{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:41:06Z","timestamp":1778895666341,"version":"3.51.4"},"reference-count":71,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T00:00:00Z","timestamp":1548633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0211229","type":"journal-article","created":{"date-parts":[[2019,1,28]],"date-time":"2019-01-28T19:31:05Z","timestamp":1548703865000},"page":"e0211229","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["Lapachol and synthetic derivatives: in vitro and in vivo activities against Bothrops snake venoms"],"prefix":"10.1371","volume":"14","author":[{"given":"Marcelo A.","family":"Strauch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6769-7899","authenticated-orcid":true,"given":"Marcelo Amorim","family":"Tomaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcos","family":"Monteiro-Machado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Lemos","family":"Cons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4583-0476","authenticated-orcid":true,"given":"Fernando Chagas","family":"Patr\u00e3o-Neto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3167-0723","authenticated-orcid":true,"given":"Jhonatha da Mota","family":"Teixeira-Cruz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus da Silva","family":"Tavares-Henriques","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e2mella Dourila","family":"Nogueira-Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara L. S.","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo R. R.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edgar","family":"Schaeffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alcides J. M.","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo A.","family":"Melo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,1,28]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1590\/0037-8682-0105-2013","article-title":"Snakebites as a largely neglected problem in the Brazilian Amazon: highlights of the epidemiological trends in the State of Amazonas","volume":"48","author":"ES Feitosa","year":"2015","journal-title":"Rev. Soc. Bras. Med. Trop"},{"issue":"9708","key":"ref2","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(09)61754-2","article-title":"Snake bite","volume":"375","author":"DA Warrell","year":"2010","journal-title":"Lancet"},{"key":"ref3","unstructured":"World Health Organization (WHO). Working to overcome the global impact of neglected tropical diseases: first WHO report on neglected tropical diseases 2010:[172p.]. Avaliable from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44440\/9789241564090_eng.pdf;jsessionid=AE619438C1DB478AA53B4D8B8F7E49E0?sequence=1\" xlink:type=\"simple\">http:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/44440\/9789241564090_eng.pdf;jsessionid=AE619438C1DB478AA53B4D8B8F7E49E0?sequence=1<\/ext-link>"},{"issue":"9708","key":"ref4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/S0140-6736(09)61159-4","article-title":"The Global Snake Bite Initiative: an antidote for snake bite","volume":"375","author":"D Williams","year":"2010","journal-title":"Lancet"},{"issue":"5","key":"ref5","first-page":"515","article-title":"Snakebites: appraisal of the global situation","volume":"76","author":"JP Chippaux","year":"1998","journal-title":"Bull. World Health Organ"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"e0005662","DOI":"10.1371\/journal.pntd.0005662","article-title":"Incidence and mortality due to snakebite in the Americas","volume":"11","author":"JP Chippaux","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrdp.2017.79","article-title":"Snakebite envenoming","volume":"3","author":"JM Guti\u00e9rrez","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"ref8","author":"AL Harvey"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"22869","DOI":"10.1016\/S0021-9258(18)50027-2","article-title":"Purification, cloning and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from <italic>Bothrops jararaca<\/italic> venom. Insights into the disintegrin-like gene family","volume":"267","author":"MJI Paine","year":"1992","journal-title":"J Biol Chem"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.toxicon.2007.03.010","article-title":"Evaluation of three Brazilian antivenom ability to antagonize myonecrosis and hemorrhage induced by <italic>Bothrops<\/italic> snake venoms in a mouse model","volume":"50","author":"NM Da Silva","year":"2007","journal-title":"Toxicon"},{"issue":"5\u20136","key":"ref11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/0041-0101(80)90087-2","article-title":"Myonecrosis, hemorrhage and edema induced by <italic>Bothrops asper<\/italic> venom in white mice","volume":"18","author":"JM Guti\u00e9rrez","year":"1980","journal-title":"Toxicon"},{"issue":"5","key":"ref12","first-page":"538","article-title":"Morphology of local tissue damage in experimental snake envenomation","volume":"52","author":"M Homma","year":"1971","journal-title":"Br J Exp Pathol"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"805","DOI":"10.4269\/ajtmh.1992.47.805","article-title":"A clinical and epidemiologic study of 292 cases of lance-headed viper bite in a Brazilian teaching hospital","volume":"47","author":"A Nishioka Sde","year":"1992","journal-title":"Am J Trop Med Hyg"},{"key":"ref14","article-title":"Venomous Animals and their Venoms, Volume II: Venomous Vertebrates","author":"G Rosenfeld","year":"1971"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S0378-8741(03)00049-7","article-title":"Snake venom neutralization by Indian medicinal plants (<italic>Vitex negundo<\/italic> and <italic>Emblica officinalis<\/italic>) root extracts.","volume":"86","author":"MI Alam","year":"2003","journal-title":"J Ethnopharmacol."},{"issue":"1\u20132","key":"ref16","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jep.2004.12.014","article-title":"Neutralizing properties of <italic>Musa paradisiaca<\/italic> L. (Musaceae) juice on phospholipase A<sub>2<\/sub>, myotoxic, hemorrhagic and lethal activities of crotalidae venoms","volume":"98","author":"MH Borges","year":"2005","journal-title":"J Ethnopharmacol."},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.jep.2007.04.002","article-title":"Neutralization of snake venom phospholipase A<sub>2<\/sub> toxins by aqueous extract of <italic>Casearia sylvestris<\/italic> (Flacourtiaceae) in mouse neuromuscular preparation","volume":"112","author":"WL Cavalcante","year":"2007","journal-title":"J Ethnopharmacol."},{"issue":"1\u20132","key":"ref18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.jep.2004.12.028","article-title":"Anticoagulant and antifibrinogenolytic properties of the aqueous extract from <italic>Bauhinia forficata<\/italic> against snake venoms","volume":"98","author":"CZ Oliveira","year":"2005","journal-title":"J Ethnopharmacol."},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jep.2009.03.025","article-title":"The protective effect of <italic>Mucuna pruriens<\/italic> seeds against snake venom poisoning","volume":"123","author":"NH Tan","year":"2009","journal-title":"J Ethnopharmacol."},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.jep.2014.05.056","article-title":"Counteraction of <italic>Bothrops<\/italic> snake venoms by <italic>Combretum leprosum<\/italic> root extract and arjunolic acid","volume":"155","author":"FF Fernandes","year":"2014","journal-title":"J Ethnopharmacol."},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/0041-0101(94)90207-0","article-title":"Inhibition of the myotoxic and hemorrhagic activities of crotalid venoms by <italic>Eclipta prostrata<\/italic> (Asteraceae) extracts and constituents","volume":"32","author":"PA Melo","year":"1994","journal-title":"Toxicon"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/0041-0101(89)90151-7","article-title":"Neutralization of lethal and myotoxic activities of South American rattlesnake venom by extracts and constituents of the plant <italic>Eclipta prostrata<\/italic> (Asteraceae)","volume":"27","author":"WB Mors","year":"1989","journal-title":"Toxicon"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.toxicon.2013.01.023","article-title":"Dexamethasone antagonizes the in vivo myotoxic and inflammatory effects of <italic>Bothrops<\/italic> venoms","volume":"69","author":"FC Patr\u00e3o-Neto","year":"2013","journal-title":"Toxicon"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jep.2012.10.033","article-title":"Antiophidic activity of the extract of the Amazon plant <italic>Humirianthera ampla<\/italic> and constituents","volume":"145","author":"MA Strauch","year":"2013","journal-title":"J Ethnopharmacol."},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jep.2008.10.004","article-title":"Red Lapachol (<italic>Tabebuia impetiginosa<\/italic>)\u2013A global ethnopharmacological commodity?","volume":"121","author":"JR G\u00f3mez Castellanos","year":"2009","journal-title":"J Ethnopharmacol."},{"key":"ref26","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3998\/ark.5550190.0008.204","article-title":"Lapachol: an overview","volume":"2","author":"H Hussain","year":"2007","journal-title":"Arkivoc"},{"issue":"4","key":"ref27","first-page":"82","article-title":"Brazilian plants so-believed active against animal\u2014venoms, especially anti-snake venons.","volume":"69","author":"CT Rizzini","year":"1988","journal-title":"Revista Brasileira de Farm\u00e1cia"},{"issue":"22","key":"ref28","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1016\/j.bmc.2011.09.025","article-title":"Pterocarpanquinones, aza-pterocarpanquinone and derivatives: Synthesis, antineoplasic activity on human malignant cell lines and antileishmanial activity on <italic>Leishmania amazonenses<\/italic>","volume":"19","author":"CD Buarque","year":"2011","journal-title":"Bioorg Med Chem"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"2731","DOI":"10.1016\/S0968-0896(02)00100-1","article-title":"Synthesis and Preliminary Pharmacological Evaluation of New (+\/-) 1,4-Naphthoquinones Structurally Related to Lapachol","volume":"10","author":"AJ Da Silva","year":"2002","journal-title":"Bioorg Med Chem"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s11101-013-9289-1","article-title":"Lapachol and its congeners as anticancer agents: a review","volume":"13","author":"F Epifano","year":"2014","journal-title":"Phytochem Rev"},{"issue":"8","key":"ref31","first-page":"1573","article-title":"Suzuki-Miyaura Coupling between 3-Iodolawsone and Arylboronic Acids. Synthesis of Lapachol Analogues with Antineoplastic and Antileishmanial Activities","volume":"28","author":"SLS Gomes","year":"2017","journal-title":"J. Braz. Chem. Soc"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0003-9861(78)80015-0","article-title":"Purification and characterization of a sulfhydryl-dependent protease from <italic>Rhodnius prolixus<\/italic> midgut","volume":"188","author":"ES Garcia","year":"1978","journal-title":"Arch Biochem Biophys"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/0003-2697(84)90242-2","article-title":"Assaying proteinases with azocoll","volume":"136","author":"R Chavira Jr","year":"1984","journal-title":"Anal Biochem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.toxicon.2015.02.010","article-title":"Occurrence of sulfated fucose branches in fucosylated chondroitin sulfate are essential for the polysaccharide effect preventing muscle damage induced by toxins and crude venom from <italic>Bothrops jararacussu<\/italic> snake","volume":"98","author":"M Monteiro-Machado","year":"2015","journal-title":"Toxicon"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/0005-2760(65)90152-9","article-title":"The action of phospholipase A on lipoproteins","volume":"98","author":"GV Marinetti","year":"1965","journal-title":"Biochim Biophys Acta"},{"issue":"3","key":"ref36","first-page":"545","article-title":"Release of creatine kinase from skeletal muscle by <italic>Bothrops<\/italic> venoms: heparin potentiation of inhibition by antivenim","volume":"21","author":"PA Melo","year":"1988","journal-title":"Braz J Med Biol Res"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/0041-0101(93)90146-A","article-title":"Antagonism of the myotoxic effects of <italic>Bothrops jararacussu<\/italic> venom and Bothropstoxin by polyanions","volume":"31","author":"PA Melo","year":"1993","journal-title":"Toxicon"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0041-0101(88)90140-7","article-title":"Release of sarcoplasmic enzymes from skeletal muscle by <italic>Bothrops jararacussu<\/italic> venom: antagonism by heparin and by the serum of South American marsupials","volume":"26","author":"PA Melo","year":"1988","journal-title":"Toxicon"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1097\/00000441-191304000-00004","article-title":"A clinical study of the coagulation time of blood","volume":"145","author":"RI Lee","year":"1913","journal-title":"Am J Med Sci"},{"issue":"3","key":"ref40","first-page":"402","article-title":"The Influence of Brazilian Biodiversity on Searching for Human Use Pharmaceuticals.","volume":"28","author":"DJ Newman","year":"2017","journal-title":"J. Braz. Chem. Soc"},{"issue":"2","key":"ref41","first-page":"1","article-title":"Structure-antitumor activity relationships among quinone derivatives","volume":"4","author":"JS Driscoll","year":"1974","journal-title":"Cancer Chemother Rep 2"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1055\/s-2006-959425","article-title":"Pharmacological screening of plants recommended by folk medicine as snake venom antidotes; IV. Protection against jararaca venom by isolated constituents","volume":"60","author":"NA Pereira","year":"1994","journal-title":"Planta Medica"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0960-894X(00)00621-1","article-title":"Synthesis and Preliminary Pharmacological Evaluation of Coumestans with Different Patterns of Oxygenation","volume":"11","author":"AJM Da Silva","year":"2001","journal-title":"Bioorg Med Chem"},{"issue":"2\u20133","key":"ref44","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.toxicon.2009.09.021","article-title":"Ability of a synthetic coumestan to antagonize <italic>Bothrops<\/italic> snake venom activities","volume":"55","author":"PA Melo","year":"2010","journal-title":"Toxicon"},{"issue":"9\u201310","key":"ref45","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/S0300-9084(00)01163-9","article-title":"Snake venom metalloproteinases: their role in the pathogenesis of local tissue damage","volume":"82","author":"JM Guti\u00e9rrez","year":"2000","journal-title":"Biochimie"},{"issue":"10","key":"ref46","doi-asserted-by":"crossref","first-page":"e304","DOI":"10.3390\/toxins8100304","article-title":"A Comprehensive View of the Structural and Functional Alterations of Extracellular Matrix by Snake Venom Metalloproteinases (SVMPs): Novel Perspectives on the Pathophysiology of Envenoming","volume":"8","author":"JM Guti\u00e9rrez","year":"2016","journal-title":"Toxins"},{"issue":"4","key":"ref47","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/toxins8040093","article-title":"Hemorrhage Caused by Snake Venom Metalloproteinases: A Journey of Discovery and Understanding","volume":"8","author":"JM Guti\u00e9rrez","year":"2016","journal-title":"Toxins"},{"issue":"8","key":"ref48","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/0041-0101(91)90079-7","article-title":"Coagulation and haemorrage victims of <italic>Bothrops jararaca<\/italic> envenoming in Brazil","volume":"29","author":"AS Kamiguti","year":"1991","journal-title":"Toxicon"},{"issue":"8","key":"ref49","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/S0041-0101(02)00104-6","article-title":"Complications of <italic>Bothrops<\/italic>, <italic>Porthidium<\/italic>, and <italic>Bothriechis<\/italic> snakebites in Colombia. A clinical andepidemiological study of 39 cases attended in a university hospital","volume":"40","author":"R Otero","year":"2002","journal-title":"Toxicon"},{"issue":"10","key":"ref50","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1110\/ps.03102403","article-title":"Amino acid sequence and crystal structure of BaP1, a metalloproteinase from <italic>Bothrops asper<\/italic> snake venom that exerts multiple tissue-damaging activities","volume":"12","author":"L Watanabe","year":"2003","journal-title":"Protein Sci"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.toxicon.2015.10.016","article-title":"Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices","volume":"108","author":"C Baldo","year":"2015","journal-title":"Toxicon"},{"key":"ref52","article-title":"The venomous reptiles of the Western Hemisphere","volume":"2","author":"DA Warrell","year":"2004"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.jmb.2005.04.072","article-title":"Inhibition of Myotoxic Activity of <italic>Bothrops asper<\/italic> Myotoxin II by the Anti-trypanosomal Drug Suramin","volume":"350","author":"MT Murakami","year":"2005","journal-title":"J Mol Biol"},{"issue":"18","key":"ref54","doi-asserted-by":"crossref","first-page":"2897","DOI":"10.1007\/s00018-008-8113-3","article-title":"Cellular pathology induced by snake venom phospholipase A<sub>2<\/sub> myotoxins and neurotoxins: common aspects of their mechanisms of action","volume":"65","author":"C Montecucco","year":"2008","journal-title":"Cell Mol Life Sci"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/0041-0101(89)90013-5","article-title":"A model to explain the pharmacological effects of snake venom phospholipases A<sub>2<\/sub>","volume":"27","author":"RM Kini","year":"1989","journal-title":"Toxicon"},{"issue":"8","key":"ref56","doi-asserted-by":"crossref","first-page":"787","DOI":"10.2174\/156802607780487678","article-title":"Chemistry and Structural Evaluation of Different Phospholipase A<sub>2<\/sub> Inhibitors in Arachidonic Acid Pathway Mediated Inflammation and Snake Venom Toxicity","volume":"7","author":"JN Narendra Sharath Chandra","year":"2007","journal-title":"Curr Top Med Chem"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.actatropica.2004.09.008","article-title":"Neutralization of four Peruvian <italic>Bothrops<\/italic> sp. snake venoms by polyvalent antivenoms produced in Peru and Costa Rica: preclinical assessment","volume":"93","author":"E Rojas","year":"2005","journal-title":"Acta Trop"},{"issue":"12","key":"ref58","doi-asserted-by":"crossref","first-page":"749","DOI":"10.5435\/00124635-201012000-00005","article-title":"Management of venomous snakebite injury to the extremities","volume":"18","author":"AW Anz","year":"2010","journal-title":"J Am Acad Orthop Surg"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1111\/j.1476-5381.1994.tb13094.x","article-title":"Mediation by bradykinin of rat paw oedema induced by collagenase from <italic>Clostridium histolyticum<\/italic>","volume":"112","author":"FJ Legat","year":"1994","journal-title":"Br J Pharmacol"},{"issue":"7","key":"ref60","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.jprot.2012.01.020","article-title":"Exploring the proteomes of the venoms of the Peruvian pit vipers <italic>Bothrops atrox<\/italic>, <italic>B<\/italic>. <italic>barnetti<\/italic> and <italic>B<\/italic>. <italic>pictus<\/italic>","volume":"75","author":"M Kohlhoff","year":"2012","journal-title":"J Proteomics"},{"issue":"10","key":"ref61","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1091\/mbc.12.10.2934","article-title":"Activation of matrix-metalloproteinase-2 and membrane-type-1-matrix-metalloproteinase in endothelial cells and induction of vascular permeability in vivo by human immunodeficiency virus-1 Tat protein and basic fibroblast growth factor","volume":"12","author":"E Toschi","year":"2001","journal-title":"Mol Biol Cell"},{"issue":"2","key":"ref62","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/0378-8741(90)90061-W","article-title":"Antiinflammatory action of lapachol","volume":"29","author":"ER De Almeida","year":"1990","journal-title":"J Ethnopharmacol"},{"issue":"5","key":"ref63","doi-asserted-by":"crossref","first-page":"109","DOI":"10.56499\/jppres15.082_3.5.109","article-title":"Anti-inflammatory activity of the methanolic extracts of leaves and stems from <italic>Tabebuia hypoleuca<\/italic> (C. Wright) Urb.","volume":"3","author":"AI Regalado","year":"2015","journal-title":"J Pharm Pharmacogn Res."},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1111\/j.1476-5381.1996.tb15475.x","article-title":"Nitric oxide: a key mediator in the early and late phase of carrageenan-induced rat paw inflammation","volume":"118","author":"D Salvemini","year":"1996","journal-title":"Br J Pharmacol"},{"issue":"25","key":"ref65","doi-asserted-by":"crossref","first-page":"12013","DOI":"10.1073\/pnas.91.25.12013","article-title":"Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain","volume":"91","author":"K Seibert","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"ref66","doi-asserted-by":"crossref","first-page":"8515","DOI":"10.3390\/molecules16108515","article-title":"Anti-inflammatory activity of alkaloids: an update from 2000 to 2010","volume":"16","author":"AL Souto","year":"2010","journal-title":"Molecules"},{"key":"ref67","first-page":"221","article-title":"Botanical study, phytochemistry and antimicrobial activity of <italic>Tabebuia aurea<\/italic>","volume":"73","author":"JM Barbosa-Filho","year":"2004","journal-title":"Phyton"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jep.2014.10.045","article-title":"<italic>Tabebuia aurea<\/italic> decreases inflammatory, myotoxic and hemorrhagic activities induced by the venom of <italic>Bothrops neuwiedi<\/italic>","volume":"158","author":"FP Reis","year":"2014","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"ref69","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"H Nagase","year":"2006","journal-title":"Cardiovasc Res"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1146\/annurev.cb.09.110193.002545","article-title":"Tumor-cell interactions with the extracellular-matrix during invasion and metastasis","volume":"9","author":"WG Stetler-Stevenson","year":"1993","journal-title":"Ann Rev Cell Biol"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ejmech.2012.04.008","article-title":"Beta-Lapachone analogs with enhanced antiproliferative activity","volume":"53","author":"C R\u00edos-Luci","year":"2012","journal-title":"Eur J Med Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0211229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,14]],"date-time":"2024-07-14T11:14:57Z","timestamp":1720955697000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0211229"}},"subtitle":[],"editor":[{"given":"Jos\u00e9 Mar\u00eda","family":"Guti\u00e9rrez","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,1,28]]},"references-count":71,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2019,1,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0211229","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,1,28]]}}}