{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T23:35:56Z","timestamp":1776209756867,"version":"3.50.1"},"reference-count":48,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T00:00:00Z","timestamp":1553212800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007637","name":"Colciencias","doi-asserted-by":"crossref","award":["141565741029"],"award-info":[{"award-number":["141565741029"]}],"id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0214245","type":"journal-article","created":{"date-parts":[[2019,3,22]],"date-time":"2019-03-22T17:26:28Z","timestamp":1553275588000},"page":"e0214245","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":30,"title":["Inflammatory status and severity of disease in dengue patients are associated with lipoprotein alterations"],"prefix":"10.1371","volume":"14","author":[{"given":"Damariz","family":"Marin-Palma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cherilyn M.","family":"Sirois","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvio","family":"Urcuqui-Inchima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9200-5698","authenticated-orcid":true,"given":"Juan C.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,3,22]]},"reference":[{"key":"ref1","unstructured":"(TDR) WHOWatSPfRaTiTD. Dengue guidelines for diagnosis, treatment, prevention and control. 2009."},{"issue":"5979","key":"ref2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1126\/science.1185181","article-title":"Cross-reacting antibodies enhance dengue virus infection in humans","volume":"328","author":"W Dejnirattisai","year":"2010","journal-title":"Science"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"e1004031","DOI":"10.1371\/journal.ppat.1004031","article-title":"First experimental in vivo model of enhanced dengue disease severity through maternally acquired heterotypic dengue antibodies","volume":"10","author":"JK Ng","year":"2014","journal-title":"PLoS pathogens"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1089\/jir.2017.0037","article-title":"Highlights for Dengue Immunopathogenesis: Antibody-Dependent Enhancement, Cytokine Storm, and Beyond","volume":"38","author":"D Kuczera","year":"2018","journal-title":"Journal of interferon & cytokine research: the official journal of the International Society for Interferon and Cytokine Research"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1086\/517807","article-title":"Pathophysiologic and prognostic role of cytokines in dengue hemorrhagic fever","volume":"177","author":"DB Bethell","year":"1998","journal-title":"The Journal of infectious diseases"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1097\/MOH.0b013e328345a3d1","article-title":"Endothelial activation, dysfunction and permeability during severe infections.","volume":"18","author":"WL Lee","year":"2011","journal-title":"Current opinion in hematology"},{"issue":"11","key":"ref7","doi-asserted-by":"crossref","first-page":"e7892","DOI":"10.1371\/journal.pone.0007892","article-title":"Gene expression profiling during early acute febrile stage of dengue infection can predict the disease outcome","volume":"4","author":"EJ Nascimento","year":"2009","journal-title":"PLoS One"},{"issue":"8","key":"ref8","doi-asserted-by":"crossref","first-page":"e6782","DOI":"10.1371\/journal.pone.0006782","article-title":"Alternative complement pathway deregulation is correlated with dengue severity","volume":"4","author":"EJ Nascimento","year":"2009","journal-title":"PLoS One"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"e0003904","DOI":"10.1371\/journal.pntd.0003904","article-title":"Lower Low-Density Lipoprotein Cholesterol Levels Are Associated with Severe Dengue Outcome.","volume":"9","author":"HH Biswas","year":"2015","journal-title":"PLoS neglected tropical diseases"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1007\/s00705-015-2433-z","article-title":"Association of lipid profile alterations with severe forms of dengue in humans","volume":"160","author":"A Duran","year":"2015","journal-title":"Archives of virology"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1086\/339539","article-title":"Changes in the plasma lipid profile as a potential predictor of clinical outcome in dengue hemorrhagic fever.","volume":"34","author":"EC van Gorp","year":"2002","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1194\/jlr.M500187-JLR200","article-title":"Differential effects of HDL subpopulations on cellular ABCA1- and SR-BI-mediated cholesterol efflux","volume":"46","author":"BF Asztalos","year":"2005","journal-title":"J Lipid Res"},{"issue":"4","key":"ref13","first-page":"423","article-title":"Inflamaci\u00f3n y respuesta inmune innata: Participaci\u00f3n de las lipoprote\u00ednas de alta densidad.","volume":"30","author":"TN Mar\u00edn-Palma D","year":"2017","journal-title":"IATREIA"},{"issue":"15","key":"ref14","doi-asserted-by":"crossref","first-page":"11278","DOI":"10.1074\/jbc.275.15.11278","article-title":"High density lipoprotein prevents oxidized low density lipoprotein-induced inhibition of endothelial nitric-oxide synthase localization and activation in caveolae","volume":"275","author":"A Uittenbogaard","year":"2000","journal-title":"J Biol Chem"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"592594","DOI":"10.1155\/2015\/592594","article-title":"Effects of Myeloperoxidase-Induced Oxidation on Antiatherogenic Functions of High-Density Lipoprotein","volume":"2015","author":"T Kameda","year":"2015","journal-title":"Journal of lipids"},{"issue":"37","key":"ref16","doi-asserted-by":"crossref","first-page":"34480","DOI":"10.1074\/jbc.M103782200","article-title":"Suppression of endothelial cell apoptosis by high density lipoproteins (HDL) and HDL-associated lysosphingolipids","volume":"276","author":"JR Nofer","year":"2001","journal-title":"J Biol Chem"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1111\/imm.12638","article-title":"High-density lipoprotein reduces inflammation from cholesterol crystals by inhibiting inflammasome activation","volume":"149","author":"SG Thacker","year":"2016","journal-title":"Immunology"},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"P Broz","year":"2016","journal-title":"Nature reviews Immunology"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/cea.12206","article-title":"The NLRP3 inflammasome: role in airway inflammation.","volume":"44","author":"H Im","year":"2014","journal-title":"Clinical and experimental allergy: journal of the British Society for Allergy and Clinical Immunology"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"e0192845","DOI":"10.1371\/journal.pone.0192845","article-title":"HIV replication is associated to inflammasomes activation, IL-1beta, IL-18 and caspase-1 expression in GALT and peripheral blood","volume":"13","author":"MG Feria","year":"2018","journal-title":"PLoS One"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1471-2334-8-86","article-title":"Multiplex cytokine profile from dengue patients: MIP-1beta and IFN-gamma as predictive factors for severity","volume":"8","author":"FA Bozza","year":"2008","journal-title":"BMC infectious diseases"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1574-695X.2001.tb01575.x","article-title":"Elevated levels of interleukin-13 and IL-18 in patients with dengue hemorrhagic fever","volume":"30","author":"AS Mustafa","year":"2001","journal-title":"FEMS immunology and medical microbiology"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1182\/blood-2012-05-430090","article-title":"CLEC5A is critical for dengue virus-induced inflammasome activation in human macrophages","volume":"121","author":"MF Wu","year":"2013","journal-title":"Blood"},{"issue":"20","key":"ref24","doi-asserted-by":"crossref","first-page":"3405","DOI":"10.1182\/blood-2013-05-504449","article-title":"Platelets mediate increased endothelium permeability in dengue through NLRP3-inflammasome activation","volume":"122","author":"ED Hottz","year":"2013","journal-title":"Blood"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.17843\/rpmesp.2018.351.3568","article-title":"Modulaci\u00f3n de los niveles de lipoprote\u00ednas de alta densidad y las citoquinas IL-1\u03b2 e IL-6 en pacientes con dengue","volume":"35","author":"E Barrientos-Arenas","year":"2018","journal-title":"Revista peruana de medicina experimental y salud publica."},{"key":"ref26","unstructured":"Diseases WHOSPfRaTiT. Dengue Guidelines for Diagnosis, Treatment, Prevention and Control. 2009. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.who.int\/tdr\/publications\/documents\/dengue-diagnosis.pdf\" xlink:type=\"simple\">http:\/\/www.who.int\/tdr\/publications\/documents\/dengue-diagnosis.pdf<\/ext-link>"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.3389\/fimmu.2018.01350","article-title":"Lower High-Density Lipoproteins Levels During Human Immunodeficiency Virus Type 1 Infection Are Associated With Increased Inflammatory Markers and Disease Progression.","volume":"9","author":"D Marin-Palma","year":"2018","journal-title":"Frontiers in immunology"},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1177\/1753425917738331","article-title":"Silica nanoparticles induce NLRP3 inflammasome activation in human primary immune cells","volume":"23","author":"DM Gomez","year":"2017","journal-title":"Innate Immun"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"e0119844","DOI":"10.1371\/journal.pone.0119844","article-title":"Involvement of neutrophil hyporesponse and the role of Toll-like receptors in human immunodeficiency virus 1 protection.","volume":"10","author":"JC Hernandez","year":"2015","journal-title":"PLoS One."},{"issue":"11","key":"ref30","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1016\/j.bbalip.2015.08.009","article-title":"Electronegative LDL induces priming and inflammasome activation leading to IL-1beta release in human monocytes and macrophages","volume":"1851","author":"M Estruch","year":"2015","journal-title":"Biochimica et biophysica acta"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"e90704","DOI":"10.1371\/journal.pone.0090704","article-title":"Caveolin-1 in lipid rafts interacts with dengue virus NS3 during polyprotein processing and replication in HMEC-1 cells.","volume":"9","author":"J Garcia Cordero","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000321892","article-title":"Statins reduce dengue virus production via decreased virion assembly","volume":"54","author":"M Martinez-Gutierrez","year":"2011","journal-title":"Intervirology"},{"issue":"1\u20132","key":"ref33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.virusres.2013.03.005","article-title":"Requirement of cholesterol in the viral envelope for dengue virus infection","volume":"174","author":"AC Carro","year":"2013","journal-title":"Virus research"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1161\/ATVBAHA.108.168690","article-title":"High-density lipoprotein reduces the human monocyte inflammatory response","volume":"28","author":"AJ Murphy","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"e2373","DOI":"10.1371\/journal.pntd.0002373","article-title":"Serum metabolome and lipidome changes in adult patients with primary dengue infection.","volume":"7","author":"L Cui","year":"2013","journal-title":"PLoS neglected tropical diseases"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.meegid.2015.03.025","article-title":"Inflammasome signaling pathways exert antiviral effect against Chikungunya virus in human dermal fibroblasts","volume":"32","author":"P Ekchariyawat","year":"2015","journal-title":"Infection, genetics and evolution: journal of molecular epidemiology and evolutionary genetics in infectious diseases"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/(SICI)1096-9071(199911)59:3<335::AID-JMV13>3.0.CO;2-E","article-title":"Sequential production of cytokines by dengue virus-infected human peripheral blood leukocyte cultures","volume":"59","author":"UC Chaturvedi","year":"1999","journal-title":"Journal of medical virology"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1078\/0171-2985-00058","article-title":"Characterisation of lymphocyte response and cytokine patterns in patients with dengue fever","volume":"204","author":"EL Azeredo","year":"2001","journal-title":"Immunobiology"},{"issue":"3","key":"ref39","first-page":"187","article-title":"Interleukin-10 as a Marker of Disease Progression in Dengue Hemorrhagic Fever.","volume":"26","author":"A Tauseef","year":"2016","journal-title":"Journal of the College of Physicians and Surgeons\u2014Pakistan: JCPSP"},{"issue":"3","key":"ref40","first-page":"172","article-title":"Cytokine patterns during dengue shock syndrome","volume":"14","author":"C Suharti","year":"2003","journal-title":"European cytokine network"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1590\/S0074-02761994000200010","article-title":"Cytokine responses to dengue infection among Puerto Rican patients","volume":"89","author":"G Kuno","year":"1994","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"3185","DOI":"10.4049\/jimmunol.177.5.3185","article-title":"Dengue virus induces expression of CXC chemokine ligand 10\/IFN-gamma-inducible protein 10, which competitively inhibits viral binding to cell surface heparan sulfate","volume":"177","author":"JP Chen","year":"2006","journal-title":"J Immunol"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4269\/ajtmh.2012.11-0469","article-title":"A three-component biomarker panel for prediction of dengue hemorrhagic fever","volume":"86","author":"AR Brasier","year":"2012","journal-title":"The American journal of tropical medicine and hygiene"},{"issue":"1","key":"ref44","first-page":"3","article-title":"The Differences Between Interleukin-6 and C-reactive Protein Levels Among Adult Patients of Dengue Infection with and without Plasma Leakage","volume":"48","author":"Suhendro Eppy","year":"2016","journal-title":"Acta medica Indonesiana"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s00011-013-0667-3","article-title":"OxLDL-induced IL-1 beta secretion promoting foam cells formation was mainly via CD36 mediated ROS production leading to NLRP3 inflammasome activation","volume":"63","author":"W Liu","year":"2014","journal-title":"Inflammation research: official journal of the European Histamine Research Society"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.virol.2013.04.003","article-title":"The increase in cholesterol levels at early stages after dengue virus infection correlates with an augment in LDL particle uptake and HMG-CoA reductase activity","volume":"442","author":"R Soto-Acosta","year":"2013","journal-title":"Virology"},{"issue":"8","key":"ref47","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1161\/01.ATV.19.8.1891","article-title":"Crystallization of free cholesterol in model macrophage foam cells","volume":"19","author":"G Kellner-Weibel","year":"1999","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"7293","key":"ref48","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/nature08938","article-title":"NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals","volume":"464","author":"P Duewell","year":"2010","journal-title":"Nature"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0214245","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:40:35Z","timestamp":1589010035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0214245"}},"subtitle":[],"editor":[{"given":"Dong-Yan","family":"Jin","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,22]]},"references-count":48,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0214245","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,22]]}}}