{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:25:26Z","timestamp":1789269926050,"version":"build-2803163510"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T00:00:00Z","timestamp":1550793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0212523","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T19:14:41Z","timestamp":1550862881000},"page":"e0212523","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["NAMPT overexpression alleviates alcohol-induced hepatic steatosis in mice"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5802-4994","authenticated-orcid":true,"given":"Xiwen","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xupeng","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanmei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-Bin","family":"Ruan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinlai","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,2,22]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/jgh.12246","article-title":"Alcoholic liver disease and pancreatitis: global health problems being addressed by the US National Institute on Alcohol Abuse and Alcoholism","volume":"28","author":"KR Warren","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nrgastro.2015.35","article-title":"Alcoholic liver disease: mechanisms of injury and targeted treatment","volume":"12","author":"A Louvet","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"Suppl 1","key":"ref3","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1111\/jgh.12030","article-title":"Alcoholic liver disease: pathogenesis, management, and novel targets for therapy","volume":"28","author":"ES Orman","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"issue":"2","key":"ref4","first-page":"103","article-title":"Pathology of Alcoholic Liver Disease","volume":"2","author":"R Celli","year":"2014","journal-title":"J Clin Transl Hepatol"},{"issue":"40","key":"ref5","doi-asserted-by":"crossref","first-page":"14672","DOI":"10.3748\/wjg.v20.i40.14672","article-title":"Ethanol and liver: recent insights into the mechanisms of ethanol-induced fatty liver","volume":"20","author":"J Liu","year":"2014","journal-title":"World J Gastroenterol"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1530-0277.2008.00827.x","article-title":"Molecular mechanisms of alcoholic fatty liver","volume":"33","author":"V Purohit","year":"2009","journal-title":"Alcoholism, clinical and experimental research"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.tibs.2006.11.006","article-title":"NAD+ metabolism in health and disease","volume":"32","author":"P Belenky","year":"2007","journal-title":"Trends in biochemical sciences"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1210\/js.2017-00092","article-title":"Targeting NAD+ in Metabolic Disease: New Insights Into an Old Molecule","volume":"1","author":"YS Elhassan","year":"2017","journal-title":"Journal of the Endocrine Society"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cmet.2017.11.002","article-title":"NAD(+) Intermediates: The Biology and Therapeutic Potential of NMN and NR","volume":"27","author":"J Yoshino","year":"2018","journal-title":"Cell metabolism"},{"issue":"9","key":"ref10","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1038\/nrendo.2015.117","article-title":"Physiological and pathophysiological roles of NAMPT and NAD metabolism","volume":"11","author":"A Garten","year":"2015","journal-title":"Nature reviews Endocrinology"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.phrs.2018.06.022","article-title":"NAMPT: A pleiotropic modulator of monocytes and macrophages","volume":"135","author":"C Travelli","year":"2018","journal-title":"Pharmacological research"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/dom.12171","article-title":"The importance of NAMPT\/NAD\/SIRT1 in the systemic regulation of metabolism and ageing","volume":"15","author":"S Imai","year":"2013","journal-title":"Diabetes, obesity & metabolism"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"e2705","DOI":"10.1038\/cddis.2017.132","article-title":"Metabolic and molecular insights into an essential role of nicotinamide phosphoribosyltransferase","volume":"8","author":"LQ Zhang","year":"2017","journal-title":"Cell death & disease"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1210\/jc.2009-2148","article-title":"Intracellular nicotinamide phosphoribosyltransferase protects against hepatocyte apoptosis and is down-regulated in nonalcoholic fatty liver disease","volume":"95","author":"TB Dahl","year":"2010","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.cmet.2011.08.014","article-title":"Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice","volume":"14","author":"J Yoshino","year":"2011","journal-title":"Cell metabolism"},{"issue":"15","key":"ref16","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1111\/bph.13513","article-title":"Hepatic NAD(+) deficiency as a therapeutic target for non-alcoholic fatty liver disease in ageing","volume":"173","author":"CC Zhou","year":"2016","journal-title":"British journal of pharmacology"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/acel.12135","article-title":"Elevated microRNA-34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT","volume":"12","author":"SE Choi","year":"2013","journal-title":"Aging cell"},{"issue":"16","key":"ref18","doi-asserted-by":"crossref","first-page":"14681","DOI":"10.1074\/jbc.M110.201061","article-title":"Hepatic FoxOs regulate lipid metabolism via modulation of expression of the nicotinamide phosphoribosyltransferase gene","volume":"286","author":"R Tao","year":"2011","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1186\/s12944-017-0464-z","article-title":"Inhibition of NAMPT aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1\/AMPKalpha\/SREBP1 signaling pathway","volume":"16","author":"LF Wang","year":"2017","journal-title":"Lipids in health and disease"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"s77","DOI":"10.7861\/clinmedicine.15-6-s77","article-title":"An overview of the genetics, mechanisms and management of NAFLD and ALD","volume":"15","author":"RJ Rowell","year":"2015","journal-title":"Clinical medicine"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1038\/nprot.2013.032","article-title":"Mouse model of chronic and binge ethanol feeding (the NIAAA model)","volume":"8","author":"A Bertola","year":"2013","journal-title":"Nat Protoc"},{"issue":"46","key":"ref22","doi-asserted-by":"crossref","first-page":"39107","DOI":"10.1074\/jbc.M112.412569","article-title":"The autophagy-related gene 14 (Atg14) is regulated by forkhead box O transcription factors and circadian rhythms and plays a critical role in hepatic autophagy and lipid metabolism","volume":"287","author":"X Xiong","year":"2012","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.bbrc.2018.04.107","article-title":"Overexpression of NRK1 ameliorates diet- and age-induced hepatic steatosis and insulin resistance","volume":"500","author":"R Fan","year":"2018","journal-title":"Biochemical and biophysical research communications"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"26746","DOI":"10.1038\/srep26746","article-title":"NAMPT knockdown attenuates atherosclerosis and promotes reverse cholesterol transport in ApoE KO mice with high-fat-induced insulin resistance","volume":"6","author":"S Li","year":"2016","journal-title":"Scientific reports"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"243","DOI":"10.2217\/dmt.12.16","article-title":"Sirtuin biology and relevance to diabetes treatment","volume":"2","author":"XC Dong","year":"2012","journal-title":"Diabetes Manag (Lond)"},{"issue":"2","key":"ref26","first-page":"88","article-title":"Sirtuin 1 signaling and alcoholic fatty liver disease","volume":"4","author":"M You","year":"2015","journal-title":"Hepatobiliary Surg Nutr"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1053\/j.gastro.2013.11.008","article-title":"Deletion of SIRT1 from hepatocytes in mice disrupts lipin-1 signaling and aggravates alcoholic fatty liver","volume":"146","author":"H Yin","year":"2014","journal-title":"Gastroenterology"},{"issue":"23","key":"ref28","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.2174\/15680266113136660213","article-title":"The histone deacetylase SIRT6: at the crossroads between epigenetics, metabolism and disease","volume":"13","author":"JP Etchegaray","year":"2013","journal-title":"Current topics in medicinal chemistry"},{"issue":"5927","key":"ref29","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1126\/science.1170803","article-title":"Circadian control of the NAD+ salvage pathway by CLOCK-SIRT1","volume":"324","author":"Y Nakahata","year":"2009","journal-title":"Science"},{"issue":"5927","key":"ref30","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1126\/science.1171641","article-title":"Circadian clock feedback cycle through NAMPT-mediated NAD+ biosynthesis","volume":"324","author":"KM Ramsey","year":"2009","journal-title":"Science"},{"key":"ref31","article-title":"The hepatic BMAL1\/AKT\/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARalpha pathway","author":"D Zhang","year":"2018","journal-title":"Hepatology"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.bbrc.2008.06.006","article-title":"Alcohol alters hepatic FoxO1, p53, and mitochondrial SIRT5 deacetylation function","volume":"373","author":"CS Lieber","year":"2008","journal-title":"Biochemical and biophysical research communications"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1016\/j.cmet.2012.04.022","article-title":"The NAD(+) precursor nicotinamide riboside enhances oxidative metabolism and protects against high-fat diet-induced obesity","volume":"15","author":"C Canto","year":"2012","journal-title":"Cell metabolism"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jhep.2016.08.024","article-title":"Inhibiting poly ADP-ribosylation increases fatty acid oxidation and protects against fatty liver disease","volume":"66","author":"K Gariani","year":"2017","journal-title":"Journal of hepatology"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.jhep.2016.10.023","article-title":"PARP inhibition protects against alcoholic and non-alcoholic steatohepatitis","volume":"66","author":"P Mukhopadhyay","year":"2017","journal-title":"Journal of hepatology"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1124\/jpet.117.243105","article-title":"Poly(ADP-Ribose) Polymerase Inhibitor PJ34 Attenuated Hepatic Triglyceride Accumulation in Alcoholic Fatty Liver Disease in Mice","volume":"364","author":"S Huang","year":"2018","journal-title":"The Journal of pharmacology and experimental therapeutics"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1111\/acer.12396","article-title":"Dietary nicotinic acid supplementation ameliorates chronic alcohol-induced fatty liver in rats","volume":"38","author":"Q Li","year":"2014","journal-title":"Alcoholism, clinical and experimental research"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.redox.2018.04.006","article-title":"Nicotinamide riboside attenuates alcohol induced liver injuries via activation of SirT1\/PGC-1alpha\/mitochondrial biosynthesis pathway","volume":"17","author":"S Wang","year":"2018","journal-title":"Redox biology"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.tem.2013.12.001","article-title":"SIRT1 and other sirtuins in metabolism","volume":"25","author":"HC Chang","year":"2014","journal-title":"Trends Endocrinol Metab"},{"issue":"29","key":"ref40","doi-asserted-by":"crossref","first-page":"20015","DOI":"10.1074\/jbc.M802187200","article-title":"SIRT1 regulates hepatocyte lipid metabolism through activating AMP-activated protein kinase","volume":"283","author":"X Hou","year":"2008","journal-title":"The Journal of biological chemistry"},{"issue":"16","key":"ref41","doi-asserted-by":"crossref","first-page":"16456","DOI":"10.1074\/jbc.M501485200","article-title":"SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}","volume":"280","author":"S Nemoto","year":"2005","journal-title":"The Journal of biological chemistry"},{"issue":"44","key":"ref42","doi-asserted-by":"crossref","first-page":"33959","DOI":"10.1074\/jbc.M110.122978","article-title":"SIRT1 deacetylates and inhibits SREBP-1C activity in regulation of hepatic lipid metabolism","volume":"285","author":"B Ponugoti","year":"2010","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.cmet.2009.02.006","article-title":"Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation","volume":"9","author":"A Purushotham","year":"2009","journal-title":"Cell metabolism"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0212523","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:41:18Z","timestamp":1589010078000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0212523"}},"subtitle":[],"editor":[{"given":"Gilles J.","family":"Guillemin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,2,22]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0212523","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,22]]}}}