{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T12:28:47Z","timestamp":1765888127522,"version":"3.37.3"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T00:00:00Z","timestamp":1552953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004286","name":"Santen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004286","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0213811","type":"journal-article","created":{"date-parts":[[2019,3,19]],"date-time":"2019-03-19T18:29:41Z","timestamp":1553020181000},"page":"e0213811","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["The effectiveness of colchicine combined with mitomycin C to prolong bleb function in trabeculectomy in rabbits"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2743-9550","authenticated-orcid":true,"given":"Taiki","family":"Kokubun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kotaro","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kota","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takahiro","family":"Akaishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Shimazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masatsugu","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiro","family":"Shiga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Tsuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Omodaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toru","family":"Nakazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,3,19]]},"reference":[{"key":"ref1","first-page":"384","article-title":"Symposium: microsurgery of the outflow channels","volume":"76","author":"JE Cairns","year":"1972","journal-title":"Trabeculectomy. Trans Am Acad Ophthalmol Otolaryngol"},{"key":"ref2","first-page":"152","article-title":"Wound healing modulation in glaucoma filtration surgery","volume":"24","author":"VP Costa","year":"1993","journal-title":"Ophthalmic Surg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/archopht.1983.01040010795021","article-title":"Histologic characteristics of filtering blebs in glaucomatous eyes","volume":"101","author":"EM Addicks","year":"1983","journal-title":"Arch Ophthalmol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1007\/BF00190712","article-title":"Histopathology of episcleral fibrosis after trabeculectomy with and without mitomycin C","volume":"234","author":"H Mietz","year":"1996","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1001\/archopht.1991.01080120077030","article-title":"Trabeculectomy with mitomycin. A comparative study with fluorouracil","volume":"109","author":"Y Kitazawa","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1111\/j.1442-9071.1996.tb01603.x","article-title":"Surgery for refractory glaucoma","volume":"24","author":"Y Kitazawa","year":"1996","journal-title":"Aust N Z J Ophthalmol"},{"key":"ref7","first-page":"1","article-title":"Anterior-Segment Optical Coherence Tomography for Predicting Postoperative Outcomes After Trabeculectomy","author":"T Kokubun","year":"2018","journal-title":"Curr Eye Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1016\/j.ophtha.2006.01.062","article-title":"Trabeculectomy with mitomycin C: outcomes and risk factors for failure in phakic open-angle glaucoma","volume":"113","author":"H Fontana","year":"2006","journal-title":"Ophthalmology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1001\/archopht.1992.01080200029011","article-title":"Hypotony maculopathy following trabeculectomy with mitomycin C","volume":"110","author":"HD Jampel","year":"1992","journal-title":"Arch Ophthalmol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1001\/archopht.1996.01100140151007","article-title":"Endophthalmitis after filtering surgery with mitomycin","volume":"114","author":"DS Greenfield","year":"1996","journal-title":"Arch Ophthalmol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1001\/archopht.1993.01090020117035","article-title":"Prolonged localized tissue effects from 5-minute exposures to fluorouracil and mitomycin C","volume":"111","author":"PT Khaw","year":"1993","journal-title":"Arch Ophthalmol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/PL00007555","article-title":"Antiinflammatory and antifibrotic properties of colchicine: implications for idiopathic pulmonary fibrosis","volume":"175","author":"P Entzian","year":"1997","journal-title":"Lung"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1001\/archopht.1986.01050200129066","article-title":"Low-dose colchicine inhibits astrocyte, fibroblast, and retinal pigment epithelial cell migration and proliferation","volume":"104","author":"M Lemor","year":"1986","journal-title":"Arch Ophthalmol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3109\/02713688908995193","article-title":"Taxol, cytochalasin B and colchicine effects on fibroblast migration and contraction: a role in glaucoma filtration surgery?","volume":"8","author":"JP Joseph","year":"1989","journal-title":"Curr Eye Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1136\/bjo.86.12.1352","article-title":"Anti-inflammatory fibrosis suppression in threatened trabeculectomy bleb failure produces good long term control of intraocular pressure without risk of sight threatening complications","volume":"86","author":"JR Fuller","year":"2002","journal-title":"Br J Ophthalmol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S0039-6257(01)00211-9","article-title":"The Draize eye test","volume":"45","author":"KR Wilhelmus","year":"2001","journal-title":"Surv Ophthalmol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/IJG.0b013e31817eee32","article-title":"A thin honeycomb-patterned film as an adhesion barrier in an animal model of glaucoma filtration surgery","volume":"18","author":"T Okuda","year":"2009","journal-title":"J Glaucoma"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1001\/archopht.1991.01080120109038","article-title":"The effects of subconjunctival mitomycin-C on glaucoma filtration surgery in rabbits","volume":"109","author":"TJ Bergstrom","year":"1991","journal-title":"Arch Ophthalmol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1001\/archopht.120.7.941","article-title":"Adenovirus-mediated gene therapy using human p21WAF-1\/Cip-1 to prevent wound healing in a rabbit model of glaucoma filtration surgery","volume":"120","author":"TW Perkins","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1021\/cr3001059","article-title":"Mitomycinoid alkaloids: mechanism of action, biosynthesis, total syntheses, and synthetic approaches","volume":"113","author":"PD Bass","year":"2013","journal-title":"Chem Rev"},{"key":"ref21","first-page":"1998","article-title":"Single exposures to antiproliferatives: long-term effects on ocular fibroblast wound-healing behavior","volume":"38","author":"NL Occleston","year":"1997","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1111\/j.1582-4934.2011.01400.x","article-title":"In vitro analyses of the anti-fibrotic effect of SPARC silencing in human Tenon\u2019s fibroblasts: comparisons with mitomycin C","volume":"16","author":"L-F Seet","year":"2012","journal-title":"J Cell Mol Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1096\/fj.03-1273rev","article-title":"TGF-\u03b2 signaling and the fibrotic response","volume":"18","author":"A Leask","year":"2004","journal-title":"FASEB J"},{"key":"ref24","first-page":"168","article-title":"Expression of connective tissue growth factor after trabeculectomy in rabbits","volume":"45","author":"H Yuan","year":"2009","journal-title":"Zhonghua Yan Ke Za Zhi"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1111\/ceo.12204","article-title":"Monocyte chemotactic protein-1 level in the aqueous humour as a prognostic factor for the outcome of trabeculectomy","volume":"42","author":"T Inoue","year":"2014","journal-title":"Clin Exp Ophthalmol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/jcp.20583","article-title":"Intraocular injection of an aptamer that binds PDGF-B: a potential treatment for proliferative retinopathies","volume":"207","author":"H Akiyama","year":"2006","journal-title":"J Cell Physiol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1111\/j.1440-1827.1996.tb03584.x","article-title":"Co-expression of TNF alpha and IL-1 beta in human acute pulmonary fibrotic diseases: an immunohistochemical analysis","volume":"46","author":"LH Pan","year":"1996","journal-title":"Pathol Int"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"7951","DOI":"10.1167\/iovs.12-10231","article-title":"Elevated levels of monocyte chemoattractant protein-1 in the aqueous humor after phacoemulsification","volume":"53","author":"M Kawai","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.2174\/1874364101509010136","article-title":"Conjunctival TGF-B Level in Primary Augmented Trabeculectomy","volume":"9","author":"GF Ng","year":"2015","journal-title":"Open Ophthalmol J"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/0163-7258(91)90067-V","article-title":"Interactions of colchicine with tubulin","volume":"51","author":"SB Hastie","year":"1991","journal-title":"Pharmacol Ther"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.ejphar.2007.07.067","article-title":"p38 and JNK MAPK, but not ERK1\/2 MAPK, play important role in colchicine-induced cortical neurons apoptosis","volume":"576","author":"Y Yang","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"ref32","article-title":"The Cellular Uptake and Apoptotic Efficiency of Colchicine is Correlated with Down-regulation of MMP-9 mRNA Expression in SW480 Colon Cancer Cells","author":"N Ozmen","year":"2018","journal-title":"Anticancer Agents Med Chem"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1002\/art.1780110210","article-title":"Colchicine: a common mechanism for its anti-inflammatory and anti-mitotic effects","volume":"11","author":"SE Malawista","year":"1968","journal-title":"Arthritis Rheum"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.transproceed.2004.05.078","article-title":"Effect of colchicine on cyclosporine nephrotoxicity, reduction of TGF-beta overexpression, apoptosis, and oxidative damage: an experimental animal study","volume":"36","author":"U Disel","year":"2004","journal-title":"Transplant Proc"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1016\/j.rmed.2007.02.006","article-title":"Effects of antifibrotic agents on TGF-\u03b21, CTGF and IFN-\u03b3 expression in patients with idiopathic pulmonary fibrosis","volume":"101","author":"EG Tzortzaki","year":"2007","journal-title":"Respir Med"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1152\/ajprenal.90649.2008","article-title":"Colchicine attenuates inflammatory cell infiltration and extracellular matrix accumulation in diabetic nephropathy","volume":"297","author":"JJ Li","year":"2009","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0304-4165(72)90302-9","article-title":"Time lag in the secretion of collagen by matrix-free tendon cells and inhibition of the secretory process by colchicine and vinblastine","volume":"264","author":"P Dehm","year":"1972","journal-title":"Biochim Biophys Acta"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1073\/pnas.69.4.892","article-title":"Inhibition of collagen secretion from bone and cultured fibroblasts by microtubular disruptive drugs","volume":"69","author":"RF Diegelmann","year":"1972","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1002\/art.1780140602","article-title":"Effects of colchicine on collagenase in cultures of rheumatoid synovium","volume":"14","author":"ED Harris","year":"1971","journal-title":"Arthritis Rheum"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/S0161-6420(92)31992-X","article-title":"Mitomycin concentration in rabbit and human ocular tissues after topical administration","volume":"99","author":"K Kawase","year":"1992","journal-title":"Ophthalmology"},{"key":"ref41","first-page":"1975","article-title":"Transforming growth factor-beta1, -beta2, and -beta3 in vivo: effects on normal and mitomycin C-modulated conjunctival scarring","volume":"40","author":"MF Cordeiro","year":"1999","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"3394","DOI":"10.1167\/iovs.02-0978","article-title":"Evaluation of anti-TGF-beta2 antibody as a new postoperative anti-scarring agent in glaucoma surgery","volume":"44","author":"AL Mead","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1016\/j.ophtha.2007.03.050","article-title":"A phase III study of subconjunctival human anti-transforming growth factor beta(2) monoclonal antibody (CAT-152) to prevent scarring after first-time trabeculectomy","volume":"114","author":"P Khaw","year":"2007","journal-title":"Ophthalmology"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S0161-6420(01)00997-6","article-title":"Human antitransforming growth factor beta(2) monoclonal antibody\u2014a new modulator of wound healing in trabeculectomy: a randomized placebo controlled clinical study","volume":"109","author":"D Siriwardena","year":"2002","journal-title":"Ophthalmology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0161-6420(88)33104-0","article-title":"Mitomycin eye drops as treatment for pterygium","volume":"95","author":"G Singh","year":"1988","journal-title":"Ophthalmology"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/0002-9394(88)90706-4","article-title":"Postoperative instillation of low-dose mitomycin C in the treatment of primary pterygium","volume":"106","author":"S Hayasaka","year":"1988","journal-title":"Am J Ophthalmol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"59","DOI":"10.3341\/kjo.1987.1.2.59","article-title":"The effect of colchicine on fibroblast proliferation after glaucoma filtering surgery","volume":"1","author":"YS Yu","year":"1987","journal-title":"Korean J Ophthalmol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0213811","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:06:04Z","timestamp":1588989964000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0213811"}},"subtitle":[],"editor":[{"given":"Demetrios G.","family":"Vavvas","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,19]]},"references-count":47,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0213811","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2019,3,19]]}}}