{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:57:57Z","timestamp":1790395077311,"version":"4.1.0"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T00:00:00Z","timestamp":1549324800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0211698","type":"journal-article","created":{"date-parts":[[2019,2,5]],"date-time":"2019-02-05T18:42:09Z","timestamp":1549392129000},"page":"e0211698","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":29,"title":["Detection of MCPG metabolites in horses with atypical myopathy"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-7281","authenticated-orcid":true,"given":"Mandy","family":"Bochnia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joerg","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Terhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Sander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Janzen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessika-M. V.","family":"Cavalleri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Zuraw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Wensch-Dorendorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5901-1394","authenticated-orcid":true,"given":"Annette","family":"Zeyner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,2,5]]},"reference":[{"key":"ref1","first-page":"355","article-title":"Acquired multiple Acyl-CoA dehydrogenase deficiency in 10 horses with atypical myopathy","volume":"18","author":"CM Westermann","year":"2008"},{"key":"ref2","first-page":"1012","article-title":"Equine multiple acyl-CoA dehydrogenase deficiency (MADD) associated with seasonal pasture myopathy in the midwestern United States","volume":"26","author":"BT Sponseller","year":"2012"},{"key":"ref3","first-page":"419","article-title":"Seasonal pasture myopathy\/atypical myopathy in North America associated with ingestion of hypoglycin A within seeds of the box elder tree","volume":"45","author":"SJ Valberg","year":"2013"},{"key":"ref4","first-page":"146","article-title":"Identification of methylenecyclopropyl acetic acid in serum of European horses with atypical myopathy","volume":"46","author":"DM Votion","year":"2014"},{"key":"ref5","first-page":"98","article-title":"Rapid diagnosis of hypoglycin A intoxication in atypical myopathy of horses","volume":"28","author":"J Sander","year":"2016"},{"key":"ref6","first-page":"1","article-title":"On the vomiting sickness of Jamaica","volume":"10","author":"H Scott","year":"1916"},{"key":"ref7","first-page":"83","article-title":"The toxicity of the ackee (<italic>Blighia sapida<\/italic>) and it relationship to the vomiting sickness of Jamaica; a review","volume":"4","author":"CH Hassall","year":"1955"},{"key":"ref8","first-page":"267","article-title":"Ackee fruit poisoning: an outbreak investigation in Haiti 2000\u20132001, and review of the literature","volume":"44","author":"R Joskow","year":"2006"},{"key":"ref9","first-page":"318","article-title":"Ackee fruit and Jamaican vomiting sickness (Blighia sapida K\u00f6enig).","volume":"55","author":"DG Barceloux","year":"2009"},{"issue":"4399","key":"ref10","first-page":"356","article-title":"Hypoglycin A, B: biologically active polypeptides from Blighia sapida","volume":"173","author":"CH Hassall","year":"1954"},{"key":"ref11","first-page":"385","article-title":"alpha-(Methylenecyclopropyl)glycine from Litchi seeds","volume":"82","author":"DO Gray","year":"1962"},{"key":"ref12","first-page":"1677","article-title":"Cyclopropyl amino acids of the genus Acer: Distribution and biosynthesis","volume":"12","author":"L Fowden","year":"1973"},{"key":"ref13","first-page":"921","article-title":"Mechanism of hypoglycaemic action of methylenecyclopropylglycine","volume":"259","author":"K Melde","year":"1989"},{"key":"ref14","first-page":"1753","article-title":"Quantification of metabolites for assessing human exposure to soapberry toxins hypoglycin A and methylenecyclopropylglycine","volume":"28","author":"SL Isenberg","year":"2015"},{"key":"ref15","first-page":"5607","article-title":"Quantification of Toxins in Soapberry (Sapindaceae) Arils: Hypoglycin and Methylencyclopropylglycine.","volume":"64","author":"SL Isenberg","year":"2016"},{"key":"ref16","first-page":"2603","article-title":"Quantification of Methylencyclopropyl Compounds and Acyl Conjugates by UPLC-MS\/MS in the study of the biochemical effects of the Ingestion of canned Ackee (<italic>Blighia sapida<\/italic>) and Lychee (<italic>Litchi chinensis<\/italic>)","volume":"65","author":"J Sander","year":"2017"},{"key":"ref17","first-page":"461","article-title":"Jamaican Vomiting Sickness: Biochemical Investigationof two cases","volume":"295","author":"K Tanaka","year":"1976"},{"key":"ref18","first-page":"1622","article-title":"Antimutagenic unusual amino acids from plants <italic>Experientia<\/italic>","volume":"41","author":"H Minakata","year":"1985"},{"key":"ref19","first-page":"395","article-title":"Metabolic consequences of methylenecyclopropylglycine poisoning in rats","volume":"274","author":"K Melde","year":"1991"},{"key":"ref20","first-page":"167","article-title":"Influence of fruit maturity on the Hypoglycin A level in ackee (Blighia sapida)","volume":"12","author":"M Brown","year":"1991"},{"key":"ref21","first-page":"3869","article-title":"Tracking hypoglycins A and B over different maturity stages: Implications for detoxification of ackee (Blighia sapida K.D. Koenig Fruits)","volume":"59","author":"CS Bowen-Forbes","year":"2011"},{"key":"ref22","first-page":"3034","article-title":"The toxicity of methylencyclopropylglycine: studies of the inhibitory effects of (methylencyclopropyl)formyl-CoA based on enzymes involved in fatty acid metabolism and the molecular basis of its inactivation of Enoyl-CoA hydratases","volume":"121","author":"D Li","year":"1999"},{"key":"ref23","first-page":"9749","article-title":"Studies on the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl)formyl-CoA hydratase by (methylenecyclopropyl)formyl-CoA: Elucidiation of the inactivation mechanism and identification of cysteine-114 as the entrapped nucleophile","volume":"123","author":"S Dakoji","year":"2001"},{"key":"ref24","first-page":"3355","article-title":"Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation","volume":"10","author":"L Wu","year":"2008"},{"key":"ref25","first-page":"7465","article-title":"On the mode of action of hypoglycin A. 3. Isolation and identification of cis-4-decene-1,10-dioic, cis, cis-4,7-decadiene-1,10-dioic, cis-4-octene-1,8-dioic, glutaric, and adipic acids, N-(methylenecyclopropyl)acetylglycine, and N-isovalerylglycine from urine of hypoglycin A-treated rats","volume":"247","author":"K Tanaka","year":"1972"},{"key":"ref26","first-page":"167","article-title":"Hypoglycin and Jamaican Vomiting Sickness <italic>Prog<\/italic>","volume":"321","author":"K Tanaka","year":"1990"},{"key":"ref27","first-page":"2817","article-title":"The antagonism of the toxicity of hypoglycin by glycine","volume":"30","author":"SS Al-Bassam","year":"1981"},{"key":"ref28","first-page":"611","article-title":"Metabolism and metabolic effects of hypoglycin <italic>Biochem<\/italic>","volume":"90","author":"C Von Holt","year":"1964"},{"key":"ref29","first-page":"207","article-title":"Ackee <italic>(Blighia sapida)<\/italic> hypoglycin A toxicity: Dose response assessment in laboratory rats","volume":"44","author":"OA Blake","year":"2006"},{"key":"ref30","first-page":"1184","article-title":"Acute encephelatitis syndrome in children in Muzaffarpur","volume":"106","author":"TJ John","year":"2014"},{"issue":"9","key":"ref31","first-page":"e0136785","article-title":"Hypoglycin A Content in Blood and Urine Discriminates Horses with Atypical Myopathy from Clinically Normal Horses Grazing on the Same Pasture","volume":"10","author":"M Bochnia","year":"2015"},{"key":"ref32","first-page":"24","article-title":"Predictive value of hypoglycin A and methylencyclopropalacetic acid conjugates in a horse with atypical myopathy in comparison to its cograzing partners","volume":"30","author":"M Bochnia","year":"2018"},{"key":"ref33","first-page":"418","article-title":"Equine atypical myopathy caused by hypoglycin A intoxication associated with ingestion of sycamore maple tree seeds","volume":"48","author":"A \u017buraw","year":"2016"},{"key":"ref34","first-page":"185","article-title":"Mechanisms of enzyme inhibition by hypoglycin, methylenecyclopropylglycine and their metabolites","volume":"21","author":"S Ghisla","year":"1990"},{"key":"ref35","first-page":"272","article-title":"Pharmacologic action of hypoglycin A and B","volume":"121","author":"KK Chen","year":"1957"},{"key":"ref36","first-page":"1843","article-title":"A revised mechanism for the inactivation of bovine liver enoyl-CoA hydratase by (methylenecyclopropyl) formyl-CoA based on unexpected results with the C114A mutant","volume":"41","author":"G Agnihotri","year":"2002"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.3201\/eid1811.111761","article-title":"Litchi-associated acute encephalitis in children, Northern Vietnam, 2004\u20132009","volume":"18","author":"J Paireau","year":"2012","journal-title":"Emerging Infect Dis"},{"issue":"2015","key":"ref38","first-page":"49","article-title":"Outbreaks of unexplained neurologic illness-Muzaffarpur, India, 2013\u20132014","volume":"64","author":"A Shrivastava","year":"2015","journal-title":"Morb. Mortal. Wkly. Rep."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.3201\/eid2408.171004","article-title":"Hypoglycemic toxins and enteroviruses as causes of outbreaks of acute encephalitis-like syndrome in children, Bac Giang Province, Northern Vietnam","volume":"24","author":"NT Phan","year":"2018","journal-title":"Emerg Infect Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0211698","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:27:54Z","timestamp":1589020074000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0211698"}},"subtitle":[],"editor":[{"given":"David A.","family":"Lightfoot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,5]]},"references-count":39,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0211698","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,5]]}}}