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international journal of clinical chemistry"},{"issue":"10","key":"ref70","doi-asserted-by":"crossref","first-page":"4005","DOI":"10.1182\/blood-2002-11-3368","article-title":"Beta 2-microglobulin as a negative regulator of the immune system: high concentrations of the protein inhibit in vitro generation of functional dendritic cells","volume":"101","author":"J Xie","year":"2003","journal-title":"Blood"},{"issue":"1\u20132","key":"ref71","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jns.2010.04.009","article-title":"Lipopolysaccharide-evoked HSPA12B expression by activation of MAPK cascade in microglial cells of the spinal cord","volume":"294","author":"Z Cui","year":"2010","journal-title":"Journal of the neurological sciences"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11064-012-0922-y","article-title":"The role of HSPA12B in regulating neuronal apoptosis","volume":"38","author":"L Kang","year":"2013","journal-title":"Neurochemical research"},{"issue":"8","key":"ref73","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1038\/cdd.2010.58","article-title":"Cracking the death code: apoptosis-related histone modifications","volume":"17","author":"J Fullgrabe","year":"2010","journal-title":"Cell death and differentiation"},{"issue":"18","key":"ref74","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1242\/jcs.169318","article-title":"A Chlamydia effector recruits CEP170 to reprogram host microtubule organization","volume":"128","author":"M Dumoux","year":"2015","journal-title":"Journal of cell science"},{"issue":"9","key":"ref75","doi-asserted-by":"crossref","first-page":"4686","DOI":"10.4049\/jimmunol.1101500","article-title":"Intracellular HMGB1 negatively regulates efferocytosis","volume":"187","author":"S Banerjee","year":"2011","journal-title":"Journal of immunology"},{"issue":"9","key":"ref76","doi-asserted-by":"crossref","first-page":"9053","DOI":"10.1007\/s13277-014-1974-1","article-title":"TPM3, a strong prognosis predictor, is involved in malignant progression through MMP family members and EMT-like activators in gliomas","volume":"35","author":"T Tao","year":"2014","journal-title":"Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"issue":"8","key":"ref77","doi-asserted-by":"crossref","first-page":"4600","DOI":"10.1074\/jbc.M113.538215","article-title":"Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis","volume":"289","author":"KI Cho","year":"2014","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.gene.2015.06.018","article-title":"Regulation and function of the human HSP90AA1 gene","volume":"570","author":"AD Zuehlke","year":"2015","journal-title":"Gene"},{"issue":"6","key":"ref79","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1007\/s00705-015-2403-5","article-title":"Critical role of eukaryotic elongation factor 1 alpha 1 (EEF1A1) in avian reovirus sigma-C-induced apoptosis and inhibition of viral growth","volume":"160","author":"Z Zhang","year":"2015","journal-title":"Archives of virology"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.2741\/1897","article-title":"Role of microtubules and myosins in Fc gamma receptor-mediated phagocytosis","volume":"11","author":"N. Araki","year":"2006","journal-title":"Frontiers in bioscience: a journal and virtual library"},{"issue":"5","key":"ref81","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.celrep.2015.07.002","article-title":"A Critical SUMO1 Modification of LKB1 Regulates AMPK Activity during Energy Stress","volume":"12","author":"J Ritho","year":"2015","journal-title":"Cell reports"},{"issue":"3","key":"ref82","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1016\/j.devcel.2009.12.022","article-title":"Ofd1, a human disease gene, regulates the length and distal structure of centrioles","volume":"18","author":"V Singla","year":"2010","journal-title":"Developmental cell"},{"issue":"7","key":"ref83","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1007\/s10620-014-3049-y","article-title":"LPS induced miR-181a promotes pancreatic cancer cell migration via targeting PTEN and MAP2K4","volume":"59","author":"J Liu","year":"2014","journal-title":"Digestive diseases and sciences"},{"issue":"2","key":"ref84","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1095\/biolreprod.107.064162","article-title":"DNA damage response during chromatin remodeling in elongating spermatids of mice","volume":"78","author":"F Leduc","year":"2008","journal-title":"Biology of reproduction"},{"issue":"8","key":"ref85","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nrm2707","article-title":"An additional role for SUMO in ubiquitin-mediated proteolysis","volume":"10","author":"MC Geoffroy","year":"2009","journal-title":"Nature reviews Molecular cell biology"},{"issue":"2","key":"ref86","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1152\/physrev.00028.2011","article-title":"Mammalian MAPK signal transduction pathways activated by stress and inflammation: a 10-year update","volume":"92","author":"JM Kyriakis","year":"2012","journal-title":"Physiological reviews"},{"issue":"4","key":"ref87","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1056\/NEJMoa1102140","article-title":"Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions","volume":"366","author":"MJ Ombrello","year":"2012","journal-title":"The New England journal of medicine"},{"issue":"18","key":"ref88","doi-asserted-by":"crossref","first-page":"15143","DOI":"10.1074\/jbc.M111.317859","article-title":"Kif2C minimal functional domain has unusual nucleotide binding properties that are adapted to microtubule depolymerization","volume":"287","author":"W Wang","year":"2012","journal-title":"The Journal of biological chemistry"},{"issue":"5","key":"ref89","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1093\/nar\/gkt1307","article-title":"The centrosomal kinase NEK2 is a novel splicing factor kinase involved in cell survival","volume":"42","author":"C Naro","year":"2014","journal-title":"Nucleic acids research"},{"issue":"3","key":"ref90","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.cell.2010.07.012","article-title":"Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein","volume":"142","author":"R Subramanian","year":"2010","journal-title":"Cell"},{"issue":"3","key":"ref91","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1091\/mbc.e05-07-0621","article-title":"Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1","volume":"17","author":"A Fourest-Lieuvin","year":"2006","journal-title":"Molecular biology of the cell"},{"issue":"9","key":"ref92","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1158\/0008-5472.CAN-13-1894","article-title":"WEE1 inhibition alleviates resistance to immune attack of tumor cells undergoing epithelial-mesenchymal transition","volume":"74","author":"DH Hamilton","year":"2014","journal-title":"Cancer research"},{"issue":"9","key":"ref93","doi-asserted-by":"crossref","first-page":"3542","DOI":"10.4049\/jimmunol.1502614","article-title":"Cutting Edge: Integrin alpha4 Is Required for Regulatory B Cell Control of Experimental Autoimmune Encephalomyelitis","volume":"196","author":"S Glatigny","year":"2016","journal-title":"Journal of immunology"},{"issue":"3","key":"ref94","doi-asserted-by":"crossref","first-page":"e1002416","DOI":"10.1371\/journal.pbio.1002416","article-title":"MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone","volume":"14","author":"C Li","year":"2016","journal-title":"PLoS biology"},{"issue":"14","key":"ref95","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1007\/s00018-013-1526-7","article-title":"Ube3a, the E3 ubiquitin ligase causing Angelman syndrome and linked to autism, regulates protein homeostasis through the proteasomal shuttle Rpn10","volume":"71","author":"SY Lee","year":"2014","journal-title":"Cellular and molecular life sciences: CMLS"},{"issue":"7381","key":"ref96","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nature10760","article-title":"The DNA damage response and cancer therapy","volume":"481","author":"CJ Lord","year":"2012","journal-title":"Nature"},{"issue":"6","key":"ref97","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/gb-2006-7-6-224","article-title":"The MAP1 family of microtubule-associated proteins","volume":"7","author":"S Halpain","year":"2006","journal-title":"Genome biology"},{"issue":"10","key":"ref98","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.febslet.2008.02.081","article-title":"product interacts with tubulin and microtubules","volume":"582","author":"T. Ikeda","year":"2008","journal-title":"FEBS letters"},{"key":"ref99","doi-asserted-by":"crossref","first-page":"6135","DOI":"10.1038\/ncomms7135","article-title":"A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting","volume":"6","author":"A Byron","year":"2015","journal-title":"Nature communications"},{"issue":"42","key":"ref100","first-page":"16471","article-title":"Synaptic regulation of microtubule dynamics in dendritic spines by calcium, F-actin, and drebrin. The Journal of neuroscience: the official journal of the","volume":"33","author":"EB Merriam","year":"2013","journal-title":"Society for Neuroscience"},{"key":"ref101","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/msb.2012.56","article-title":"PLAU inferred from a correlation network is critical for suppressor function of regulatory T cells","volume":"8","author":"F He","year":"2012","journal-title":"Molecular systems biology"},{"issue":"6","key":"ref102","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1111\/jcmm.12054","article-title":"Mechanotransduction at focal adhesions: integrating cytoskeletal mechanics in migrating cells","volume":"17","author":"JC Kuo","year":"2013","journal-title":"Journal of cellular and molecular medicine"},{"key":"ref103","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1186\/1471-2407-10-238","article-title":"Resveratrol suppresses IGF-1 induced human colon cancer cell proliferation and elevates apoptosis via suppression of IGF-1R\/Wnt and activation of p53 signaling pathways","volume":"10","author":"J Vanamala","year":"2010","journal-title":"BMC cancer"},{"issue":"2","key":"ref104","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1083\/jcb.200708130","article-title":"The small GTPase Rab2 functions in the removal of apoptotic cells in Caenorhabditis elegans","volume":"180","author":"PM Mangahas","year":"2008","journal-title":"The Journal of cell biology"},{"issue":"8","key":"ref105","doi-asserted-by":"crossref","first-page":"2781","DOI":"10.1523\/JNEUROSCI.5156-10.2010","article-title":"Presenilin is necessary for efficient proteolysis through the autophagy-lysosome system in a gamma-secretase-independent manner","volume":"31","author":"KM Neely","year":"2011","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"1","key":"ref106","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.bbrc.2006.01.125","article-title":"Caveolin regulates microtubule polymerization in the vascular smooth muscle cells","volume":"342","author":"J Kawabe","year":"2006","journal-title":"Biochemical and biophysical research communications"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209592","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T17:34:20Z","timestamp":1588959260000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209592"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,21]]},"references-count":106,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209592","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,21]]}}}