{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:00:05Z","timestamp":1773291605725,"version":"3.50.1"},"reference-count":66,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T00:00:00Z","timestamp":1545004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0209120","type":"journal-article","created":{"date-parts":[[2018,12,17]],"date-time":"2018-12-17T18:53:14Z","timestamp":1545072794000},"page":"e0209120","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Laboratory strains of Bacillus anthracis exhibit pervasive alteration in expression of proteins related to sporulation under laboratory conditions relative to genetically related wild strains"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1190-5596","authenticated-orcid":true,"given":"Owen P.","family":"Leiser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason K.","family":"Blackburn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted L.","family":"Hadfield","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen W.","family":"Kreuzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David S.","family":"Wunschel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cindy J.","family":"Bruckner-Lea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,12,17]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.mam.2009.08.001","article-title":"The <italic>Bacillus anthracis<\/italic> spore","volume":"30","author":"A. Driks","year":"2009","journal-title":"Mol Aspects Med"},{"issue":"7268","key":"ref2","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1038\/nature08480","article-title":"Genome evolution and adaptation in a long-term experiment with <italic>Escherichia coli<\/italic>","volume":"461","author":"JE Barrick","year":"2009","journal-title":"Nature"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1007\/s00239-002-2423-0","article-title":"Rates of DNA sequence evolution in experimental populations of <italic>Escherichia coli<\/italic> during 20,000 generations","volume":"56","author":"RE Lenski","year":"2003","journal-title":"J Mol Evol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1101\/sqb.2009.74.018","article-title":"Genome-wide mutational diversity in an evolving population of <italic>Escherichia coli<\/italic>","volume":"74","author":"JE Barrick","year":"2009","journal-title":"Cold Spring Harb Symp Quant Biol"},{"issue":"7615","key":"ref5","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1038\/nature18959","article-title":"Tempo and mode of genome evolution in a 50,000-generation experiment","volume":"536","author":"O Tenaillon","year":"2016","journal-title":"Nature"},{"issue":"3","key":"ref6","first-page":"394","article-title":"Selection of laboratory wild-type phenotype from natural isolates of <italic>Escherichia coli<\/italic> in chemostats","volume":"9","author":"R Mikkola","year":"1992","journal-title":"Mol Biol Evol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1111\/1462-2920.12208","article-title":"The nature of laboratory domestication changes in freshly isolated <italic>Escherichia coli<\/italic> strains","volume":"16","author":"G Eydallin","year":"2014","journal-title":"Environ Microbiol"},{"issue":"12","key":"ref8","doi-asserted-by":"crossref","first-page":"e1004872","DOI":"10.1371\/journal.pgen.1004872","article-title":"Mutations in global regulators lead to metabolic selection during adaptation to complex environments","volume":"10","author":"G Saxer","year":"2014","journal-title":"PLoS Genet"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"e11556","DOI":"10.1371\/journal.pone.0011556","article-title":"Whole-genome sequencing reveals distinct mutational patterns in closely related laboratory and naturally propagated <italic>Francisella tularensis<\/italic> strains","volume":"5","author":"A Sj\u00f6din","year":"2010","journal-title":"PLoS One"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"e0142997","DOI":"10.1371\/journal.pone.0142997","article-title":"Investigation of <italic>Yersinia pestis<\/italic> laboratory adaptation through a combined genomics and proteomics approach","volume":"10","author":"OP Leiser","year":"2015","journal-title":"PLoS One"},{"key":"ref11","first-page":"12","article-title":"Protein abundances can distinguish between naturally-occurring and laboratory strains of <italic>Yersinia pestis<\/italic>, the causative agent of plague","author":"ED Merkley","year":"2017","journal-title":"Plos One"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1111\/j.1574-6976.2011.00310.x","article-title":"Recent progress in <italic>Bacillus subtilis<\/italic> sporulation","volume":"36","author":"D Higgins","year":"2012","journal-title":"FEMS Microbiol Rev"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1038\/nrmicro750","article-title":"Regulation of endospore formation in <italic>Bacillus subtilis<\/italic>","volume":"1","author":"J. Errington","year":"2003","journal-title":"Nat Rev Microbiol"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/S1097-2765(00)80377-9","article-title":"Control of development by altered localization of a transcription factor in <italic>B<\/italic>. <italic>subtilis<\/italic>","volume":"4","author":"JD Quisel","year":"1999","journal-title":"Mol Cell"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"3446","DOI":"10.1128\/JB.182.12.3446-3451.2000","article-title":"Control of sporulation gene expression in <italic>Bacillus subtilis<\/italic> by the chromosome partitioning proteins Soj (ParA) and Spo0J (ParB)","volume":"182","author":"JD Quisel","year":"2000","journal-title":"J Bacteriol"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S1097-2765(00)80378-0","article-title":"Dynamic movement of the ParA-like Soj protein of <italic>B<\/italic>. <italic>subtilis<\/italic> and its dual role in nucleoid organization and developmental regulation","volume":"4","author":"AL Marston","year":"1999","journal-title":"Mol Cell"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0201979","article-title":"The positioning of the asymmetric septum during sporulation in Bacillus subtilis","volume":"13","author":"I Barak","year":"2018","journal-title":"Plos One"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1128\/JB.188.3.1159-1164.2006","article-title":"Suppression of engulfment defects in Bacillus subtilis by elevated expression of the motility regulon","volume":"188","author":"AR Perez","year":"2006","journal-title":"J Bacteriol"},{"issue":"24","key":"ref19","doi-asserted-by":"crossref","first-page":"6357","DOI":"10.1128\/JB.00937-10","article-title":"Regulation of CodY activity through modulation of intracellular branched-chain amino acid pools","volume":"192","author":"SR Brinsmade","year":"2010","journal-title":"J Bacteriol"},{"issue":"20","key":"ref20","doi-asserted-by":"crossref","first-page":"5637","DOI":"10.1128\/JB.05510-11","article-title":"Dissecting complex metabolic integration provides direct genetic evidence for CodY activation by guanine nucleotides","volume":"193","author":"SR Brinsmade","year":"2011","journal-title":"J Bacteriol"},{"issue":"9","key":"ref21","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1101\/gad.874201","article-title":"<italic>Bacillus subtilis<\/italic> CodY represses early-stationary-phase genes by sensing GTP levels","volume":"15","author":"M Ratnayake-Lecamwasam","year":"2001","journal-title":"Genes Dev"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00294-016-0656-5","article-title":"CodY, a master integrator of metabolism and virulence in Gram-positive bacteria","volume":"63","author":"SR Brinsmade","year":"2017","journal-title":"Curr Genet"},{"issue":"6","key":"ref23","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1128\/JB.02041-12","article-title":"Identification of CodY targets in <italic>Bacillus anthracis<\/italic> by genome-wide in vitro binding analysis","volume":"195","author":"A Chateau","year":"2013","journal-title":"J Bacteriol"},{"issue":"10","key":"ref24","doi-asserted-by":"crossref","first-page":"4437","DOI":"10.1128\/IAI.00716-09","article-title":"The global regulator CodY regulates toxin gene expression in <italic>Bacillus anthracis<\/italic> and is required for full virulence","volume":"77","author":"W van Schaik","year":"2009","journal-title":"Infect Immun"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"1911","DOI":"10.1128\/JB.185.6.1911-1922.2003","article-title":"Additional targets of the <italic>Bacillus subtilis<\/italic> global regulator CodY identified by chromatin immunoprecipitation and genome-wide transcript analysis","volume":"185","author":"V Molle","year":"2003","journal-title":"J Bacteriol"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1111\/j.1365-2958.1995.tb02378.x","article-title":"A gene required for nutritional repression of the <italic>Bacillus subtilis<\/italic> dipeptide permease operon","volume":"15","author":"FJ Slack","year":"1995","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1365-2958.1993.tb01125.x","article-title":"Transition-State Regulators\u2014Sentinels of <italic>Bacillus subtilis<\/italic> postexponential gene-expression","volume":"7","author":"MA Strauch","year":"1993","journal-title":"Mol Microbiol"},{"issue":"13","key":"ref28","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1128\/JB.181.13.4114-4117.1999","article-title":"ScoC regulates peptide transport and sporulation initiation in <italic>Bacillus subtilis<\/italic>","volume":"181","author":"A Koide","year":"1999","journal-title":"J Bacteriol"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/mmi.12102","article-title":"Spo0A links <italic>de novo<\/italic> fatty acid synthesis to sporulation and biofilm development in <italic>Bacillus subtilis<\/italic>","volume":"87","author":"ME Pedrido","year":"2013","journal-title":"Mol Microbiol"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1046\/j.1365-2958.1998.01004.x","article-title":"<italic>De novo<\/italic> fatty acid synthesis is required for establishment of cell type-specific gene transcription during sporulation in <italic>Bacillus subtilis<\/italic>","volume":"29","author":"GE Schujman","year":"1998","journal-title":"Mol Microbiol"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0092-8674(02)00698-0","article-title":"Asymmetric cell division in <italic>B<\/italic>. <italic>subtilis<\/italic> involves a spiral-like intermediate of the cytokinetic protein FtsZ","volume":"109","author":"S Ben-Yehuda","year":"2002","journal-title":"Cell"},{"issue":"17","key":"ref32","doi-asserted-by":"crossref","first-page":"4881","DOI":"10.1128\/JB.184.17.4881-4890.2002","article-title":"Genome-wide analysis of the stationary-phase sigma factor (sigma-H) regulon of <italic>Bacillus subtilis<\/italic>","volume":"184","author":"RA Britton","year":"2002","journal-title":"J Bacteriol"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.mib.2004.10.001","article-title":"Sporulation of <italic>Bacillus subtilis<\/italic>","volume":"7","author":"PJ Piggot","year":"2004","journal-title":"Curr Opin Microbiol"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1046\/j.1365-2958.2003.03264.x","article-title":"A role for division-site-selection protein MinD in regulation of internucleoid jumping of Soj (ParA) protein in <italic>Bacillus subtilis<\/italic>","volume":"47","author":"S Autret","year":"2003","journal-title":"Mol Microbiol"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1111\/j.1365-2958.2007.05896.x","article-title":"Spore cortex formation in <italic>Bacillus subtilis<\/italic> is regulated by accumulation of peptidoglycan precursors under the control of sigma K","volume":"65","author":"P Vasudevan","year":"2007","journal-title":"Mol Microbiol"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"3659","DOI":"10.1093\/nar\/gkt050","article-title":"Structure-function relationships of two paralogous single-stranded DNA-binding proteins from <italic>Streptomyces coelicolor<\/italic>: implication of SsbB in chromosome segregation during sporulation","volume":"41","author":"T Paradzik","year":"2013","journal-title":"Nucleic Acids Res"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1271\/bbb.67.2245","article-title":"Expression profiling of translation-associated genes in sporulating <italic>Bacillus subtilis<\/italic> and consequence of sporulation by gene inactivation","volume":"67","author":"Y Ohashi","year":"2003","journal-title":"Biosci Biotech Bioch"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.mam.2009.08.003","article-title":"The ecology of <italic>Bacillus anthracis<\/italic>","volume":"30","author":"M Hugh-Jones","year":"2009","journal-title":"Mol Aspects Med"},{"key":"ref39","first-page":"59","article-title":"Emerging and Endemic Pathogens: Advances in Surveillance, Detection and Identification","author":"JK Blackburn","year":"2010"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.4269\/ajtmh.2007.77.1103","article-title":"Modeling the geographic distribution of <italic>Bacillus anthracis<\/italic>, the causative agent of anthrax disease, for the contiguous United States using predictive ecologic niche modeling","volume":"77","author":"JK Blackburn","year":"2007","journal-title":"Am J Trop Med Hyg"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"art13","DOI":"10.1890\/ES12-00245.1","article-title":"Soil ingestion, nutrition and the seasonality of anthrax in herbivores of Etosha National Park","volume":"4","author":"WC Turner","year":"2013","journal-title":"Ecosphere"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1080\/00045608.2014.914834","article-title":"Spatial and temporal tatterns of atnthrax in white-tailed deer, <italic>Odocoileus virginianus<\/italic>, and hematophagous flies in West Texas during the summertime anthrax risk period","volume":"104","author":"JK Blackburn","year":"2014","journal-title":"Ann Assoc Am Geogr"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"393","DOI":"10.7589\/2013-08-204","article-title":"Dances with anthrax: Wolves (<italic>Canis lupus<\/italic>) kill anthrax bacteremic plains bison (<italic>Bison bison bison<\/italic>) in southwestern Montana","volume":"50","author":"JK Blackburn","year":"2014","journal-title":"J Wildl Dis"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.bbrc.2015.12.019","article-title":"Overexpression of the pleiotropic regulator CodY decreases sporulation, attachment and pellicle formation in <italic>Bacillus anthracis<\/italic>","volume":"469","author":"M Gopalani","year":"2016","journal-title":"Biochem Biophys Res Commun"},{"issue":"14","key":"ref45","doi-asserted-by":"crossref","first-page":"8063","DOI":"10.1073\/pnas.140209597","article-title":"The transcriptional profile of early to middle sporulation in <italic>Bacillus subtilis<\/italic>","volume":"97","author":"P Fawcett","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00284-002-4013-1","article-title":"ScoC mediates catabolite repression of sporulation in <italic>Bacillus subtilis<\/italic>","volume":"47","author":"SH Shafikhani","year":"2003","journal-title":"Curr Microbiol"},{"issue":"3","key":"ref47","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1111\/j.1365-2958.1994.tb00436.x","article-title":"Identification of a second oligopeptide transport system in <italic>Bacillus subtilis<\/italic> and determination of its role in sporulation","volume":"13","author":"A Koide","year":"1994","journal-title":"Mol Microbiol"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/mmi.13056","article-title":"Interactive regulation by the <italic>Bacillus subtilis<\/italic> global regulators CodY and ScoC","volume":"97","author":"BR Belitsky","year":"2015","journal-title":"Mol Microbiol"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00018-002-8431-9","article-title":"<italic>Bacillus subtilis<\/italic> sporulation and stationary phase gene expression","volume":"59","author":"ZE Phillips","year":"2002","journal-title":"Cell Mol Life Sci"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1046\/j.1365-2958.2003.03818.x","article-title":"The Spo0A regulon of <italic>Bacillus subtilis<\/italic>","volume":"50","author":"V Molle","year":"2003","journal-title":"Mol Microbiol"},{"issue":"9","key":"ref51","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1111\/j.1365-2958.1989.tb00270.x","article-title":"The transition-state transcription regulator Abrb of <italic>Bacillus subtilis<\/italic> is autoregulated during vegetative growth","volume":"3","author":"MA Strauch","year":"1989","journal-title":"Mol Microbiol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1099\/00221287-144-4-895","article-title":"Effects on <italic>Bacillus subtilis<\/italic> of conditional expression of the <italic>accBC<\/italic> operon encoding subunits of acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis","volume":"144","author":"CA Perez","year":"1998","journal-title":"Microbiology-(UK)"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1574-6968.2009.01888.x","article-title":"The master transcription factor Spo0A is required for poly(3-hydroxybutyrate) (PHB) accumulation and expression of genes involved in PHB biosynthesis in <italic>Bacillus thuringiensis<\/italic>","volume":"304","author":"HJ Chen","year":"2010","journal-title":"FEMS Microbiol Lett"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1128\/MMBR.67.1.52-65.2003","article-title":"Cytokinesis in bacteria","volume":"67","author":"J Errington","year":"2003","journal-title":"Microbiol Mol Biol Rev"},{"issue":"8","key":"ref55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003931","article-title":"<italic>Bacillus anthracis<\/italic> diversity and geographic potential across Nigeria, Cameroon and Chad: Further support of a novel West African lineage","volume":"9","author":"JK Blackburn","year":"2015","journal-title":"Plos Neglected Tropical Diseases"},{"issue":"D1","key":"ref56","doi-asserted-by":"crossref","first-page":"D447","DOI":"10.1093\/nar\/gkv1145","article-title":"2016 update of the PRIDE database and its related tools","volume":"44","author":"JA Vizcaino","year":"2016","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/nbt.2839","article-title":"ProteomeXchange provides globally coordinated proteomics data submission and dissemination","volume":"32","author":"JA Vizcaino","year":"2014","journal-title":"Nat Biotechnol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mimet.2015.08.008","article-title":"Improved proteomic analysis following trichloroacetic acid extraction of <italic>Bacillus anthracis<\/italic> spore proteins","volume":"118","author":"BL Deatherage Kaiser","year":"2015","journal-title":"J Microbiol Methods"},{"issue":"22","key":"ref59","doi-asserted-by":"crossref","first-page":"7796","DOI":"10.1021\/ac061133r","article-title":"Chemically etched open tubular and monolithic emitters for nanoelectrospray ionization mass spectrometry","volume":"78","author":"RT Kelly","year":"2006","journal-title":"Anal Chem"},{"key":"ref60","article-title":"MaxLFQ allows accurate proteome-wide label-free quantification by delayed normalization and maximal peptide ratio extraction","author":"J Cox","year":"2014","journal-title":"Mol Cell Proteomics"},{"issue":"12","key":"ref61","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"J Cox","year":"2008","journal-title":"Nat Biotechnol"},{"issue":"Database issue","key":"ref62","doi-asserted-by":"crossref","first-page":"D581","DOI":"10.1093\/nar\/gkt1099","article-title":"PATRIC, the bacterial bioinformatics database and analysis resource","volume":"42","author":"AR Wattam","year":"2014","journal-title":"Nucleic Acids Res"},{"issue":"17","key":"ref63","doi-asserted-by":"crossref","first-page":"3389","DOI":"10.1093\/nar\/25.17.3389","article-title":"Gapped BLAST and PSI-BLAST: a new generation of protein database search programs","volume":"25","author":"SF Altschul","year":"1997","journal-title":"Nucleic Acids Res"},{"issue":"13","key":"ref64","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1093\/bioinformatics\/btn217","article-title":"DAnTE: a statistical tool for quantitative analysis of -omics data","volume":"24","author":"AD Polpitiya","year":"2008","journal-title":"Bioinformatics"},{"issue":"D1","key":"ref65","doi-asserted-by":"crossref","first-page":"D353","DOI":"10.1093\/nar\/gkw1092","article-title":"KEGG: new perspectives on genomes, pathways, diseases and drugs","volume":"45","author":"M Kanehisa","year":"2017","journal-title":"Nucleic Acids Res"},{"issue":"Database issue","key":"ref66","doi-asserted-by":"crossref","first-page":"D231","DOI":"10.1093\/nar\/gkt1253","article-title":"eggNOG v4.0: nested orthology inference across 3686 organisms","volume":"42","author":"S Powell","year":"2014","journal-title":"Nucleic Acids Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209120","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T01:33:09Z","timestamp":1605663189000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209120"}},"subtitle":[],"editor":[{"given":"Adam","family":"Driks","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,17]]},"references-count":66,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,17]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209120","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,17]]}}}