{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:00:39Z","timestamp":1787022039922,"version":"build-2736575974"},"reference-count":69,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T00:00:00Z","timestamp":1550016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Key R&D Program of China","award":["2016YFA0501800"],"award-info":[{"award-number":["2016YFA0501800"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31871431"],"award-info":[{"award-number":["31871431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"crossref","award":["81522033"],"award-info":[{"award-number":["81522033"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"the Shanghai Committee of Science and Technology, China","award":["16JC1404000"],"award-info":[{"award-number":["16JC1404000"]}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM067113"],"award-info":[{"award-number":["GM067113"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA063834"],"award-info":[{"award-number":["CA063834"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA196878"],"award-info":[{"award-number":["CA196878"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["GM51586"],"award-info":[{"award-number":["GM51586"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Waters corporation Shanghai Science & Technology Co Ltd","award":["Salary"],"award-info":[{"award-number":["Salary"]}]},{"name":"Waters corporation Shanghai Science & Technology Co Ltd","award":["Salary"],"award-info":[{"award-number":["Salary"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0211796","type":"journal-article","created":{"date-parts":[[2019,2,13]],"date-time":"2019-02-13T14:10:06Z","timestamp":1550067006000},"page":"e0211796","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":58,"title":["SIRT5 deficiency suppresses mitochondrial ATP production and promotes AMPK activation in response to energy stress"],"prefix":"10.1371","volume":"14","author":[{"given":"Mengli","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxia","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinye","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukun","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun-Liang","family":"Guan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunzeng","family":"Zou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Ye","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,2,13]]},"reference":[{"issue":"5968","key":"ref1","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1126\/science.1179689","article-title":"Regulation of cellular metabolism by protein lysine acetylation","volume":"327","author":"S Zhao","year":"2010","journal-title":"Science"},{"issue":"6057","key":"ref2","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1126\/science.1207861","article-title":"Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase","volume":"334","author":"J Du","year":"2011","journal-title":"Science"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/j.molcel.2015.05.022","article-title":"SIRT5 Regulates both Cytosolic and Mitochondrial Protein Malonylation with Glycolysis as a Major Target","volume":"59","author":"Y Nishida","year":"2015","journal-title":"Molecular cell"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1016\/j.cmet.2014.03.014","article-title":"Lysine glutarylation is a protein posttranslational modification regulated by SIRT5","volume":"19","author":"M Tan","year":"2014","journal-title":"Cell metabolism"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1016\/j.cell.2011.08.008","article-title":"Identification of 67 histone marks and histone lysine crotonylation as a new type of histone modification","volume":"146","author":"M Tan","year":"2011","journal-title":"Cell"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1074\/mcp.M700021-MCP200","article-title":"Lysine propionylation and butyrylation are novel post-translational modifications in histones","volume":"6","author":"Y Chen","year":"2007","journal-title":"Molecular & cellular proteomics: MCP"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.molcel.2013.06.001","article-title":"SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways","volume":"50","author":"J Park","year":"2013","journal-title":"Molecular cell"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.molcel.2014.03.027","article-title":"Nonenzymatic protein acylation as a carbon stress regulated by sirtuin deacylases","volume":"54","author":"GR Wagner","year":"2014","journal-title":"Molecular cell"},{"issue":"4","key":"ref9","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.celrep.2013.07.024","article-title":"Lysine succinylation is a frequently occurring modification in prokaryotes and eukaryotes and extensively overlaps with acetylation","volume":"4","author":"BT Weinert","year":"2013","journal-title":"Cell reports"},{"issue":"40","key":"ref10","doi-asserted-by":"crossref","first-page":"29036","DOI":"10.1074\/jbc.M113.486753","article-title":"Widespread and enzyme-independent Nepsilon-acetylation and Nepsilon-succinylation of proteins in the chemical conditions of the mitochondrial matrix","volume":"288","author":"GR Wagner","year":"2013","journal-title":"The Journal of biological chemistry"},{"issue":"16","key":"ref11","doi-asserted-by":"crossref","first-page":"4320","DOI":"10.1073\/pnas.1519858113","article-title":"Metabolomics-assisted proteomics identifies succinylation and SIRT5 as important regulators of cardiac function","volume":"113","author":"S Sadhukhan","year":"2016","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"7684","key":"ref12","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1038\/nature25003","article-title":"KAT2A coupled with the alpha-KGDH complex acts as a histone H3 succinyltransferase","volume":"552","author":"Y Wang","year":"2017","journal-title":"Nature"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1016\/j.celrep.2018.01.030","article-title":"Carnitine Palmitoyltransferase 1A Has a Lysine Succinyltransferase Activity","volume":"22","author":"K Kurmi","year":"2018","journal-title":"Cell reports"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"e0122297","DOI":"10.1371\/journal.pone.0122297","article-title":"SIRT3 and SIRT5 regulate the enzyme activity and cardiolipin binding of very long-chain acyl-CoA dehydrogenase","volume":"10","author":"Y Zhang","year":"2015","journal-title":"PloS one"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1080\/15548627.2015.1009778","article-title":"SIRT5 regulation of ammonia-induced autophagy and mitophagy","volume":"11","author":"L Polletta","year":"2015","journal-title":"Autophagy"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1016\/j.cmet.2013.11.013","article-title":"SIRT5 regulates the mitochondrial lysine succinylome and metabolic networks","volume":"18","author":"MJ Rardin","year":"2013","journal-title":"Cell metabolism"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"6984","DOI":"10.18632\/oncotarget.14346","article-title":"Desuccinylation of pyruvate kinase M2 by SIRT5 contributes to antioxidant response and tumor growth","volume":"8","author":"Y Xiangyun","year":"2017","journal-title":"Oncotarget"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.1016\/j.celrep.2017.05.065","article-title":"SIRT5 Desuccinylates and Activates Pyruvate Kinase M2 to Block Macrophage IL-1beta Production and to Prevent DSS-Induced Colitis in Mice","volume":"19","author":"F Wang","year":"2017","journal-title":"Cell reports"},{"issue":"24","key":"ref19","doi-asserted-by":"crossref","first-page":"10239","DOI":"10.1074\/jbc.M117.785022","article-title":"Lysine desuccinylase SIRT5 binds to cardiolipin and regulates the electron transport chain","volume":"292","author":"Y Zhang","year":"2017","journal-title":"The Journal of biological chemistry"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"811","DOI":"10.15252\/embr.201541643","article-title":"SIRT5 promotes IDH2 desuccinylation and G6PD deglutarylation to enhance cellular antioxidant defense","volume":"17","author":"L Zhou","year":"2016","journal-title":"EMBO reports"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.molcel.2015.10.017","article-title":"NADP(+)-IDH Mutations Promote Hypersuccinylation that Impairs Mitochondria Respiration and Induces Apoptosis Resistance","volume":"60","author":"F Li","year":"2015","journal-title":"Molecular cell"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"29790","DOI":"10.1038\/srep29790","article-title":"Protein Kinase C Epsilon Promotes Cerebral Ischemic Tolerance Via Modulation of Mitochondrial Sirt5.","volume":"6","author":"KC Morris-Blanco","year":"2016","journal-title":"Scientific reports"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"8357","DOI":"10.1038\/ncomms9357","article-title":"MAP4K family kinases act in parallel to MST1\/2 to activate LATS1\/2 in the Hippo pathway","volume":"6","author":"Z Meng","year":"2015","journal-title":"Nature communications"},{"issue":"7184","key":"ref24","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature06734","article-title":"The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth","volume":"452","author":"HR Christofk","year":"2008","journal-title":"Nature"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.cmet.2011.09.004","article-title":"Genetically encoded fluorescent sensors for intracellular NADH detection","volume":"14","author":"Y Zhao","year":"2011","journal-title":"Cell metabolism"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/nprot.2006.478","article-title":"Organelle isolation: functional mitochondria from mouse liver, muscle and cultured fibroblasts","volume":"2","author":"C Frezza","year":"2007","journal-title":"Nature protocols"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1016\/j.tiv.2007.01.011","article-title":"Target identification of drug induced mitochondrial toxicity using immunocapture based OXPHOS activity assays","volume":"21","author":"S Nadanaciva","year":"2007","journal-title":"Toxicology in vitro: an international journal published in association with BIBRA"},{"issue":"13","key":"ref28","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1021\/es400490f","article-title":"Effect of bisphenol A on rat metabolic profiling studied by using capillary electrophoresis time-of-flight mass spectrometry","volume":"47","author":"J Zeng","year":"2013","journal-title":"Environmental science & technology"},{"key":"ref29","doi-asserted-by":"crossref","DOI":"10.1002\/0471142905.hg1903s63","article-title":"Evaluation of the mitochondrial respiratory chain and oxidative phosphorylation system using polarography and spectrophotometric enzyme assays","author":"A Barrientos","year":"2009","journal-title":"Current protocols in human genetics"},{"issue":"18","key":"ref30","doi-asserted-by":"crossref","first-page":"8277","DOI":"10.1073\/pnas.88.18.8277","article-title":"Segregation of atrial-specific and inducible expression of an atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy","volume":"88","author":"HA Rockman","year":"1991","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI30634","article-title":"IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system","volume":"117","author":"S Sanada","year":"2007","journal-title":"The Journal of clinical investigation"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"H1765","DOI":"10.1152\/ajpheart.00559.2011","article-title":"New approaches in small animal echocardiography: imaging the sounds of silence","volume":"301","author":"R Ram","year":"2011","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1097\/FJC.0b013e31827a0278","article-title":"Olmesartan attenuates cardiac remodeling through DLL4\/Notch1 pathway activation in pressure overload mice","volume":"61","author":"J You","year":"2013","journal-title":"Journal of cardiovascular pharmacology"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"2053","DOI":"10.1016\/j.ultrasmedbio.2013.04.022","article-title":"Evaluation of bi-ventricular coronary flow patterns using high-frequency ultrasound in mice with transverse aortic constriction","volume":"39","author":"J Wu","year":"2013","journal-title":"Ultrasound in medicine & biology"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"e2005707","DOI":"10.1371\/journal.pbio.2005707","article-title":"Mitochondrial nicotinamide adenine dinucleotide reduced (NADH) oxidation links the tricarboxylic acid (TCA) cycle with methionine metabolism and nuclear DNA methylation","volume":"16","author":"OA Lozoya","year":"2018","journal-title":"PLoS biology"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.cmet.2015.07.008","article-title":"Reversal of Mitochondrial Transhydrogenase Causes Oxidative Stress in Heart Failure.","volume":"22","author":"AG Nickel","year":"2015","journal-title":"Cell metabolism"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1161\/CIRCRESAHA.108.175919","article-title":"Enhancing mitochondrial Ca2+ uptake in myocytes from failing hearts restores energy supply and demand matching","volume":"103","author":"T Liu","year":"2008","journal-title":"Circulation research"},{"issue":"24","key":"ref38","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1128\/MCB.06120-11","article-title":"Tyrosine phosphorylation of lactate dehydrogenase A is important for NADH\/NAD(+) redox homeostasis in cancer cells","volume":"31","author":"J Fan","year":"2011","journal-title":"Molecular and cellular biology"},{"issue":"6036","key":"ref39","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1126\/science.1200094","article-title":"AMPK is a direct adenylate charge-regulated protein kinase","volume":"332","author":"JS Oakhill","year":"2011","journal-title":"Science"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1172\/JCI19874","article-title":"CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations","volume":"113","author":"JW Scott","year":"2004","journal-title":"The Journal of clinical investigation"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1093\/cvr\/cvq250","article-title":"Mitochondrial SIRT3 and heart disease","volume":"88","author":"VB Pillai","year":"2010","journal-title":"Cardiovascular research"},{"issue":"2","key":"ref42","first-page":"H769","article-title":"Maximum oxidative phosphorylation capacity of the mammalian heart","volume":"272","author":"VK Mootha","year":"1997","journal-title":"The American journal of physiology"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.yjmcc.2015.09.005","article-title":"Characterization of the cardiac succinylome and its role in ischemia-reperfusion injury","volume":"88","author":"JA Boylston","year":"2015","journal-title":"Journal of molecular and cellular cardiology"},{"issue":"27","key":"ref44","doi-asserted-by":"crossref","first-page":"10630","DOI":"10.1074\/jbc.RA118.002187","article-title":"Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload","volume":"293","author":"KA Hershberger","year":"2018","journal-title":"The Journal of biological chemistry"},{"issue":"5407","key":"ref45","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1126\/science.283.5407.1488","article-title":"Oxidative phosphorylation at the fin de siecle","volume":"283","author":"M Saraste","year":"1999","journal-title":"Science"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1111\/acel.12200","article-title":"Genetic analysis of dTSPO, an outer mitochondrial membrane protein, reveals its functions in apoptosis, longevity, and Ab42-induced neurodegeneration","volume":"13","author":"R Lin","year":"2014","journal-title":"Aging cell"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.jacc.2012.09.036","article-title":"Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance","volume":"61","author":"S Larsen","year":"2013","journal-title":"Journal of the American College of Cardiology"},{"issue":"12","key":"ref48","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1161\/CIRCULATIONAHA.108.787440","article-title":"Resveratrol prevents the prohypertrophic effects of oxidative stress on LKB1","volume":"119","author":"VW Dolinsky","year":"2009","journal-title":"Circulation"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1161\/HYPERTENSIONAHA.108.114702","article-title":"AMP activated protein kinase-alpha2 deficiency exacerbates pressure-overload-induced left ventricular hypertrophy and dysfunction in mice","volume":"52","author":"P Zhang","year":"2008","journal-title":"Hypertension"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1016\/j.ultrasmedbio.2012.01.018","article-title":"Early estimation of left ventricular systolic pressure and prediction of successful aortic constriction in a mouse model of pressure overload by ultrasound biomicroscopy","volume":"38","author":"J Wu","year":"2012","journal-title":"Ultrasound in medicine & biology"},{"issue":"8","key":"ref51","doi-asserted-by":"crossref","first-page":"3588","DOI":"10.1172\/JCI69080","article-title":"CHIP protects against cardiac pressure overload through regulation of AMPK","volume":"123","author":"JC Schisler","year":"2013","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.jmb.2008.07.048","article-title":"Substrates and regulation mechanisms for the human mitochondrial sirtuins Sirt3 and Sirt5","volume":"382","author":"C Schlicker","year":"2008","journal-title":"J Mol Biol"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.cell.2009.02.026","article-title":"SIRT5 Deacetylates carbamoyl phosphate synthetase 1 and regulates the urea cycle","volume":"137","author":"T Nakagawa","year":"2009","journal-title":"Cell"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"4623","DOI":"10.1091\/mbc.e05-01-0033","article-title":"Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins","volume":"16","author":"E Michishita","year":"2005","journal-title":"Molecular biology of the cell"},{"issue":"24","key":"ref55","doi-asserted-by":"crossref","first-page":"8807","DOI":"10.1128\/MCB.01636-07","article-title":"Mammalian Sir2 homolog SIRT3 regulates global mitochondrial lysine acetylation","volume":"27","author":"DB Lombard","year":"2007","journal-title":"Molecular and cellular biology"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"2806","DOI":"10.1038\/srep02806","article-title":"Metabolic characterization of a Sirt5 deficient mouse model","volume":"3","author":"J Yu","year":"2013","journal-title":"Scientific reports"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbr.2014.12.035","article-title":"Protective role of SIRT5 against motor deficit and dopaminergic degeneration in MPTP-induced mice model of Parkinson's disease","volume":"281","author":"L Liu","year":"2015","journal-title":"Behavioural brain research"},{"key":"ref58","article-title":"SIRT5 inhibits peroxisomal ACOX1 to prevent oxidative damage and is downregulated in liver cancer","author":"XF Chen","year":"2018","journal-title":"EMBO reports"},{"issue":"7","key":"ref59","doi-asserted-by":"crossref","first-page":"3225","DOI":"10.1096\/fj.13-245241","article-title":"SIRT5 is under the control of PGC-1alpha and AMPK and is involved in regulation of mitochondrial energy metabolism","volume":"28","author":"M Buler","year":"2014","journal-title":"FASEB journal: official publication of the Federation of American Societies for Experimental Biology"},{"issue":"2","key":"ref60","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1158\/0008-5472.CAN-17-1912","article-title":"SHMT2 Desuccinylation by SIRT5 Drives Cancer Cell Proliferation","volume":"78","author":"X Yang","year":"2018","journal-title":"Cancer research"},{"issue":"48","key":"ref61","doi-asserted-by":"crossref","first-page":"19767","DOI":"10.1074\/jbc.M117.809897","article-title":"Sirtuin 5 is required for mouse survival in response to cardiac pressure overload","volume":"292","author":"KA Hershberger","year":"2017","journal-title":"The Journal of biological chemistry"},{"issue":"7134","key":"ref62","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1038\/nature05602","article-title":"p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload","volume":"446","author":"M Sano","year":"2007","journal-title":"Nature"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"H138","DOI":"10.1152\/ajpheart.00004.2017","article-title":"Ultrasound biomicroscopy validation of a murine model of cardiac hypertrophic preconditioning: comparison with a hemodynamic assessment","volume":"313","author":"J Huang","year":"2017","journal-title":"American journal of physiology Heart and circulatory physiology"},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1152\/physiolgenomics.00061.2005","article-title":"Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure","volume":"23","author":"BA Rothermel","year":"2005","journal-title":"Physiological genomics"},{"issue":"4","key":"ref65","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.emboj.7600110","article-title":"LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK\/PAR-1","volume":"23","author":"JM Lizcano","year":"2004","journal-title":"The EMBO journal"},{"issue":"51","key":"ref66","doi-asserted-by":"crossref","first-page":"35839","DOI":"10.1074\/jbc.M109.057273","article-title":"Cardiac-specific deletion of LKB1 leads to hypertrophy and dysfunction","volume":"284","author":"Y Ikeda","year":"2009","journal-title":"The Journal of biological chemistry"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1161\/CIRCRESAHA.114.302364","article-title":"Mutation in the gamma2-subunit of AMP-activated protein kinase stimulates cardiomyocyte proliferation and hypertrophy independent of glycogen storage","volume":"114","author":"M Kim","year":"2014","journal-title":"Circulation research"},{"issue":"5","key":"ref68","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1002\/jcb.21197","article-title":"Long-term activation of adenosine monophosphate-activated protein kinase attenuates pressure-overload-induced cardiac hypertrophy","volume":"100","author":"HL Li","year":"2007","journal-title":"Journal of cellular biochemistry"},{"issue":"8","key":"ref69","doi-asserted-by":"crossref","first-page":"e103793","DOI":"10.1371\/journal.pone.0103793","article-title":"AdipoR1\/APPL1 potentiates the protective effects of globular adiponectin on angiotensin II-induced cardiac hypertrophy and fibrosis in neonatal rat atrial myocytes and fibroblasts","volume":"9","author":"T Cao","year":"2014","journal-title":"PloS one"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0211796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T16:47:38Z","timestamp":1588956458000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0211796"}},"subtitle":[],"editor":[{"given":"Guo-Chang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,13]]},"references-count":69,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0211796","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,13]]}}}