{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T06:53:09Z","timestamp":1790837589108,"version":"4.1.0"},"reference-count":70,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/publicdomain\/zero\/1.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K99GM126147-01"],"award-info":[{"award-number":["1K99GM126147-01"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0214250","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T13:47:45Z","timestamp":1553780865000},"page":"e0214250","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":100,"title":["Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8878-0413","authenticated-orcid":true,"given":"Amanda H.","family":"Kahn-Kirby","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiko","family":"Amagata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celine I.","family":"Maeder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet J.","family":"Mei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Sideris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuko","family":"Kosaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Hinman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A.","family":"Malone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel J.","family":"Bruegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leslie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virna","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Shrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin G.","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joey C.","family":"Latham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Euan A.","family":"Ashley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew T.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Bertini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosalba","family":"Carrozzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Dionisi-Vici","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly A.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory M.","family":"Enns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Gahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynne","family":"Wolfe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Russell P.","family":"Saneto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon C.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey K.","family":"Trimmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew B.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles R.","family":"Holst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/S1474-4422(15)00148-9","article-title":"Mitochondrial dysfunction and seizures: The neuronal energy crisis","volume":"14","author":"G Zsurka","year":"2015","journal-title":"Lancet Neurol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1542\/peds.2006-1866","article-title":"Long-term Outcome and Clinical Spectrum of 73 Pediatric Patients With Mitochondrial Diseases","volume":"119","author":"F-G Debray","year":"2007","journal-title":"Pediatrics"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1055\/s-2008-1076737","article-title":"Epilepsy and respiratory chain defects in children with mitochondrial encephalopathies","volume":"39","author":"DS Khurana","year":"2008","journal-title":"Neuropediatrics"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1469-8749.2011.04214.x","article-title":"Mitochondrial disease and epilepsy.","volume":"54","author":"S Rahman","year":"2012","journal-title":"Dev Med Child Neurol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.cell.2017.09.021","article-title":"Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease","volume":"171","author":"BR Stockwell","year":"2017","journal-title":"Cell"},{"issue":"9\u201310","key":"ref6","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1101\/gad.314674.118","article-title":"Regulation of lipid peroxidation and ferroptosis in diverse species","volume":"32","author":"M Conrad","year":"2018","journal-title":"Genes Dev"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"497","DOI":"10.2174\/1568026013394741","article-title":"Oxytosis: A novel form of programmed cell death","volume":"1","author":"S Tan","year":"2001","journal-title":"Curr Top Med Chem"},{"issue":"April","key":"ref8","doi-asserted-by":"crossref","first-page":"214","DOI":"10.3389\/fnins.2018.00214","article-title":"Oxytosis\/Ferroptosis-(Re-) Emerging Roles for Oxidative Stress-Dependent Non-apoptotic Cell Death in Diseases of the Central Nervous System.","volume":"12","author":"J Lewerenz","year":"2018","journal-title":"Front Neurosci"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.cmet.2008.07.005","article-title":"Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12\/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death","volume":"8","author":"A Seiler","year":"2008","journal-title":"Cell Metab"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1016\/j.cell.2012.03.042","article-title":"Ferroptosis: An iron-dependent form of nonapoptotic cell death","volume":"149","author":"SJ Dixon","year":"2012","journal-title":"Cell"},{"key":"ref11","first-page":"1","article-title":"Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice","volume":"3","author":"JP Friedmann Angeli","year":"2014","journal-title":"Nat Cell Biol"},{"key":"ref12","first-page":"1","article-title":"Selenium Utilization by GPX4 Is Required to Prevent Hydroperoxide-Induced Ferroptosis","author":"I Ingold","year":"2017","journal-title":"Cell"},{"issue":"1\u20132","key":"ref13","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.cell.2013.12.010","article-title":"Regulation of ferroptotic cancer cell death by GPX4","volume":"156","author":"WS Yang","year":"2014","journal-title":"Cell"},{"key":"ref14","article-title":"ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition","author":"S Doll","year":"2016","journal-title":"Nat Chem Biol"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1038\/nchembio.2238","article-title":"Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis","volume":"13","author":"VE Kagan","year":"2016","journal-title":"Nat Chem Biol"},{"issue":"44","key":"ref16","doi-asserted-by":"crossref","first-page":"43508","DOI":"10.1074\/jbc.M307075200","article-title":"Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration","volume":"278","author":"S Khanna","year":"2003","journal-title":"J Biol Chem"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"e0201369","DOI":"10.1371\/journal.pone.0201369","article-title":"Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase.","volume":"13","author":"A Hinman","year":"2018","journal-title":"PLoS One"},{"key":"ref18","article-title":"Resolving the Role of Lipoxygenases in the Initiation and Execution of Ferroptosis.","author":"R Shah","year":"2018","journal-title":"ACS Cent Sci"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1016\/j.cell.2017.09.044","article-title":"PEBP1 Wardens Ferroptosis by Enabling Lipoxygenase Generation of Lipid Death Signals","volume":"171","author":"SE Wenzel","year":"2017","journal-title":"Cell"},{"issue":"7","key":"ref20","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1136\/jmedgenet-2013-102218","article-title":"Mutations in the enzyme glutathione peroxidase 4 cause Sedaghatian-type spondylometaphyseal dysplasia","volume":"51","author":"AC Smith","year":"2014","journal-title":"J Med Genet"},{"issue":"17","key":"ref21","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1002\/ajmg.a.31376","article-title":"Sedaghatian spondylometaphyseal dysplasia with pachygyria and absence of the corpus callosum","volume":"140A","author":"SJ English","year":"2006","journal-title":"Am J Med Genet A"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1002\/ajmg.a.35306","article-title":"Simplified gyral pattern with cerebellar hypoplasia in Sedaghatian type spondylometaphyseal dysplasia: A clinical report and review of the literature","volume":"158 A","author":"C Aygun","year":"2012","journal-title":"Am J Med Genet Part A"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1097\/NEN.0000000000000123","article-title":"Neuropathologic features of pontocerebellar hypoplasia type 6","volume":"73","author":"JT Joseph","year":"2014","journal-title":"J Neuropathol Exp Neurol"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/NEN.0000000000000209","article-title":"Neuropathologic Characterization of Pontocerebellar Hypoplasia Type 6 Associated With Cardiomyopathy and Hydrops Fetalis and Severe Multisystem Respiratory Chain Deficiency due to Novel RARS2 Mutations","volume":"74","author":"NZ Lax","year":"2015","journal-title":"J Neuropathol Exp Neurol"},{"key":"ref25","first-page":"1","article-title":"Dissecting the neuronal vulnerability underpinning Alpers\u2019 syndrome: a clinical and neuropathological study","author":"H Hayhurst","year":"2018","journal-title":"Brain Pathol"},{"issue":"9","key":"ref26","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1177\/088307380201700904","article-title":"Lipid peroxidation and antioxidative enzyme activities in childhood epilepsy","volume":"17","author":"D Turkdogan","year":"2002","journal-title":"J Child Neurol"},{"issue":"6","key":"ref27","doi-asserted-by":"crossref","first-page":"527","DOI":"10.2174\/1570159X12666140923205715","article-title":"Antioxidants as a preventive treatment for epileptic process: a review of the current status.","volume":"12","author":"B Martinc","year":"2014","journal-title":"Curr Neuropharmacol"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1086\/521227","article-title":"Deleterious Mutation in the Mitochondrial Arginyl\u2013Transfer RNA Synthetase Gene Is Associated with Pontocerebellar Hypoplasia","volume":"81","author":"S Edvardson","year":"2007","journal-title":"Am J Hum Genet"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/brain\/awq287","article-title":"Clinical, neuroradiological and genetic findings in pontocerebellar hypoplasia","volume":"134","author":"Y Namavar","year":"2011","journal-title":"Brain"},{"key":"ref30","article-title":"RARS2 Mutations: Is Pontocerebellar Hypoplasia Type 6 a Mitochondrial Encephalopathy?","author":"T van Dijk","year":"2017","journal-title":"JIMD Rep"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s10545-012-9487-9","article-title":"Pontocerebellar hypoplasia type 6 caused by mutations in RARS2: Definition of the clinical spectrum and molecular findings in five patients","volume":"36","author":"D Cassandrini","year":"2013","journal-title":"J Inherit Metab Dis"},{"issue":"7","key":"ref32","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/jhg.2015.31","article-title":"A novel mutation in the promoter of RARS2 causes pontocerebellar hypoplasia in two siblings","volume":"60","author":"Z Li","year":"2015","journal-title":"J Hum Genet"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1111\/epi.13358","article-title":"RARS2 mutations in a sibship with infantile spasms","volume":"57","author":"A Ngoh","year":"2016","journal-title":"Epilepsia"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"787956","DOI":"10.1155\/2014\/787956","article-title":"The Mitochondrial Aminoacyl tRNA Synthetases: Genes and Syndromes","volume":"2014","author":"D Diodato","year":"2014","journal-title":"Int J Cell Biol"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10545-011-9413-6","article-title":"Further delineation of pontocerebellar hypoplasia type 6 due to mutations in the gene encoding mitochondrial arginyl-tRNA synthetase, RARS2","volume":"35","author":"E Glamuzina","year":"2012","journal-title":"J Inherit Metab Dis"},{"issue":"1","key":"ref36","first-page":"140","article-title":"Novel homozygous RARS2 mutation in two siblings without pontocerebellar hypoplasia\u2014further expansion of the phenotypic spectrum. Orphanet J Rare Dis","volume":"11","author":"S L\u00fchl","year":"2016","journal-title":"Internet]"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.ejpn.2016.02.012","article-title":"RARS2 mutations cause early onset epileptic encephalopathy without ponto-cerebellar hypoplasia.","volume":"20","author":"D Nishri","year":"2016","journal-title":"Eur J Paediatr Neurol"},{"issue":"8","key":"ref38","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/ajmg.a.33531","article-title":"Pontocerebellar hypoplasia type 6: A British case with PEHO-like features","volume":"152","author":"J Rankin","year":"2010","journal-title":"Am J Med Genet Part A"},{"key":"ref39","first-page":"S110","article-title":"EPI-743 reduces seizure frequency in RARS2 defect syndrome","volume":"36","author":"D Martinelli","year":"2013","journal-title":"J Inherit Metab Dis"},{"issue":"18","key":"ref40","doi-asserted-by":"crossref","first-page":"1904","DOI":"10.1001\/jama.2011.613","article-title":"The NIH Undiagnosed Diseases Program: lessons learned","volume":"305","author":"WA Gahl","year":"2011","journal-title":"JAMA"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/gim.0b013e318232a005","article-title":"The National Institutes of Health Undiagnosed Diseases Program: insights into rare diseases","volume":"14","author":"WA Gahl","year":"2012","journal-title":"Genet Med"},{"issue":"4","key":"ref42","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ymgme.2016.01.007","article-title":"The NIH Undiagnosed Diseases Program and Network: Applications to modern medicine","volume":"117","author":"WA Gahl","year":"2016","journal-title":"Mol Genet Metab"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ajhg.2017.01.006","article-title":"The Undiagnosed Diseases Network: Accelerating Discovery about Health and Disease","volume":"100","author":"RB Ramoni","year":"2017","journal-title":"Am J Hum Genet"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.chembiol.2008.02.010","article-title":"Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells","volume":"15","author":"WS Yang","year":"2008","journal-title":"Chem Biol"},{"issue":"2","key":"ref45","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1021\/np020462l","article-title":"Exploring sponge-derived terpenoids for their potency and selectivity against 12-human, 15-human, and 15-soybean lipoxygenases","volume":"66","author":"T Amagata","year":"2003","journal-title":"J Nat Prod"},{"issue":"2","key":"ref46","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1006\/abio.1995.0063","article-title":"A colorimetric method for the determination of lipoxygenase activity suitable for use in a high throughput assay format","volume":"231","author":"NB Waslidge","year":"1995","journal-title":"Anal Biochem"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"e100001","DOI":"10.1371\/journal.pone.0100001","article-title":"Degree of Glutathione Deficiency and Redox Imbalance Depend on Subtype of Mitochondrial Disease and Clinical Status","volume":"9","author":"GM Enns","year":"2014","journal-title":"PLoS One"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1096\/fj.09-143974","article-title":"Neuronal selenoprotein expression is required for interneuron development and prevents seizures and neurodegeneration","volume":"24","author":"EK Wirth","year":"2010","journal-title":"FASEB J"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s12011-014-9920-z","article-title":"Cerebellar hypoplasia in mice lacking selenoprotein biosynthesis in neurons","volume":"158","author":"EK Wirth","year":"2014","journal-title":"Biol Trace Elem Res"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0390-17.2018","article-title":"Mitochondrial Ultrastructure Is Coupled to Synaptic Performance at Axonal Release Sites.","volume":"5","author":"C Cser\u00e9p","year":"2018","journal-title":"Eneuro"},{"issue":"10","key":"ref51","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1111\/j.1460-9568.2006.04814.x","article-title":"Populations of hippocampal inhibitory neurons express different levels of cytochrome c","volume":"23","author":"AI Guly\u00e1s","year":"2006","journal-title":"Eur J Neurosci"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1038\/jcbfm.2014.104","article-title":"Highly energized inhibitory interneurons are a central element for information processing in cortical networks","volume":"34","author":"O Kann","year":"2014","journal-title":"J Cereb Blood Flow Metab"},{"issue":"9","key":"ref53","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1038\/jcbfm.2013.94","article-title":"Cerebral Energy Metabolism and the Brain\u2019s Functional Network Architecture: An Integrative Review","volume":"33","author":"L-D Lord","year":"2013","journal-title":"J Cereb Blood Flow Metab"},{"issue":"4","key":"ref54","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.ajhg.2010.09.007","article-title":"Mutations disrupting selenocysteine formation cause progressive cerebello-cerebral atrophy","volume":"87","author":"O Agamy","year":"2010","journal-title":"Am J Hum Genet"},{"key":"ref55","article-title":"Consequences of mutations and inborn errors of selenoprotein biosynthesis and functions","author":"N Fradejas-Villar","year":"2018","journal-title":"Free Radic Biol Med"},{"issue":"4","key":"ref56","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1212\/WNL.0000000000001787","article-title":"Selenoprotein biosynthesis defect causes progressive encephalopathy with elevated lactate","volume":"85","author":"A-K Anttonen","year":"2015","journal-title":"Neurology"},{"issue":"3","key":"ref57","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s12011-014-0060-2","article-title":"Selenoproteins in nervous system development and function","volume":"161","author":"MW Pitts","year":"2014","journal-title":"Biol Trace Elem Res"},{"issue":"8755","key":"ref58","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1016\/0140-6736(91)93130-2","article-title":"Glutathione peroxidase deficiency and childhood seizures","volume":"337","author":"GF Weber","year":"1991","journal-title":"Lancet (London, England)"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1750-1172-6-50","article-title":"Classification, diagnosis and potential mechanisms in pontocerebellar hypoplasia.","volume":"6","author":"Y Namavar","year":"2011","journal-title":"Orphanet J Rare Dis"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"e2237","DOI":"10.1038\/cddis.2016.111","article-title":"Mitochondrial energy imbalance and lipid peroxidation cause cell death in Friedreich\u2019s ataxia","volume":"7","author":"R Abeti","year":"2016","journal-title":"Cell Death Dis"},{"issue":"10","key":"ref61","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.seizure.2012.09.003","article-title":"Oxidative stress in patients with epilepsy is independent of antiepileptic drugs.","volume":"21","author":"B Menon","year":"2012","journal-title":"Seizure"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.freeradbiomed.2013.01.003","article-title":"Oxidative damage to macromolecules in human Parkinson disease and the rotenone model","volume":"62","author":"LH Sanders","year":"2013","journal-title":"Free Radic Biol Med"},{"key":"ref63","doi-asserted-by":"crossref","DOI":"10.1177\/2326409817733012","article-title":"Epilepsy and Mitochondrial Dysfunction.","volume":"5","author":"RP Saneto","year":"2017","journal-title":"J Inborn Errors Metab Screen"},{"key":"ref64","article-title":"Correction to: Impaired Bioenergetics in Mutant Mitochondrial DNA Determines Cell Fate during Seizure-Like Activity","volume":"1","author":"S Kovac","year":"2018","journal-title":"Mol Neurobiol"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.redox.2017.08.015","article-title":"Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis.","volume":"14","author":"S Masaldan","year":"2018","journal-title":"Redox Biol"},{"key":"ref66","article-title":"Ferroptosis as a novel therapeutic target for Friedreich\u2019s ataxia","author":"MG Cotticelli","year":"2019","journal-title":"J Pharmacol Exp Ther"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.eplepsyres.2017.07.003","article-title":"Effects of antiepileptic drugs on mitochondrial functions, morphology, kinetics, biogenesis, and survival","volume":"136","author":"J Finsterer","year":"2017","journal-title":"Epilepsy Res"},{"issue":"1","key":"ref68","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s11011-006-9039-9","article-title":"Valproic acid aggravates epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA","volume":"22","author":"C-M Lin","year":"2007","journal-title":"Metab Brain Dis"},{"issue":"1","key":"ref69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13023-018-0822-6","article-title":"Severe hepatopathy and neurological deterioration after start of valproate treatment in a 6-year-old child with mitochondrial tryptophanyl-tRNA synthetase deficiency","volume":"13","author":"E Vantroys","year":"2018","journal-title":"Orphanet J Rare Dis"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ymgme.2011.10.009","article-title":"Initial experience in the treatment of inherited mitochondrial disease with EPI-743","volume":"105","author":"GM Enns","year":"2012","journal-title":"Mol Genet Metab"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0214250","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T18:41:59Z","timestamp":1588963319000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0214250"}},"subtitle":[],"editor":[{"given":"Giuseppe","family":"Biagini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":70,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0214250","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]}}}