{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T04:55:16Z","timestamp":1790744116354,"version":"4.1.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T00:00:00Z","timestamp":1551225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0211536","type":"journal-article","created":{"date-parts":[[2019,2,27]],"date-time":"2019-02-27T18:33:26Z","timestamp":1551292406000},"page":"e0211536","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":10,"title":["Peripheral-blood b-cell subset disturbances in inflammatory joint diseases induced by Tropheryma whipplei"],"prefix":"10.1371","volume":"14","author":[{"given":"Ma\u00eblle","family":"Le Goff","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divi","family":"Cornec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewi","family":"Guellec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Marhadour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Val\u00e9rie","family":"Devauchelle-Pensec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandrine","family":"Jousse-Joulin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Herbette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2474-7099","authenticated-orcid":true,"given":"Jean Michel","family":"Cauvin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clara","family":"Le Guillou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5098-5002","authenticated-orcid":true,"given":"Yves","family":"Renaudineau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Jamin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques Olivier","family":"Pers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8454-7067","authenticated-orcid":true,"given":"Alain","family":"Saraux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,2,27]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1099\/00207713-51-4-1471","article-title":"Description of Tropheryma whipplei gen. nov., sp. nov., the Whipple\u2019s disease bacillus","volume":"51","author":"B La Scola","year":"2001","journal-title":"Int J Syst Evol Microbiol"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"57","DOI":"10.2217\/fmb.12.124","article-title":"Tropheryma whipplei as a commensal bacterium","volume":"8","author":"AK Keita","year":"2013","journal-title":"Future Microbiol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/S1473-3099(15)00537-X","article-title":"Tropheryma whipplei infection and Whipple\u2019s disease","volume":"16","author":"T Marth","year":"2016","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1586\/14737159.1.3.299","article-title":"Molecular technique in Whipple\u2019s disease","volume":"1","author":"F Fenollar","year":"2001","journal-title":"Expert Rev Mol Diagn"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM199207303270501","article-title":"Identification of the uncultured bacillus of Whipple\u2019s disease","volume":"327","author":"David A. Relman","year":"1992","journal-title":"N Engl J Med"},{"issue":"8765","key":"ref6","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/0140-6736(91)90545-Z","article-title":"Phylogeny of the Whipple\u2019s-disease-associated bacterium","volume":"338","author":"KH Wilson","year":"1991","journal-title":"Lancet"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1128\/JCM.40.3.1119-1120.2002","article-title":"Quantitative Detection of Tropheryma whipplei DNA by Real-Time PCR","volume":"40","author":"F Fenollar","year":"2002","journal-title":"J Clin Microbiol"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1002\/art.22596","article-title":"Cultivation of Tropheryma whipplei from the synovial fluid in Whipple\u2019s arthritis","volume":"56","author":"X Pu\u00e9chal","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1164\/rccm.201601-0162LE","article-title":"Presence of Tropheryma whipplei in different body sites in a cohort of healthy subjects","volume":"194","author":"S Qin","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jinf.2014.05.008","article-title":"Tropheryma whipplei and Whipple\u2019s disease","volume":"69","author":"F Fenollar","year":"2014","journal-title":"J Infect"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1086\/590559","article-title":"Value of Tropheryma whipplei quantitative polymerase chain reaction assay for the diagnosis of Whipple disease: usefulness of saliva and stool specimens for first-line screening","volume":"47","author":"F Fenollar","year":"2008","journal-title":"Clin Infect Dis"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1086\/528693","article-title":"Prevalence of asymptomatic Tropheryma whipplei carriage among humans and nonhuman primates","volume":"197","author":"F Fenollar","year":"2008","journal-title":"J Infect Dis"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s15010-002-3083-0","article-title":"Prevalence of Tropheryma whipplei DNA in patients with various gastrointestinal diseases and in healthy controls","volume":"31","author":"L Amsler","year":"2003","journal-title":"Infection"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1097\/MD.0b013e3181f204a8","article-title":"Systemic Tropheryma whipplei: Clinical presentation of 142 patients with infections diagnosed or confirmed in a reference center","volume":"89","author":"J-C Lagier","year":"2010","journal-title":"Medicine (Baltimore)"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jns.2017.01.048","article-title":"Whipple\u2019s disease","volume":"377","author":"R El-Abassi","year":"2017","journal-title":"J Neurol Sci"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1080\/17843286.2016.1256586","article-title":"Whipple\u2019s disease","volume":"71","author":"T Marth","year":"2016","journal-title":"Acta Clin Belg"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1473-3099(08)70042-2","article-title":"Whipple\u2019s disease: new aspects of pathogenesis and treatment","volume":"8","author":"T Schneider","year":"2008","journal-title":"Lancet Infect Dis"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMra062477","article-title":"Whipple\u2019s Disease","volume":"356","author":"F Fenollar","year":"2007","journal-title":"N Engl J Med"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/1529-0131(199904)42:4<812::AID-ANR27>3.0.CO;2-S","article-title":"Whipple\u2019s arthritis: Direct detection of Tropheryma whippelii in synovial fluid and tissue","volume":"42","author":"J Desmond O\u2019Duffy","year":"1999","journal-title":"Arthritis Rheum"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"247","DOI":"10.2217\/fmb-2017-0178","article-title":"Acute infections caused by Tropheryma whipplei","volume":"12","author":"J-C Lagier","year":"2017","journal-title":"Future Microbiol"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/apt.13140","article-title":"Systematic review: Whipple\u2019s disease (Tropheryma whipplei infection) and its unmasking by tumour necrosis factor inhibitors","volume":"41","author":"T Marth","year":"2015","journal-title":"Aliment Pharmacol Ther"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0200645","article-title":"Usefulness of polymerase chain reaction for diagnosing Whipple\u2019s disease in rheumatology","volume":"13","author":"M Herbette","year":"2018","journal-title":"PlosOne"},{"issue":"15","key":"ref23","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1097\/MD.0000000000000714","article-title":"Gastrointestinal diagnosis of classical Whipple disease: Clinical, endoscopic, and histopathologic features in 191 patients","volume":"94","author":"U G\u00fcnther","year":"2015","journal-title":"Medicine (Baltimore)"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1053\/j.gastro.2009.07.066","article-title":"Impaired immune functions of monocytes and macrophages in Whipple\u2019s disease","volume":"138","author":"V Moos","year":"2010","journal-title":"Gastroenterology"},{"issue":"9","key":"ref25","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1086\/491745","article-title":"Whipple disease: intestinal infiltrating cells exhibit a transcriptional pattern of M2\/alternatively activated macrophages","volume":"192","author":"B Desnues","year":"2005","journal-title":"J Infect Dis"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s00384-005-0778-6","article-title":"Decreased levels of interleukin-12p40 in the serum of patients with Whipple\u2019s disease","volume":"21","author":"A Kalt","year":"2006","journal-title":"Int J Colorectal Dis"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1053\/gast.1997.v113.pm9247462","article-title":"Defects of monocyte interleukin 12 production and humoral immunity in Whipple\u2019s disease","volume":"113","author":"T Marth","year":"1997","journal-title":"Gastroenterology"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1053\/gast.2002.36583","article-title":"Dysregulated peripheral and mucosal Th1\/Th2 response in Whipple\u2019s disease","volume":"123","author":"T Marth","year":"2002","journal-title":"Gastroenterology"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1586\/eri.12.4","article-title":"The role of T cells in the pathogenesis of classical Whipple\u2019s disease","volume":"10","author":"V Moos","year":"2012","journal-title":"Expert Rev Anti Infect Ther"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.4049\/jimmunol.177.3.2015","article-title":"Reduced peripheral and mucosal Tropheryma whipplei-specific Th1 response in patients with Whipple\u2019s disease","volume":"177","author":"V Moos","year":"2006","journal-title":"J Immunol"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1053\/j.gastro.2009.01.051","article-title":"The HLA Alleles DRB1*13 and DQB1*06 are associated to Whipple\u2019s disease","volume":"136","author":"M Martinetti","year":"2009","journal-title":"Gastroenterology"},{"issue":"11","key":"ref32","doi-asserted-by":"crossref","first-page":"710","DOI":"10.7326\/0003-4819-153-11-201012070-00004","article-title":"The immune reconstitution inflammatory syndrome in Whipple disease: A cohort study","volume":"153","author":"GE Feurle","year":"2010","journal-title":"Ann Intern Med"},{"key":"ref33","article-title":"Could lymphocyte profiling be useful to diagnose systemic autoimmune diseases?","author":"G Carvajal Alegria","year":"2017","journal-title":"Clin Rev Allergy Immunol"},{"issue":"9","key":"ref34","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.autrev.2016.07.010","article-title":"Cellular analyses in the monitoring of autoimmune diseases","volume":"15","author":"U Sack","year":"2016","journal-title":"Autoimmun Rev"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1136\/ard.2008.096172","article-title":"Is the blood B-cell subset profile diagnostic for Sjogren syndrome?","volume":"68","author":"A Binard","year":"2009","journal-title":"Ann Rheum Dis"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1093\/rheumatology\/kex169","article-title":"Correction of abnormal B-cell subset distribution by interleukin-6 receptor blockade in polymyalgia rheumatica","volume":"56","author":"G Carvajal Alegria","year":"2017","journal-title":"Rheumatology"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1093\/jac\/dkt310","article-title":"Treatment of classic Whipple\u2019s disease: from in vitro results to clinical outcome","volume":"69","author":"J-C Lagier","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1128\/JCM.01517-12","article-title":"The rise of Tropheryma whipplei: a 12-year retrospective study of PCR diagnoses in our reference center","volume":"50","author":"S Edouard","year":"2012","journal-title":"J Clin Microbiol"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1086\/597277","article-title":"<italic>Tropheryma whipplei<\/italic> glycosylation in the pathophysiologic profile of Whipple\u2019s disease","volume":"199","author":"CJ Bonhomme","year":"2009","journal-title":"J Infect Dis"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1007\/s10096-008-0528-0","article-title":"Serological microarray for a paradoxical diagnostic of Whipple\u2019s disease","volume":"27","author":"CJ Bonhomme","year":"2008","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.32340","article-title":"IRF4 haploinsufficiency in a family with Whipple&apos;s disease","volume":"7","author":"A Gu\u00e9rin","year":"2018","journal-title":"Elife"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"688","DOI":"10.4049\/jimmunol.180.2.688","article-title":"Cutting edge: Anti-tumor necrosis factor therapy in rheumatoid arthritis inhibits memory B lymphocytes via effects on lymphoid germinal centers and follicular dendritic cell networks","volume":"180","author":"JH Anolik","year":"2008","journal-title":"J Immunol"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1002\/art.38736","article-title":"Distinct effects of methotrexate and etanercept on the B cell compartment in patients with juvenile idiopathic arthritis: MTX and etanercept differentially affect B cells in JIA","volume":"66","author":"S Glaesener","year":"2014","journal-title":"Arthritis Rheumatol"},{"issue":"6","key":"ref44","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1136\/ard.61.6.554","article-title":"Classification criteria for Sj\u00f6gren\u2019s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group","volume":"61","author":"C Vitali","year":"2002","journal-title":"Ann Rheum Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0211536","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:11:49Z","timestamp":1588972309000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0211536"}},"subtitle":[],"editor":[{"given":"Yolande","family":"Richard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,27]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0211536","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,27]]}}}