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A Guide to U.S. Military Casualty Statistics: Operation Freedom\u2019s Sentinel, Operation Inherent Resolve, Operation New Dawn, Operation Iraqi Freedom, and Operation Enduring Freedom. Congressional Research Service; 2015."},{"key":"ref3","unstructured":"Friedman M. PTSD History and Overview\u2014PTSD: National Center for PTSD [General Information]. Washington, DC: U. S. 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Evaluation of the anxiolytic effects of chrysin, a Passiflora incarnata extract, in the laboratory rat. (0094\u20136354 (Print))."},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"11","DOI":"10.14719\/pst.2015.2.1.91","article-title":"Investigation of Effects of L-Theanine on PTSD-induced Changes in Rat Neurobehavior","volume":"2","author":"TE Ceremuga","year":"2015","journal-title":"Plant Science Today"},{"key":"ref23","unstructured":"Ceremuga Te Fau\u2014Valdivieso D, Valdivieso D Fau\u2014Kenner C, Kenner C Fau\u2014Lucia A, Lucia A Fau\u2014Lathrop K, Lathrop K Fau\u2014Stailey O, Stailey O Fau\u2014Bailey H, et al. Evaluation of the anxiolytic and antidepressant effects of asiatic acid, a compound from Gotu kola or Centella asiatica, in the male Sprague Dawley rat. (0094\u20136354 (Print))."},{"key":"ref24","unstructured":"Heese T, Jenkinson J Fau\u2014Love C, Love C Fau\u2014Milam R, Milam R Fau\u2014Perkins L, Perkins L Fau\u2014Adams C, Adams C Fau\u2014McCall S, et al. Anxiolytic effects of L-theanine\u2014a component of green tea\u2014when combined with midazolam, in the male Sprague-Dawley rat. (0094\u20136354 (Print))."},{"key":"ref25","unstructured":"Leiter E, Hitchcock G Fau\u2014Godwin S, Godwin S Fau\u2014Johnson M, Johnson M Fau\u2014Sedgwick W, Sedgwick W Fau\u2014Jones W, Jones W Fau\u2014McCall S, et al. Evaluation of the anxiolytic properties of myristicin, a component of nutmeg, in the male Sprague-Dawley rat. (0094\u20136354 (Print))."},{"key":"ref26","unstructured":"Faul F, Erdfelder E Fau\u2014Lang A-G, Lang Ag Fau\u2014Buchner A, Buchner A. G*Power 3: a flexible statistical power analysis program for the social, behavioral, and biomedical sciences. (1554-351X (Print))."},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/0006-3223(94)00369-E","article-title":"Delayed startle sensitization distinguishes rats exposed to one or three stress sessions: further evidence toward an animal model of PTSD","volume":"38","author":"RJ Servatius","year":"1995","journal-title":"Biol Psychiatry"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"S Pellow","year":"1985","journal-title":"J Neurosci Methods"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"R Morris","year":"1984","journal-title":"Journal of Neuroscience Methods"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","DOI":"10.1186\/s12868-017-0345-4","article-title":"Identifying the appropriate time for deep brain stimulation to achieve spatial memory improvement on the Morris water maze","volume":"18","author":"DU Jeong","year":"2017","journal-title":"BMC Neuroscience"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-0173(01)00067-4","article-title":"Applications of the Morris water maze in the study of learning and memory","volume":"36","author":"R D\u2019Hooge","year":"2001","journal-title":"Brain Res Brain Res Rev"},{"key":"ref32","article-title":"Assessment of spatial memory using the radial arm maze and Morris water maze","author":"GL Wenk","year":"2004","journal-title":"Curr Protoc Neurosci"},{"key":"ref33","article-title":"Current Protocols in Neuroscience","author":"V Castagn\u00e9","year":"2011"},{"key":"ref34","unstructured":"Mertz H. Stress and the Gut. In: Disorders UCfFGM, editor. UNC School of Medicine. Chapel Hill, NC: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.MED.UNC.EDU\/IBS\" xlink:type=\"simple\">www.MED.UNC.EDU\/IBS<\/ext-link>; 2011."},{"issue":"5","key":"ref35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/j.physbeh.2007.04.009","article-title":"Chronic Psychological Stress Enhances Nociceptive Processing in the Urinary Bladder in High-Anxiety Rats","volume":"91","author":"MT Robbins","year":"2007","journal-title":"Physiology & behavior"},{"key":"ref36","article-title":"Statistical power analysis for the behavioral sciences \/ Jacob Cohen","author":"J Cohen","year":"1977"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1111\/jcmm.13161","article-title":"Post-traumatic stress disorder and beyond: an overview of rodent stress models","volume":"21","author":"J Schoner","year":"2017","journal-title":"J Cell Mol Med"},{"key":"ref38","doi-asserted-by":"crossref","unstructured":"Barone F, E Barton M, F White R, J Legos J, Kikkawa H, Shimamura M, et al. Inhibition of Phosphodiesterase Type 4 Decreases Stress-Induced Defecation in Rats and Mice2008. 11\u20137 p.","DOI":"10.1159\/000107662"},{"issue":"89","key":"ref39","article-title":"Animal models of post-traumatic stress disorder: face validity","volume":"7","author":"S GOSWAMI","year":"2013","journal-title":"Frontiers in Neuroscience"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2147\/nedt.2007.3.2.185","article-title":"Role of pregabalin in the treatment of generalized anxiety disorder","volume":"3","author":"DS Baldwin","year":"2007","journal-title":"Neuropsychiatr Dis Treat"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"883","DOI":"10.2147\/NDT.S36453","article-title":"Pregabalin for the treatment of generalized anxiety disorder: an update","volume":"9","author":"DS Baldwin","year":"2013","journal-title":"Neuropsychiatr Dis Treat"},{"issue":"7","key":"ref42","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/hipo.20188","article-title":"Influence of predator stress on the consolidation versus retrieval of long-term spatial memory and hippocampal spinogenesis","volume":"16","author":"DM Diamond","year":"2006","journal-title":"Hippocampus"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.neuroscience.2005.07.049","article-title":"Glucocorticoids interact with emotion-induced noradrenergic activation in influencing different memory functions","volume":"138","author":"B Roozendaal","year":"2006","journal-title":"Neuroscience"},{"issue":"1","key":"ref44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0165-1781(98)00030-4","article-title":"Acute and long-term behavioral correlates of underwater trauma\u2014potential relevance to stress and post-stress syndromes","volume":"79","author":"G Richter-Levin","year":"1998","journal-title":"Psychiatry Research"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/0006-3223(93)90001-T","article-title":"Criteria for rationally evaluating animal models of posttraumatic stress disorder","volume":"33","author":"R Yehuda","year":"1993","journal-title":"Biol Psychiatry"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/bjp.2008.259","article-title":"Effects of pregabalin on visceral pain responses and colonic compliance in rats","volume":"155","author":"A Ravnefjord","year":"2008","journal-title":"Br J Pharmacol"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"1983","DOI":"10.1097\/00001756-200408260-00030","article-title":"Dimensional complexity of the neuronal activity in a rat model of depression","volume":"15","author":"E Dremencov","year":"2004","journal-title":"Neuroreport"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"712","DOI":"10.4088\/JCP.v61n1002","article-title":"How fast are antidepressants?","volume":"61","author":"AJ Gelenberg","year":"2000","journal-title":"J Clin Psychiatry"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209494","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T14:33:50Z","timestamp":1589034830000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209494"}},"subtitle":[],"editor":[{"given":"Alexandra","family":"Kavushansky","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,12,31]]},"references-count":48,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2018,12,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209494","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,12,31]]}}}