{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T08:30:06Z","timestamp":1787905806341,"version":"build-2784847793"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008385","name":"Fondazione per la Ricerca sulla Fibrosi Cistica","doi-asserted-by":"publisher","award":["Grant FFC# 20\/2012"],"award-info":[{"award-number":["Grant FFC# 20\/2012"]}],"id":[{"id":"10.13039\/501100008385","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003196","name":"Ministero della Salute","doi-asserted-by":"publisher","award":["RF-2010-2316176,"],"award-info":[{"award-number":["RF-2010-2316176,"]}],"id":[{"id":"10.13039\/501100003196","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0213497","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T17:27:31Z","timestamp":1553275651000},"page":"e0213497","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":27,"title":["Methicillin-resistant Staphylococcus aureus eradication in cystic fibrosis patients: A randomized multicenter study"],"prefix":"10.1371","volume":"14","author":[{"given":"Daniela","family":"Dolce","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Neri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Grisotto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Campana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Novella","family":"Ravenni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Miselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica","family":"Camera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Zavataro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesare","family":"Braggion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersilia V.","family":"Fiscarelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzina","family":"Lucidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Cariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Girelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia","family":"Faelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Colombo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Lucanto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariangela","family":"Lombardo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Magazz\u00f9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Tosco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Raia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Manara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Pasolli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Federica","family":"Armanini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1583-5794","authenticated-orcid":true,"given":"Nicola","family":"Segata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annibale","family":"Biggeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-5381","authenticated-orcid":true,"given":"Giovanni","family":"Taccetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"ref1","unstructured":"European Cystic Fibrosis Patient Registry. Annual report 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.ecfs.eu\/projects\/ecfs-patient-registry\/annual-reports\" xlink:type=\"simple\">https:\/\/www.ecfs.eu\/projects\/ecfs-patient-registry\/annual-reports<\/ext-link>"},{"key":"ref2","unstructured":"Cystic Fibrosis Foundation Patient Registry. Annual report 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cff.org\/Research\/Researcher-Resources\/Patient-Registry\/\" xlink:type=\"simple\">https:\/\/www.cff.org\/Research\/Researcher-Resources\/Patient-Registry\/<\/ext-link>"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1164\/rccm.200802-327OC","article-title":"Persistent methicillin-resistant <italic>Staphylococcus aureus<\/italic> and rate of FEV1 decline in cystic fibrosis","volume":"178","author":"EC Dasenbrook","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2386","DOI":"10.1001\/jama.2010.791","article-title":"Association between respiratory tract methicillin-resistant <italic>Staphylococcus aureus<\/italic> and survival in cystic fibrosis","volume":"303","author":"EC Dasenbrook","year":"2010","journal-title":"JAMA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.jhin.2006.10.011","article-title":"Successful decolonization of methicillin-resistant <italic>Staphylococcus aureus<\/italic> in paediatric patients with cystic fibrosis (CF) using a three-step protocol","volume":"65","author":"M Macfarlane","year":"2007","journal-title":"J Hosp Infect"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/ppul.10231","article-title":"Methicillin resistant <italic>Staphylococcus aureus<\/italic> in children with cystic fibrosis: an eradication protocol","volume":"36","author":"A Solis","year":"2003","journal-title":"Pediatr Pulmonol"},{"key":"ref7","first-page":"CD009650","article-title":"Interventions for the eradication of meticillin-resistant <italic>Staphylococcus aureus<\/italic> (MRSA) in people with cystic fibrosis","volume":"7","author":"DK Lo","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00064-2015","article-title":"MRSA eradication of newly acquired lower respiratory tract infection in cystic fibrosis","volume":"2","author":"E Valli\u00e8res","year":"2016","journal-title":"ERJ Open Res"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1002\/ppul.23519","article-title":"Eradication of methicillin resistant <italic>Staphylococcus aureus<\/italic> detected for the first time in cystic fibrosis: A single center observational study","volume":"51","author":"M Kappler","year":"2016","journal-title":"Pediatr Pulmonol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/thoraxjnl-2016-208949","article-title":"Microbiological efficacy of early MRSA treatment in cystic fibrosis in a randomised controlled trial.","volume":"72","author":"MS Muhlebach","year":"2017","journal-title":"Thorax"},{"key":"ref11","article-title":"Suggestions for prevention and infection control","year":"2004"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1136\/thoraxjnl-2011-200832","article-title":"Early antibiotic treatment for <italic>Pseudomonas aeruginosa<\/italic> eradication in patients with cystic fibrosis: a randomised multicentre study comparing two different protocols","volume":"67","author":"G Taccetti","year":"2012","journal-title":"Thorax"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jcf.2014.06.003","article-title":"Open label study of inhaled aztreonam for <italic>Pseudomonas<\/italic> eradication in children with cystic fibrosis: The ALPINE study","volume":"14","author":"HA Tiddens","year":"2015","journal-title":"J Cyst Fibros"},{"key":"ref14","unstructured":"Repubblica Italiana. Gazzetta ufficiale. Disposizioni per la prevenzione e la cura della fibrosi cistica. (GU Serie Generale n.305 del 30-12-1993) Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.gazzettaufficiale.it\" xlink:type=\"simple\">http:\/\/www.gazzettaufficiale.it<\/ext-link>"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.jcf.2018.02.006","article-title":"European Cystic Fibrosis Society standards of care best practice guidelines: the 2018 revision.","volume":"17","author":"C Castellani","year":"2018","journal-title":"J Cyst Fibros"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jpeds.2016.09.064","article-title":"Diagnosis of Cystic Fibrosis: Consensus Guidelines from the Cystic Fibrosis Foundation","volume":"181","author":"PM Farrell","year":"2017","journal-title":"J Pediatr"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1056\/NEJM199409083311003","article-title":"Effect of aerosolized recombinant human DNase on exacerbations of respiratory symptoms and on pulmonary function in patients with cystic fibrosis","volume":"331","author":"HJ Fuchs","year":"1994","journal-title":"N Engl J Med"},{"key":"ref18","unstructured":"CONSORT Website. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.consort-statement.org\/\" xlink:type=\"simple\">http:\/\/www.consort-statement.org\/<\/ext-link>"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"319e38","DOI":"10.1183\/09031936.05.00034805","article-title":"Standardisation of spirometry","volume":"26","author":"MR Miller","year":"2005","journal-title":"Eur Respir J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1086\/313461","article-title":"Involvement of Panton-Valentine Leukocidin\u2013producing <italic>Staphylococcus aureus<\/italic> in primary skin infections and pneumonia","volume":"29","author":"G Lina","year":"1999","journal-title":"Clinical Infectious Diseases"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"3374","DOI":"10.1128\/AAC.00275-07","article-title":"Update to the multiplex PCR strategy for assignment of mec element types in <italic>Staphylococcus aureus<\/italic>","volume":"51","author":"C Milheiri\u04abo","year":"2007","journal-title":"Antimicrob Agents Chemother"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"e7","DOI":"10.1093\/nar\/gkw837","article-title":"MetaMLST: multi-locus strain-level bacterial typing from metagenomic samples","volume":"45","author":"M Zolfo","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1186\/1756-0500-5-642","article-title":"DNAGear- a free software for spa type identification in Staphylococcus aureus","volume":"5","author":"F AL-Tam","year":"2012","journal-title":"BMC Res Notes"},{"key":"ref24","unstructured":"The UK Cystic Fibrosis Trust Infection Control Working Group. Methicillin-resistant Staphylococcus aureus (MRSA) April 2008 Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cysticfibrosis.org.uk\/the-work-we-do\/clinical-care\/consensus-documents\" xlink:type=\"simple\">https:\/\/www.cysticfibrosis.org.uk\/the-work-we-do\/clinical-care\/consensus-documents<\/ext-link>"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.jcf.2011.06.005","article-title":"Molecular epidemiology of meticillin-resistant Staphylococcus aureus in Italian cystic fibrosis patients: a national overview","volume":"10","author":"P Cocchi","year":"2011","journal-title":"J Cyst Fibros"},{"issue":"Suppl 3","key":"ref26","doi-asserted-by":"crossref","first-page":"S225","DOI":"10.1086\/376525","article-title":"Allergic bronchopulmonary aspergillosis in cystic fibrosis\u2014state of the art: Cystic Fibrosis Foundation Consensus Conference","volume":"37","author":"DA Stevens","year":"2003","journal-title":"Clin Infect Dis"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1164\/rccm.200604-571ST","article-title":"ATS Mycobacterial Diseases Subcommittee; American Thoracic Society; Infectious Disease Society of America. An official ATS\/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases","volume":"175","author":"DE Griffith","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1001\/archpediatrics.2011.136","article-title":"Comparative efficacy and safety of 4 randomized regimens to treat early <italic>Pseudomonas aeruginosa<\/italic> infection in children with cystic fibrosis","volume":"165","author":"MM Treggiari","year":"2011","journal-title":"Arch Pediatr Adolesc Med"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1093\/jac\/dkp065","article-title":"Guidelines (2008) for the prophylaxis and treatment of methicillin-resistant <italic>Staphylococcus aureus<\/italic> (MRSA) infections in the United Kingdom","volume":"63","author":"FK Gould","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/S0924-8579(02)00173-5","article-title":"Characterization of methicillin-resistant <italic>Staphylococcus aureus<\/italic> strains susceptible to tobramycin","volume":"20","author":"D Talon","year":"2002","journal-title":"Int J Antimicrob Agents"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"3452","DOI":"10.1128\/JCM.37.11.3452-3457.1999","article-title":"Emergence and spread in French hospitals of methicillin-resistant <italic>Staphylococcus aureus<\/italic> with increasing susceptibility to gentamicin and other antibiotics","volume":"37","author":"H Leli\u00e8vre","year":"1999","journal-title":"J Clin Microbiol."},{"key":"ref32","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1016\/j.ijmm.2013.09.012","article-title":"Extended <italic>Staphylococcus aureus<\/italic> persistence in cystic fibrosis is associated with bacterial adaptation","volume":"303","author":"N Hirschhausen","year":"2013","journal-title":"Int J Med Microbiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"7481","DOI":"10.1073\/pnas.1018249108","article-title":"Evolutionary dynamics of bacteria in a human host environment","volume":"108","author":"L Yang","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.jcf.2012.12.003","article-title":"Association between <italic>Staphylococcus aureus<\/italic> alone or combined with <italic>Pseudomonas aeruginosa<\/italic> and the clinical condition of patients with cystic fibrosis","volume":"12","author":"D Hubert","year":"2013","journal-title":"J Cyst Fibros"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.jcf.2015.10.014","article-title":"A longitudinal analysis of chronic MRSA and <italic>Pseudomonas aeruginosa<\/italic> co-infection in cystic fibrosis: A single-center study","volume":"15","author":"ML Maliniak","year":"2016","journal-title":"J Cyst Fibros"},{"issue":"9538","key":"ref36","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/S0140-6736(06)69303-3","article-title":"Community-acquired MRSA: can we control it?","volume":"368","author":"IM Gould","year":"2006","journal-title":"Lancet"},{"issue":"9538","key":"ref37","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/S0140-6736(06)68853-3","article-title":"Emergence and resurgence of meticillin-resistant Staphylococcus aureus as a public-health threat","volume":"368","author":"H Grundmann","year":"2006","journal-title":"Lancet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1086\/597291","article-title":"Eradication of methicillin-resistant Staphylococcus aureus carriage: a systematic review","volume":"48","author":"HS Ammerlaan","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref39","first-page":"CD011581","article-title":"Treatment for chronic methicillin-sensitive Staphylococcus aureus pulmonary infection in people with cystic fibrosis","volume":"7","author":"MI Ahmed","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.jcf.2011.02.004","article-title":"Treatment intensity and characteristics of MRSA infection in cystic fibrosis.","volume":"10","author":"MS Muhlebach","year":"2011","journal-title":"J Cyst Fibros"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1136\/thoraxjnl-2016-209605","article-title":"Treatment decisions for MRSA in patients with cystic fibrosis (CF): when is enough, enough?","volume":"72","author":"SC Bell","year":"2017","journal-title":"Thorax"},{"key":"ref42","first-page":"259","article-title":"Joint Task Force on Practice Parameters; American Academy of Allergy, Asthma and Immunology; American College of Allergy, Asthma and Immunology; Joint Council of Allergy, Asthma and Immunology. Drug allergy: an updated practice parameter","volume":"105","year":"2010","journal-title":"Ann Allergy Asthma Immunol"},{"key":"ref43","unstructured":"A Study of AeroVanc for the treatment of MRSA infection in CF patients. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03181932\" xlink:type=\"simple\">https:\/\/clinicaltrials.gov\/ct2\/show\/NCT03181932<\/ext-link>"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0213497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,3]],"date-time":"2020-12-03T00:01:56Z","timestamp":1606953716000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0213497"}},"subtitle":[],"editor":[{"given":"Iratxe","family":"Puebla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":43,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0213497","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,22]]}}}