{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T13:21:56Z","timestamp":1790083316553,"version":"4.0.1"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T00:00:00Z","timestamp":1547596800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100011131","name":"Maine Agricultural and Forest Experiment Station","doi-asserted-by":"crossref","award":["MEO-21501"],"award-info":[{"award-number":["MEO-21501"]}],"id":[{"id":"10.13039\/100011131","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000199","name":"NRAC","doi-asserted-by":"publisher","award":["2010-38580-21074"],"award-info":[{"award-number":["2010-38580-21074"]}],"id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0209178","type":"journal-article","created":{"date-parts":[[2019,1,16]],"date-time":"2019-01-16T18:35:50Z","timestamp":1547663750000},"page":"e0209178","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":62,"title":["Sea lice, Lepeophtheirus salmonis (Kr\u00f8yer 1837), infected Atlantic salmon (Salmo salar L.) are more susceptible to infectious salmon anemia virus"],"prefix":"10.1371","volume":"14","author":[{"given":"Sarah E.","family":"Barker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6042-7143","authenticated-orcid":true,"given":"Ian R.","family":"Bricknell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Covello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Purcell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D.","family":"Fast","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wolters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9552-4576","authenticated-orcid":true,"given":"Deborah A.","family":"Bouchard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,16]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1086\/691981","article-title":"The Cost of Lice: Quantifying the Impacts of Parasitic Sea Lice on Farmed Salmon","volume":"32","author":"J Abolofia","year":"2017","journal-title":"Mar Resour Econ"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.pt.2006.08.006","article-title":"Ecology of sea lice parasitic on farmed and wild fish","volume":"22","author":"MJ Costello","year":"2006","journal-title":"Trends Parasitol"},{"key":"ref3","first-page":"471","article-title":"Annual Review of Marine Science","volume":"7","author":"KD Lafferty","year":"2015"},{"key":"ref4","first-page":"1","article-title":"Fish Disease Causing Economic Impact in Global Aquaculture","author":"HD Rodger","year":"2016"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1111\/jfd.12061","article-title":"Salmon lice\u2014impact on wild salmonids and salmon aquaculture","volume":"36","author":"O Torrissen","year":"2013","journal-title":"Journal of Fish Diseases"},{"key":"ref6","unstructured":"Butler R. In Vitro Modelling of he Immunological Interactions Between teh Salmon Louse <italic>L. salmonis<\/italic> and the Atlantic Salmon <italic>Salmo salar<\/italic> L. PhD Thesis; Univeristy of Aberdeen; 2001."},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1007\/s00436-009-1523-9","article-title":"Preliminary studies on the isolation of bacteria from sea lice, <italic>Lepeophtheirus salmonis<\/italic>, infecting farmed salmon in British Columbia, Canada","volume":"105","author":"DE Barker","year":"2009","journal-title":"Parasitology Research"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3354\/dao02414","article-title":"Vector potential of the salmon louse <italic>Lepeophtheirus salmonis<\/italic> in the transmission of infectious haematopoietic necrosis virus (IHNV)","volume":"97","author":"E Jakob","year":"2011","journal-title":"Diseases of Aquatic Organisms"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3354\/aei00023","article-title":"Area protection may reduce salmon louse infection risk to wild salmonids","volume":"1","author":"PA Bjorn","year":"2011","journal-title":"Aquaculture Environment Interactions"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.aquaculture.2012.08.003","article-title":"Result of an epidemiological study of sea lice infestation in South Connemara, West of Ireland","volume":"364","author":"D Jackson","year":"2012","journal-title":"Aquaculture"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1645\/GE-685R1.1","article-title":"The occurrence of <italic>Lepeophtheirus salmonis<\/italic> and <italic>Caligus clemensi<\/italic> (Copepoda: Caligidae) on three-spine stickleback <italic>Gasterosteus aculeatus<\/italic> in coastal British Columbia","volume":"92","author":"SRM Jones","year":"2006","journal-title":"Journal of Parasitology"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3354\/aei00094","article-title":"Using sentinel cages to estimate infestation pressure on salmonids from sea lice in Loch Shieldaig, Scotland","volume":"5","author":"CC Pert","year":"2014","journal-title":"Aquaculture Environment Interactions"},{"issue":"1\u20134","key":"ref13","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.aquaculture.2007.05.025","article-title":"Behavioural studies of host, non-host and mate location by the Sea Louse, <italic>Caligus rogercresseyi<\/italic> Boxshall &amp; Bravo, 2000 (Copepoda: Caligidae)","volume":"271","author":"J Pino-Marambio","year":"2007","journal-title":"Aquaculture"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2761.2008.01004.x","article-title":"A review of host finding behaviour in the parasitic sea louse, <italic>Lepeophtheirus salmonis<\/italic> (Caligidae: Copepoda)","volume":"32","author":"AJ Mordue","year":"2009","journal-title":"Journal of Fish Diseases"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"380","DOI":"10.3856\/vol43-issue2-fulltext-15","article-title":"<italic>Caligus rogercresseyi<\/italic>: possible vector in the horizontal transmission of the virus of infectious salmon anaemia","volume":"43","author":"K Oelckers","year":"2015","journal-title":"Latin American Journal of Aquatic Research"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3354\/dao016079","article-title":"Isolation of <italic>Aeromonas salmonicida<\/italic> From Salmon Lice Lepeophtheirus salmonis and Marine Plankton","volume":"16","author":"L Nese","year":"1993","journal-title":"Diseases of Aquatic Organisms"},{"issue":"2","key":"ref17","first-page":"100","article-title":"Comparative defense-associated responses in salmon skin elicited by the ectoparasite <italic>Lepeophtheirus salmonis<\/italic>. Comparative Biochemistry and Physiology D-Genomics &amp;","volume":"7","author":"LM Braden","year":"2012","journal-title":"Proteomics"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.dci.2013.08.019","article-title":"Fish immune responses to parasitic copepod (namely sea lice) infection","volume":"43","author":"MD Fast","year":"2014","journal-title":"Developmental and Comparative Immunology"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1111\/j.1365-3024.2007.00932.x","article-title":"<italic>Lepeophtheirus salmonis<\/italic> secretory\/excretory products and their effects on Atlantic salmon immune gene regulation","volume":"29","author":"MD Fast","year":"2007","journal-title":"Parasite Immunology"},{"issue":"1\u20132","key":"ref20","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.exppara.2004.04.001","article-title":"<italic>Lepeophtheirus salmonis<\/italic>: characterization of prostaglandin E-2 in secretory products of the salmon louse by RP-HPLC and mass spectrometry","volume":"107","author":"MD Fast","year":"2004","journal-title":"Experimental Parasitology"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.fsi.2014.03.014","article-title":"Modulation of cellular innate immunity by <italic>Lepeophtheirus salmonis<\/italic> secretory products","volume":"38","author":"DL Lewis","year":"2014","journal-title":"Fish & Shellfish Immunology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/1471-2164-9-498","article-title":"Local and systemic gene expression responses of Atlantic salmon <italic>(Salmo salar<\/italic> L.) to infection with the salmon louse (<italic>Lepeophtheirus salmonis<\/italic>)","volume":"9","author":"S Skugor","year":"2008","journal-title":"Bmc Genomics"},{"key":"ref23","unstructured":"Braden LM, Poley JD, Byrne PJ, Fast MD, editors. Functional transcriptomic characterization of Lepeophethrius salmonis, rejection by coho salmon (<italic>Oncorhynchus kisutch<\/italic>). 11th International sea lice conference,; 2016; Westport, Ireland, September 26\u201328, 2016."},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"9016","DOI":"10.1128\/JVI.71.12.9016-9023.1997","article-title":"Characterization of infectious salmon anemia virus, an orthomyxo-like virus isolated from Atlantic salmon (<italic>Salmo salar<\/italic> L.)","volume":"71","author":"K Falk","year":"1997","journal-title":"Journal of Virology"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.1128\/JVI.71.10.7681-7686.1997","article-title":"Genomic characterization of the virus causing infectious salmon anemia in Atlantic salmon (<italic>Salmo salar<\/italic> L.): An orthomyxo-like virus in a teleost","volume":"71","author":"S Mjaaland","year":"1997","journal-title":"Journal of Virology"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3354\/dao045009","article-title":"Isolation and identification of infectious salmon anaemia virus (ISAV) from coho salmon in Chile","volume":"45","author":"FSB Kibenge","year":"2001","journal-title":"Diseases of Aquatic Organisms"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"2136","DOI":"10.1128\/JVI.73.3.2136-2142.1999","article-title":"The putative polymerase sequence of infectious salmon anemia virus suggests a new genus within the Orthomyxoviridae","volume":"73","author":"B Krossoy","year":"1999","journal-title":"Journal of Virology"},{"issue":"3","key":"ref28","first-page":"238","article-title":"Genomic relationships of the North American isolate of infectious salmon anemia virus (ISAV) to the Norwegian strain of ISAV (vol 35, pg 139, 1999)","volume":"36","author":"S Blake","year":"1999","journal-title":"Diseases of Aquatic Organisms"},{"issue":"3","key":"ref29","first-page":"238","article-title":"Isolation of infectious salmon anemia virus (ISAV) from Atlantic salmon in New Brunswick, Canada (vol 35, pg 131, 1999)","volume":"36","author":"D Bouchard","year":"1999","journal-title":"Diseases of Aquatic Organisms"},{"issue":"6","key":"ref30","first-page":"286","article-title":"Infectious salmon anaemia","volume":"19","author":"T Hastings","year":"1999","journal-title":"Bulletin of the European Association of Fish Pathologists"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0034-5288(91)90017-I","article-title":"A Morphological-Study Of The Gross And Light Microscopic Lesions Of Infectious-Anemia In Atlantic Salmon (<italic>Salmo salar<\/italic>)","volume":"51","author":"O Evensen","year":"1991","journal-title":"Research in Veterinary Science"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1034\/j.1600-0463.2002.100401.x","article-title":"Infectious salmon anaemia virus\u2014An orthomyxovirus causing an emerging infection in Atlantic salmon","volume":"110","author":"E Rimstad","year":"2002","journal-title":"Apmis"},{"issue":"3\u20134","key":"ref33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.aquaculture.2011.02.014","article-title":"Disease interaction and pathogens exchange between wild and farmed fish populations with special reference to Norway","volume":"315","author":"LH Johansen","year":"2011","journal-title":"Aquaculture"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1111\/jfd.12070","article-title":"Co-infection patterns of infectious salmon anaemia and sea lice in farmed Atlantic salmon, Salmo salar L., in southern Chile (20072009)","volume":"36","author":"P Valdes-Donoso","year":"2013","journal-title":"Journal of Fish Diseases"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1365-2761.2012.01412.x","article-title":"Enhanced detection of infectious salmon anaemia virus using a low-speed centrifugation technique in three fish cell lines","volume":"36","author":"SD Molloy","year":"2013","journal-title":"Journal of Fish Diseases"},{"key":"ref36","first-page":"493","article-title":"A simple method of estimating fifty percent endpoints","volume":"27","author":"LJ Reed","year":"1938","journal-title":"The American Journal of Hygiene"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/j.1469-7998.1991.tb04799.x","article-title":"The Settlement And Attachment Of Early Stages Of The Salmon Louse, <italic>Lepeophtheirus salmonis<\/italic> (Copepoda, Caligidae) On The Salmon Host, Salmo salar","volume":"224","author":"JE Bron","year":"1991","journal-title":"Journal of Zoology"},{"issue":"3","key":"ref38","first-page":"532","article-title":"A Reagent For The Single-Step Simultaneous Isolation Of Rna, Dna And Proteins From Cell And Tissue Samples","volume":"15","author":"P. Chomczynski","year":"1993","journal-title":"Biotechniques"},{"issue":"6","key":"ref39","first-page":"942","article-title":"Modification Of The Tri-Reagent (Tm) Procedure For Isolation Of Rna From Polysaccharide-Rich And Proteoglycan-Rich Sources","volume":"19","author":"P Chomczynski","year":"1995","journal-title":"Biotechniques"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/abio.1995.1126","article-title":"Substitution Of Chloroform By Bromochloropropane In The Single-Step Method Of Rna Isolation","volume":"225","author":"P Chomczynski","year":"1995","journal-title":"Analytical Biochemistry"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"P Chomczynski","year":"1987","journal-title":"Analytical Biochemistry"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-7-research0034","article-title":"Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"J Vandesompele","year":"2002","journal-title":"Genome Biology"},{"key":"ref43","article-title":"Risk Factors associated with mortalities attributed to ISAV","author":"KL Hammell","year":"2005"},{"issue":"3\u20134","key":"ref44","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.prevetmed.2005.07.010","article-title":"Risk factors for outbreaks of infectious salmon anemia in farmed <italic>Atlantic salmon<\/italic>, Salmo salar","volume":"72","author":"CA McClure","year":"2005","journal-title":"Preventive Veterinary Medicine"},{"issue":"6","key":"ref45","first-page":"213","article-title":"<italic>Lepeophtheirus salmonis<\/italic>\u2013a possible vector in the spread of diseases on salmonids","volume":"11","author":"A Nylund","year":"1991","journal-title":"Bulletin of the European Association of Fish Pathologists"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3354\/dao02262","article-title":"Epidemiological investigation into the re-emergence and control of an outbreak of infectious salmon anaemia in the Shetland Islands, Scotland","volume":"91","author":"G. Murray A","year":"2010","journal-title":"Diseases Of Aquatic Organisms"},{"key":"ref47","first-page":"133","article-title":"New Diagnostic Technology: Applications in Animal Health and Biologics Controls","author":"M Snow"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.dci.2014.09.015","article-title":"Signatures of resistance to <italic>Lepeophtheirus salmonis<\/italic> include a T(H)2-type response at the louse-salmon interface","volume":"48","author":"LM Braden","year":"2015","journal-title":"Developmental and Comparative Immunology"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1471-2164-13-130","article-title":"Gene expression in Atlantic salmon skin in response to infection with the parasitic copepod <italic>Lepeophtheirus salmonis<\/italic>, cortisol implant, and their combination","volume":"13","author":"A Krasnov","year":"2012","journal-title":"Bmc Genomics"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/jfd.12024","article-title":"CpG inclusion in feed reduces sea lice, <italic>Lepeophtheirus salmonis<\/italic>, numbers following re-infection","volume":"36","author":"SL Purcell","year":"2013","journal-title":"Journal of Fish Diseases"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/j.fsi.2014.10.038","article-title":"Difference in skin immune responses to infection with salmon louse (<italic>Lepeophtheirus salmonis<\/italic>) in Atlantic salmon (<italic>Salmo salar<\/italic> L.) of families selected for resistance and susceptibility","volume":"42","author":"H Holm","year":"2015","journal-title":"Fish & Shellfish Immunology"},{"key":"ref52","doi-asserted-by":"crossref","DOI":"10.1186\/s13071-016-1921-7","article-title":"Nutrigenomic effects of glucosinolates on liver, muscle and distal kidney in parasitefree and salmon louse infected Atlantic salmon","volume":"9","author":"S Skugor","year":"2016","journal-title":"Parasites & Vectors"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.fsi.2007.10.005","article-title":"Induction of interferon system genes in Atlantic salmon by the imidazoquinoline S-27609, a ligand for toll-like receptor 7","volume":"24","author":"O Kileng","year":"2008","journal-title":"Fish & Shellfish Immunology"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.fsi.2006.11.011","article-title":"Infectious salmon anemia virus is a powerful inducer of key genes of the type I interferon system of Atlantic salmon, but is not inhibited by interferon","volume":"23","author":"O Kileng","year":"2007","journal-title":"Fish & Shellfish Immunology"},{"issue":"1","key":"ref55","doi-asserted-by":"crossref","first-page":"219","DOI":"10.20506\/rst.28.1.1867","article-title":"Protective role of interferon-induced Mx GTPases against influenza viruses","volume":"28","author":"O Holler","year":"2009","journal-title":"Revue Scientifique Et Technique-Office International Des Epizooties"},{"issue":"2","key":"ref56","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/08830185.2017.1291640","article-title":"Emerging avian influenza infections: Current understanding of innate immune response and molecular pathogenesis","volume":"36","author":"A Mishra","year":"2017","journal-title":"International Reviews of Immunology"},{"issue":"36","key":"ref57","doi-asserted-by":"crossref","first-page":"4695","DOI":"10.1016\/j.vaccine.2014.05.059","article-title":"Protection of Atlantic salmon against virus infection by intramuscular injection of IFNc expression plasmid","volume":"32","author":"CJ Chang","year":"2014","journal-title":"Vaccine"},{"issue":"9","key":"ref58","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137767","article-title":"Individual Monitoring of Immune Response in Atlantic Salmon <italic>Salmo salar<\/italic> following Experimental Infection with Infectious Salmon Anaemia Virus (ISAV)","volume":"10","author":"B Collet","year":"2015","journal-title":"Plos One"},{"issue":"12","key":"ref59","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a010272","article-title":"Epigenetics and Bacterial Infections","volume":"2","author":"H Bierne","year":"2012","journal-title":"Cold Spring Harbor Perspectives in Medicine"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039080","article-title":"Activation of Type III Interferon Genes by Pathogenic Bacteria in Infected Epithelial Cells and Mouse Placenta","volume":"7","author":"H Bierne","year":"2012","journal-title":"Plos One"},{"key":"ref61","unstructured":"Brown ABJ, Braden LM, Whyte SK, Groman DB, Fast MD, editors. Vaccine induced protection against furunculosis in Arctic charr, <italic>Salvelinus alpinus<\/italic>. 42nd Annual Eastern Fish Health Workshop; 2017; East Lansing Michigan, USA."},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.molimm.2012.03.021","article-title":"Transcriptional response of Atlantic salmon (<italic>Salmo salar<\/italic>) after primary versus secondary exposure to infectious salmon anemia virus (ISAV)","volume":"51","author":"F LeBlanc","year":"2012","journal-title":"Molecular Immunology"},{"issue":"3","key":"ref63","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.fsi.2007.01.005","article-title":"Effect of early infectious salmon anaemia virus (ISAV) infection on expression of MHC pathway genes and type I and II interferon in Atlantic salmon (<italic>Salmo salar<\/italic> L.) tissues","volume":"23","author":"SM Jorgensen","year":"2007","journal-title":"Fish & Shellfish Immunology"},{"key":"ref64","article-title":"Effect of infectious salmon anemia virus (ISAV) infection and poly I:C treatment on expression of different stress related genes in Atlantic salmon (<italic>Salmo salar<\/italic> L.) cells","author":"AR Kvello","year":"2007","journal-title":"Oslo: Oslo"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.actatropica.2017.09.027","article-title":"The roles of galectins in parasitic infections","volume":"177","author":"WK Shi","year":"2018","journal-title":"Acta Tropica"},{"issue":"1\u20132","key":"ref66","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.virusres.2008.04.019","article-title":"Transcriptomic analysis of responses to infectious salmon anemia virus infection in macrophage-like cells","volume":"136","author":"BL Schiotz","year":"2008","journal-title":"Virus Research"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1042\/BJ20121425","article-title":"Crystal structure of the TRIM25 B30.2 (PRYSPRY) domain: a key component of antiviral signalling","volume":"456","author":"AA D'Cruz","year":"2013","journal-title":"Biochemical Journal"},{"issue":"2","key":"ref68","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.fsi.2010.03.007","article-title":"Genetic markers of the immune response of Atlantic salmon (Salmo salar) to infectious salmon anemia virus (ISAV)","volume":"29","author":"F LeBlanc","year":"2010","journal-title":"Fish & Shellfish Immunology"},{"issue":"6977","key":"ref69","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1038\/nature02343","article-title":"The cytoplasmic body component TRIM5 alpha restricts HIV-1 infection in Old World monkeys","volume":"427","author":"M Stremlau","year":"2004","journal-title":"Nature"},{"issue":"11","key":"ref70","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/j.1365-2761.2005.00667.x","article-title":"Mortality patterns in infectious salmon anaemia virus outbreaks in New Brunswick","volume":"28","author":"KL Hammell","year":"2005","journal-title":"Canada. Journal of Fish Diseases"},{"issue":"11","key":"ref71","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1111\/j.1365-2761.2005.00668.x","article-title":"Risk factors associated with mortalities attributed to infectious salmon anaemia virus in New Brunswick, Canada","volume":"28","author":"KL Hammell","year":"2005","journal-title":"Journal of Fish Diseases"},{"issue":"2\u20133","key":"ref72","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3354\/dao063119","article-title":"Application of surveillance data in evaluation of diagnostic tests for infectious salmon anemia","volume":"63","author":"CA McClure","year":"2005","journal-title":"Dis Aquat Org"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0213232","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,3,5]],"date-time":"2019-03-05T00:00:00Z","timestamp":1551744000000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209178","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,22]],"date-time":"2020-11-22T18:05:45Z","timestamp":1606068345000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209178"}},"subtitle":[],"editor":[{"given":"Masami","family":"Fujiwara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,16]]},"references-count":72,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209178","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0213232","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,16]]}}}