{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:00:40Z","timestamp":1787022040486,"version":"build-2736575974"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T00:00:00Z","timestamp":1546560000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010731","name":"Faculty of Medicine, Chiang Mai University","doi-asserted-by":"publisher","award":["Grant no 071\/2560"],"award-info":[{"award-number":["Grant no 071\/2560"]}],"id":[{"id":"10.13039\/501100010731","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Center of Excellence, Chiang Mai University","award":["-"],"award-info":[{"award-number":["-"]}]},{"DOI":"10.13039\/501100004192","name":"National Science and Technology Development Agency","doi-asserted-by":"publisher","award":["Grant no P-15-50169"],"award-info":[{"award-number":["Grant no P-15-50169"]}],"id":[{"id":"10.13039\/501100004192","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0210289","type":"journal-article","created":{"date-parts":[[2019,1,4]],"date-time":"2019-01-04T13:37:44Z","timestamp":1546609064000},"page":"e0210289","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Role of genomic DNA methylation in detection of cytologic and histologic abnormalities in high risk HPV-infected women"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3914-1604","authenticated-orcid":true,"given":"Wiyada","family":"Dankai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surapan","family":"Khunamornpong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sumalee","family":"Siriaunkgul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aungsumalee","family":"Soongkhaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arphawan","family":"Janpanao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utaiwan","family":"Utaipat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nakarin","family":"Kitkumthorn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Apiwat","family":"Mutirangura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jatupol","family":"Srisomboon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5488-8119","authenticated-orcid":true,"given":"Suree","family":"Lekawanvijit","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,1,4]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"E359","DOI":"10.1002\/ijc.29210","article-title":"Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012","volume":"136","author":"J Ferlay","year":"2015","journal-title":"International journal of cancer"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1002\/ijc.25396","article-title":"Human papillomavirus type distribution in 30,848 invasive cervical cancers worldwide: Variation by geographical region, histological type and year of publication","volume":"128","author":"N Li","year":"2011","journal-title":"International journal of cancer"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/path.1866","article-title":"HPV-mediated cervical carcinogenesis: concepts and clinical implications","volume":"208","author":"PJ Snijders","year":"2006","journal-title":"The Journal of pathology"},{"issue":"10","key":"ref4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.7326\/0003-4819-132-10-200005160-00009","article-title":"Accuracy of the Papanicolaou test in screening for and follow-up of cervical cytologic abnormalities: a systematic review","volume":"132","author":"K Nanda","year":"2000","journal-title":"Annals of internal medicine"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"e0119755","DOI":"10.1371\/journal.pone.0119755","article-title":"Primary screening for cervical cancer based on high-risk human papillomavirus (HPV) detection and HPV 16 and HPV 18 genotyping, in comparison to cytology","volume":"10","author":"T Agorastos","year":"2015","journal-title":"PloS one"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1002\/cncr.20425","article-title":"DNA methylation profiling of cervical squamous intraepithelial lesions using liquid-based cytology specimens: an approach that utilizes receiver-operating characteristic analysis","volume":"102","author":"KS Gustafson","year":"2004","journal-title":"Cancer"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1093\/jnci\/djh031","article-title":"TSLC1 gene silencing in cervical cancer cell lines and cervical neoplasia","volume":"96","author":"RD Steenbergen","year":"2004","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1002\/path.2367","article-title":"Association between dense CADM1 promoter methylation and reduced protein expression in high-grade CIN and cervical SCC","volume":"215","author":"RM Overmeer","year":"2008","journal-title":"J Pathol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1002\/path.2598","article-title":"Repression of MAL tumour suppressor activity by promoter methylation during cervical carcinogenesis","volume":"219","author":"RM Overmeer","year":"2009","journal-title":"J Pathol"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1158\/1940-6207.CAPR-14-0237","article-title":"Methylation analysis of the FAM19A4 gene in cervical scrapes is highly efficient in detecting cervical carcinomas and advanced CIN2\/3 lesions","volume":"7","author":"LM De Strooper","year":"2014","journal-title":"Cancer Prev Res (Phila)"},{"issue":"34","key":"ref11","doi-asserted-by":"crossref","first-page":"31014","DOI":"10.1074\/jbc.M203620200","article-title":"The tumor suppressor protein TSLC1 is involved in cell-cell adhesion","volume":"277","author":"M Masuda","year":"2002","journal-title":"The Journal of biological chemistry"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"2656","DOI":"10.3892\/ijo.2015.2945","article-title":"Hypermethylation of the tumor-suppressor cell adhesion molecule 1 in human papillomavirus-transformed cervical carcinoma cells","volume":"46","author":"HJ Woo","year":"2015","journal-title":"International journal of oncology"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1158\/1078-0432.CCR-10-2548","article-title":"Combined promoter methylation analysis of CADM1 and MAL: an objective triage tool for high-risk human papillomavirus DNA-positive women","volume":"17","author":"AT Hesselink","year":"2011","journal-title":"Clin Cancer Res"},{"issue":"9","key":"ref14","doi-asserted-by":"crossref","first-page":"2218","DOI":"10.1002\/ijc.25890","article-title":"Combined CADM1 and MAL promoter methylation analysis to detect (pre-)malignant cervical lesions in high-risk HPV-positive women","volume":"129","author":"RM Overmeer","year":"2011","journal-title":"International journal of cancer"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1158\/1055-9965.EPI-14-0347","article-title":"Combined CADM1\/MAL methylation and cytology testing for colposcopy triage of high-risk HPV-positive women","volume":"23","author":"LM De Strooper","year":"2014","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1002\/ijc.28138","article-title":"CADM1 and MAL promoter methylation levels in hrHPV-positive cervical scrapes increase proportional to degree and duration of underlying cervical disease","volume":"133","author":"M Bierkens","year":"2013","journal-title":"International journal of cancer"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1002\/jlb.59.1.61","article-title":"The role of MIP-1 alpha in inflammation and hematopoiesis","volume":"59","author":"DN Cook","year":"1996","journal-title":"Journal of leukocyte biology"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/path.4210","article-title":"Methylation-specific digital karyotyping of HPV16E6E7-expressing human keratinocytes identifies novel methylation events in cervical carcinogenesis","volume":"231","author":"RD Steenbergen","year":"2013","journal-title":"The Journal of pathology"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"992","DOI":"10.1002\/ijc.29824","article-title":"Comparing the performance of FAM19A4 methylation analysis, cytology and HPV16\/18 genotyping for the detection of cervical (pre)cancer in high-risk HPV-positive women of a gynecologic outpatient population (COMETH study)","volume":"138","author":"R Luttmer","year":"2016","journal-title":"International journal of cancer"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/bjc.2016.200","article-title":"FAM19A4 methylation analysis in self-samples compared with cervical scrapes for detecting cervical (pre)cancer in HPV-positive women","volume":"115","author":"R Luttmer","year":"2016","journal-title":"Br J Cancer"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1159\/000450595","article-title":"Virtues and Weaknesses of DNA Methylation as a Test for Cervical Cancer Prevention","volume":"60","author":"AT Lorincz","year":"2016","journal-title":"Acta cytologica"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/ijc.30781","article-title":"Discovery and validation of candidate host DNA methylation markers for detection of cervical precancer and cancer","volume":"141","author":"MA Clarke","year":"2017","journal-title":"International journal of cancer"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1010428317694573","DOI":"10.1177\/1010428317694573","article-title":"Aberrant gene-specific DNA methylation signature analysis in cervical cancer","volume":"39","author":"S Bhat","year":"2017","journal-title":"Tumour biology: the journal of the International Society for Oncodevelopmental Biology and Medicine"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1097\/IGC.0000000000000582","article-title":"Methylation of Cervical Neoplastic Cells Infected With Human Papillomavirus 16","volume":"26","author":"EY Ki","year":"2016","journal-title":"International journal of gynecological cancer: official journal of the International Gynecological Cancer Society"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"246936","DOI":"10.4061\/2011\/246936","article-title":"Human papillomavirus types 52 and 58 are prevalent in uterine cervical squamous lesions from Japanese women","volume":"2011","author":"K Takehara","year":"2011","journal-title":"Pathology research international"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.7150\/jca.14971","article-title":"Prevalence and Genotype Distribution of HPV Infection in China: Analysis of 51,345 HPV Genotyping Results from China&apos;s Largest CAP Certified Laboratory","volume":"7","author":"Z Zeng","year":"2016","journal-title":"Journal of Cancer"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"e0158184","DOI":"10.1371\/journal.pone.0158184","article-title":"Genotyping for Human Papillomavirus (HPV) 16\/18\/52\/58 Has a Higher Performance than HPV16\/18 Genotyping in Triaging Women with Positive High-risk HPV Test in Northern Thailand","volume":"11","author":"S Khunamornpong","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.ygyno.2016.02.012","article-title":"Validation of the FAM19A4\/mir124-2 DNA methylation test for both lavage- and brush-based self-samples to detect cervical (pre)cancer in HPV-positive women","volume":"141","author":"LM De Strooper","year":"2016","journal-title":"Gynecologic oncology"},{"issue":"4","key":"ref29","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1002\/(SICI)1097-0215(19970207)70:4<408::AID-IJC6>3.0.CO;2-#","article-title":"Human papillomavirus types 52 and 58 are prevalent in cervical cancers from Chinese women","volume":"70","author":"S Huang","year":"1997","journal-title":"International journal of cancer"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","first-page":"593","DOI":"10.3346\/jkms.1999.14.6.593","article-title":"Detection and typing of human papillomavirus DNA by PCR using consensus primers in various cervical lesions of Korean women","volume":"14","author":"T Hwang","year":"1999","journal-title":"Journal of Korean medical science"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1002\/ijc.24495","article-title":"Distribution of human papillomavirus types in cervical cancers in Hong Kong: current situation and changes over the last decades","volume":"125","author":"PK Chan","year":"2009","journal-title":"International journal of cancer"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1086\/382896","article-title":"A large case-control study of cervical cancer risk associated with human papillomavirus infection in Japan, by nucleotide sequencing-based genotyping","volume":"189","author":"T Asato","year":"2004","journal-title":"The Journal of infectious diseases"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/s13148-016-0263-9","article-title":"Molecular Pap smear: HPV genotype and DNA methylation of ADCY8, CDH8, and ZNF582 as an integrated biomarker for high-grade cervical cytology","volume":"8","author":"J Shen-Gunther","year":"2016","journal-title":"Clin Epigenetics"},{"issue":"5 Suppl 1","key":"ref34","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1097\/LGT.0b013e318287d329","article-title":"2012 updated consensus guidelines for the management of abnormal cervical cancer screening tests and cancer precursors","volume":"17","author":"LS Massad","year":"2013","journal-title":"Journal of lower genital tract disease"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"e0180618","DOI":"10.1371\/journal.pone.0180618","article-title":"Previous cervical cytology and high-risk human papillomavirus testing in a cohort of patients with invasive cervical carcinoma in Shandong Province, China","volume":"12","author":"L Zhang","year":"2017","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0210289","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T00:24:32Z","timestamp":1588983872000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0210289"}},"subtitle":[],"editor":[{"given":"Maria Lina","family":"Tornesello","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,4]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0210289","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,4]]}}}