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J. Behav. Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/1529-0131(200002)13:1<51::AID-ART8>3.0.CO;2-Q","article-title":"A naturalistic evaluation of cortisol secretion in persons with fibromyalgia and rheumatoid arthritis","volume":"13","author":"D Catley","year":"2000","journal-title":"Arthritis Care Res"},{"key":"ref40","unstructured":"Lopes KMDC. Os efeitos cr\u00f4nicos do exerc\u00edcio f\u00edsico aer\u00f3bio nos n\u00edveis de serotonina e depress\u00e3o em mulheres com idade entre 50 a 72 anos. M.Sc. Thesis, Universidade Cat\u00f3lica de Bras\u00edlia, 2001. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.nuteses.temp.ufu.br\/tde_busca\/processaPesquisa.php?pesqExecutada=2&id=933&listaDetalhes%5B%5D=933&processar=Processar\" xlink:type=\"simple\">http:\/\/www.nuteses.temp.ufu.br\/tde_busca\/processaPesquisa.php?pesqExecutada=2&amp;id=933&amp;listaDetalhes%5B%5D=933&amp;processar=Processar<\/ext-link>."},{"key":"ref41","doi-asserted-by":"crossref","first-page":"521","DOI":"10.2340\/16501977-0814","article-title":"Effects of a prolonged exercise programme on key health outcomes in women with fibromyalgia: a randomized controlled trial","volume":"43","author":"B Sa\u00f1udo","year":"2011","journal-title":"J Rehabil Med"},{"key":"ref42","article-title":"Aerobic exercise upregulates the BDNF-Serotonin systems and improves the cognitive function in rats","author":"A Pietrelli","year":"2018","journal-title":"Neurobiology of Learning and Memory"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/j.1476-5381.1974.tb08562.x","article-title":"Effects on plasma and brain tryptophan in the rat of drugs and hormones that influence the concentration of unesterified fatty acid in the plasma","volume":"50","author":"G Curzon","year":"1974","journal-title":"Br J Pharmac"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1123\/ijsn.5.s1.s29","article-title":"Carbohydrates, branched-chain amino acids, and endurance: the central fatigue hypothesis","volume":"5","author":"JM Davis","year":"1995","journal-title":"Int J Sports Nutr"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1152\/jappl.1971.31.6.834","article-title":"Muscle glycogen utilization during prolonged exercise on successive days","volume":"31","author":"DL Costil","year":"1971","journal-title":"J. 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