{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:15:21Z","timestamp":1787062521297,"version":"build-2736575974"},"reference-count":51,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T00:00:00Z","timestamp":1548374400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["15jk0210004h0027"],"award-info":[{"award-number":["15jk0210004h0027"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["25460834"],"award-info":[{"award-number":["25460834"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18jk0210004j0101"],"award-info":[{"award-number":["18jk0210004j0101"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["17jk0210004j0001"],"award-info":[{"award-number":["17jk0210004j0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["16jk0210004j0001"],"award-info":[{"award-number":["16jk0210004j0001"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H26-Kokui-Shitei-001"],"award-info":[{"award-number":["H26-Kokui-Shitei-001"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0209938","type":"journal-article","created":{"date-parts":[[2019,1,25]],"date-time":"2019-01-25T13:35:51Z","timestamp":1548423351000},"page":"e0209938","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Genetic characterization of Mycoplasma pneumoniae isolated in Osaka between 2011 and 2017: Decreased detection rate of macrolide-resistance and increase of p1 gene type 2 lineage strains"],"prefix":"10.1371","volume":"14","author":[{"given":"Chihiro","family":"Katsukawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3198-4263","authenticated-orcid":true,"given":"Tsuyoshi","family":"Kenri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keigo","family":"Shibayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"693","DOI":"10.3389\/fmicb.2016.00693","article-title":"Epidemiology of <italic>Mycoplasma pneumoniae<\/italic> Infections in Japan and Therapeutic Strategies for Macrolide-Resistant <italic>M<\/italic>. <italic>pneumoniae<\/italic>","volume":"7","author":"T Yamazaki","year":"2016","journal-title":"Frontiers in microbiology"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1128\/CMR.00114-16","article-title":"<italic>Mycoplasma pneumoniae<\/italic> from the Respiratory Tract and Beyond","volume":"30","author":"KB Waites","year":"2017","journal-title":"Clinical microbiology reviews"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.3389\/fmicb.2016.00513","article-title":"A Compendium for <italic>Mycoplasma pneumoniae<\/italic>","volume":"7","author":"GL Parrott","year":"2016","journal-title":"Frontiers in microbiology"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"800","DOI":"10.3389\/fmicb.2016.00800","article-title":"Clinical Features of Severe or Fatal <italic>Mycoplasma pneumoniae<\/italic> Pneumonia","volume":"7","author":"K Izumikawa","year":"2016","journal-title":"Frontiers in microbiology"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1348-0421.2001.tb01293.x","article-title":"Characteristics of macrolide-resistant <italic>Mycoplasma pneumoniae<\/italic> strains isolated from patients and induced with erythromycin in vitro","volume":"45","author":"N Okazaki","year":"2001","journal-title":"Microbiology and immunology"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s10156-009-0021-4","article-title":"Macrolide-resistant <italic>Mycoplasma pneumoniae<\/italic>: characteristics of isolates and clinical aspects of community-acquired pneumonia","volume":"16","author":"M Morozumi","year":"2010","journal-title":"Journal of infection and chemotherapy: official journal of the Japan Society of Chemotherapy"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"974","DOI":"10.3389\/fmicb.2016.00974","article-title":"<italic>Mycoplasma pneumoniae<\/italic>: Current Knowledge on Macrolide Resistance and Treatment","volume":"7","author":"S Pereyre","year":"2016","journal-title":"Frontiers in microbiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"329","DOI":"10.3389\/fmicb.2016.00329","article-title":"Infection with and Carriage of <italic>Mycoplasma pneumoniae<\/italic> in Children","volume":"7","author":"PM Meyer Sauteur","year":"2016","journal-title":"Frontiers in microbiology"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1093\/infdis\/139.6.681","article-title":"Long-term epidemiology of infections with <italic>Mycoplasma pneumoniae<\/italic>","volume":"139","author":"HM Foy","year":"1979","journal-title":"The Journal of infectious diseases"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1017\/S0950268800054327","article-title":"Changes in the epidemiological pattern of <italic>Mycoplasma pneumoniae<\/italic> infections in Denmark. A 30 years survey","volume":"101","author":"K Lind","year":"1988","journal-title":"Epidemiology and infection"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"99","DOI":"10.2807\/esm.03.10.00095-en","article-title":"Epidemiology of <italic>Mycoplasma pneumoniae<\/italic> infections in Poland: 28 years of surveillance in Warsaw 1970\u20131997","volume":"3","author":"W Rastawicki","year":"1998","journal-title":"Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.jinf.2008.02.018","article-title":"<italic>Mycoplasma pneumoniae<\/italic> in Korean children: the epidemiology of pneumonia over an 18-year period","volume":"56","author":"BW Eun","year":"2008","journal-title":"The Journal of infection"},{"issue":"5","key":"ref13","article-title":"Surveillance status and recent data for <italic>Mycoplasma pneumoniae<\/italic> infections in the European Union and European Economic Area, January 2012","volume":"17","author":"A Lenglet","year":"2012","journal-title":"Euro surveillance: bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fmicb.2016.00157","article-title":"<italic>Mycoplasma pneumoniae<\/italic> Epidemiology in England and Wales: A National Perspective","volume":"7","author":"RJ Brown","year":"2016","journal-title":"Frontiers in microbiology"},{"issue":"1","key":"ref15","first-page":"76","article-title":"Molecular typing of <italic>Mycoplasma pneumoniae<\/italic> isolated from pediatric patients in Tokyo","volume":"68","author":"H Kubota","year":"2015","journal-title":"Japan. Japanese journal of infectious diseases"},{"issue":"1","key":"ref16","first-page":"16","article-title":"Gene Mutations Associated with Macrolide-resistance and <italic>p1<\/italic> Gene Typing of <italic>Mycoplasma pneumoniae<\/italic> Isolated in Yamagata, Japan, between 2004 and 2013","volume":"89","author":"Y Suzuki","year":"2015","journal-title":"Kansenshogaku zasshi The Journal of the Japanese Association for Infectious Diseases"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"2252","DOI":"10.1128\/AAC.00048-13","article-title":"Therapeutic efficacy of macrolides, minocycline, and tosufloxacin against macrolide-resistant <italic>Mycoplasma pneumoniae<\/italic> pneumonia in pediatric patients","volume":"57","author":"Y Kawai","year":"2013","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1128\/jcm.4.3.225-226.1976","article-title":"Comparison of the sensitivity of two methods for isolation of <italic>Mycoplasma pneumoniae<\/italic>","volume":"4","author":"RB Craven","year":"1976","journal-title":"Journal of clinical microbiology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1128\/JCM.32.1.11-16.1994","article-title":"Direct PCR enables detection of <italic>Mycoplasma pneumoniae<\/italic> in patients with respiratory tract infections","volume":"32","author":"JH Tjhie","year":"1994","journal-title":"Journal of clinical microbiology"},{"key":"ref20","unstructured":"Cousin A, de Barbeyrac B, Charron A, Renaudin H, B\u00e9b\u00e9ar C, editors. Analysis of RFLPs of amplified cytadhesin P1 gene for epidemiological study of Mycoplasma pneumoniae. 10th International Congress of the International Organization for Mycoplasmology (IOM); 1994; Bordeaux, France."},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1128\/JCM.34.2.447-449.1996","article-title":"Epidemiological study of <italic>Mycoplasma pneumoniae<\/italic> infections in japan based on PCR-restriction fragment length polymorphism of the <italic>P1<\/italic> cytadhesin gene","volume":"34","author":"T Sasaki","year":"1996","journal-title":"Journal of clinical microbiology"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1017\/S0950268899003313","article-title":"Molecular typing of <italic>Mycoplasma pneumoniae<\/italic> strains by PCR-based methods and pulsed-field gel electrophoresis. Application to French and Danish isolates","volume":"124","author":"A Cousin-Allery","year":"2000","journal-title":"Epidemiology and infection"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1128\/IAI.67.9.4557-4562.1999","article-title":"Identification of a new variable sequence in the <italic>P1<\/italic> cytadhesin gene of <italic>Mycoplasma pneumoniae<\/italic>: evidence for the generation of antigenic variation by DNA recombination between repetitive sequences","volume":"67","author":"T Kenri","year":"1999","journal-title":"Infection and immunity"},{"issue":"Pt 7","key":"ref24","doi-asserted-by":"crossref","first-page":"2182","DOI":"10.1099\/mic.0.028506-0","article-title":"Sequence variations in RepMP2\/3 and RepMP4 elements reveal intragenomic homologous DNA recombination events in <italic>Mycoplasma pneumoniae<\/italic>","volume":"155","author":"EB Spuesens","year":"2009","journal-title":"Microbiology"},{"issue":"24","key":"ref25","doi-asserted-by":"crossref","DOI":"10.1128\/genomeA.00513-17","article-title":"Complete Genome Sequences of the <italic>p1<\/italic> Gene Type 2b and 2c Strains <italic>Mycoplasma pneumoniae<\/italic> KCH-402 and KCH-405","volume":"5","author":"T Kenri","year":"2017","journal-title":"Genome announcements"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"e0174701","DOI":"10.1371\/journal.pone.0174701","article-title":"Comprehensive bioinformatics analysis of <italic>Mycoplasma pneumoniae<\/italic> genomes to investigate underlying population structure and type-specific determinants","volume":"12","author":"MH Diaz","year":"2017","journal-title":"PloS one"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1046\/j.1365-2958.2003.03282.x","article-title":"Localization of <italic>Mycoplasma pneumoniae<\/italic> cytadherence-associated protein HMW2 by fusion with green fluorescent protein: implications for attachment organelle structure","volume":"47","author":"MF Balish","year":"2003","journal-title":"Molecular microbiology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1128\/IAI.35.3.809-817.1982","article-title":"Identification of <italic>Mycoplasma pneumoniae<\/italic> proteins associated with hemadsorption and virulence","volume":"35","author":"DC Krause","year":"1982","journal-title":"Infection and immunity"},{"issue":"Pt 4","key":"ref29","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1099\/jmm.0.47634-0","article-title":"Genotyping analysis of <italic>Mycoplasma pneumoniae<\/italic> clinical strains in Japan between 1995 and 2005: type shift phenomenon of <italic>M<\/italic>. <italic>pneumoniae<\/italic> clinical strains","volume":"57","author":"T Kenri","year":"2008","journal-title":"Journal of medical microbiology"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"642","DOI":"10.7883\/yoken.JJID.2017.276","article-title":"Multiple-Locus Variable-Number Tandem-Repeat Analysis of <italic>Mycoplasma pneumoniae<\/italic> Isolates between 2004 and 2014 in Yamagata, Japan: Change in Molecular Characteristics during an 11-year Period","volume":"70","author":"Y Suzuki","year":"2017","journal-title":"Japanese journal of infectious diseases"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3201\/eid2310.170106","article-title":"Macrolide-Resistant <italic>Mycoplasma pneumoniae<\/italic> Infection, Japan, 2008\u20132015","volume":"23","author":"T Tanaka","year":"2017","journal-title":"Emerging infectious diseases"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"4624","DOI":"10.1128\/AAC.48.12.4624-4630.2004","article-title":"Characterization and molecular analysis of macrolide-resistant <italic>Mycoplasma pneumoniae<\/italic> clinical isolates obtained in Japan","volume":"48","author":"M Matsuoka","year":"2004","journal-title":"Antimicrobial agents and chemotherapy"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1128\/AAC.49.6.2302-2306.2005","article-title":"Emergence of macrolide-resistant <italic>Mycoplasma pneumoniae<\/italic> with a 23S rRNA gene mutation","volume":"49","author":"M Morozumi","year":"2005","journal-title":"Antimicrobial agents and chemotherapy"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fmicb.2016.00039","article-title":"Antibody Response to <italic>Mycoplasma pneumoniae<\/italic>: Protection of Host and Influence on Outbreaks?","volume":"7","author":"R Dumke","year":"2016","journal-title":"Frontiers in microbiology"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.3892\/etm.2017.4721","article-title":"Pediatric clinical features of <italic>Mycoplasma pneumoniae<\/italic> infection are associated with bacterial P1 genotype","volume":"14","author":"L Fan","year":"2017","journal-title":"Experimental and therapeutic medicine"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"e0170253","DOI":"10.1371\/journal.pone.0170253","article-title":"Changes in Molecular Characteristics of <italic>Mycoplasma pneumoniae<\/italic> in Clinical Specimens from Children in Beijing between 2003 and 2015","volume":"12","author":"H Sun","year":"2017","journal-title":"PloS one"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"e0141702","DOI":"10.1371\/journal.pone.0141702","article-title":"Culture-Independent Detection and Genotyping of <italic>Mycoplasma pneumoniae<\/italic> in Clinical Specimens from Beijing, China","volume":"10","author":"F Zhao","year":"2015","journal-title":"PloS one"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.3201\/eid2408.180081","article-title":"Clonal Expansion of Macrolide-Resistant Sequence Type 3 <italic>Mycoplasma pneumoniae<\/italic>, South Korea","volume":"24","author":"JK Lee","year":"2018","journal-title":"Emerging infectious diseases"},{"issue":"11","key":"ref39","doi-asserted-by":"crossref","first-page":"3560","DOI":"10.1128\/JCM.01983-15","article-title":"Emergence of Macrolide-Resistant <italic>Mycoplasma pneumoniae<\/italic> in Hong Kong Is Linked to Increasing Macrolide Resistance in Multilocus Variable-Number Tandem-Repeat Analysis Type 4-5-7-2","volume":"53","author":"PL Ho","year":"2015","journal-title":"Journal of clinical microbiology"},{"issue":"6","key":"ref40","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1111\/j.1469-0691.2009.02968.x","article-title":"Occurrence of macrolide-resistant <italic>Mycoplasma pneumoniae<\/italic> strains in Germany","volume":"16","author":"R Dumke","year":"2010","journal-title":"Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"9","key":"ref41","doi-asserted-by":"crossref","DOI":"10.3201\/eid1909.121466","article-title":"Macrolide-resistant <italic>Mycoplasma pneumoniae<\/italic> in humans, Ontario, Canada, 2010\u20132011","volume":"19","author":"A Eshaghi","year":"2013","journal-title":"Emerging infectious diseases"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1128\/JCM.02597-14","article-title":"Investigations of <italic>Mycoplasma pneumoniae<\/italic> infections in the United States: trends in molecular typing and macrolide resistance from 2006 to 2013","volume":"53","author":"MH Diaz","year":"2015","journal-title":"Journal of clinical microbiology"},{"issue":"3","key":"ref43","article-title":"Molecular Detection and Characterization of <italic>Mycoplasma pneumoniae<\/italic> Among Patients Hospitalized With Community-Acquired Pneumonia in the United States","volume":"2","author":"MH Diaz","year":"2015","journal-title":"Open forum infectious diseases"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"e0173635","DOI":"10.1371\/journal.pone.0173635","article-title":"Therapeutic efficacy of azithromycin, clarithromycin, minocycline and tosufloxacin against macrolide-resistant and macrolide-sensitive <italic>Mycoplasma pneumoniae<\/italic> pneumonia in pediatric patients","volume":"12","author":"N Ishiguro","year":"2017","journal-title":"PloS one"},{"issue":"Pt 2","key":"ref45","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1099\/mic.0.045591-0","article-title":"Variation in a surface-exposed region of the <italic>Mycoplasma pneumoniae<\/italic> P40 protein as a consequence of homologous DNA recombination between RepMP5 elements","volume":"157","author":"EB Spuesens","year":"2011","journal-title":"Microbiology"},{"issue":"5","key":"ref46","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1111\/j.1365-2958.2010.07288.x","article-title":"The <italic>Mycoplasma genitalium<\/italic> MG352-encoded protein is a Holliday junction resolvase that has a non-functional orthologue in <italic>Mycoplasma pneumoniae<\/italic>","volume":"77","author":"M Sluijter","year":"2010","journal-title":"Molecular microbiology"},{"issue":"15","key":"ref47","doi-asserted-by":"crossref","first-page":"5297","DOI":"10.1128\/AEM.00024-10","article-title":"Targeted chromosomal knockouts in <italic>Mycoplasma pneumoniae<\/italic>","volume":"76","author":"R Krishnakumar","year":"2010","journal-title":"Applied and environmental microbiology"},{"issue":"2","key":"ref48","article-title":"Whole-Genome Sequencing of Macrolide-Resistant <italic>Mycoplasma pneumoniae<\/italic> Strain S355","volume":"4","author":"S Li","year":"2016","journal-title":"Isolated in China. Genome announcements"},{"issue":"12","key":"ref49","doi-asserted-by":"crossref","first-page":"4117","DOI":"10.1128\/JCM.01696-09","article-title":"Identification of P1 variants of <italic>Mycoplasma pneumoniae<\/italic> by use of high-resolution melt analysis","volume":"47","author":"SB Schwartz","year":"2009","journal-title":"Journal of clinical microbiology"},{"issue":"Pt 11","key":"ref50","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1099\/jmm.0.046441-0","article-title":"Identification of <italic>Mycoplasma pneumoniae<\/italic> type 2b variant strains in Japan","volume":"61","author":"T Kenri","year":"2012","journal-title":"Journal of medical microbiology"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.diagmicrobio.2013.08.008","article-title":"Detection of <italic>Mycoplasma pneumoniae<\/italic> P1 subtype variations by denaturing gradient gel electrophoresis","volume":"78","author":"J Xiao","year":"2014","journal-title":"Diagnostic microbiology and infectious disease"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0209938","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,10]],"date-time":"2022-09-10T20:00:32Z","timestamp":1662840032000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0209938"}},"subtitle":[],"editor":[{"given":"Mitchell F.","family":"Balish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,25]]},"references-count":51,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0209938","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,25]]}}}