{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T03:10:36Z","timestamp":1789787436525,"version":"4.0.1"},"reference-count":85,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","award":["EY107037"],"award-info":[{"award-number":["EY107037"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30-EY025585"],"award-info":[{"award-number":["P30-EY025585"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["Doris and Jules Stein Professorship"],"award-info":[{"award-number":["Doris and Jules Stein Professorship"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"crossref","award":["EY025145"],"award-info":[{"award-number":["EY025145"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0213960","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T13:50:37Z","timestamp":1554904237000},"page":"e0213960","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Ciliary genes arl13b, ahi1 and cc2d2a differentially modify expression of visual acuity phenotypes but do not enhance retinal degeneration due to mutation of cep290 in zebrafish"],"prefix":"10.1371","volume":"14","author":[{"given":"Emma M.","family":"Lessieur","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2164-2358","authenticated-orcid":true,"given":"Ping","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabrielle C.","family":"Nivar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Piccillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Fogerty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Rozic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9348-6542","authenticated-orcid":true,"given":"Brian D.","family":"Perkins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"issue":"16","key":"ref1","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1056\/NEJMra1010172","article-title":"Ciliopathies","volume":"364","author":"F Hildebrandt","year":"2011","journal-title":"N Engl J Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0070-2153(08)00813-2","article-title":"Ciliary dysfunction in developmental abnormalities and diseases","volume":"85","author":"N Sharma","year":"2008","journal-title":"Curr Top Dev Biol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1186\/2046-2530-1-22","article-title":"Photoreceptor sensory cilia and ciliopathies: focus on CEP290, RPGR and their interacting proteins","volume":"1","author":"RA Rachel","year":"2012","journal-title":"Cilia"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1086\/507318","article-title":"Mutations in the CEP290 (NPHP6) gene are a frequent cause of Leber congenital amaurosis","volume":"79","author":"AI den Hollander","year":"2006","journal-title":"Am J Hum Genet"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/j.preteyeres.2008.05.003","article-title":"Leber congenital amaurosis: genes, proteins and disease mechanisms","volume":"27","author":"AI den Hollander","year":"2008","journal-title":"Prog Retin Eye Res"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1002\/humu.21337","article-title":"CEP290, a gene with many faces: mutation overview and presentation of CEP290base","volume":"31","author":"F Coppieters","year":"2010","journal-title":"Hum Mutat"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1136\/jmedgenet-2015-103087","article-title":"Joubert syndrome: a model for untangling recessive disorders with extreme genetic heterogeneity","volume":"52","author":"R Bachmann-Gagescu","year":"2015","journal-title":"J Med Genet"},{"key":"ref8","article-title":"Leber Congenital Amaurosis Associated with Mutations in CEP290, Clinical Phenotype, and Natural History in Preparation for Trials of Novel Therapies","author":"L Sheck","year":"2018","journal-title":"Ophthalmology"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1002\/humu.20565","article-title":"Centrosomal-ciliary gene CEP290\/NPHP6 mutations result in blindness with unexpected sparing of photoreceptors and visual brain: implications for therapy of Leber congenital amaurosis","volume":"28","author":"AV Cideciyan","year":"2007","journal-title":"Hum Mutat"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"2608","DOI":"10.1167\/iovs.09-3734","article-title":"Differential macular morphology in patients with RPE65-, CEP290-, GUCY2D-, and AIPL1-related Leber congenital amaurosis","volume":"51","author":"S Pasadhika","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref11","first-page":"412","article-title":"Ocular and extra-ocular features of patients with Leber congenital amaurosis and mutations in CEP290","volume":"18","author":"S Yzer","year":"2012","journal-title":"Mol Vis"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.ajhg.2008.10.002","article-title":"CC2D2A is mutated in Joubert syndrome and interacts with the ciliopathy-associated basal body protein CEP290","volume":"83","author":"NT Gorden","year":"2008","journal-title":"Am J Hum Genet"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1083\/jcb.201501013","article-title":"The ciliary transition zone functions in cell adhesion but is dispensable for axoneme assembly in C. elegans","volume":"210","author":"C Schouteden","year":"2015","journal-title":"J Cell Biol"},{"issue":"13","key":"ref14","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1093\/hmg\/ddv123","article-title":"CEP290 alleles in mice disrupt tissue-specific cilia biogenesis and recapitulate features of syndromic ciliopathies","volume":"24","author":"RA Rachel","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref15","first-page":"389","article-title":"Ciliary and Flagellar Membranes","author":"JC Besharse","year":"1990"},{"issue":"32","key":"ref16","doi-asserted-by":"crossref","first-page":"E4400","DOI":"10.1073\/pnas.1510111112","article-title":"Accumulation of non-outer segment proteins in the outer segment underlies photoreceptor degeneration in Bardet-Biedl syndrome","volume":"112","author":"P Datta","year":"2015","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"e1002416","DOI":"10.1371\/journal.pbio.1002416","article-title":"MKS5 and CEP290 Dependent Assembly Pathway of the Ciliary Transition Zone","volume":"14","author":"C Li","year":"2016","journal-title":"PLoS biology"},{"issue":"8","key":"ref18","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ng.891","article-title":"A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition","volume":"43","author":"FR Garcia-Gonzalo","year":"2011","journal-title":"Nat Genet"},{"issue":"32","key":"ref19","doi-asserted-by":"crossref","first-page":"28276","DOI":"10.1074\/jbc.M111.237560","article-title":"Accumulation of the Raf-1 kinase inhibitory protein (Rkip) is associated with Cep290-mediated photoreceptor degeneration in ciliopathies","volume":"286","author":"CA Murga-Zamalloa","year":"2011","journal-title":"J Biol Chem"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1093\/hmg\/ddl107","article-title":"In-frame deletion in a novel centrosomal\/ciliary protein CEP290\/NPHP6 perturbs its interaction with RPGR and results in early-onset retinal degeneration in the rd16 mouse","volume":"15","author":"B Chang","year":"2006","journal-title":"Hum Mol Genet"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1093\/hmg\/ddr022","article-title":"Cone photoreceptors are the main targets for gene therapy of NPHP5 (IQCB1) or NPHP6 (CEP290) blindness: generation of an all-cone Nphp6 hypomorph mouse that mimics the human retinal ciliopathy","volume":"20","author":"AV Cideciyan","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.tvjl.2009.08.010","article-title":"Widespread retinal degenerative disease mutation (rdAc) discovered among a large number of popular cat breeds","volume":"186","author":"M Menotti-Raymond","year":"2010","journal-title":"Vet J"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/jhered\/esm019","article-title":"Mutation in CEP290 discovered for cat model of human retinal degeneration","volume":"98","author":"M Menotti-Raymond","year":"2007","journal-title":"The Journal of heredity"},{"key":"ref24","article-title":"Basal exon skipping and nonsense-associated altered splicing allows bypassing complete CEP290 loss-of-function in individuals with unusually mild retinal disease","author":"I Barny","year":"2018","journal-title":"Hum Mol Genet"},{"issue":"291","key":"ref25","doi-asserted-by":"crossref","first-page":"291ra97","DOI":"10.1126\/scitranslmed.aaa5370","article-title":"Basal exon skipping and genetic pleiotropy: A predictive model of disease pathogenesis","volume":"7","author":"TG Drivas","year":"2015","journal-title":"Sci Transl Med"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1083\/jcb.201012116","article-title":"MKS and NPHP modules cooperate to establish basal body\/transition zone membrane associations and ciliary gate function during ciliogenesis","volume":"192","author":"CL Williams","year":"2011","journal-title":"J Cell Biol"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.ajhg.2011.11.005","article-title":"TMEM237 is mutated in individuals with a Joubert syndrome related disorder and expands the role of the TMEM family at the ciliary transition zone","volume":"89","author":"L Huang","year":"2011","journal-title":"Am J Hum Genet"},{"issue":"11","key":"ref28","doi-asserted-by":"crossref","first-page":"e1005627","DOI":"10.1371\/journal.pgen.1005627","article-title":"Conserved Genetic Interactions between Ciliopathy Complexes Cooperatively Support Ciliogenesis and Ciliary Signaling","volume":"11","author":"LE Yee","year":"2015","journal-title":"PLoS Genet"},{"key":"ref29","article-title":"A common allele in RPGRIP1L is a modifier of retinal degeneration in ciliopathies","author":"H Khanna","year":"2009","journal-title":"Nat Genet"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.cell.2011.04.019","article-title":"Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways","volume":"145","author":"L Sang","year":"2011","journal-title":"Cell"},{"issue":"Pt 23","key":"ref31","doi-asserted-by":"crossref","first-page":"5575","DOI":"10.1242\/jcs.02665","article-title":"The C. elegans homologs of nephrocystin-1 and nephrocystin-4 are cilia transition zone proteins involved in chemosensory perception","volume":"118","author":"ME Winkelbauer","year":"2005","journal-title":"J Cell Sci"},{"issue":"20","key":"ref32","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.15252\/embj.201488044","article-title":"Formation of the transition zone by Mks5\/Rpgrip1L establishes a ciliary zone of exclusion (CIZE) that compartmentalises ciliary signalling proteins and controls PIP2 ciliary abundance","volume":"34","author":"VL Jensen","year":"2015","journal-title":"EMBO J"},{"key":"ref33","article-title":"Genetic screening of LCA in Belgium: predominance of CEP290 and identification of potential modifier alleles in AHI1 of CEP290-related phenotypes","author":"F Coppieters","year":"2010","journal-title":"Hum Mutat"},{"key":"ref34","article-title":"ARL13B, a Joubert Syndrome-associated protein, is critical for retinogenesis and elaboration of mouse photoreceptor outer segments","author":"TL Dilan","year":"2018","journal-title":"J Neurosci"},{"issue":"10","key":"ref35","doi-asserted-by":"crossref","first-page":"4517","DOI":"10.1167\/iovs.16-19898","article-title":"Arl13b Interacts With Vangl2 to Regulate Cilia and Photoreceptor Outer Segment Length in Zebrafish","volume":"57","author":"P Song","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"23","key":"ref36","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.1091\/mbc.e10-12-0994","article-title":"Arl13b regulates ciliogenesis and the dynamic localization of Shh signaling proteins","volume":"22","author":"CE Larkins","year":"2011","journal-title":"Mol Biol Cell"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","first-page":"3646","DOI":"10.1167\/iovs.09-5074","article-title":"A novel nonsense mutation in CEP290 induces exon skipping and leads to a relatively mild retinal phenotype","volume":"51","author":"KW Littink","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"2942","DOI":"10.1167\/iovs.15-18996","article-title":"Mutation of wrb, a Component of the Guided Entry of Tail-Anchored Protein Pathway, Disrupts Photoreceptor Synapse Structure and Function","volume":"57","author":"LL Daniele","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref39","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1167\/iovs.04-0682","article-title":"Contrast sensitivity, spatial and temporal tuning of the larval zebrafish optokinetic response","volume":"46","author":"O Rinner","year":"2005","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1167\/iovs.16-20326","article-title":"The Ciliopathy Gene ahi1 Is Required for Zebrafish Cone Photoreceptor Outer Segment Morphogenesis and Survival","volume":"58","author":"EM Lessieur","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"5","key":"ref41","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1083\/jcb.201111009","article-title":"Dishevelled stabilization by the ciliopathy protein Rpgrip1l is essential for planar cell polarity","volume":"198","author":"A Mahuzier","year":"2012","journal-title":"J Cell Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s13630-018-0056-1","article-title":"Assaying sensory ciliopathies using calcium biosensor expression in zebrafish ciliated olfactory neurons","volume":"7","author":"JGM Bergboer","year":"2018","journal-title":"Cilia"},{"issue":"6","key":"ref43","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.stem.2016.03.021","article-title":"Identification and Correction of Mechanisms Underlying Inherited Blindness in Human iPSC-Derived Optic Cups","volume":"18","author":"DA Parfitt","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"10","key":"ref44","doi-asserted-by":"crossref","first-page":"4525","DOI":"10.1172\/JCI69448","article-title":"Disruption of CEP290 microtubule\/membrane-binding domains causes retinal degeneration","volume":"123","author":"TG Drivas","year":"2013","journal-title":"J Clin Invest"},{"issue":"12","key":"ref45","doi-asserted-by":"crossref","first-page":"2482","DOI":"10.1093\/hmg\/ddt100","article-title":"Pathogenic NPHP5 mutations impair protein interaction with Cep290, a prerequisite for ciliogenesis","volume":"22","author":"M Barbelanne","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"Pt 11","key":"ref46","doi-asserted-by":"crossref","first-page":"1907","DOI":"10.1242\/jcs.029397","article-title":"The intraflagellar transport protein IFT57 is required for cilia maintenance and regulates IFT-particle-kinesin-II dissociation in vertebrate photoreceptors","volume":"121","author":"BL Krock","year":"2008","journal-title":"J Cell Sci"},{"issue":"20","key":"ref47","doi-asserted-by":"crossref","first-page":"4041","DOI":"10.1093\/hmg\/ddr332","article-title":"The ciliopathy gene cc2d2a controls zebrafish photoreceptor outer segment development through a role in Rab8-dependent vesicle trafficking","volume":"20","author":"R Bachmann-Gagescu","year":"2011","journal-title":"Hum Mol Genet"},{"issue":"6291","key":"ref48","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1126\/science.aaf6419","article-title":"Zebrafish models of idiopathic scoliosis link cerebrospinal fluid flow defects to spine curvature","volume":"352","author":"DT Grimes","year":"2016","journal-title":"Science"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1136\/jmg.2007.052027","article-title":"Mutation analysis of NPHP6\/CEP290 in patients with Joubert syndrome and Senior-Loken syndrome","volume":"44","author":"J Helou","year":"2007","journal-title":"J Med Genet"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S1097-2765(02)00635-4","article-title":"Nonsense-associated altered splicing: a frame-dependent response distinct from nonsense-mediated decay","volume":"10","author":"J Wang","year":"2002","journal-title":"Mol Cell"},{"issue":"1","key":"ref51","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1142\/S0219635213500015","article-title":"Detection and resolution of drifting gratings by motion detectors in the fish retina","volume":"12","author":"V Maximov","year":"2013","journal-title":"J Integr Neurosci"},{"key":"ref52","unstructured":"Purves D AG, Fitzpatrick D, et al. Neuroscience 2nd edition: Sunderland; 2001."},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1017\/S0952523899165076","article-title":"ERG assessment of zebrafish retinal development","volume":"16","author":"S Saszik","year":"1999","journal-title":"Vis Neurosci"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/dvdy.1188","article-title":"Rod contributions to the electroretinogram of the dark-adapted developing zebrafish","volume":"222","author":"J Bilotta","year":"2001","journal-title":"Dev Dyn"},{"issue":"Pt 9","key":"ref55","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1113\/jphysiol.2010.204156","article-title":"Ectopic expression of cone-specific G-protein-coupled receptor kinase GRK7 in zebrafish rods leads to lower photosensitivity and altered responses","volume":"589","author":"F Vogalis","year":"2011","journal-title":"J Physiol"},{"issue":"19","key":"ref56","doi-asserted-by":"crossref","first-page":"8603","DOI":"10.1523\/JNEUROSCI.19-19-08603.1999","article-title":"Genetic disorders of vision revealed by a behavioral screen of 400 essential loci in zebrafish","volume":"19","author":"SC Neuhauss","year":"1999","journal-title":"J Neurosci"},{"issue":"5","key":"ref57","first-page":"546","article-title":"Specific binding of peanut lectin to a class of retinal photoreceptor cells. A species comparison","volume":"25","author":"JC Blanks","year":"1984","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"9","key":"ref58","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1600-0854.2010.01085.x","article-title":"Zebrafish class 1 phosphatidylinositol transfer proteins: PITPbeta and double cone cell outer segment integrity in retina","volume":"11","author":"KE Ile","year":"2010","journal-title":"Traffic"},{"issue":"3","key":"ref59","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1242\/dev.109.3.567","article-title":"Early onset of phenotype and cell patterning in the embryonic zebrafish retina","volume":"109","author":"KD Larison","year":"1990","journal-title":"Development"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.ceb.2017.03.012","article-title":"Gates for soluble and membrane proteins, and two trafficking systems (IFT and LIFT), establish a dynamic ciliary signaling compartment","volume":"47","author":"VL Jensen","year":"2017","journal-title":"Curr Opin Cell Biol"},{"issue":"21","key":"ref61","doi-asserted-by":"crossref","first-page":"8857","DOI":"10.1073\/pnas.0701681104","article-title":"Deletion of PrBP\/delta impedes transport of GRK1 and PDE6 catalytic subunits to photoreceptor outer segments","volume":"104","author":"H Zhang","year":"2007","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1093\/hmg\/ddr520","article-title":"The X-linked retinitis pigmentosa protein RP2 facilitates G protein traffic","volume":"21","author":"N Schwarz","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"3","key":"ref63","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1096\/fj.14-257915","article-title":"Mistrafficking of prenylated proteins causes retinitis pigmentosa 2","volume":"29","author":"H Zhang","year":"2015","journal-title":"FASEB J"},{"issue":"16","key":"ref64","doi-asserted-by":"crossref","first-page":"4648","DOI":"10.1093\/hmg\/ddv197","article-title":"Knockout of RP2 decreases GRK1 and rod transducin subunits and leads to photoreceptor degeneration in zebrafish","volume":"24","author":"F Liu","year":"2015","journal-title":"Hum Mol Genet"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.gde.2016.05.009","article-title":"Retina regeneration in zebrafish","volume":"40","author":"J Wan","year":"2016","journal-title":"Curr Opin Genet Dev"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.exer.2013.07.012","article-title":"Regulation of Muller glial dependent neuronal regeneration in the damaged adult zebrafish retina","volume":"123","author":"RA Gorsuch","year":"2014","journal-title":"Exp Eye Res"},{"issue":"6","key":"ref67","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.preteyeres.2011.06.004","article-title":"The rod photoreceptor lineage of teleost fish","volume":"30","author":"DL Stenkamp","year":"2011","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/0012-1606(87)90338-1","article-title":"Germinal cells in the goldfish retina that produce rod photoreceptors","volume":"122","author":"PA Raymond","year":"1987","journal-title":"Dev Biol"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1006\/dbio.2001.0163","article-title":"Putative stem cells and the lineage of rod photoreceptors in the mature retina of the goldfish","volume":"232","author":"DC Otteson","year":"2001","journal-title":"Dev Biol"},{"issue":"7","key":"ref70","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1038\/nrn3723","article-title":"Muller glial cell reprogramming and retina regeneration","volume":"15","author":"D. Goldman","year":"2014","journal-title":"Nature reviews Neuroscience"},{"issue":"1","key":"ref71","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/hmg\/ddt394","article-title":"BBS mutations modify phenotypic expression of CEP290-related ciliopathies","volume":"23","author":"Y Zhang","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"2","key":"ref72","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/ng.519","article-title":"AHI1 is required for photoreceptor outer segment development and is a modifier for retinal degeneration in nephronophthisis","volume":"42","author":"CM Louie","year":"2010","journal-title":"Nat Genet"},{"issue":"4","key":"ref73","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1172\/JCI60981","article-title":"Combining Cep290 and Mkks ciliopathy alleles in mice rescues sensory defects and restores ciliogenesis","volume":"122","author":"RA Rachel","year":"2012","journal-title":"J Clin Invest"},{"issue":"27","key":"ref74","doi-asserted-by":"crossref","first-page":"9893","DOI":"10.1073\/pnas.1322373111","article-title":"Murine Joubert syndrome reveals Hedgehog signaling defects as a potential therapeutic target for nephronophthisis","volume":"111","author":"AM Hynes","year":"2014","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"ref75","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/s13059-016-1099-5","article-title":"Characterizing the morbid genome of ciliopathies","volume":"17","author":"R Shaheen","year":"2016","journal-title":"Genome biology"},{"issue":"18","key":"ref76","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1093\/hmg\/ddq275","article-title":"Interaction of retinitis pigmentosa GTPase regulator (RPGR) with RAB8A GTPase: implications for cilia dysfunction and photoreceptor degeneration","volume":"19","author":"CA Murga-Zamalloa","year":"2010","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref77","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.devcel.2014.11.018","article-title":"Reverse genetic screening reveals poor correlation between morpholino-induced and mutant phenotypes in zebrafish","volume":"32","author":"FO Kok","year":"2015","journal-title":"Dev Cell"},{"issue":"10","key":"ref78","doi-asserted-by":"crossref","first-page":"e1007000","DOI":"10.1371\/journal.pgen.1007000","article-title":"Guidelines for morpholino use in zebrafish","volume":"13","author":"DYR Stainier","year":"2017","journal-title":"PLoS Genet"},{"issue":"7564","key":"ref79","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1038\/nature14580","article-title":"Genetic compensation induced by deleterious mutations but not gene knockdowns","volume":"524","author":"A Rossi","year":"2015","journal-title":"Nature"},{"issue":"1","key":"ref80","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.celrep.2017.12.038","article-title":"Primary Cilium-Mediated Retinal Pigment Epithelium Maturation Is Disrupted in Ciliopathy Patient Cells","volume":"22","author":"HL May-Simera","year":"2018","journal-title":"Cell reports"},{"issue":"3","key":"ref81","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/1097-4695(20000905)44:3<289::AID-NEU1>3.0.CO;2-H","article-title":"Light-induced rod and cone cell death and regeneration in the adult albino zebrafish (Danio rerio) retina","volume":"44","author":"TS Vihtelic","year":"2000","journal-title":"J Neurobiol"},{"issue":"1","key":"ref82","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1007\/BF00239223","article-title":"Regeneration of the goldfish retina after exposure to different doses of ouabain","volume":"202","author":"W Maier","year":"1979","journal-title":"Cell Tissue Res"},{"issue":"5","key":"ref83","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/neu.480190504","article-title":"Regeneration of goldfish retina: rod precursors are a likely source of regenerated cells","volume":"19","author":"PA Raymond","year":"1988","journal-title":"Journal of neurobiology"},{"issue":"5828","key":"ref84","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/293141a0","article-title":"Genesis of rods in teleost fish retina","volume":"293","author":"PR Johns","year":"1981","journal-title":"Nature"},{"issue":"3","key":"ref85","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/(SICI)1096-9861(19980511)394:3<271::AID-CNE1>3.0.CO;2-Z","article-title":"Birth and fate of proliferative cells in the inner nuclear layer of the mature fish retina","volume":"394","author":"D Julian","year":"1998","journal-title":"J Comp Neurol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0213960","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T14:17:04Z","timestamp":1663251424000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0213960"}},"subtitle":[],"editor":[{"given":"Stephan C.F.","family":"Neuhauss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":85,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,10]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0213960","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/569822","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,10]]}}}