{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T10:42:10Z","timestamp":1762252930564,"version":"3.37.3"},"reference-count":50,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T00:00:00Z","timestamp":1550620800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0211436","type":"journal-article","created":{"date-parts":[[2019,2,20]],"date-time":"2019-02-20T19:27:29Z","timestamp":1550690849000},"page":"e0211436","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Involvement of gliadin, a component of wheat gluten, in increased intestinal permeability leading to non-steroidal anti-inflammatory drug-induced small-intestinal damage"],"prefix":"10.1371","volume":"14","author":[{"given":"Sunao","family":"Shimada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9305-1637","authenticated-orcid":true,"given":"Tetsuya","family":"Tanigawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinobu","family":"Nakata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoki","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigehiro","family":"Itani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akira","family":"Higashimori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuji","family":"Nadatani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koji","family":"Otani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koichi","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuhei","family":"Hosomi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuaki","family":"Nagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriko","family":"Kamata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hirokazu","family":"Yamagami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Shiba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,2,20]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/S1542-3565(04)00603-2","article-title":"Visible small-intestinal mucosal injury in chronic NSAID users","volume":"3","author":"DY Graham","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1159\/000190403","article-title":"Evaluation of small bowel injury in patients with rheumatoid arthritis by capsule endoscopy: effects of anti-rheumatoid arthritis drugs","volume":"78","author":"S Sugimori","year":"2008","journal-title":"Digestion"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S1542-3565(04)00619-6","article-title":"Video capsule endoscopy to prospectively assess small bowel injury with celecoxib, naproxen plus omeprazole, and placebo","volume":"3","author":"JL Goldstein","year":"2005","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1053\/j.gastro.2005.03.020","article-title":"A quantitative analysis of NSAID-induced small bowel pathology by capsule enteroscopy","volume":"128","author":"L Maiden","year":"2005","journal-title":"Gastroenterology"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1016\/j.dld.2012.12.005","article-title":"Risk factors for severe nonsteroidal anti-inflammatory drug-induced small intestinal damage","volume":"45","author":"T Watanabe","year":"2013","journal-title":"Dig Liver Dis"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1016\/j.cgh.2008.06.021","article-title":"Small bowel injury by low-dose enteric-coated aspirin and treatment with misoprostol: a pilot study","volume":"6","author":"T Watanabe","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1\u20133","key":"ref7","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ejphar.2013.02.010","article-title":"Rebamipide inhibits indomethacin-induced small intestinal injury: possible involvement of intestinal microbiota modulation by upregulation of alpha-defensin 5","volume":"704","author":"T Tanigawa","year":"2013","journal-title":"Eur J Pharmacol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1053\/j.gastro.2017.10.049","article-title":"Mechanisms of Damage to the Gastrointestinal Tract From Nonsteroidal Anti-Inflammatory Drugs","volume":"154","author":"I Bjarnason","year":"2018","journal-title":"Gastroenterology"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1136\/gut.2007.125963","article-title":"Non-steroidal anti-inflammatory drug-induced small intestinal damage is Toll-like receptor 4 dependent","volume":"57","author":"T Watanabe","year":"2008","journal-title":"Gut"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1111\/j.1476-5381.1977.tb07522.x","article-title":"Mechanisms underlying gastric mucosal damage induced by indomethacin and bile-salts, and the actions of prostaglandins","volume":"60","author":"BJ Whittle","year":"1977","journal-title":"British journal of pharmacology"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"G722","DOI":"10.1152\/ajpgi.00387.2009","article-title":"Effect of indomethacin on bile acid-phospholipid interactions: implication for small intestinal injury induced by nonsteroidal anti-inflammatory drugs","volume":"298","author":"Y Zhou","year":"2010","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref12","article-title":"Sex differences in NSAID-induced perturbation of human intestinal barrier function and microbiota","author":"S Edogawa","year":"2018","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1136\/gut.43.4.506","article-title":"Intestinal permeability and inflammation in patients on NSAIDs","volume":"43","author":"G Sigthorsson","year":"1998","journal-title":"Gut"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.fm.2006.07.004","article-title":"Chemistry of gluten proteins","volume":"24","author":"H. Wieser","year":"2007","journal-title":"Food microbiology"},{"key":"ref15","first-page":"h4347","article-title":"Celiac disease and non-celiac gluten sensitivity","volume":"351","author":"B Lebwohl","year":"2015","journal-title":"BMJ (Clinical research ed)"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1080\/00365520500235334","article-title":"Gliadin, zonulin and gut permeability: Effects on celiac and non-celiac intestinal mucosa and intestinal cell lines","volume":"41","author":"S Drago","year":"2006","journal-title":"Scand J Gastroenterol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"771","DOI":"10.3390\/nu5030771","article-title":"The dietary intake of wheat and other cereal grains and their role in inflammation","volume":"5","author":"K de Punder","year":"2013","journal-title":"Nutrients"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1007\/s00125-014-3265-1","article-title":"Dietary gluten and the development of type 1 diabetes","volume":"57","author":"JC Antvorskov","year":"2014","journal-title":"Diabetologia"},{"issue":"3","key":"ref19","first-page":"242","article-title":"Autoantibodies against gliadin in rheumatoid arthritis and primary Sjogren's syndrome patients","volume":"68","author":"A Koszarny","year":"2015","journal-title":"Wiadomosci lekarskie (Warsaw, Poland: 1960)"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.msard.2018.10.019","article-title":"The role of gluten in multiple sclerosis: A systematic review","volume":"27","author":"HL Thomsen","year":"2018","journal-title":"Multiple sclerosis and related disorders"},{"issue":"12","key":"ref21","doi-asserted-by":"crossref","first-page":"e1700879","DOI":"10.1002\/mnfr.201700879","article-title":"Green Tea Polyphenols Mitigate Gliadin-Mediated Inflammation and Permeability in Vitro","volume":"62","author":"CB Van Buiten","year":"2018","journal-title":"Molecular nutrition & food research"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s12865-015-0104-1","article-title":"Effect of anti-gliadin IgY antibody on epithelial intestinal integrity and inflammatory response induced by gliadin","volume":"16","author":"N Gujral","year":"2015","journal-title":"BMC immunology"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1007\/s10238-014-0325-2","article-title":"Gliadin-dependent cytokine production in a bidimensional cellular model of celiac intestinal mucosa","volume":"15","author":"O Vincentini","year":"2015","journal-title":"Clinical and experimental medicine"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2008.03.023","article-title":"Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3","volume":"135","author":"KM Lammers","year":"2008","journal-title":"Gastroenterology"},{"issue":"39","key":"ref25","doi-asserted-by":"crossref","first-page":"16799","DOI":"10.1073\/pnas.0906773106","article-title":"Identification of human zonulin, a physiological modulator of tight junctions, as prehaptoglobin-2","volume":"106","author":"A Tripathi","year":"2009","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0016-5085(97)70225-7","article-title":"Nonsteroidal anti-inflammatory drug enteropathy in rats: role of permeability, bacteria, and enterohepatic circulation","volume":"112","author":"BK Reuter","year":"1997","journal-title":"Gastroenterology"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"1832","DOI":"10.1016\/0016-5085(93)90667-2","article-title":"Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans","volume":"104","author":"I Bjarnason","year":"1993","journal-title":"Gastroenterology"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1080\/10408398.2012.654863","article-title":"Biochemical and functional properties of wheat gliadins: a review","volume":"55","author":"S Barak","year":"2015","journal-title":"Critical reviews in food science and nutrition"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1203\/00006450-197911000-00010","article-title":"Toxicity of wheat flour proteins and protein-derived peptides for in vitro developing intestine from rat fetus","volume":"13","author":"G De Ritis","year":"1979","journal-title":"Pediatric research"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2567.2010.03378.x","article-title":"Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease","volume":"132","author":"KM Lammers","year":"2011","journal-title":"Immunology"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"e0138338","DOI":"10.1371\/journal.pone.0138338","article-title":"Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1","volume":"10","author":"KM Lammers","year":"2015","journal-title":"PLoS One"},{"key":"ref32","article-title":"Mechanisms of NLRP3 inflammasome activation and its role in NSAID-induced enteropathy","author":"A Higashimori","year":"2015","journal-title":"Mucosal Immunol"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ajpath.2012.03.039","article-title":"High mobility group box 1 promotes small intestinal damage induced by nonsteroidal anti-inflammatory drugs through Toll-like receptor 4","volume":"181","author":"Y Nadatani","year":"2012","journal-title":"Am J Pathol"},{"issue":"22","key":"ref34","article-title":"Analysis of Intestinal Permeability in Mice","volume":"4","author":"JaN Gupta","year":"2014","journal-title":"Bio-protocol"},{"issue":"1\u20133","key":"ref35","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.schres.2009.08.009","article-title":"Novel immune response to gluten in individuals with schizophrenia","volume":"118","author":"D Samaroo","year":"2010","journal-title":"Schizophrenia research"},{"issue":"9","key":"ref36","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s00535-009-0102-2","article-title":"Present status and strategy of NSAIDs-induced small bowel injury","volume":"44","author":"K Higuchi","year":"2009","journal-title":"J Gastroenterol"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1007\/s00204-006-0149-2","article-title":"Role of bile in pathogenesis of indomethacin-induced enteropathy","volume":"81","author":"M Jacob","year":"2007","journal-title":"Archives of toxicology"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/BF00920471","article-title":"Mechanisms of acute and chronic intestinal inflammation induced by indomethacin","volume":"17","author":"T Yamada","year":"1993","journal-title":"Inflammation"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.ajpath.2012.10.014","article-title":"Lipopolysaccharide causes an increase in intestinal tight junction permeability in vitro and in vivo by inducing enterocyte membrane expression and localization of TLR-4 and CD14","volume":"182","author":"S Guo","year":"2013","journal-title":"Am J Pathol"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.4049\/jimmunol.1402598","article-title":"Lipopolysaccharide Regulation of Intestinal Tight Junction Permeability Is Mediated by TLR4 Signal Transduction Pathway Activation of FAK and MyD88","volume":"195","author":"S Guo","year":"2015","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1053\/gast.2002.35391","article-title":"HMGB1 B box increases the permeability of Caco-2 enterocytic monolayers and impairs intestinal barrier function in mice","volume":"123","author":"PL Sappington","year":"2002","journal-title":"Gastroenterology"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"G906","DOI":"10.1152\/ajpgi.00043.2007","article-title":"Bile acids modulate tight junction structure and barrier function of Caco-2 monolayers via EGFR activation","volume":"294","author":"F Raimondi","year":"2008","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1124\/jpet.106.113019","article-title":"Regulation of oxidant-induced intestinal permeability by metalloprotease-dependent epidermal growth factor receptor signaling","volume":"321","author":"CB Forsyth","year":"2007","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"e107421","DOI":"10.1371\/journal.pone.0107421","article-title":"Ethanol impairs intestinal barrier function in humans through mitogen activated protein kinase signaling: a combined in vivo and in vitro approach","volume":"9","author":"E Elamin","year":"2014","journal-title":"PLoS One"},{"issue":"Pt 24","key":"ref45","doi-asserted-by":"crossref","first-page":"4435","DOI":"10.1242\/jcs.113.24.4435","article-title":"Human zonulin, a potential modulator of intestinal tight junctions","volume":"113","author":"W Wang","year":"2000","journal-title":"Journal of cell science"},{"issue":"4","key":"ref46","doi-asserted-by":"crossref","first-page":"2512","DOI":"10.4049\/jimmunol.176.4.2512","article-title":"Gliadin stimulation of murine macrophage inflammatory gene expression and intestinal permeability are MyD88-dependent: role of the innate immune response in Celiac disease","volume":"176","author":"KE Thomas","year":"2006","journal-title":"Journal of immunology (Baltimore, Md: 1950)"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/j.1365-2982.2008.01139.x","article-title":"Protease-activated receptor 2 and gut permeability: a review","volume":"20","author":"L Bueno","year":"2008","journal-title":"Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1136\/gut.2009.183608","article-title":"Lysosomal accumulation of gliadin p31-43 peptide induces oxidative stress and tissue transglutaminase-mediated PPARgamma downregulation in intestinal epithelial cells and coeliac mucosa","volume":"59","author":"A Luciani","year":"2010","journal-title":"Gut"},{"issue":"6","key":"ref49","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2982.2012.01921.x","article-title":"Intestinal barrier function in health and gastrointestinal disease","volume":"24","author":"M Camilleri","year":"2012","journal-title":"Neurogastroenterology and motility: the official journal of the European Gastrointestinal Motility Society"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1002\/ibd.21403","article-title":"Importance of disrupted intestinal barrier in inflammatory bowel diseases","volume":"17","author":"SY Salim","year":"2011","journal-title":"Inflammatory bowel diseases"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0211436","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,12]],"date-time":"2022-09-12T05:21:25Z","timestamp":1662960085000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0211436"}},"subtitle":[],"editor":[{"given":"Karol","family":"Sestak","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,20]]},"references-count":50,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0211436","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,2,20]]}}}