{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:38:03Z","timestamp":1790307483214,"version":"4.1.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T00:00:00Z","timestamp":1544572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0209236","type":"journal-article","created":{"date-parts":[[2018,12,12]],"date-time":"2018-12-12T18:45:13Z","timestamp":1544640313000},"page":"e0209236","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Evaluating the impact of meloxicam oral suspension administered at parturition on subsequent production, health, and culling in dairy cows: A randomized clinical field trial"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0796-6820","authenticated-orcid":true,"given":"Daniel A.","family":"Shock","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Renaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"Roche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Poliquin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger","family":"Thomson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merle E.","family":"Olson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,12]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cvfa.2013.04.003","article-title":"Using Nonesterified Fatty Acids and \u03b2-Hydroxybutyrate Concentrations During the Transition Period for Herd-Level Monitoring of Increased Risk of Disease and Decreased Reproductive and Milking Performance","volume":"29","author":"PA Ospina","year":"2013","journal-title":"Vet Clin North Am Food Anim Pract. Elsevier"},{"issue":"9","key":"ref2","doi-asserted-by":"crossref","first-page":"4201","DOI":"10.3168\/jds.2007-0023","article-title":"Body Condition Score and Body Weight Effects on Dystocia and Stillbirths and Consequent Effects on Postcalving Performance","volume":"90","author":"DP Berry","year":"2007","journal-title":"J Dairy Sci. Elsevier"},{"key":"ref3","article-title":"Rebuhn\u2019s Diseases of Dairy Cattle","author":"TJ Divers","year":"2017"},{"key":"ref4","article-title":"Veterinary reproductionh and obstetrics","author":"D Noakes","year":"2009"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cvfa.2013.04.003","article-title":"Using nonesterified fatty acids and \u03b2-hydroxybutyrate concentrations during the transition period for herd-level monitoring of increased risk of disease and decreased reproductive and milking performance","volume":"29","author":"PA Ospina","year":"2013","journal-title":"Vet Clin North Am Food Anim Pract"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.applanim.2011.10.020","article-title":"Pain and discomfort caused by parturition in cows and sows","volume":"135","author":"E Mainau","year":"2011","journal-title":"Appl Anim Behav Sci. Elsevier B.V."},{"key":"ref7","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1017\/S0962728600024301","article-title":"Assessing pain in animals","volume":"11","author":"K Rutherford","year":"2002","journal-title":"Anim Welf"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"3682","DOI":"10.3168\/jds.2012-6214","article-title":"Effects of meloxicam on milk production, behavior, and feed intake in dairy cows following assisted calving","volume":"96","author":"NC Newby","year":"2013","journal-title":"J Dairy Sci. Elsevier"},{"issue":"102","key":"ref9","article-title":"Efficacy of oral meloxicam suspension for prevention of pain and inflammation following band and surgical castration in calves","volume":"12","author":"ME Olson","year":"2016","journal-title":"BMC Vet Res"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1016\/S0195-5616(08)70007-X","article-title":"Nonsteroidal anti-inflammatory analgesics: Indications and contraindications for pain management in dogs and cats","volume":"30","author":"KA Mathews","year":"2000","journal-title":"Vet Clin North Am\u2014Small Anim Pract. Elsevier Inc."},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.3168\/jds.2006-445","article-title":"Plasma Paraoxonase, Health, Inflammatory Conditions, and Liver Function in Transition Dairy Cows","volume":"90","author":"M Bionaz","year":"2007","journal-title":"J Dairy Sci. Elsevier"},{"issue":"2","key":"ref12","doi-asserted-by":"crossref","first-page":"621","DOI":"10.3168\/jds.2008-1526","article-title":"Short communication: Haptoglobin as an early indicator of metritis","volume":"92","author":"JM Huzzey","year":"2009","journal-title":"J Dairy Sci. Elsevier"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"672","DOI":"10.3168\/jds.2015-10048","article-title":"Hot topic: Early postpartum treatment of commercial dairy cows with nonsteroidal antiinflammatory drugs increases whole-lactation milk yield","volume":"99","author":"AJ Carpenter","year":"2016","journal-title":"J Dairy Sci. Elsevier"},{"issue":"12","key":"ref14","doi-asserted-by":"crossref","first-page":"7709","DOI":"10.3168\/jds.2013-7088","article-title":"Sodium salicylate treatment in early lactation increases whole-lactation milk and milk fat yield in mature dairy cows","volume":"96","author":"JK Farney","year":"2013","journal-title":"J Dairy Sci. Elsevier"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"149","DOI":"10.2147\/VMRR.S112200","article-title":"The use of meloxicam oral suspension to treat musculoskeletal lameness in cattle","volume":"Volume 7","author":"D Nagel","year":"2016","journal-title":"Vet Med Res Reports"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"2502","DOI":"10.3168\/jds.S0022-0302(98)70142-0","article-title":"Recommendations for recording and calculating the incidence of selected clinical diseases of dairy cattle","volume":"81","author":"DF Kelton","year":"1998","journal-title":"J Dairy Sci"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"2476","DOI":"10.3168\/jds.2011-4766","article-title":"Incidence of subclinical mastitis in Dutch dairy heifers in the first 100 days in lactation and associated risk factors","volume":"95","author":"IMGA Santman-Berends","year":"2012","journal-title":"J Dairy Sci. Elsevier"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"4099","DOI":"10.3168\/jds.2011-5127","article-title":"Health recording in Canadian Holsteins: Data and genetic parameters","volume":"95","author":"A Koeck","year":"2012","journal-title":"J Dairy Sci. Elsevier"},{"key":"ref19","article-title":"Meloxicam administration either prior to or after parturition: Effects on behavior, health, and production in dairy cows","author":"T Swartz","year":"2018","journal-title":"J Dairy Res"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/jcp.21922","article-title":"Activation of nuclear factor kappa B in mammary epithelium promotes milk loss during mammary development and infection","volume":"222","author":"L Connelly","year":"2010","journal-title":"J Cell Physiol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1023\/A:1020347818725","article-title":"Mammary gland immunity and mastitis susceptibility","volume":"2","author":"LM Sordillo","year":"2002","journal-title":"J Mammary Gland Biol Neoplasia"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"2847","DOI":"10.3168\/jds.2012-5855","article-title":"The effect of meloxicam on pain sensitivity, rumination time, and clinical signs in dairy cows with endotoxin-induced clinical mastitis","volume":"96","author":"CE Fitzpatrick","year":"2013","journal-title":"J Dairy Sci. Elsevier"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"4939","DOI":"10.3168\/jds.2011-5064","article-title":"The effects of experimentally induced Escherichia coli mastitis and flunixin meglumine administration on activity measures, feed intake, and milk parameters","volume":"95","author":"EE Yeiser","year":"2012","journal-title":"J Dairy Sci. Elsevier"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","first-page":"4421","DOI":"10.3168\/jds.2009-2284","article-title":"Effect of treatment with the nonsteroidal antiinflammatory meloxicam on milk production, somatic cell count, probability of re-treatment, and culling of dairy cows with mild clinical mastitis","volume":"92","author":"S McDougall","year":"2009","journal-title":"J Dairy Sci. Elsevier"},{"issue":"01","key":"ref25","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1017\/S0022029917000863","article-title":"Effects of chronic mastitis and its treatment with ketoprofen on the milk ejection curve","volume":"85","author":"A Zecconi","year":"2018","journal-title":"J Dairy Res"},{"key":"ref26","doi-asserted-by":"crossref","DOI":"10.1079\/9781845935504.0000","article-title":"Mastitis Control in Dairy Herds","author":"R Blowey","year":"2010"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1080\/09712119.2013.842485","article-title":"Changes in the concentrations of selected acute phase proteins and variables of energetic profile in dairy cows after parturition","volume":"42","author":"C T\u00f3thov\u00e1","year":"2014","journal-title":"J Appl Anim Res. Taylor & Francis"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"4544","DOI":"10.3168\/jds.2014-9181","article-title":"The associations between postpartum serum haptoglobin concentration and metabolic status, calving difficulties, retained fetal membranes, and metritis","volume":"98","author":"A Pohl","year":"2015","journal-title":"J Dairy Sci. Elsevier"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.3168\/jds.2014-8584","article-title":"Body condition score at calving affects systemic and hepatic transcriptome indicators of inflammation and nutrient metabolism in grazing dairy cows","volume":"98","author":"H Akbar","year":"2015","journal-title":"J Dairy Sci. Elsevier"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.prevetmed.2017.09.015","article-title":"Culling from the actors\u2019 perspectives\u2014Decision-making criteria for culling in Qu\u00e9bec dairy herds enrolled in a veterinary preventive medicine program","volume":"148","author":"D Haine","year":"2017","journal-title":"Prev Vet Med. Elsevier B.V."}],"updated-by":[{"DOI":"10.1371\/journal.pone.0229872","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000}},{"DOI":"10.1371\/journal.pone.0210326","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,12,31]],"date-time":"2018-12-31T00:00:00Z","timestamp":1546214400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209236","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,12]],"date-time":"2023-09-12T02:47:14Z","timestamp":1694486834000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209236"}},"subtitle":[],"editor":[{"given":"Juan J","family":"Loor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,12]]},"references-count":30,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209236","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0210326","asserted-by":"object"},{"id-type":"doi","id":"10.1371\/journal.pone.0229872","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,12]]}}}