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Nickel compounds and metallic nickel. Report on Carcinogens, Fourteenth Edition. 2016."},{"key":"ref51","first-page":"1","article-title":"NTP Toxicology and Carcinogenesis Studies of Nickel Oxide (CAS No. 1313-99-1) in F344 Rats and B6C3F1 Mice (Inhalation Studies)","volume":"451","year":"1996","journal-title":"National Toxicology Program technical report series"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1093\/carcin\/bgy031","article-title":"Application of the key characteristics of carcinogens in cancer hazard identification","volume":"39","author":"KZ Guyton","year":"2018","journal-title":"Carcinogenesis"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.taap.2007.06.020","article-title":"Effect of short-term stainless steel welding fume inhalation exposure on lung inflammation, injury, and defense responses in rats","volume":"223","author":"JM Antonini","year":"2007","journal-title":"Toxicology and applied pharmacology"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3109\/08958378.2010.548838","article-title":"Short-term inhalation of stainless steel welding fume causes sustained lung toxicity but no tumorigenesis in lung tumor susceptible A\/J mice","volume":"23","author":"PC Zeidler-Erdely","year":"2011","journal-title":"Inhal Toxicol"},{"issue":"8914","key":"ref55","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0140-6736(94)91056-1","article-title":"Lobar pneumonia: an occupational disease in welders","volume":"344","author":"D Coggon","year":"1994","journal-title":"Lancet (London, England)"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/aje\/kwf188","article-title":"Exposure to metal fume and infectious pneumonia","volume":"157","author":"KT Palmer","year":"2003","journal-title":"American journal of epidemiology"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1136\/thoraxjnl-2014-206129","article-title":"Pneumococcal vaccination for welders","volume":"70","author":"D Coggon","year":"2015","journal-title":"Thorax"},{"issue":"7","key":"ref58","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1136\/thoraxjnl-2016-208464","article-title":"Are welders more at risk of respiratory infections?","volume":"71","author":"D Coggon","year":"2016","journal-title":"Thorax"},{"issue":"8","key":"ref59","doi-asserted-by":"crossref","first-page":"6997","DOI":"10.1021\/nn402145t","article-title":"Dysregulation of macrophage activation profiles by engineered nanoparticles","volume":"7","author":"V Kodali","year":"2013","journal-title":"ACS nano"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/j.1365-2249.2006.02998.x","article-title":"Alveolar macrophage function is altered in patients with lung cancer","volume":"143","author":"DS Pouniotis","year":"2006","journal-title":"Clinical and experimental immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T22:22:46Z","timestamp":1588976566000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209413"}},"subtitle":[],"editor":[{"given":"Amitava","family":"Mukherjee","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,26]]},"references-count":60,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209413","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,26]]}}}