{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T23:35:36Z","timestamp":1769556936723,"version":"3.49.0"},"reference-count":53,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T00:00:00Z","timestamp":1551657600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Korea Healthcare Technology","award":["HI13C1527"],"award-info":[{"award-number":["HI13C1527"]}]},{"name":"Basic Science Research Program","award":["NRF-2015R1D1A1A01056798"],"award-info":[{"award-number":["NRF-2015R1D1A1A01056798"]}]},{"name":"Basic Science Research Program","award":["NRF-2018R1D1A1B07047213"],"award-info":[{"award-number":["NRF-2018R1D1A1B07047213"]}]},{"name":"Ministry of the Interior and Safety and the National Research Foundation","award":["NRF-2016R1A2B4008316"],"award-info":[{"award-number":["NRF-2016R1A2B4008316"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0213186","type":"journal-article","created":{"date-parts":[[2019,3,4]],"date-time":"2019-03-04T18:32:25Z","timestamp":1551724345000},"page":"e0213186","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":44,"title":["Class I histone deacetylase inhibitor MS-275 attenuates vasoconstriction and inflammation in angiotensin II-induced hypertension"],"prefix":"10.1371","volume":"14","author":[{"given":"Yuhee","family":"Ryu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-4828","authenticated-orcid":true,"given":"Hae Jin","family":"Kee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simei","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Mi","family":"Seok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sin Young","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwi Ran","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Jung","family":"Kee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Pflieger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Kurz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyung-Seok","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Myung Ho","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,3,4]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.gheart.2012.12.004","article-title":"Hypertension and cardiovascular disease: contributions of the framingham heart study","volume":"8","author":"SS Franklin","year":"2013","journal-title":"Glob Heart"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/2230-8229.128775","article-title":"Prevalence of hypertension and associated cardiovascular risk factors in Central India","volume":"21","author":"AS Bhadoria","year":"2014","journal-title":"J Family Community Med"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1097\/HJH.0000000000000930","article-title":"Impact of hypertension on mortality and cardiovascular disease burden in patients with cardiovascular risk factors from a general practice setting: the ESCARVAL-risk study","volume":"34","author":"J Redon","year":"2016","journal-title":"J Hypertens"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.phrs.2017.11.003","article-title":"Hypertension and cardiovascular risk: General aspects","volume":"129","author":"SE Kjeldsen","year":"2018","journal-title":"Pharmacol Res"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/MNH.0000000000000089","article-title":"Vascular effects of dietary salt","volume":"24","author":"DG Edwards","year":"2015","journal-title":"Curr Opin Nephrol Hypertens"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1007\/s11906-999-0030-9","article-title":"The sympathetic nervous system and baroreflexes in hypertension and hypotension","volume":"1","author":"JL Izzo Jr.","year":"1999","journal-title":"Curr Hypertens Rep"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"4","DOI":"10.2174\/15701611113119990140","article-title":"Sympathetic overactivity in hypertension and cardiovascular disease","volume":"12","author":"AJ Manolis","year":"2014","journal-title":"Curr Vasc Pharmacol"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.amjhyper.2004.11.032","article-title":"Mechanisms for the clinical benefits of angiotensin II receptor blockers","volume":"18","author":"RE Schmieder","year":"2005","journal-title":"Am J Hypertens"},{"issue":"Suppl 12","key":"ref9","first-page":"S258","article-title":"Angiotensin II and long-term arterial pressure regulation: the overriding dominance of the kidney","volume":"10","author":"JE Hall","year":"1999","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/cphy.c150008","article-title":"Salt, Angiotensin II, Superoxide, and Endothelial Function","volume":"6","author":"MA Boegehold","year":"2015","journal-title":"Compr Physiol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"302","DOI":"10.2174\/1874192401004010302","article-title":"The endothelium and its role in regulating vascular tone","volume":"4","author":"A Sandoo","year":"2010","journal-title":"Open Cardiovasc Med J"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"222","DOI":"10.5830\/CVJA-2011-068","article-title":"Endothelial dysfunction: the early predictor of atherosclerosis","volume":"23","author":"M Mudau","year":"2012","journal-title":"Cardiovasc J Afr"},{"issue":"16","key":"ref13","doi-asserted-by":"crossref","first-page":"9220","DOI":"10.1073\/pnas.95.16.9220","article-title":"Superoxide generation by endothelial nitric oxide synthase: the influence of cofactors","volume":"95","author":"J Vasquez-Vivar","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/j.1471-4159.2012.07872.x","article-title":"Uncoupling of eNOS causes superoxide anion production and impairs NO signaling in the cerebral microvessels of hph-1 mice","volume":"122","author":"AV Santhanam","year":"2012","journal-title":"J Neurochem"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1074\/jbc.M805403200","article-title":"Quantitative regulation of intracellular endothelial nitric-oxide synthase (eNOS) coupling by both tetrahydrobiopterin-eNOS stoichiometry and biopterin redox status: insights from cells with tet-regulated GTP cyclohydrolase I expression","volume":"284","author":"MJ Crabtree","year":"2009","journal-title":"J Biol Chem"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1042\/CS20070108","article-title":"Mechanisms for the role of tetrahydrobiopterin in endothelial function and vascular disease","volume":"113","author":"TS Schmidt","year":"2007","journal-title":"Clin Sci (Lond)"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/HYPERTENSIONAHA.109.142422","article-title":"Reactive oxygen species, NADPH oxidases, and hypertension","volume":"56","author":"SR Datla","year":"2010","journal-title":"Hypertension"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1046\/j.1523-1755.2003.00702.x","article-title":"Oxidative stress and dysregulation of superoxide dismutase and NADPH oxidase in renal insufficiency","volume":"63","author":"ND Vaziri","year":"2003","journal-title":"Kidney Int"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1089\/ars.2011.3999","article-title":"Superoxide dismutases: role in redox signaling, vascular function, and diseases","volume":"15","author":"T Fukai","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18071414","article-title":"Histone Deacetylase Inhibitors as Anticancer Drugs","volume":"18","author":"T Eckschlager","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.4068\/cmj.2016.52.1.1","article-title":"HDAC and HDAC Inhibitor: From Cancer to Cardiovascular Diseases","volume":"52","author":"S Yoon","year":"2016","journal-title":"Chonnam Med J"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"H1894","DOI":"10.1152\/ajpheart.01039.2011","article-title":"HDAC4 mediates development of hypertension via vascular inflammation in spontaneous hypertensive rats","volume":"302","author":"T Usui","year":"2012","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"E39","DOI":"10.1152\/ajpendo.00267.2017","article-title":"Histone deacetylase inhibition ameliorates hypertension and hyperglycemia in a model of Cushing&apos;s syndrome","volume":"314","author":"HA Lee","year":"2018","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.1038\/ijo.2017.166","article-title":"Role of the histone deacetylase inhibitor valproic acid in high-fat diet-induced hypertension via inhibition of HDAC1\/angiotensin II axis","volume":"41","author":"J Choi","year":"2017","journal-title":"Int J Obes (Lond)"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"467","DOI":"10.4196\/kjpp.2015.19.5.467","article-title":"Trichostatin A Modulates Angiotensin II-induced Vasoconstriction and Blood Pressure Via Inhibition of p66shc Activation","volume":"19","author":"G Kang","year":"2015","journal-title":"Korean J Physiol Pharmacol"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1097\/HJH.0000000000001081","article-title":"Histone deacetylase and GATA-binding factor 6 regulate arterial remodeling in angiotensin II-induced hypertension","volume":"34","author":"GR Kim","year":"2016","journal-title":"J Hypertens"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.yjmcc.2011.04.005","article-title":"Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension","volume":"51","author":"DD Lemon","year":"2011","journal-title":"Journal of molecular and cellular cardiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.vph.2015.04.006","article-title":"Tubastatin A suppresses renal fibrosis via regulation of epigenetic histone modification and Smad3-dependent fibrotic genes","volume":"72","author":"SY Choi","year":"2015","journal-title":"Vascul Pharmacol"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.4070\/kcj.2016.0266","article-title":"Expression of Class I and Class II a\/b Histone Deacetylase is Dysregulated in Hypertensive Animal Models","volume":"47","author":"HJ Kee","year":"2017","journal-title":"Korean Circ J"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"15607","DOI":"10.1038\/s41598-017-15925-1","article-title":"Gallic Acid Reduces Blood Pressure and Attenuates Oxidative Stress and Cardiac Hypertrophy in Spontaneously Hypertensive Rats","volume":"7","author":"L Jin","year":"2017","journal-title":"Sci Rep"},{"issue":"7","key":"ref31","doi-asserted-by":"crossref","first-page":"2647","DOI":"10.1073\/pnas.1213364110","article-title":"HDAC3-selective inhibitor enhances extinction of cocaine-seeking behavior in a persistent manner","volume":"110","author":"M Malvaez","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.2353\/ajpath.2008.070762","article-title":"Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK\/p38 MAP kinase pathway","volume":"172","author":"V Koka","year":"2008","journal-title":"Am J Pathol"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1161\/01.HYP.0000182660.74266.6d","article-title":"Vascular hypertrophy in angiotensin II-induced hypertension is mediated by vascular smooth muscle cell-derived H2O2","volume":"46","author":"Y Zhang","year":"2005","journal-title":"Hypertension"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/HJH.0000000000000587","article-title":"Mechanisms and consequences of endothelial nitric oxide synthase dysfunction in hypertension","volume":"33","author":"Q Li","year":"2015","journal-title":"J Hypertens"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.3858\/emm.2012.44.10.068","article-title":"Increased arginase II activity contributes to endothelial dysfunction through endothelial nitric oxide synthase uncoupling in aged mice","volume":"44","author":"WS Shin","year":"2012","journal-title":"Exp Mol Med"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1161\/HYPERTENSIONAHA.108.112094","article-title":"Acute inhibition of guanosine triphosphate cyclohydrolase 1 uncouples endothelial nitric oxide synthase and elevates blood pressure","volume":"52","author":"S Wang","year":"2008","journal-title":"Hypertension"},{"issue":"Suppl 1","key":"ref37","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1177\/1358836X0501000102","article-title":"Endogenous production of nitric oxide synthase inhibitors","volume":"10","author":"S Anthony","year":"2005","journal-title":"Vasc Med"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"R740","DOI":"10.1152\/ajpregu.90875.2008","article-title":"Asymmetric dimethylarginine in angiotensin II-induced hypertension","volume":"298","author":"JM Sasser","year":"2010","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"7","key":"ref39","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.1161\/ATVBAHA.111.228833","article-title":"DDAH says NO to ADMA","volume":"31","author":"JP Cooke","year":"2011","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1161\/HYPERTENSIONAHA.110.154567","article-title":"HDAC inhibition attenuates inflammatory, hypertrophic, and hypertensive responses in spontaneously hypertensive rats","volume":"56","author":"JP Cardinale","year":"2010","journal-title":"Hypertension"},{"key":"ref41","first-page":"808353","article-title":"Pathophysiology of vascular remodeling in hypertension","volume":"2013","author":"NF Renna","year":"2013","journal-title":"Int J Hypertens"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0735-1097(96)00251-3","article-title":"The renin-angiotensin system and vascular hypertrophy","volume":"28","author":"C. Rosendorff","year":"1996","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref43","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1527-5299.2002.00723.x","article-title":"The renin-angiotensin-aldosterone system and vascular remodeling","volume":"8","author":"Y. Sun","year":"2002","journal-title":"Congest Heart Fail"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1111\/jcmm.13122","article-title":"Histone deacetylase inhibitors promote eNOS expression in vascular smooth muscle cells and suppress hypoxia-induced cell growth","volume":"21","author":"X Tan","year":"2017","journal-title":"J Cell Mol Med"},{"issue":"6","key":"ref45","doi-asserted-by":"crossref","DOI":"10.3390\/nu10060731","article-title":"Targeting Histone Deacetylases with Natural and Synthetic Agents: An Emerging Anticancer Strategy","volume":"10","author":"AK Singh","year":"2018","journal-title":"Nutrients"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"482","DOI":"10.3389\/fphar.2016.00482","article-title":"The Angiotensin-(1\u20137)\/Mas Axis Counteracts Angiotensin II-Dependent and -Independent Pro-inflammatory Signaling in Human Vascular Smooth Muscle Cells","volume":"7","author":"LA Villalobos","year":"2016","journal-title":"Front Pharmacol"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1161\/01.HYP.0000146907.82869.f2","article-title":"Upregulation of vascular arginase in hypertension decreases nitric oxide-mediated dilation of coronary arterioles","volume":"44","author":"C Zhang","year":"2004","journal-title":"Hypertension"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/oby.20969","article-title":"Arginase promotes endothelial dysfunction and hypertension in obese rats","volume":"23","author":"FK Johnson","year":"2015","journal-title":"Obesity (Silver Spring)"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/01.hjh.0000166837.78559.93","article-title":"Arginase inhibition reduces endothelial dysfunction and blood pressure rising in spontaneously hypertensive rats","volume":"23","author":"C Demougeot","year":"2005","journal-title":"J Hypertens"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/cvr\/cvq081","article-title":"Cardiovascular effects of arginase inhibition in spontaneously hypertensive rats with fully developed hypertension","volume":"87","author":"T Bagnost","year":"2010","journal-title":"Cardiovasc Res"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.freeradbiomed.2016.08.003","article-title":"Inhibition of histone deacetylase reduces transcription of NADPH oxidases and ROS production and ameliorates pulmonary arterial hypertension","volume":"99","author":"F Chen","year":"2016","journal-title":"Free Radic Biol Med"},{"issue":"7","key":"ref52","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1038\/sj.bjp.0707166","article-title":"HDAC inhibitors as anti-inflammatory agents","volume":"150","author":"IM Adcock","year":"2007","journal-title":"Br J Pharmacol"},{"issue":"3","key":"ref53","doi-asserted-by":"crossref","first-page":"309","DOI":"10.2174\/156802609788085250","article-title":"Histone deacetylase inhibitors in inflammatory disease","volume":"9","author":"MA Halili","year":"2009","journal-title":"Curr Top Med Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0213186","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:32:20Z","timestamp":1588998740000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0213186"}},"subtitle":[],"editor":[{"given":"Michael","family":"Bader","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,4]]},"references-count":53,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,4]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0213186","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,4]]}}}