{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,2]],"date-time":"2026-01-02T17:15:41Z","timestamp":1767374141500,"version":"3.37.3"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T00:00:00Z","timestamp":1550188800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0211122","type":"journal-article","created":{"date-parts":[[2019,2,15]],"date-time":"2019-02-15T13:23:29Z","timestamp":1550237009000},"page":"e0211122","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Real-life experience of lusutrombopag for cirrhotic patients with low platelet counts being prepared for invasive procedures"],"prefix":"10.1371","volume":"14","author":[{"given":"Hitomi","family":"Takada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masayuki","family":"Kurosaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroyuki","family":"Nakanishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuka","family":"Takahashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Itakura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaoru","family":"Tsuchiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Yasui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuharu","family":"Tamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenta","family":"Takaura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Komiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayu","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youhei","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wann","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mao","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takao","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiya","family":"Watakabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobuyuki","family":"Enomoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0055-8229","authenticated-orcid":true,"given":"Namiki","family":"Izumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.jhep.2008.03.009","article-title":"Thrombocytopenia associated with chronic liver disease","volume":"48","author":"N Afdhal","year":"2008","journal-title":"J Hepatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/j.1365-2036.2006.02889.x","article-title":"Review article: thrombocytopenia in chronic liver disease and pharmacologic treatment options","volume":"23","author":"EG Giannini","year":"2006","journal-title":"Aliment Pharmacol Ther"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s40265-015-0525-4","article-title":"Lusutrombopag: First Global Approval","volume":"76","author":"ES Kim","year":"2016","journal-title":"Drugs"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Y Kanda","year":"2013","journal-title":"Bone Marrow Transplant"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s12328-017-0735-2","article-title":"Lusutrombopag increases hematocytes in a compensated liver cirrhosis patient","volume":"10","author":"A Sakamaki","year":"2017","journal-title":"Clin J Gastroenterol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1002\/hep.510280535","article-title":"Blunted thrombopoietin response to interferon alfa-induced thrombocytopenia during treatment for hepatitis C","volume":"28","author":"M Peck-Radosavljevic","year":"1998","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.mayocp.2015.11.015","article-title":"Incidence and Risk Factors for Adverse Events Related to Image-Guided Liver Biopsy","volume":"91","author":"JH Boyum","year":"2016","journal-title":"Mayo Clin Proc"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.cgh.2010.06.018","article-title":"Incidence of bleeding following invasive procedures in patients with thrombocytopenia and advanced liver disease","volume":"8","author":"EG Giannini","year":"2010","journal-title":"Clin Gastroenterol Hepatol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1093\/ajcp\/94.6.747","article-title":"Lack of increased bleeding after liver biopsy in patients with mild hemostatic abnormalities","volume":"94","author":"PA McVay","year":"1990","journal-title":"Am J Clin Pathol"},{"key":"ref10","first-page":"603","article-title":"Laparoscopic liver biopsy in patients with coagulopathy, portal hypertension, and ascites","volume":"61","author":"WB Inabnet","year":"1995","journal-title":"Am Surg"},{"key":"ref11","first-page":"JCO2017761734","article-title":"Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update","volume":"28","author":"CA Schiffer","year":"2017","journal-title":"J Clin Oncol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S1590-8658(03)00219-6","article-title":"Non-invasive predictors of the presence of large oesophageal varices in patients with cirrhosis","volume":"35","author":"KC Thomopoulos","year":"2003","journal-title":"Dig Liver Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/00004836-200201000-00016","article-title":"Prediction of esophageal varices in patients with cirrhosis","volume":"34","author":"R Madhotra","year":"2002","journal-title":"J Clin Gastroenterol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1086\/423384","article-title":"Strong association of hepatitis C virus (HCV) infection and thrombocytopenia: implications from a survey of a community with hyperendemic HCV infection","volume":"39","author":"CS Wang","year":"2004","journal-title":"Clin Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1111\/j.1530-0277.1989.tb00408.x","article-title":"Hematological complications of alcoholism","volume":"13","author":"HS Ballard","year":"1989","journal-title":"Alcohol Clin Exp Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1042\/cs0990207","article-title":"Thrombopoietin levels in serum and liver tissue in patients with chronic viral hepatitis and hepatocellular carcinoma","volume":"99","author":"M Okubo","year":"2000","journal-title":"Clin Sci (Lond)"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"3158","DOI":"10.1200\/JCO.2003.08.003","article-title":"Importance of predosing of recombinant human thrombopoietin to reduce chemotherapy-induced early thrombocytopenia","volume":"21","author":"S Vadhan-Raj","year":"2003","journal-title":"J Clin Oncol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1562","DOI":"10.1016\/S0140-6736(09)60255-5","article-title":"New-generation drugs that stimulate platelet production in chronic immune thrombocytopenic purpura","volume":"373","author":"AT Nurden","year":"2009","journal-title":"Lancet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1056\/NEJMc1211471","article-title":"Eltrombopag before procedures in patients with cirrhosis and thrombocytopenia","volume":"367","author":"T Lisman","year":"2012","journal-title":"N Engl J Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3748","DOI":"10.1182\/blood-2009-05-224766","article-title":"Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim","volume":"114","author":"DJ Kuter","year":"2009","journal-title":"Blood"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1016\/j.jhep.2014.07.007","article-title":"Phase II study of avatrombopag in thrombocytopenic patients with cirrhosis undergoing an elective procedure","volume":"61","author":"NA Terrault","year":"2014","journal-title":"J Hepatol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3099","DOI":"10.1002\/cncr.11447","article-title":"Pharmacoeconomic analysis of oprelvekin (recombinant human interleukin-11) for secondary prophylaxis of thrombocytopenia in solid tumor patients receiving chemotherapy","volume":"97","author":"SB Cantor","year":"2003","journal-title":"Cancer"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1002\/hep.21231","article-title":"Elevated levels of von Willebrand Factor in cirrhosis support platelet adhesion despite reduced functional capacity","volume":"44","author":"T Lisman","year":"2006","journal-title":"Hepatology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.taap.2017.05.018","article-title":"Von Willebrand factor deficiency reduces liver fibrosis in mice","volume":"328","author":"N Joshi","year":"2017","journal-title":"Toxicol Appl Pharmacol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0211122","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:26:23Z","timestamp":1588969583000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0211122"}},"subtitle":[],"editor":[{"given":"Yun-Wen","family":"Zheng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,15]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0211122","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,2,15]]}}}