{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T01:37:28Z","timestamp":1792633048419,"version":"4.5.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"12","license":[{"start":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T00:00:00Z","timestamp":1545264000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0209448","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T18:28:41Z","timestamp":1545330521000},"page":"e0209448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Association of fatty pancreas with pancreatic endocrine and exocrine function"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0603-5306","authenticated-orcid":true,"given":"Hayato","family":"Miyake","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junichi","family":"Sakagami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroaki","family":"Yasuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshio","family":"Sogame","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryusuke","family":"Kato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanetoshi","family":"Suwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuyuki","family":"Dainaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoki","family":"Takata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isao","family":"Yokota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Itoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,12,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1038\/nrgastro.2011.4","article-title":"The clinical significance of pancreatic steatosis","volume":"8","author":"MM Smits","year":"2011","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.pan.2014.06.004","article-title":"Role of pancreatic fat in the outcomes of pancreatitis","volume":"14","author":"C Acharya","year":"2014","journal-title":"Pancreatology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e53","DOI":"10.1038\/ctg.2014.5","article-title":"Association of pancreatic fatty infiltration with pancreatic ductal adenocarcinoma","volume":"5","author":"M Hori","year":"2014","journal-title":"Clin Transl Gastroenterol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"10878","DOI":"10.1073\/pnas.91.23.10878","article-title":"Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships","volume":"91","author":"Y Lee","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e000297","DOI":"10.1161\/JAHA.113.000297","article-title":"Enigmatic ectopic fat: prevalence of nonalcoholic fatty pancreas disease and its associated factors in a Chinese Population","volume":"3","author":"CY Wang","year":"2014","journal-title":"J Am Heart Assoc"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3892\/etm.2015.2925","article-title":"MRI chemical shift imaging of the fat content of the pancreas and liver of patients with type 2 diabetes mellitus","volume":"11","author":"J Chai","year":"2016","journal-title":"Exp Ther Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1210\/jc.2010-1722","article-title":"Ectopic fat storage in the pancreas, liver, and abdominal fat depots: impact on beta-cell function in individuals with impaired glucose metabolism","volume":"96","author":"NJ van der Zijl","year":"2011","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1002\/ca.20543","article-title":"Pancreas volumes in humans from birth to age one hundred taking into account sex, obesity, and presence of type-2 diabetes","volume":"20","author":"Y Saisho","year":"2007","journal-title":"Clin Anat"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"67","DOI":"10.2214\/ajr.149.1.67","article-title":"Sonographic findings in pancreatic lipomatosis","volume":"149","author":"CB So","year":"1987","journal-title":"AJR Am J Roentgenol"},{"key":"ref10","first-page":"OL01","article-title":"Pancreatic lipomatosis: complete replacement of pancreas by fat","volume":"9","author":"P Ambesh","year":"2015","journal-title":"J Clin Diagn Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"588","DOI":"10.5152\/tjg.2018.17696","article-title":"Can pancreatic steatosis affect exocrine functions of pancreas?","volume":"29","author":"M Tahtaci","year":"2018","journal-title":"The Turkish journal of gastroenterology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"e75","DOI":"10.1097\/MPA.0000000000000893","article-title":"Pancreatic Steatosis Is Not Associated With Exocrine Pancreatic Function in Overweight Type 2 Diabetes Patients","volume":"46","author":"KEW Vendrik","year":"2017","journal-title":"Pancreas"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.pan.2014.07.004","article-title":"Prevalence of exocrine pancreatic insufficiency in type 2 diabetes mellitus with poor glycemic control","volume":"14","author":"V Terzin","year":"2014","journal-title":"Pancreatology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1507\/endocrj.EJ14-0456","article-title":"Increment of serum C-peptide measured by glucagon test closely correlates with human relative beta-cell area","volume":"62","author":"Y Fujita","year":"2015","journal-title":"Endocr J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1136\/gut.17.1.27","article-title":"Oral administration of a chymotrypsin-labile peptide\u2014a new test of exocrine pancreatic function in man (PFT)","volume":"17","author":"K Gyr","year":"1976","journal-title":"Gut"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1148\/radiol.13122883","article-title":"Quantitative assessment of pancreatic fat by using unenhanced CT: pathologic correlation and clinical implications","volume":"271","author":"SY Kim","year":"2014","journal-title":"Radiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1148\/radiol.2391050361","article-title":"Macrovesicular hepatic steatosis in living liver donors: use of CT for quantitative and qualitative assessment","volume":"239","author":"SH Park","year":"2006","journal-title":"Radiology"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1097\/SLA.0b013e31827827d0","article-title":"Prediction of pancreatic anastomotic failure after pancreatoduodenectomy: the use of preoperative, quantitative computed tomography to measure remnant pancreatic volume and body composition","volume":"257","author":"Y Kirihara","year":"2013","journal-title":"Ann Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.3748\/wjg.v22.i34.7660","article-title":"Exploring the metabolic syndrome: nonalcoholic fatty pancreas disease","volume":"22","author":"R Catanzaro","year":"2016","journal-title":"World J Gastroenterol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"415","DOI":"10.4239\/wjd.v5.i4.415","article-title":"Pancreatic steatosis: is it related to either obesity or diabetes mellitus?","volume":"5","author":"R Pezzilli","year":"2014","journal-title":"World J Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/ijo.2009.245","article-title":"Pancreatic steatosis: harbinger of type 2 diabetes in obese rodents","volume":"34","author":"Y Lee","year":"2010","journal-title":"Int J Obes"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1973","DOI":"10.1016\/0016-5085(85)90029-0","article-title":"Diagnosis of chronic pancreatitis","volume":"88","author":"C Niederau","year":"1985","journal-title":"Gastroenterology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11894-001-0004-9","article-title":"Pancreatic function tests: when to choose, what to use","volume":"3","author":"WG Boeck","year":"2001","journal-title":"Curr Gastroenterol Rep"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1080\/13651820701504157","article-title":"Nonalcoholic fatty pancreas disease","volume":"9","author":"A Mathur","year":"2007","journal-title":"HPB"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.3748\/wjg.15.1869","article-title":"Clinical implications of fatty pancreas: correlations between fatty pancreas and metabolic syndrome","volume":"15","author":"JS Lee","year":"2009","journal-title":"World J Gastroenterol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"212","DOI":"10.3164\/jcbn.09-83","article-title":"A Mouse model of metabolic syndrome: insulin resistance, fatty liver and non-alcoholic fatty pancreas disease (NAFPD) in C57BL\/6 mice fed a high fat diet","volume":"46","author":"JC Fraulob","year":"2010","journal-title":"J Clin Biochem Nutr"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1159\/000199436","article-title":"Nuclear magnetic resonance spectroscopy-based metabolomics of the fatty pancreas: implicating fat in pancreatic pathology","volume":"9","author":"NJ Zyromski","year":"2009","journal-title":"Pancreatology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0046-8177(84)80294-4","article-title":"Incidence and diagnostic significance of minor pathologic changes in the adult pancreas at autopsy: a systematic study of 112 autopsies in patients without known pancreatic disease","volume":"15","author":"BH Stamm","year":"1984","journal-title":"Hum Pathol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00247-005-1520-9","article-title":"Pancreatic lipomatosis in an infant with cystic fibrosis","volume":"35","author":"KS Sodhi","year":"2005","journal-title":"Pediatr Radiol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1148\/radiology.210.3.r99mr08611","article-title":"Cystic fibrosis in adolescents and adults: fatty replacement of the pancreas\u2014CT evaluation and functional correlation","volume":"210","author":"P Soyer","year":"1999","journal-title":"Radiology"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1148\/rg.263055101","article-title":"Review of the abdominal manifestations of cystic fibrosis in the adult patient","volume":"26","author":"MB Robertson","year":"2006","journal-title":"Radiographics"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1016\/j.jpeds.2007.12.013","article-title":"Magnetic resonance imaging findings of the pancreas in patients with Shwachman-Diamond syndrome and mutations in the SBDS gene","volume":"152","author":"S Toiviainen-Salo","year":"2008","journal-title":"J Pediatr"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1148\/radiology.194.2.7824726","article-title":"Uneven fatty replacement of the pancreas: evaluation with CT","volume":"194","author":"S Matsumoto","year":"1995","journal-title":"Radiology"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0236915","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2020,7,23]],"date-time":"2020-07-23T00:00:00Z","timestamp":1595462400000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,8]],"date-time":"2022-09-08T22:13:05Z","timestamp":1662675185000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209448"}},"subtitle":[],"editor":[{"given":"Zolt\u00e1n","family":"Rakonczay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,20]]},"references-count":33,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209448","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0236915","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,20]]}}}