{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:03:42Z","timestamp":1789085022881,"version":"build-2803163510"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["PAG07996"],"award-info":[{"award-number":["PAG07996"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IO1BX002234"],"award-info":[{"award-number":["IO1BX002234"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IO1BX001660"],"award-info":[{"award-number":["IO1BX001660"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0212235","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T17:29:57Z","timestamp":1554312597000},"page":"e0212235","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["A vascular smooth muscle cell X-box binding protein 1 and transglutaminase 2 regulatory circuit limits neointimal hyperplasia"],"prefix":"10.1371","volume":"14","author":[{"given":"Ramon L.","family":"Serrano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert M.","family":"Graham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru Liu-","family":"Bryan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5368-7473","authenticated-orcid":true,"given":"Robert","family":"Terkeltaub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2134","DOI":"10.1161\/ATVBAHA.115.305420","article-title":"XBP1-Deficiency Abrogates Neointimal Lesion of Injured Vessels Via Cross Talk With the PDGF Signaling","volume":"35","author":"L Zeng","year":"2015","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"6943","DOI":"10.1038\/srep06943","article-title":"Reduction of endoplasmic reticulum stress inhibits neointima formation after vascular injury","volume":"4","author":"S Ishimura","year":"2014","journal-title":"Sci Rep"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.3346\/jkms.2014.29.3.363","article-title":"Intimal hyperplasia in loop-injured carotid arteries is attenuated in transglutaminase 2-null mice","volume":"29","author":"SK Min","year":"2014","journal-title":"J Korean Med Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1159\/000369461","article-title":"Transglutaminase 2 promotes PDGF-mediated activation of PDGFR\/Akt1 and \u03b2-catenin signaling in vascular smooth muscle cells and supports neointima formation","volume":"51","author":"M Nurminskaya","year":"2014","journal-title":"J Vasc Res"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.atherosclerosis.2012.04.001","article-title":"RAGE signaling mediates post-injury arterial neointima formation by suppression of liver kinase B1 and AMPK activity","volume":"222","author":"W Yu","year":"2012","journal-title":"Atherosclerosis"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e0185820","DOI":"10.1371\/journal.pone.0185820","article-title":"The epigenetic factor PCAF regulates vascular inflammation and is essential for intimal hyperplasia development","volume":"12","author":"RCM de Jong","year":"2017","journal-title":"PLoS One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"e39106","DOI":"10.1371\/journal.pone.0039106","article-title":"Vanin-1 pantetheinase drives smooth muscle cell activation in post-arterial injury neointimal hyperplasia","volume":"7","author":"KJ Dammanahalli","year":"2012","journal-title":"PLoS One"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"5321","DOI":"10.1096\/fj.201700327R","article-title":"IFN-\u03b3 aggravates neointimal hyperplasia by inducing endoplasmic reticulum stress and apoptosis in macrophages by promoting ubiquitin-dependent liver X receptor- degradation","volume":"31","author":"Q Zhao","year":"2017","journal-title":"FASEB J"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1021\/bm5007757","article-title":"Macromolecular approaches to prevent thrombosis and intimal hyperplasia following percutaneous coronary intervention","volume":"15","author":"RA Scott","year":"2014","journal-title":"Biomacromolecules"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1152\/physrev.00001.2011","article-title":"The unfolded protein response: integrating stress signals through the stress sensor IRE1\u03b1","volume":"91","author":"C Hetz","year":"2011","journal-title":"Physiol Rev"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/ncb0311-184","article-title":"Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress","volume":"13","author":"I Tabas","year":"2011","journal-title":"Nat Cell Biol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"GS Hotamisligil","year":"2010","journal-title":"Cell"},{"key":"ref13","article-title":"Endoplasmic reticulum stress signalling\u2014from basic mechanisms to clinical applications","author":"A Almanza","year":"2018","journal-title":"FEBS J."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/j.ejcb.2018.05.002","article-title":"The unknown face of IRE1\u2014Beyond ER stress","volume":"97","author":"A Abdullah","year":"2018","journal-title":"Eur J Cell Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.molcel.2018.07.019","article-title":"Integrated Functions of Membrane Property Sensors and a Hidden Side of the Unfolded Protein Response","volume":"71","author":"R Covino","year":"2018","journal-title":"Mol Cell"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.cmet.2009.03.003","article-title":"Reduced apoptosis and plaque necrosis in advanced atherosclerotic lesions of Apoe-\/- and Ldlr-\/- mice lacking CHOP","volume":"9","author":"E Thorp","year":"2009","journal-title":"Cell Metab"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1161\/CIRCULATIONAHA.110.014050","article-title":"Involvement of endoplasmic stress protein C\/EBP homologous protein in arteriosclerosis acceleration with augmented biological stress responses","volume":"124","author":"J Gao","year":"2011","journal-title":"Circulation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s10495-017-1396-9","article-title":"Structural aspects of transglutaminase 2: functional, structural, and regulatory diversity","volume":"22","author":"CS Lee","year":"2017","journal-title":"Apoptosis"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00726-016-2320-2","article-title":"Transglutaminase-2: evolution from pedestrian protein to a promising therapeutic target","volume":"49","author":"N Agnihotri","year":"2017","journal-title":"Amino Acids"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1161\/CIRCRESAHA.107.154260","article-title":"Transglutaminase 2 is central to induction of the arterial calcification program by smooth muscle cells","volume":"102","author":"KA Johnson","year":"2008","journal-title":"Circ Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1016\/j.jvs.2012.09.062","article-title":"Transglutaminase type 2 in human abdominal aortic aneurysm is a potential factor in the stabilization of extracellular matrix","volume":"57","author":"S Shin","year":"2013","journal-title":"J Vasc Surg"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"251","DOI":"10.2174\/138945008783755601","article-title":"Intimal hyperplasia in murine models","volume":"9","author":"DY Hui","year":"2008","journal-title":"Curr Drug Targets"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1073\/pnas.0711094105","article-title":"Unfolded protein response transcription factor XBP-1 does not influence prion replication or pathogenesis","volume":"105","author":"C Hetz","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1126\/science.1082095","article-title":"LRP: role in vascular wall integrity and protection from atherosclerosis","volume":"300","author":"P Boucher","year":"2003","journal-title":"Science"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"20673","DOI":"10.1074\/jbc.M010846200","article-title":"Targeted inactivation of Gh\/tissue transglutaminase II","volume":"276","author":"N Nanda","year":"2001","journal-title":"J Biol Chem"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/0003-2697(92)90594-W","article-title":"A microtiter plate transglutaminase assay utilizing 5-(biotinamido)pentylamine as substrate","volume":"205","author":"TF Slaughter","year":"1992","journal-title":"Anal Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cmet.2006.11.002","article-title":"PERK EIF2AK3 control of pancreatic beta cell differentiation and proliferation is required for postnatal glucose homeostasis","volume":"4","author":"W Zhang","year":"2006","journal-title":"Cell Metab"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1038\/nprot.2009.128","article-title":"Detection of protein SUMOylation in vivo","volume":"4","author":"MH Tatham","year":"2009","journal-title":"Nat Protoc"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1074\/jbc.273.4.2288","article-title":"Modulation of the in situ activity of tissue transglutaminase by calcium and GTP","volume":"273","author":"J Zhang","year":"1998","journal-title":"J Biol Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.cellsig.2014.05.008","article-title":"Regulation of chondrocyte differentiation by IRE1 depends on its enzymatic activity","volume":"26","author":"FJ Guo","year":"2014","journal-title":"Cell Signal"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1159\/000443039","article-title":"IRE1 Signaling Pathways Involved in Mammalian Cell Fate Determination","volume":"38","author":"J Wu","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"2775","DOI":"10.4049\/jimmunol.0900993","article-title":"SUMOylation of Tissue Transglutaminase as Link between Oxidative Stress and Inflammation","volume":"183","author":"A Luciani","year":"2009","journal-title":"J Immunol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1161\/CIRCRESAHA.115.307730","article-title":"The Ubiquitin-Like SUMO System and Heart Function: From Development to Disease","volume":"118","author":"L Mendler","year":"2016","journal-title":"Circ Res"},{"key":"ref34","first-page":"45","article-title":"SUMOylation in gene regulation, human disease, and therapeutic action","volume":"5","author":"XJ Yang","year":"2013","journal-title":"F1000Prime Rep"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3497","DOI":"10.1007\/s00018-016-2255-5","article-title":"The recognition of ubiquitinated proteins by the proteasome","volume":"73","author":"GL Grice","year":"2016","journal-title":"Cell Mol Life Sci"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.cell.2008.07.021","article-title":"XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease","volume":"134","author":"A Kaser","year":"2008","journal-title":"Cell"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"2151","DOI":"10.1084\/jem.20090738","article-title":"XBP1 governs late events in plasma cell differentiation and is not required for antigen-specific memory B cell development","volume":"206","author":"DJ Todd","year":"2009","journal-title":"J Exp Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/ni.1857","article-title":"TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages","volume":"11","author":"F Martinon","year":"2010","journal-title":"Nat Immunol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/cdd.2009.14","article-title":"Preventing oxidative stress: a new role for XBP1","volume":"16","author":"Y Liu","year":"2009","journal-title":"Cell Death Differ"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e23067","DOI":"10.1371\/journal.pone.0023067","article-title":"The redox state of transglutaminase 2 controls arterial remodeling","volume":"6","author":"J van den Akker","year":"2011","journal-title":"PLoS One"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41586-018-0597-x","article-title":"IRE1-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity","volume":"562","author":"M Song","year":"2018","journal-title":"Nature"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0212235","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T06:44:35Z","timestamp":1589006675000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0212235"}},"subtitle":[],"editor":[{"given":"Gianfranco","family":"Pintus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0212235","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]}}}