{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T14:13:40Z","timestamp":1781619220254,"version":"3.54.5"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T00:00:00Z","timestamp":1548720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004916","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado do Amazonas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0209223","type":"journal-article","created":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T18:37:20Z","timestamp":1548787040000},"page":"e0209223","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Lithium is able to minimize olanzapine oxidative-inflammatory induction on macrophage cells"],"prefix":"10.1371","volume":"14","author":[{"given":"Marcelo Soares","family":"Fernandes","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda","family":"Barbisan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f4nica Farina","family":"Azzolin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Ant\u00f4nio Schmidt","family":"do Prado-Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cibele Ferreira","family":"Teixeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivo Em\u00edlio","family":"da Cruz Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Elias","family":"Assmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogerio Tomasi","family":"Riffel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta Maria Medeiros Frescura","family":"Duarte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ednea Maia","family":"Aguiar- Ribeiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2960-7047","authenticated-orcid":true,"given":"Ivana Beatrice M\u00e2nica","family":"da Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006569.pub3","article-title":"Ziprasidone versus other atypical antipsychotics for schizophrenia","author":"K Komossa","year":"2009","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1111\/acps.12896","article-title":"Mixed states in bipolar and major depressive disorders: systematic review and quality appraisal of guidelines","volume":"138","author":"N Verdolini","year":"2018","journal-title":"Acta Psychiatr. Scand"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.jad.2017.02.012","article-title":"H\u00f6istad M Maintenance therapy with second generation antipsychotics for bipolar disorder\u2014A systematic review and meta-analysis","volume":"213","author":"L Lindstr\u00f6m","year":"2017","journal-title":"J Affect Disord"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.euroneuro.2017.01.002","article-title":"Benefits and harms of atypical antipsychotics for agitation in adults with dementia","volume":"27","author":"MR Farlow","year":"2017","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1176\/appi.neuropsych.14100265","article-title":"Anxiety in Huntington's Disease","volume":"27","author":"M Dale","year":"2015","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41537-018-0053-9","article-title":"Risk of weight gain for specific antipsychotic drugs: a meta-analysis","volume":"4","author":"J Spertus","year":"2018","journal-title":"NPJ Schizophr"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1007\/s00520-017-3864-8","article-title":"Olanzapine for prevention of chemotherapy-induced nausea and vomiting in children and adolescents: a multi-center, feasibility study","volume":"26","author":"J Flank","year":"2018","journal-title":"Support Care Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.critrevonc.2017.02.017","article-title":"Efficacy and safety of olanzapine for the prevention of chemotherapy-induced nausea and vomiting: A systematic review and meta-analysis","volume":"112","author":"J Yoodee","year":"2017","journal-title":"Crit Rev Oncol Hematol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/j.euroneuro.2015.03.002","article-title":"Olanzapine depot exposure in male rats: Dose-dependent lipogenic effects without concomitant weight gain","volume":"25","author":"J Fern\u00f8","year":"2015","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phrs.2015.07.022","article-title":"Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology","volume":"101","author":"LE Rojo","year":"2015","journal-title":"Pharmacol Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/j.molmed.2013.05.001","article-title":"Chronic adipose tissue inflammation: all immune cells on the stage","volume":"19","author":"G Cildir","year":"2013","journal-title":"Trends Mol Med."},{"key":"ref12","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.brainres.2010.05.060","article-title":"Olanzapine-induced accumulation of adipose tissue is associated with an inflammatory state","volume":"1350","author":"M Victoriano","year":"2010","journal-title":"Brain Res"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1016\/j.bbrc.2014.07.005","article-title":"Atypical antipsychotics induce both proinflammatory and adipogenic gene expression in human adipocytes in vitro","volume":"450","author":"AK S\u00e1rv\u00e1ri","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00213-011-2555-2","article-title":"Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters","volume":"221","author":"KJ Davey","year":"2012","journal-title":"Psychopharmacology (Berl)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1177\/0269881114555250","article-title":"Effects of olanzapine on the elevation of macrophage infiltration and pro-inflammatory cytokine expression in female rats","volume":"28","author":"Q Zhang","year":"2014","journal-title":"J Psychopharmacol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.psyneuen.2018.05.021","article-title":"Effects of chronic antipsychotic drug exposure on the expression of Translocator Protein and inflammatory markers in rat adipose tissue","volume":"95","author":"A Calevro","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"4997","DOI":"10.1172\/JCI93090","article-title":"Macrophage migration inhibitory factor mediates metabolic dysfunction induced by atypical antipsychotic therapy","volume":"128","author":"D Cui","year":"2018","journal-title":"J Clin Invest"},{"key":"ref18","article-title":"Unresolved Issues for Utilization of Atypical Antipsychotics in Schizophrenia: Antipsychotic Polypharmacy and Metabolic Syndrome","volume":"18","author":"SW Jeon","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1007\/s40262-016-0370-y","article-title":"Drug Interactions with Lithium: An Update","volume":"55","author":"PR Finley","year":"2016","journal-title":"Clin Pharmacokinet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1111\/jcpp.12735","article-title":"Practitioner Review: The effects of atypical antipsychotics and mood stabilisers in the treatment of depressive symptoms in paediatric bipolar disorder","volume":"58","author":"T Atkin","year":"2017","journal-title":"J Child Psychol Psychiatry"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"4151594","DOI":"10.1155\/2017\/4151594","article-title":"Xanthine-Catechin Mixture Enhances Lithium-Induced Anti-Inflammatory Response in Activated Macrophages In Vitro","volume":"2017","author":"F Barbisan","year":"2017","journal-title":"Biomed Res Int"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.gene.2018.02.046","article-title":"Genetic or pharmacological superoxide-hydrogen peroxide imbalances modulate the in vitro effects of lithium on glycogen synthase kinase-3\u03b2","volume":"655","author":"F Barbisan","year":"2018","journal-title":"Gene"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.cyto.2017.10.017","article-title":"Ziprasidone, a second-generation antipsychotic drug, triggers a macrophage inflammatory response in vitro","volume":"106","author":"T Duarte","year":"2018","journal-title":"Cytokine"},{"key":"ref24","article-title":"Clinical Pharmacokinetics of Atypical Antipsychotics: An Update","author":"MC Mauri","year":"2018","journal-title":"Clin Pharmacokinet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"T Mosmann","year":"1983","journal-title":"J Immunol Methods"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.tiv.2015.12.001","article-title":"Superoxide-hydrogen peroxide imbalance interferes with colorectal cancer cells viability, proliferation and oxaliplatin response","volume":"32","author":"VF Azzolin","year":"2016","journal-title":"Toxicol Vitr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.biochi.2010.04.017","article-title":"Antioxidant properties of 4-methylcoumarins in in vitro cell-free systems","volume":"92","author":"G Morabito","year":"2010","journal-title":"Biochimie"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1017\/S0967199416000307","article-title":"Seminal cell-free DNA levels measured by PicoGreen fluorochrome are associated with sperm fertility criteria","volume":"25","author":"F Costa","year":"2017","journal-title":"Zygote."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1007\/s00213-015-4079-7","article-title":"Haloperidol and Risperidone at high concentrations activate an in vitro inflammatory response of RAW 264.7 macrophage cells by induction of apoptosis and modification of cytokine levels","volume":"233","author":"IE da Cruz Jung","year":"2016","journal-title":"Psychopharmacology (Berl)"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"353","DOI":"10.14573\/altex.1710081","article-title":"Good cell culture practice for stem cells & stem-cell-derived models","volume":"35","author":"A. Pamies","year":"2018","journal-title":"ALTEX"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1247\/csf.13012","article-title":"The antipsychotic olanzapine induces apoptosis in insulin-secreting pancreatic \u03b2 cells by blocking PERK-mediated translational attenuation","volume":"38","author":"R Ozasa","year":"2013","journal-title":"Cell Struct Funct."},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-2006-931475","article-title":"In vitro toxicity of clozapine, olanzapine, and quetiapine on granulocyte-macrophage progenitors (GM-CFU)","volume":"39","author":"A Pessina","year":"2006","journal-title":"Pharmacopsychiatry"},{"issue":"11","key":"ref33","first-page":"6177","article-title":"Olanzapine, an Atypical Antipsychotic, Inhibits Survivin Expression and Sensitizes Cancer Cells to Chemotherapeutic Agents","volume":"37","author":"T Sanomachi","year":"2017","journal-title":"Anticancer Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.jpsychires.2018.08.017","article-title":"Second generation atypical antipsychotics olanzapine and aripiprazole reduce expression and secretion of inflammatory cytokines in human immune cells","volume":"105","author":"B Stapel","year":"2018","journal-title":"J Psychiatr Res"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000441521","article-title":"Inflammatory Cytokines and Antipsychotic-Induced Weight Gain: Review and Clinical Implications","volume":"2","author":"TM Fonseka","year":"2016","journal-title":"Mol Neuropsychiatry"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","article-title":"Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases","volume":"148","author":"E Beurel","year":"2015","journal-title":"Pharmacol Ther"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jad.2017.03.054","article-title":"Reducing the rehospitalization risk after a manic episode: A population based cohort study of lithium, valproate, olanzapine, quetiapine and aripiprazole in monotherapy and combinations","volume":"217","author":"L Wing\u00e5rd","year":"2017","journal-title":"J Affect Disord"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1089\/cap.2016.0046","article-title":"Melatonin for Reducing Weight Gain Following Administration of Atypical Antipsychotic Olanzapine for Adolescents with Bipolar Disorder: A Randomized, Double-Blind, Placebo-Controlled Trial","volume":"27","author":"SA Mostafavi","year":"2017","journal-title":"J Child Adolesc Psychopharmacol"},{"key":"ref39","article-title":"Clinical Pharmacokinetics of Atypical Antipsychotics: An Update","author":"MC Mauri","year":"2018","journal-title":"Clin Pharmacokinet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jad.2017.12.026","article-title":"Lithium, Stress, and Resilience in Bipolar Disorder: Deciphering this key homeostatic synaptic plasticity regulator","volume":"233","author":"R Machado-Vieira","year":"2018","journal-title":"J Affect Disord"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1185\/03007995.2012.666961","article-title":"Safety and efficacy of olanzapine monotherapy and olanzapine with a mood stabilizer in 18-week treatment of manic\/mixed episodes for Japanese patients with bipolar I disorder","volume":"28","author":"H Katagiri","year":"2012","journal-title":"Curr Med Res Opin"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6425","DOI":"10.1002\/jcp.26429","article-title":"Macrophage plasticity, polarization, and function in health and disease","volume":"233","author":"A Shapouri-Moghaddam","year":"2018","journal-title":"J Cell Physiol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.cimid.2009.07.001","article-title":"Innate immune responses of primary murine macrophage-lineage cells and RAW 264.7 cells to ligands of Toll-like receptors 2, 3, and 4","volume":"33","author":"LJ Berghaus","year":"2010","journal-title":"Comp Immunol Microbiol Infect Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"532","DOI":"10.3389\/fimmu.2014.00532","article-title":"Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages","volume":"5","author":"M Rath","year":"2014","journal-title":"Front Immunol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"496","DOI":"10.5604\/17322693.1150133","article-title":"Different pathways of macrophage activation and polarization","volume":"69","author":"U Juhas","year":"2015","journal-title":"Postepy Hig Med Dosw (Online)"},{"key":"ref46","first-page":"2795090","article-title":"The Reactive Oxygen Species in Macrophage Polarization: Reflecting Its Dual Role in Progression and Treatment of Human Diseases","volume":"2016","author":"HY Tan","year":"2016","journal-title":"Oxid Med Cell Longev"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/01.pra.0000388627.36781.6a","article-title":"Clozapine treatment causes oxidation of proteins involved in energy metabolism in lymphoblastoid cells: a possible mechanism for antipsychotic-induced metabolic alterations","volume":"16","author":"MR Baig","year":"2010","journal-title":"J Psychiatr Pract"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"e59012","DOI":"10.1371\/journal.pone.0059012","article-title":"Clozapine-induced mitochondria alterations and inflammation in brain and insulin-responsive cells","volume":"8","author":"V1 Contreras-Shannon","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.euroneuro.2018.01.004","article-title":"Second generation antipsychotic-induced mitochondrial alterations: Implications for increased risk of metabolic syndrome in patients with schizophrenia","volume":"28","author":"G Scaini","year":"2018","journal-title":"Eur Neuropsychopharmacol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1002\/1873-3468.12964","article-title":"Role of mitochondrial ROS in the brain: from physiology to neurodegeneration","volume":"592","author":"PR Angelova","year":"2018","journal-title":"FEBS Lett"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.jpsychires.2016.02.001","article-title":"Mitochondrial dysfunction and lipid peroxidation in rat frontal cortex by chronic NMDA administration can be partially prevented by lithium treatment","volume":"76","author":"HK Kim","year":"2016","journal-title":"J Psychiatr Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-014-3655-6","article-title":"Lithium increases leukocyte mitochondrial complex I activity in bipolar disorder during depressive episodes","volume":"232","author":"RT de Sousa","year":"2015","journal-title":"Psychopharmacology (Berl)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:49:22Z","timestamp":1589021362000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209223"}},"subtitle":[],"editor":[{"given":"Oleg","family":"Lunov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,29]]},"references-count":52,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209223","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,29]]}}}