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Trachoma control. A guide for programme managers. Geneva; 2006. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/iris\/bitstream\/10665\/43405\/1\/9241546905_eng.pdf\" xlink:type=\"simple\">http:\/\/apps.who.int\/iris\/bitstream\/10665\/43405\/1\/9241546905_eng.pdf<\/ext-link>."},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"162","DOI":"10.3109\/09286586.2015.1035792","article-title":"Inter-Rater agreement between trachoma graders: comparison of grades given in field conditions versus grades from photographic review","volume":"22","author":"S Gebresillasie","year":"2015","journal-title":"Ophthalmic Epidemiol"},{"key":"ref5","unstructured":"Hann CE, Chase JG, Revie JA, Hewett D, Shaw GM. Diabetic Retinopathy Screening Using Computer Vision. In: 7th IFAC Symposium on Modelling and Control in Biomedical Systems. vol. 42; 2009. p. 298\u2013303. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474667015378903\" xlink:type=\"simple\">http:\/\/www.sciencedirect.com\/science\/article\/pii\/S1474667015378903<\/ext-link>."},{"key":"ref6","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.compmedimag.2008.08.009","article-title":"Automatic detection of diabetic retinopathy exudates from non-dilated retinal images using mathematical morphology methods","volume":"32","author":"A Sopharak","year":"2008","journal-title":"Comput Med Imaging Graph"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1109\/TMI.2016.2535865","article-title":"Lung Pattern Classification for Interstitial Lung Diseases Using a Deep Convolutional Neural Network","volume":"35","author":"M Anthimopoulos","year":"2016","journal-title":"IEEE Trans Med Imaging"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/09286580490514577","article-title":"How reliable is the clinical exam in detecting ocular chlamydial infection?","volume":"11","author":"K Miller","year":"2004","journal-title":"Ophthalmic Epidemiol"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"6133","DOI":"10.1167\/iovs.11-7419","article-title":"How reliable are tests for trachoma?\u2014a latent class approach","volume":"52","author":"CW See","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1097\/00061198-199902000-00014","article-title":"Neural networks for visual field analysis: how do they compare with other algorithms?","volume":"8","author":"T Lietman","year":"1999","journal-title":"J Glaucoma"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.procs.2016.07.014","article-title":"Convolutional Neural Networks for Diabetic Retinopathy","volume":"90","author":"H Pratt","year":"2016","journal-title":"Procedia Computer Science"},{"key":"ref12","article-title":"Imagenet classification with deep convolutional neural networks","author":"A Krizhevsky","year":"2012","journal-title":"Advances in neural information processing systems"},{"key":"ref13","first-page":"1","article-title":"Very Deep Convolutional Networks for Large-Scale Image Recoginition","author":"K Simonyan","year":"2015","journal-title":"Intl Conf on Learning Representations (ICLR)"},{"issue":"9669","key":"ref14","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/S0140-6736(09)60323-8","article-title":"Assessment of herd protection against trachoma due to repeated mass antibiotic distributions: a cluster-randomised trial","volume":"373","author":"JI House","year":"2009","journal-title":"Lancet"},{"issue":"6","key":"ref15","first-page":"743","article-title":"A cluster-randomized trial to assess the efficacy of targeting trachoma treatment to children","volume":"64","author":"A Amza","year":"2017","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ref16","first-page":"477","article-title":"A simple system for the assessment of trachoma and its complications","volume":"65","author":"B Thylefors","year":"1987","journal-title":"Bull WHO"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1109\/TPAMI.2005.17","article-title":"Skin segmentation using color pixel classification: analysis and comparison","volume":"27","author":"SL Phung","year":"2005","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"ref18","article-title":"Learning OpenCV 3: Computer Vision in C++ with the OpenCV Library","author":"A Kaehler","year":"2017"},{"key":"ref19","article-title":"Neural networks and learning machines","author":"S Haykin","year":"2009"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/0022-247X(62)90004-5","article-title":"The numerical solution of variational problems","volume":"5","author":"S Dreyfus","year":"1962","journal-title":"J Math Anal Appl"},{"key":"ref21","unstructured":"Buja A, Werner S, Shen Y. Loss Functions for Binary Class Probability Estimation and Classification: Structure and Applications; 2005. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www-stat.wharton.upenn.edu\/~buja\/PAPERS\/paper-proper-scoring.pdf\" xlink:type=\"simple\">http:\/\/www-stat.wharton.upenn.edu\/~buja\/PAPERS\/paper-proper-scoring.pdf<\/ext-link>."},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1017\/CBO9781139168229","article-title":"Machine vision","author":"WE Snyder","year":"2010"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/0042-6989(80)90065-6","article-title":"Two-dimensional spectral analysis of cortical receptive field profiles","volume":"20","author":"JG Daugman","year":"1980","journal-title":"Vision res"},{"key":"ref24","unstructured":"Pizer SM, Johnston RE, Ericksen JP, Yankaskas BC, Muller KE. Contrast-limited adaptive histogram equalization: speed and effectiveness. In: Proceedings of the first conference on Visualization in Biomedical Computing, May 22\u201325, Atlanta, GA. IEEE Computer Society Press; 1990. p. 337\u2013345. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1109\/VBC.1990.109340\" xlink:type=\"simple\">10.1109\/VBC.1990.109340<\/ext-link><\/comment>"},{"key":"ref25","doi-asserted-by":"crossref","DOI":"10.1002\/0471722138","article-title":"Introduction to Stochastic Search and Optimization","author":"JC Spall","year":"2003"},{"key":"ref26","unstructured":"Zeiler MD. ADADELTA: an adaptive learning rate method. arXiv preprint arXiv:12125701. 2012."},{"key":"ref27","unstructured":"Ioffe S, Szegedy C. Batch normalization: Accelerating deep network training by reducing internal covariate shift. arXiv preprint arXiv:150203167. 2015."},{"issue":"1","key":"ref28","first-page":"1929","article-title":"Dropout: a simple way to prevent neural networks from overfitting","volume":"15","author":"N Srivastava","year":"2014","journal-title":"J Mach Learn Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1177\/001316446002000104","article-title":"A coefficient of agreement for nominal scales","volume":"20","author":"J Cohen","year":"1960","journal-title":"Educ Psychol Meas"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3109\/09286586.2015.1037401","article-title":"The Global Trachoma Mapping Project: Methodology of a 34-Country Population-Based Study","volume":"22","author":"AW Solomon","year":"2015","journal-title":"Ophthalmic Epidemiol"},{"issue":"3","key":"ref31","first-page":"279","article-title":"Blinding and non-blinding trachoma: assessment of intensity of upper tarsal inflammatory disease and disabling lesions","volume":"52","author":"CR Dawson","year":"1975","journal-title":"Bull WHO"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1136\/bjo.2008.144147","article-title":"Comparison of clinical and photographic assessment of trachoma","volume":"93","author":"KG Roper","year":"2009","journal-title":"Br J Ophthalmol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0210463","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:13:33Z","timestamp":1588968813000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0210463"}},"subtitle":[],"editor":[{"given":"Ryan E.","family":"Wiegand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,11]]},"references-count":32,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0210463","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,11]]}}}