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Persistent viremia\u2014Is this still an ongoing problem in antiretroviral treatment in Germany? 16th European Aids Conference (EACS) 2017 Milan, Italy. 2017."},{"key":"ref51","first-page":"531","article-title":"Sch\u00e4tzung der Zahl der HIV-Neuinfektionen und der Gesamtzahl von Menschen mit HIV in Deutschland, Stand Ende 2016","volume":"47","author":"M an der Heiden","year":"2017","journal-title":"Epid Bull"},{"key":"ref52","unstructured":"Hauser A, Hofmann A, Meixenberger K, Altmann B, Hanke K, Fiedler S, et al. 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