB Marcondes","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"14","DOI":"10.2807\/1560-7917.ES2014.19.14.20761","article-title":"Potential for Zika virus transmission through blood transfusion demonstrated during an outbreak in French Polynesia, November 2013 to February 2014","volume":"19","author":"D Musso","year":"2014","journal-title":"Eurosurveillance"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3201\/eid2102.141363","article-title":"Potential sexual transmission of zika virus","volume":"21","author":"D Musso","year":"2015","journal-title":"Emerg Infect Dis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.medmal.2014.04.008","article-title":"Current Zika virus epidemiology and recent epidemics","volume":"44","author":"S Ioos","year":"2014","journal-title":"Med Mal Infect"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1056\/NEJMoa0805715","article-title":"Zika Virus Outbreak on Yap Island, Federated States of Micronesia","volume":"360","author":"M Duffy","year":"2009","journal-title":"N Engl J Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1056\/NEJMoa1600651","article-title":"Zika Virus Associated with Microcephaly","volume":"374","author":"J Mlakar","year":"2016","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: A case study","author":"G Calvet","year":"2016","journal-title":"Lancet Infect Dis"},{"key":"ref9","first-page":"1","article-title":"Zika Virus Infects Human Cortical Neural Progenitors and Attenuates Their Growth","author":"H Tang","year":"2016","journal-title":"Stem Cell. Elsevier Inc."},{"key":"ref10","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1126\/science.aaf6116","article-title":"Zika virus impairs growth in human neurospheres and brain organoids","volume":"352","author":"P Garcez","year":"2016","journal-title":"Science (80-)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/j.stem.2016.04.014","article-title":"Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3","volume":"19","author":"J Dang","year":"2016","journal-title":"Cell Stem Cell. Elsevier Inc"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.antiviral.2017.07.010","article-title":"Replication of the Zika virus in different iPSC-derived neuronal cells and implications to assess efficacy of antivirals","volume":"145","author":"K Lanko","year":"2017","journal-title":"Antiviral Res. Netherlands"},{"key":"ref13","doi-asserted-by":"crossref","unstructured":"Dyer O. Zika virus spreads across Americas as concerns mount over birth defects. BMJ (Clinical research ed.). England; 2015.","DOI":"10.1136\/bmj.h6983"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5935\/0004-2749.20160002","article-title":"Ophthalmological findings in infants with microcephaly and presumable intra-uterus Zika virus infection","volume":"79","author":"C V Ventura","year":"2016","journal-title":"Arq Bras Oftalmol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1089\/biores.2016.0004","article-title":"Pathogenesis of Zika Virus-Associated Embryopathy","volume":"5","author":"AR Mawson","year":"2016","journal-title":"Biores Open Access"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"e0004695","DOI":"10.1371\/journal.pntd.0004695","article-title":"The Viral Polymerase Inhibitor 7-Deaza-2\u2019-C-Methyladenosine Is a Potent Inhibitor of In Vitro Zika Virus Replication and Delays Disease Progression in a Robust Mouse Infection Model","volume":"10","author":"J Zmurko","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref17","first-page":"1","article-title":"A Mouse Model of Zika Virus Pathogenesis","volume":"19","author":"HM Lazear","year":"2016","journal-title":"Cell Host Microbe. Elsevier Inc."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"e1006258","DOI":"10.1371\/journal.ppat.1006258","article-title":"A novel Zika virus mouse model reveals strain specific differences in virus pathogenesis and host inflammatory immune responses","volume":"13","author":"S Tripathi","year":"2017","journal-title":"PLOS Pathog"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"12204","DOI":"10.1038\/ncomms12204","article-title":"A rhesus macaque model of Asian-lineage Zika virus infection","volume":"7","author":"DM Dudley","year":"2016","journal-title":"Nat Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1448","DOI":"10.1038\/nm.4206","article-title":"Zika viral dynamics and shedding in rhesus and cynomolgus macaques","volume":"22","author":"CE Osuna","year":"2016","journal-title":"Nat Med"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ebiom.2016.09.022","article-title":"Characterization of a 2016 Clinical Isolate of Zika Virus in Non-human Primates","volume":"12","author":"XF Li","year":"2016","journal-title":"EBioMedicine. The Authors"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1038\/nm.4193","article-title":"Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate","volume":"22","author":"KM Adams Waldorf","year":"2016","journal-title":"Nat Med"},{"key":"ref23","doi-asserted-by":"crossref","DOI":"10.1016\/0035-9203(54)90006-1","article-title":"Zika Virus: A report on three cases of human infection during an epidemic of jaundice in Nigeria","volume":"48","author":"F Macnamara","year":"1954","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref24","first-page":"1","article-title":"A unique case of human Zika virus infection in association with severe liver injury and coagulation disorders","volume":"7","author":"Y Wu","year":"2017","journal-title":"Sci Rep"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.trstmh.2005.10.007","article-title":"Pathogenesis of liver involvement during dengue viral infections","volume":"100","author":"SL Seneviratne","year":"2006","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1099\/vir.0.031617-0","article-title":"Infection of hepatocytes with 17-D vaccine-strain yellow fever virus induces a strong pro-inflammatory host response","volume":"92","author":"SE Woodson","year":"2011","journal-title":"J Gen Virol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/0035-9203(73)90020-5","article-title":"Letter: Liver pathology in yellow fever","volume":"67","author":"JA Kerr","year":"1973","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref28","first-page":"1","article-title":"Characterization of primary human hepatocyte spheroids as a model system for drug-induced liver injury, liver function and disease","volume":"6","author":"CC Bell","year":"2016","journal-title":"Sci Rep. Nature Publishing Group"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1002\/hep.26414","article-title":"Proteome-wide analyses of human hepatocytes during differentiation and dedifferentiation","volume":"58","author":"C Rowe","year":"2013","journal-title":"Hepatology"},{"key":"ref30","first-page":"565","article-title":"Stem cell-derived hepatocytes: a novel model for hepatitis E virus replication","volume":"64","author":"N Helsen","year":"2016","journal-title":"J Hepatol. European Association for the Study of the Liver"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"12193","DOI":"10.1073\/pnas.1412631111","article-title":"Modeling host interactions with hepatitis B virus using primary and induced pluripotent stem cell-derived hepatocellular systems","volume":"111","author":"a Shlomai","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.jhep.2016.10.009","article-title":"Human stem cell-derived hepatocytes as a model for hepatitis B virus infection, spreading and virus-host interactions","volume":"66","author":"Y Xia","year":"2017","journal-title":"J Hepatol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"45698","DOI":"10.1038\/srep45698","article-title":"Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection","volume":"7","author":"F Sakurai","year":"2017","journal-title":"Sci Rep. England"},{"key":"ref34","first-page":"246","article-title":"Human pluripotent stem cell-derived hepatocytes support complete replication of hepatitis C virus","volume":"57","author":"P Roelandt","year":"2012","journal-title":"J Hepatol. European Association for the Study of the Liver"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2544","DOI":"10.1073\/pnas.1121400109","article-title":"Modeling hepatitis C virus infection using human induced pluripotent stem cells","volume":"109","author":"RE Schwartz","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.stemcr.2014.04.018","article-title":"Modulating innate immunity improves hepatitis C virus infection and replication in stem cell-derived hepatocytes","volume":"3","author":"X Zhou","year":"2014","journal-title":"Stem cell reports. The Authors"},{"key":"ref37","article-title":"Productive hepatitis C virus infection of stem cell-derived hepatocytes reveals a critical transition to viral permissiveness during differentiation","volume":"8","author":"X Wu","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.stemcr.2016.07.012","article-title":"Modeling Dengue Virus-Hepatic Cell Interactions Using Human Pluripotent Stem Cell-Derived Hepatocyte-like Cells","volume":"7","author":"J Lang","year":"2016","journal-title":"Stem cell reports. United States"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.stemcr.2016.06.013","article-title":"H3K27me3 Does Not Orchestrate the Expression of Lineage-Specific Markers in hESC-Derived Hepatocytes In Vitro","volume":"7","author":"J Vanhove","year":"2016","journal-title":"Stem Cell Reports. The Authors"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1590\/0074-02760150192","article-title":"First report of autochthonous transmission of Zika virus in Brazil","volume":"110","author":"C Zanluca","year":"2015","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3855\/jidc.8217","article-title":"Zika virus outbreak in Brazil","volume":"10","author":"J Heukelbach","year":"2016","journal-title":"J Infect Dev Ctries"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1128\/AAC.48.10.3944-3953.2004","article-title":"A 7-deaza-adenosine analog is a potent and selective inhibitor of hepatitis C virus replication with excellent pharmacokinetic properties","volume":"48","author":"DB Olsen","year":"2004","journal-title":"Antimicrob Agents Chemother"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"49164","DOI":"10.1074\/jbc.M305041200","article-title":"Characterization of resistance to non-obligate chain-terminating ribonucleoside analogs that inhibit hepatitis C virus replication in vitro","volume":"278","author":"G Migliaccio","year":"2003","journal-title":"J Biol Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.antiviral.2013.09.015","article-title":"Favipiravir (T-705), a novel viral RNA polymerase inhibitor","volume":"100","author":"Y Furuta","year":"2013","journal-title":"Antiviral Res"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika Virus Infection in Human Skin Cells","volume":"89","author":"R Hamel","year":"2015","journal-title":"J Virol"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0004658","article-title":"A Susceptible Mouse Model for Zika Virus Infection","volume":"10","author":"SD Dowall","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.chom.2016.05.009","article-title":"Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling","volume":"19","author":"A Grant","year":"2016","journal-title":"Cell Host Microbe. Elsevier"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e1006164","DOI":"10.1371\/journal.ppat.1006164","article-title":"Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells","volume":"13","author":"JR Bowen","year":"2017","journal-title":"PLOS Pathog"},{"key":"ref49","first-page":"2689","article-title":"Regulating intracellular antiviral defense and permissiveness to hepatitis C virus RNA replication through a cellular RNA helicase","volume":"79","author":"R Sumpter","journal-title":"RIG-I"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jfma.2016.02.002","article-title":"Zika virus infection-the next wave after dengue?","volume":"115","author":"SSY Wong","year":"2016","journal-title":"J Formos Med Assoc. Published by Elsevier Taiwan LLC"},{"key":"ref51","first-page":"1","article-title":"Zika Virus infection of rhesus macaques leads to viral persistence in multiple tissues","volume":"13","author":"AJ Hirsch","year":"2017","journal-title":"PLoS Pathog"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"3471","DOI":"10.1016\/j.celrep.2017.11.087","article-title":"Transcriptional Changes during Naturally Acquired Zika Virus Infection Render Dendritic Cells Highly Conducive to Viral Replication","volume":"21","author":"X Sun","year":"2017","journal-title":"Cell Rep"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209097","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T17:22:45Z","timestamp":1589044965000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209097"}},"subtitle":[],"editor":[{"given":"Kui","family":"Li","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,19]]},"references-count":52,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209097","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,12,19]]}}}