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l\u2019environnement et du travail (ANSES). Actualisation des rep\u00e8res du PNNS: r\u00e9visions des rep\u00e8res relatifs \u00e0 l\u2019activit\u00e9 physique et \u00e0 la s\u00e9dentarit\u00e9. Maisons-Alfort: ANSES; 2016. 584 p. (Avis de l\u2019Anses-Rapport d\u2019expertise collective). 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