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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.hpra.ie\/docs\/default-source\/Safety-Notices\/human-medicines\u20143rd-party-publications\u2014hpra-suspension-of-marketing-of-nimesulide-containing-medicines-document.pdf?sfvrsn=0\" xlink:type=\"simple\">http:\/\/www.hpra.ie\/docs\/default-source\/Safety-Notices\/human-medicines\u20143rd-party-publications\u2014hpra-suspension-of-marketing-of-nimesulide-containing-medicines-document.pdf?sfvrsn=0<\/ext-link>."},{"key":"ref15","unstructured":"EMA. Assessment report for Nimesulide containing medicinal products for systemic use: European Medicines Agency; [updated 2012 Apr 19]. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Referrals_document\/Nimesulide_31\/WC500125574.pdf\" xlink:type=\"simple\">http:\/\/www.ema.europa.eu\/docs\/en_GB\/document_library\/Referrals_document\/Nimesulide_31\/WC500125574.pdf<\/ext-link>."},{"issue":"10","key":"ref16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1016\/j.jclinepi.2009.06.005","article-title":"Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement","volume":"62","author":"D Moher","year":"2009","journal-title":"Journal of Clinical Epidemiology"},{"key":"ref17","article-title":"The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomized studies in meta-analyses","author":"G Wells","year":"2014"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/ijms17010014","article-title":"RUCAM in Drug and Herb Induced Liver Injury: The Update","volume":"17","author":"G Danan","year":"2016","journal-title":"International Journal of Molecular Sciences"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"453","DOI":"10.2165\/00002018-200225060-00010","article-title":"Use of measures of disproportionality in pharmacovigilance","volume":"25","author":"AC Egberts","year":"2002","journal-title":"Drug safety"},{"key":"ref20","unstructured":"Cochrane Handbook for Systematic Reviews of Interventions The Cochrane Collaboration; 2011. 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