{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T14:02:56Z","timestamp":1740146576054,"version":"3.37.3"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T00:00:00Z","timestamp":1552521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the National Research Foundation of Korea (NRF) funded by the Ministry of Science, ICT & Future Planning","award":["NRF-2014R1A1A1006572"],"award-info":[{"award-number":["NRF-2014R1A1A1006572"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0213586","type":"journal-article","created":{"date-parts":[[2019,3,14]],"date-time":"2019-03-14T17:36:45Z","timestamp":1552585005000},"page":"e0213586","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Chronic administration of LIMK2 inhibitors alleviates cavernosal veno-occlusive dysfunction through suppression of cavernosal fibrosis in a rat model of erectile dysfunction after cavernosal nerve injury"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5549-9756","authenticated-orcid":true,"given":"Juhyun","family":"Park","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hwancheol","family":"Son","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Sun","family":"Chai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Soo Woong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae-Seung","family":"Paick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7288-1706","authenticated-orcid":true,"given":"Min Chul","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1111\/j.1743-6109.2009.01351.x","article-title":"Erectile function recovery rate after radical prostatectomy: a meta-analysis","volume":"6","author":"R Tal","year":"2009","journal-title":"The journal of sexual medicine"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.eururo.2012.05.046","article-title":"Systematic review and meta-analysis of studies reporting potency rates after robot-assisted radical prostatectomy","volume":"62","author":"V Ficarra","year":"2012","journal-title":"European urology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1111\/jsm.12135","article-title":"Back to baseline: erectile function recovery after radical prostatectomy from the patients' perspective","volume":"10","author":"CJ Nelson","year":"2013","journal-title":"The journal of sexual medicine"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/nrurol.2015.72","article-title":"Landmarks in erectile function recovery after radical prostatectomy","volume":"12","author":"E Weyne","year":"2015","journal-title":"Nature reviews Urology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.4111\/icu.2016.57.S2.S172","article-title":"Nerve-sparing techniques and results in robot-assisted radical prostatectomy","volume":"57","author":"HH Tavukcu","year":"2016","journal-title":"Investigative and clinical urology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"73","DOI":"10.5534\/wjmh.2016.34.2.73","article-title":"Postprostatectomy Erectile Dysfunction: A Review","volume":"34","author":"P Capogrosso","year":"2016","journal-title":"The world journal of men's health"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1097\/MOU.0b013e3283136462","article-title":"Penile rehabilitation following radical prostatectomy","volume":"18","author":"JP Mulhall","year":"2008","journal-title":"Current opinion in urology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/j.1939-4640.2003.tb02668.x","article-title":"Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum","volume":"24","author":"S Leungwattanakij","year":"2003","journal-title":"Journal of andrology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/sj.ijir.3900328","article-title":"Is there a role of hypoxemia in penile fibrosis: a viewpoint presented to the Society for the Study of Impotence","volume":"10","author":"RB Moreland","year":"1998","journal-title":"International journal of impotence research"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/sj.ijir.3901596","article-title":"Effect of sildenafil administration on penile hypoxia induced by cavernous neurotomy in the rat","volume":"20","author":"L Vignozzi","year":"2008","journal-title":"International journal of impotence research"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1056\/NEJMra1300575","article-title":"Fibrosis\u2014a common pathway to organ injury and failure","volume":"372","author":"DC Rockey","year":"2015","journal-title":"The New England journal of medicine"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"657","DOI":"10.2217\/fca.11.51","article-title":"Rho kinase as a therapeutic target in cardiovascular disease","volume":"7","author":"M Surma","year":"2011","journal-title":"Future cardiology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1161\/CIRCULATIONAHA.105.584623","article-title":"Decreased perivascular fibrosis but not cardiac hypertrophy in ROCK1+\/- haploinsufficient mice","volume":"112","author":"Y Rikitake","year":"2005","journal-title":"Circulation"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1093\/cvr\/cvp135","article-title":"Rho kinase-1 mediates cardiac fibrosis by regulating fibroblast precursor cell differentiation","volume":"83","author":"SB Haudek","year":"2009","journal-title":"Cardiovascular research"},{"key":"ref15","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.93187","article-title":"Fibroblast deletion of ROCK2 attenuates cardiac hypertrophy, fibrosis, and diastolic dysfunction","volume":"2","author":"T Shimizu","year":"2017","journal-title":"JCI insight"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3389\/fphar.2015.00276","article-title":"The Function of Rho-Associated Kinases ROCK1 and ROCK2 in the Pathogenesis of Cardiovascular Disease","volume":"6","author":"S Hartmann","year":"2015","journal-title":"Frontiers in pharmacology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1111\/j.1743-6109.2010.02147.x","article-title":"Involvement of sphingosine-1-phosphate\/RhoA\/Rho-kinase signaling pathway in corporal fibrosis following cavernous nerve injury in male rats","volume":"8","author":"MC Cho","year":"2011","journal-title":"The journal of sexual medicine"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1111\/jsm.12903","article-title":"Involvement of Rho-Kinase\/LIM Kinase\/Cofilin Signaling Pathway in Corporal Fibrosis after Cavernous Nerve Injury in Male Rats","volume":"12","author":"SH Song","year":"2015","journal-title":"The journal of sexual medicine"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1016\/j.juro.2010.06.094","article-title":"Activated RhoA\/Rho kinase impairs erectile function after cavernous nerve injury in rats","volume":"184","author":"C Gratzke","year":"2010","journal-title":"The Journal of urology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.juro.2012.09.104","article-title":"Inhibition of Rho-kinase improves erectile function, increases nitric oxide signaling and decreases penile apoptosis in a rat model of cavernous nerve injury","volume":"189","author":"JL Hannan","year":"2013","journal-title":"The Journal of urology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.ejcb.2010.09.009","article-title":"Differing contributions of LIMK and ROCK to TGFbeta-induced transcription, motility and invasion","volume":"90","author":"P Morin","year":"2011","journal-title":"European journal of cell biology"},{"key":"ref22","article-title":"Role of inhibiting LIM-kinase2 in improving erectile function through suppression of corporal fibrosis in a rat model of cavernous nerve injury","author":"J Park","year":"2018","journal-title":"Asian journal of andrology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.juro.2014.10.099","article-title":"Restoration of erectile function by suppression of corporal apoptosis, fibrosis and corporal veno-occlusive dysfunction with rho-kinase inhibitors in a rat model of cavernous nerve injury","volume":"193","author":"MC Cho","year":"2015","journal-title":"The Journal of urology"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1111\/j.1743-6109.2008.01105.x","article-title":"Fibrosis and loss of smooth muscle in the corpora cavernosa precede corporal veno-occlusive dysfunction (CVOD) induced by experimental cavernosal nerve damage in the rat","volume":"6","author":"MG Ferrini","year":"2009","journal-title":"The journal of sexual medicine"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.urology.2006.05.011","article-title":"Vardenafil prevents fibrosis and loss of corporal smooth muscle that occurs after bilateral cavernosal nerve resection in the rat","volume":"68","author":"MG Ferrini","year":"2006","journal-title":"Urology"},{"key":"ref26","first-page":"203","article-title":"Chronic daily tadalafil prevents the corporal fibrosis and veno-occlusive dysfunction that occurs after cavernosal nerve resection","volume":"101","author":"I Kovanecz","year":"2008","journal-title":"BJU international"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/sj.ijir.3901612","article-title":"Long-term continuous sildenafil treatment ameliorates corporal veno-occlusive dysfunction (CVOD) induced by cavernosal nerve resection in rats","volume":"20","author":"I Kovanecz","year":"2008","journal-title":"International journal of impotence research"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1111\/j.1743-6109.2012.02913.x","article-title":"Separate or combined treatments with daily sildenafil, molsidomine, or muscle-derived stem cells prevent erectile dysfunction in a rat model of cavernosal nerve damage","volume":"9","author":"I Kovanecz","year":"2012","journal-title":"The journal of sexual medicine"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/j.ijrobp.2017.06.2449","article-title":"Cavernous Nerve Injury by Radiation Therapy May Potentiate Erectile Dysfunction in Rats","volume":"99","author":"J Mahmood","year":"2017","journal-title":"International journal of radiation oncology, biology, physics"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jns.2005.06.003","article-title":"Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial","volume":"238","author":"M Shibuya","year":"2005","journal-title":"Journal of the neurological sciences"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1002\/j.1460-2075.1996.tb00574.x","article-title":"Rho-associated kinase, a novel serine\/threonine kinase, as a putative target for small GTP binding protein Rho","volume":"15","author":"T Matsui","year":"1996","journal-title":"The EMBO journal"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"758","DOI":"10.2174\/1570161112666140613115813","article-title":"Pleiotropic effects of the rho-kinase inhibitor fasudil after subarachnoid hemorrhage: a review of preclinical and clinical studies","volume":"12","author":"S Satoh","year":"2014","journal-title":"Current vascular pharmacology"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1007\/s40265-014-0333-2","article-title":"Ripasudil: first global approval","volume":"74","author":"KP Garnock-Jones","year":"2014","journal-title":"Drugs"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1021\/ml500367g","article-title":"Discovery and Development of LX7101, a Dual LIM-Kinase and ROCK Inhibitor for the Treatment of Glaucoma","volume":"6","author":"BA Harrison","year":"2015","journal-title":"ACS medicinal chemistry letters"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1111\/j.1742-4658.2009.07031.x","article-title":"Control of transforming growth factor beta signal transduction by small GTPases","volume":"276","author":"D Kardassis","year":"2009","journal-title":"The FEBS journal"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/1008-682X.189209","article-title":"Reduced corporal fibrosis to protect erectile function by inhibiting the Rho-kinase\/LIM-kinase\/cofilin pathway in the aged transgenic rat harboring human tissue kallikrein 1","volume":"19","author":"K Cui","year":"2017","journal-title":"Asian journal of andrology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1016\/j.biocel.2013.05.013","article-title":"Identification of DAPK as a scaffold protein for the LIMK\/cofilin complex in TNF-induced apoptosis","volume":"45","author":"J Ivanovska","year":"2013","journal-title":"The international journal of biochemistry & cell biology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0213586","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T14:14:02Z","timestamp":1694700842000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0213586"}},"subtitle":[],"editor":[{"given":"Vinayak","family":"Shenoy","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,14]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0213586","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,3,14]]}}}