{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T12:13:22Z","timestamp":1782821602439,"version":"3.54.5"},"reference-count":72,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000200","name":"United States Agency for International Development","doi-asserted-by":"crossref","award":["2233"],"award-info":[{"award-number":["2233"]}],"id":[{"id":"10.13039\/100000200","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0213911","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T17:39:51Z","timestamp":1553794791000},"page":"e0213911","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["Induction and maintenance of bi-functional (IFN-\u03b3 + IL-2+ and IL-2+ TNF-\u03b1+) T cell responses by DNA prime MVA boosted subtype C prophylactic vaccine tested in a Phase I trial in India"],"prefix":"10.1371","volume":"14","author":[{"given":"Sivasankaran","family":"Munusamy Ponnan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sathyamurthy","family":"Pattabiram","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kannan","family":"Thiruvengadam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajat","family":"Goyal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikhil","family":"Singla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joyeeta","family":"Mukherjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta","family":"Chatrath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Bergin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakub","family":"T. Kopycinski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jill","family":"Gilmour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6464-1219","authenticated-orcid":true,"given":"Sriram","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malathy","family":"Muthu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudha","family":"Subramaniam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumya","family":"Swaminathan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srikanth","family":"Prasad Tripathy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6299-8211","authenticated-orcid":true,"given":"Hanna Elizabeth","family":"Luke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"issue":"11","key":"ref1","doi-asserted-by":"crossref","first-page":"766","DOI":"10.7326\/0003-4819-154-11-201106070-00345","article-title":"Thirty years of HIV and AIDS: future challenges and opportunities","volume":"154","author":"CW Dieffenbach","year":"2011","journal-title":"Annals of internal medicine"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/mi.2008.35","article-title":"Effective CD4+ T-cell restoration in gut-associated lymphoid tissue of HIV-infected patients is associated with enhanced Th17 cells and polyfunctional","volume":"1","author":"M Macal","year":"2008","journal-title":"HIV-specific T-cell responses. Mucosal immunology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/COH.0b013e32833d17ac","article-title":"HIV Vaccines-Lessons learned and the way forward","volume":"5","author":"JH Kim","year":"2010","journal-title":"Current Opinion in HIV and AIDS"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1097\/COH.0b013e3282faa461","article-title":"Wanted: correlates of vaccine-induced protection against simian immunodeficiency virus","volume":"3","author":"TC Friedrich","year":"2008","journal-title":"Current opinion in HIV and AIDS"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/gt.2009.148","article-title":"Progress and prospects: immune responses to viral vectors","volume":"17","author":"S Nayak","year":"2010","journal-title":"Gene therapy"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1099\/vir.0.83384-0","article-title":"Immune-response profiles induced by human immunodeficiency virus type 1 vaccine DNA, protein or mixed-modality immunization: increased protection from pathogenic simian\u2013human immunodeficiency virus viraemia with protein\/DNA combination","volume":"89","author":"G Koopman","year":"2008","journal-title":"Journal of General Virology"},{"key":"ref7","first-page":"422","article-title":"Application of prime-boost as a novel vaccination strategy against microbial pathogens","author":"D Gaspari","year":"2011","journal-title":"FORMATEX"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1086\/592507","article-title":"Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara","volume":"198","author":"E Sandstr\u00f6m","year":"2008","journal-title":"The Journal of infectious diseases"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0128714","article-title":"Pathogen-Specific T Cell Polyfunctionality Is a Correlate of T Cell Efficacyand Immune Protection","volume":"10","author":"A Boyd","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s00281-006-0025-4","article-title":"Polyfunctional analysis of human t cell responses: importance in vaccine immunogenicity and natural infection","volume":"28","author":"G Makedonas","year":"2006","journal-title":"Springer seminars in immunopathology"},{"issue":"13","key":"ref11","doi-asserted-by":"crossref","first-page":"5773","DOI":"10.1073\/pnas.92.13.5773","article-title":"Persistent high frequency of human immunodeficiency virus-specific cytotoxic T cells in peripheral blood of infected donors","volume":"92","author":"PA Moss","year":"1995","journal-title":"Proc Natl Acad Sci U SA"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/imr.12069","article-title":"CD 8+ T\u2010cell effector function and transcriptional regulation during HIV pathogenesis","volume":"254","author":"KR Demers","year":"2013","journal-title":"Immunological reviews"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1099\/vir.0.004614-0","article-title":"Broad, high-magnitude and multifunctional CD4+ and CD8+ T-cell responses elicited by a DNA and modified vaccinia Ankara vaccine containing human immunodeficiency virus type 1 subtype C genes in baboons","volume":"90","author":"WA Burgers","year":"2009","journal-title":"Journal of General Virology"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"6376","DOI":"10.4049\/jimmunol.169.11.6376","article-title":"Presence of HIV-1 Gag-specific IFN-\u03b3+ IL-2+ and CD28+ IL-2+ CD4 T cell responses is associated with nonprogression in HIV-1 infection","volume":"169","author":"MJ Boaz","year":"2002","journal-title":"The Journal of Immunology"},{"issue":"16","key":"ref15","doi-asserted-by":"crossref","first-page":"8468","DOI":"10.1128\/JVI.00228-07","article-title":"Multiple-cytokine-producing antiviral CD4 T cells are functionally superior to single-cytokine-producing cells","volume":"81","author":"S Kannanganat","year":"2007","journal-title":"Journal of virology"},{"key":"ref16","first-page":"532","article-title":"ANRS EP36 HIV CONTROLLERS study group. 2007. HIV controllers: how do they tame the virus?","volume":"28","author":"A S\u00e1ez-Ciri\u00f3n","journal-title":"Trends in Immunology"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.4049\/jimmunol.167.1.181","article-title":"Functional heterogeneity of cytokines and cytolytic effector molecules in human CD8+ T lymphocytes","volume":"167","author":"JK Sandberg","year":"2001","journal-title":"The Journal of Immunology"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1099\/vir.0.82493-0","article-title":"Clinical experience with plasmid DNA-and modified vaccinia virus Ankara-vectored human immunodeficiency virus type 1 clade A vaccine focusing on T-cell induction","volume":"88","author":"T Hanke","year":"2007","journal-title":"Journal of general virology"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/eji.200839167","article-title":"Increased detection of proliferating, polyfunctional, HIV\u20101\u2010specific T cells in DNA\u2010modified vaccinia virus Ankara\u2010vaccinated human volunteers by cultured IFN\u2010\u03b3 ELISPOT assay","volume":"39","author":"N Winstone","year":"2009","journal-title":"European journal of immunology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/nm.1935","article-title":"Effector memory T cell responses are associated with protection of rhesus monkeys from mucosal simian immunodeficiency virus challenge","volume":"15","author":"SG Hansen","year":"2009","journal-title":"Nat. Med"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"e16921","DOI":"10.1371\/journal.pone.0016921","article-title":"A DNA vaccine encoding multiple HIV CD4 epitopes elicits vigorous polyfunctional, long-lived CD4+ and CD8+ T cell responses","volume":"6","author":"DS Rosa","year":"2011","journal-title":"PLoS One"},{"key":"ref22","first-page":"CVI","article-title":"Immunogenicity and safety of a booster dose of an investigational adjuvanted polyprotein HIV-1 vaccine in healthy adults and effect of administration of chloroquine","volume":"3","author":"G Leroux-Roels","year":"2014","journal-title":"Clinical and Vaccine Immunology"},{"issue":"10","key":"ref23","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1086\/592507","article-title":"HIV Immunogenicity Study 01\/02 Team. Broad immunogenicity of a multigene, multiclade HIV-1 DNA vaccine boosted with heterologous HIV-1 recombinant modified vaccinia virus Ankara","volume":"198","author":"E Sandstr\u00f6m","year":"2008","journal-title":"J Infect Dis"},{"issue":"46","key":"ref24","doi-asserted-by":"crossref","first-page":"8417","DOI":"10.1016\/j.vaccine.2011.08.001","article-title":"Broad and potent immune responses to a low dose intradermal HIV-1 DNA boosted with HIV-1 recombinant MVA among healthy adults in Tanzania","volume":"29","author":"M Bakari","year":"2011","journal-title":"Vaccine"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1093\/infdis\/jiq105","article-title":"Phase 1 safety and immunogenicity testing of DNA and recombinant modified vaccinia Ankara vaccines expressing HIV-1 virus-like particles","volume":"203","author":"PA Goepfert","year":"2011","journal-title":"Journal of Infectious Diseases"},{"key":"ref26","first-page":"CVI","article-title":"Safety and immunogenicity of DNA prime and Modified Vaccinia Ankara virus HIV subtype C vaccine boost in healthy adults","volume":"23","author":"P Hayes","year":"2013","journal-title":"Clinical and vaccine immunology"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"e55831","DOI":"10.1371\/journal.pone.0055831","article-title":"Safety and immunogenicity of DNA and MVA HIV-1 subtype C vaccine prime-boost regimens: a phase I randomised Trial in HIV-uninfected Indian volunteers","volume":"8","author":"S Mehendale","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1097\/QAI.0b013e3181651b9d","article-title":"Design, construction, and characterization of a dual-promoter multigenic DNA vaccine directed against an HIV-1 subtype C\/B\u2032 recombinant","volume":"47","author":"Y Huang","year":"2008","journal-title":"JAIDS Journal of Acquired Immune Deficiency Syndromes"},{"key":"ref29","unstructured":"Stiles T, Grant V. Good clinical laboratory practice (GCLP). A quality system for laboratories that undertake the analysis of samples from clinical trials, (2011) p 1\u201318.ISBN 978-1-904610-00-7.BARQA, Ipswich, United Kingdom."},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1089\/aid.2009.0096","article-title":"A Phase 1 study to evaluate the safety and immunogenicity of a recombinant HIV type 1 subtype C-modified vaccinia Ankara virus vaccine candidate in Indian volunteers","volume":"25","author":"VD Ramanathan","year":"2009","journal-title":"AIDS research and human retroviruses"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"e14330","DOI":"10.1371\/journal.pone.0014330","article-title":"Equivalence of ELISpot assays demonstrated between major HIV network laboratories","volume":"5","author":"DK Gill","year":"2010","journal-title":"PLoS One"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"e8617","DOI":"10.1371\/journal.pone.0008617","article-title":"Phase 1 safety and immunogenicity evaluation of ADVAX, a multigenic, DNA-based clade C\/B&apos;HIV-1 candidate vaccine","volume":"5","author":"S Vasan","year":"2010","journal-title":"PLoS One"},{"issue":"5\u20136","key":"ref33","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1016\/S0264-410X(02)00407-3","article-title":"Memory T cells and vaccines","volume":"21","author":"MT Esser","year":"2003","journal-title":"Vaccine"},{"issue":"1","key":"ref34","first-page":"a007252","article-title":"Vaccine design for CD8 T lymphocyte responses","volume":"1","author":"RA Koup","year":"2011","journal-title":"Cold Spring Harbor perspectives in medicine"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"6103","DOI":"10.1128\/JVI.68.9.6103-6110.1994","article-title":"Virus-specific CD8+ cytotoxic T-lymphocyte activity associated with control of viremia in primary human immunodeficiency virus type 1 infection","volume":"68","author":"P Borrow","year":"1994","journal-title":"Journal of virology"},{"issue":"7","key":"ref36","doi-asserted-by":"crossref","first-page":"4650","DOI":"10.1128\/JVI.68.7.4650-4655.1994","article-title":"Temporal association of cellular immune responses with the initial control of viremia in primary human immunodeficiency virus type 1 syndrome","volume":"68","author":"RA Koup","year":"1994","journal-title":"Journal of virology"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1586\/erv.10.106","article-title":"Prime\u2013boost immunization with poxvirus or adenovirus vectors as a strategy to develop a protective vaccine for HIV-1","volume":"9","author":"RM Paris","year":"2010","journal-title":"Expert review of vaccines"},{"issue":"12","key":"ref38","doi-asserted-by":"crossref","first-page":"4781","DOI":"10.1182\/blood-2005-12-4818","article-title":"HIV nonprogressors preferentially maintain highly functional HIV-specific CD8+","volume":"107","author":"MR Betts","year":"2006","journal-title":"T cells. Blood"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1172\/JCI80566","article-title":"HIV-specific CD8+ T cells and HIV eradication","volume":"126","author":"RB Jones","year":"2016","journal-title":"The Journal of clinical investigation"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1080\/21645515.2015.1035502","article-title":"DNA vaccines, electroporation and their applications in cancer treatment","volume":"11","author":"SH Lee","year":"2015","journal-title":"Human vaccines & immunotherapeutics"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.4049\/jimmunol.171.5.2538","article-title":"Prime-boost vaccination with HIV-1 Gag protein and cytosine phosphate guanosine oligodeoxynucleotide, followed by adenovirus, induces sustained and robust humoral and cellular immune responses","volume":"171","author":"M Tritel","year":"2003","journal-title":"The Journal of Immunology"},{"issue":"2","key":"ref42","first-page":"71","article-title":"DNA immunization as an efficient strategy for vaccination","volume":"1","author":"A Bolhassani","year":"2009","journal-title":"Avicenna journal of medical biotechnology"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"e0203037","DOI":"10.1371\/journal.pone.0203037","article-title":"Induction of circulating T follicular helper cells and regulatory T cells correlating with HIV-1 gp120 variable loop antibodies by a subtype C prophylactic vaccine tested in a Phase I trial inIndia","volume":"13","author":"S Munusamy Ponnan","year":"2018","journal-title":"PLoS One"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"e9015","DOI":"10.1371\/journal.pone.0009015","article-title":"Priming immunization with DNA augments immunogenicity of recombinant adenoviral vectors for both HIV-1 specific antibody and T-cell responses","volume":"5","author":"RA Koup","year":"2010","journal-title":"PloS one"},{"issue":"11","key":"ref45","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1128\/JVI.78.11.5535-5545.2004","article-title":"Memory CD8 T-cell differentiation during viral infection","volume":"78","author":"EJ Wherry","year":"2004","journal-title":"Journal of virology"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/QAI.0b013e3181869a88","article-title":"Substantial intrapatient differences in the breadth and specificity of HIV-specific CD8+ T-cell interferon-\u03b3 and proliferation responses","volume":"49","author":"LR McKinnon","year":"2008","journal-title":"JAIDS Journal of Acquired Immune Deficiency Syndromes"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"4512","DOI":"10.1073\/pnas.0408773102","article-title":"Characterization of functional and phenotypic changes in anti-Gag vaccine-induced Tcell responses and their role in protection after HIV-1 infection","volume":"102","author":"MR Betts","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1128\/JVI.01754-06","article-title":"Proliferative capacity of epitope-specific CD8 T-cell responses is inversely related to viral load in chronic human immunodeficiency virus type 1 infection","volume":"81","author":"CL Day","year":"2007","journal-title":"Journal of virology"},{"issue":"20","key":"ref49","doi-asserted-by":"crossref","first-page":"7239","DOI":"10.1073\/pnas.0502393102","article-title":"HIV-1-specific IFN-\u03b3\/IL-2-secreting CD8 T cells support CD4-independent proliferation of HIV-1-specific CD8 T cells","volume":"102","author":"SC Zimmerli","year":"2005","journal-title":"Proceedings of the National Academy of Sciences"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1084\/jem.20071331","article-title":"An HIV-1 clade C DNA prime, NYVAC boost vaccine regimen induces reliable, polyfunctional, and long-lasting T cell responses","volume":"205","author":"A Harari","year":"2008","journal-title":"Journal of experimental medicine"},{"issue":"11","key":"ref51","doi-asserted-by":"crossref","first-page":"5540","DOI":"10.1128\/JVI.02031-09","article-title":"Enhanced anti-HIV functional activity associated with Gag-specific CD8 T-cell responses","volume":"84","author":"B Julg","year":"2010","journal-title":"Journal of virology"},{"issue":"1","key":"ref52","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1186\/1479-5876-9-208","article-title":"Definition of the viral targets of protective HIV-1-specific T cell responses","volume":"9","author":"B Mothe","year":"2011","journal-title":"Journal of translational medicine"},{"issue":"1","key":"ref53","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nm1520","article-title":"CD8+ T-cell responses to different HIV proteins have discordant associations with viral load","volume":"13","author":"P Kiepiela","year":"2007","journal-title":"Nature medicine"},{"issue":"18","key":"ref54","doi-asserted-by":"crossref","first-page":"9578","DOI":"10.1128\/JVI.05060-11","article-title":"Enhanced control of pathogenic Simian immunodeficiency virus SIVmac239 replication in macaques immunized with an interleukin-12 plasmid and a DNA prime-viral vector boost vaccine regimen","volume":"85","author":"N Winstone","year":"2011","journal-title":"Journal of virology"},{"issue":"11","key":"ref55","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1086\/345482","article-title":"Inverse Correlation between Memory Gag-Specific Cytotoxic T Lymphocytes and Viral Replication in Human Immunodeficiency Virus\u2013Infected Children","volume":"186","author":"F Buseyne","year":"2002","journal-title":"The Journal of infectious diseases"},{"issue":"5403","key":"ref56","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1126\/science.283.5403.857","article-title":"Control of viremia in simian immunodeficiency virus infection by CD8+ lymphocytes","volume":"283","author":"JE Schmitz","year":"1999","journal-title":"Science"},{"issue":"1","key":"ref57","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.immuni.2013.07.003","article-title":"Preexisting high frequencies of memory CD8+ T cells favor rapid memory differentiation and preservation of proliferative potential upon boosting","volume":"39","author":"KA Fraser","year":"2013","journal-title":"Immunity"},{"issue":"373","key":"ref58","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aag2285","article-title":"Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies","volume":"9","author":"C Petrovas","year":"2017","journal-title":"Science translational medicine"},{"issue":"1 Supplement","key":"ref59","article-title":"Defining limits on efficacy of CD8 T cell-based HIV vaccines","volume":"196","author":"VV Ganusov","year":"2016","journal-title":"The Journal of Immunology"},{"issue":"1","key":"ref60","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1097\/QAD.0b013e328340fe55","article-title":"Comprehensive analysis of virus-specific T-cells provides clues for the failure of therapeutic immunization with ALVAC-HIV vaccine","volume":"25","author":"L Papagno","year":"2011","journal-title":"Aids"},{"issue":"4","key":"ref61","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.vaccine.2005.08.041","article-title":"Phase I clinical trial safety of DNA-and modified virus Ankara-vectored human immunodeficiency virus type 1 (HIV-1) vaccines administered alone and in a prime-boost regime to healthy HIV-1-uninfected volunteers","volume":"24","author":"I Cebere","year":"2006","journal-title":"Vaccine"},{"key":"ref62","article-title":"Predicting the impact of CD8+ T cell polyfunctionality on HIV disease progression","author":"F Graw","year":"2014","journal-title":"Journal of virology"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"5372","DOI":"10.4049\/jimmunol.173.9.5372","article-title":"Vaccination in humans generates broad T cell cytokine responses","volume":"173","author":"SC De Rosa","year":"2004","journal-title":"J. Immunol"},{"issue":"11","key":"ref64","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1097\/QAD.0000000000001122","article-title":"Adenovirus-based HIV-1 vaccine candidates tested in efficacy trials elicit CD8+ T cells with limited breadth of HIV-1 inhibition","volume":"30","author":"PJ Hayes","year":"2016","journal-title":"Aids"},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1084\/jem.20062363","article-title":"Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses","volume":"204","author":"ML Precopio","year":"2007","journal-title":"Journal of Experimental Medicine"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.immuni.2007.08.010","article-title":"Human immunodeficiency virus controllers: mechanisms of durable virus control in the absence of antiretroviral therapy","volume":"27","author":"SG Deeks","year":"2007","journal-title":"Immunity"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/1742-4690-5-112","article-title":"Mechanisms of HIV non-progression; robust and sustained CD4+ T-cell proliferative responses to p24 antigen correlate with control of viraemia and lack of disease progression after long-term transfusion-acquired HIV-1 infection","volume":"5","author":"WB Dyer","year":"2008","journal-title":"Retrovirology"},{"issue":"22","key":"ref68","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.1016\/j.vaccine.2008.03.019","article-title":"Immunization with an HIV-1 immunogen induces CD4+ and CD8+ HIV-1-specific polyfunctional responses in patients with chronic HIV-1 infection receiving antiretroviral therapy","volume":"26","author":"L Valor","year":"2008","journal-title":"Vaccine"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1128\/JVI.01958-08","article-title":"Evidence of CD8+ T-cell-mediated selective pressure on human immunodeficiency virus type 1 nef in HLA-B* 57+ elite suppressors","volume":"83","author":"JR Bailey","year":"2009","journal-title":"Journal of virology"},{"issue":"2","key":"ref70","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1002\/eji.200737768","article-title":"Polyfunctional T cell responses are a hallmark of HIV\u20102 infection","volume":"38","author":"MG Duvall","year":"2008","journal-title":"European journal of immunology"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0264-410X(03)00538-3","article-title":"Therapeutic vaccination with MVA-HIV-1 nef elicits Nef-specific T-helper cell responses in chronically HIV-1 infected individuals","volume":"22","author":"A Cosma","year":"2003","journal-title":"Vaccine"},{"issue":"19","key":"ref72","doi-asserted-by":"crossref","first-page":"2225","DOI":"10.1016\/j.vaccine.2016.03.021","article-title":"A therapeutic HIV-1 vaccine enhances anti-HIV-1 immune responses in patients under highly active antiretroviral therapy","volume":"34","author":"FY Tung","year":"2016","journal-title":"Vaccine"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0213911","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T09:16:36Z","timestamp":1607073396000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0213911"}},"subtitle":[],"editor":[{"given":"David Joseph","family":"Diemert","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":72,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0213911","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]}}}