{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T07:06:49Z","timestamp":1791875209742,"version":"4.3.4"},"reference-count":40,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0214421","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T17:46:51Z","timestamp":1553795211000},"page":"e0214421","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Genetic variation in CCR2 and CXCL12 genes impacts on CD4 restoration in patients initiating cART with advanced immunesupression"],"prefix":"10.1371","volume":"14","author":[{"given":"Clara","family":"Restrepo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Gutierrez-Rivas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yolanda M.","family":"Pacheco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcial","family":"Garc\u00eda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e0","family":"Blanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luz M.","family":"Medrano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda A.","family":"Navarrete-Mu\u00f1oz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e9lix","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Miralles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Dalmau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Luis","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"G\u00f3rgolas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfonso","family":"Cabello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8783-0450","authenticated-orcid":true,"given":"Salvador","family":"Resino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7172-049X","authenticated-orcid":true,"given":"Jos\u00e9 M.","family":"Benito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Rall\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"on behalf of CoRIS and the HIV Biobank integrated in the Spanish AIDS Research Network Project RIS\/EPICLIN 10_2015","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"issue":"3","key":"ref1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1086\/695852","article-title":"The absence of CD4+ T cell count recovery despite receipt of virologically suppressive highly active antiretroviral therapy: clinical risk, immunological gaps, and therapeutic options","volume":"48","author":"L Gazzola","year":"2009","journal-title":"Clin Infect Dis"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1086\/597093","article-title":"Incomplete peripheral CD4+ cell count restoration in HIV-infected patients receiving long-term antiretroviral treatment","volume":"48","author":"CF Kelley","year":"2009","journal-title":"Clin Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"670957","DOI":"10.1155\/2012\/670957","article-title":"Incomplete immune recovery in HIV infection: mechanisms, relevance for clinical care, and possible solutions","volume":"2012","author":"JC Gaardbo","year":"2012","journal-title":"Clin Dev Immunol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"e87160","DOI":"10.1371\/journal.pone.0087160","article-title":"Immuno-virological discordance and the risk of non-AIDS and AIDS events in a large observational cohort of HIV-patients","volume":"9","author":"A Zoufaly","year":"2014","journal-title":"Europe. PLoS One"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1086\/510746","article-title":"CD4+ cell count 6 years after commencement of highly active antiretroviral therapy in persons with sustained virologic suppression","volume":"44","author":"RD Moore","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1086\/651689","article-title":"Nadir CD4 T cell count as predictor and high CD4 T cell intrinsic apoptosis as final mechanism of poor CD4 T cell recovery in virologically suppressed HIV-infected patients: clinical implications","volume":"50","author":"E Negredo","year":"2010","journal-title":"Clin Infect Dis"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"e1001510","DOI":"10.1371\/journal.pmed.1001510","article-title":"Risk factors and outcomes for late presentation for HIV-positive persons in Europe: results from the Collaboration of Observational HIV Epidemiological Research Europe Study (COHERE)","volume":"10","author":"A Mocroft","year":"2013","journal-title":"PLoS Med"},{"issue":"15","key":"ref8","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1097\/QAD.0b013e32834640e6","article-title":"Old age and anti-cytomegalovirus immunity are associated with altered T-cell reconstitution in HIV-1-infected patients","volume":"25","author":"V Appay","year":"2011","journal-title":"AIDS"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1086\/432618","article-title":"Impact of hepatitis C virus on immune restoration in HIV-infected patients who start highly active antiretroviral therapy: a meta-analysis","volume":"41","author":"MF Miller","year":"2005","journal-title":"Clin Infect Dis"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1097\/QAD.0b013e328337b957","article-title":"CD4 T-cell hyperactivation and susceptibility to cell death determine poor CD4 T-cell recovery during suppressive HAART","volume":"24","author":"M Massanella","year":"2010","journal-title":"AIDS"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1471-2334-11-43","article-title":"High T-cell immune activation and immune exhaustion among individuals with suboptimal CD4 recovery after 4 years of antiretroviral therapy in an African cohort","volume":"11","author":"D Nakanjako","year":"2011","journal-title":"BMC Infect Dis"},{"issue":"9","key":"ref12","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1093\/cid\/cir552","article-title":"Reduced thymic output is a major mechanism of immune reconstitution failure in HIV-infected patients after long-term antiretroviral therapy","volume":"53","author":"T Li","year":"2011","journal-title":"Clin Infect Dis"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1086\/507313","article-title":"Immunogenetics of CD4 lymphocyte count recovery during antiretroviral therapy: An AIDS Clinical Trials Group study","volume":"194","author":"DW Haas","year":"2006","journal-title":"J Infect Dis"},{"issue":"11","key":"ref14","doi-asserted-by":"crossref","first-page":"e27349","DOI":"10.1371\/journal.pone.0027349","article-title":"KIR-HLA genotypes in HIV-infected patients lacking immunological recovery despite effective antiretroviral therapy","volume":"6","author":"A Soria","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1111\/eci.12539","article-title":"IL7RA polymorphisms predict the CD4+ recovery in HIV patients on cART","volume":"45","author":"M Guzm\u00e1n-Fulgencio","year":"2015","journal-title":"Eur J Clin Invest"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"e010998","DOI":"10.1136\/bmjopen-2015-010998","article-title":"Association of immune recovery with hyperlipidaemia and apolipoprotein gene polymorphisms following highly active antiretroviral therapy in a cohort of Chinese HIV patients","volume":"6","author":"DP Chan","year":"2016","journal-title":"BMJ Open"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.smim.2006.07.007","article-title":"Genetics of resistance to HIV infection: Role of co-receptors and co-receptor ligands","volume":"18","author":"F Arenzana-Seisdedos","year":"2006","journal-title":"Semin Immunol"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"782","DOI":"10.7326\/0003-4819-135-9-200111060-00008","article-title":"Effects of CCR5-Delta32, CCR2-64I, and SDF-1 3&apos;A alleles on HIV-1 disease progression: An international meta-analysis of individual-patient data","volume":"135","author":"JP Ioannidis","year":"2001","journal-title":"Ann Intern Med"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbrc.2010.04.095","article-title":"Role of chemokine and cytokine polymorphisms in the progression of HIV-1 disease","volume":"396","author":"SD Mahajan","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"issue":"15","key":"ref20","doi-asserted-by":"crossref","first-page":"10002","DOI":"10.1073\/pnas.142313799","article-title":"Modulating influence on HIV\/AIDS by interacting RANTES gene variants","volume":"99","author":"P An","year":"2002","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"5349","key":"ref21","first-page":"389","article-title":"Genetic restriction of AIDS pathogenesis by an SDF-1 chemokine gene variant. ALIVE Study, Hemophilia Growth and Development Study (HGDS), Multicenter AIDSCohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC).","volume":"279","author":"C Winkler","year":"1998","journal-title":"Science"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1086\/315650","article-title":"Shorter survival of SDF1-3&apos;A\/3&apos;A homozygotes linked to CD4+ T cell decrease in advanced human immunodeficiency virus type 1 infection","volume":"182","author":"A Brambilla","year":"2000","journal-title":"J Infect Dis"},{"issue":"5328","key":"ref23","first-page":"959","article-title":"Contrasting genetic influence of CCR2 and CCR5 variants on HIV-1 infection and disease progression. Hemophilia Growth and Development Study (HGDS), Multicenter AIDS Cohort Study (MACS), Multicenter Hemophilia Cohort Study (MHCS), San Francisco City Cohort (SFCC), ALIVE Study.","volume":"277","author":"MW Smith","year":"1997","journal-title":"Science"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00002030-200005050-00008","article-title":"Effect of chemokine receptor gene polymorphisms on the response to potent antiretroviral therapy","volume":"14","author":"TR O'Brien","year":"2000","journal-title":"AIDS"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/01.qai.0000188990.57760.e3","article-title":"Recovery of CD4+ T Cells in HIV patients with a stable virologic response to antiretroviral therapy is associated with polymorphisms of interleukin-6 and central major histocompatibility complex genes","volume":"41","author":"S Fernandez","year":"2006","journal-title":"J Acquir Immune Defic Syndr"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1089\/aid.2006.22.153","article-title":"Analysis of CCR5, CCR2, CX3CR1, and SDF1 polymorphisms in HIV-positive treated patients: impact on response to HAART and on peripheral T lymphocyte counts","volume":"22","author":"B Puissant","year":"2006","journal-title":"AIDS Res Hum Retroviruses"},{"key":"ref27","first-page":"23","article-title":"[Spanish cohort of na\u00efve HIV-infected patients (CoRIS): rationale, organization and initial results] In spanish.","volume":"25","author":"AM Caro-Murillo","year":"2007","journal-title":"Enferm Infecc Microbiol Clin"},{"issue":"9","key":"ref28","first-page":"645","article-title":"[The Cohort of the Spanish HIV Research Network (CoRIS) and its associated biobank; organizational issues, main findings and losses to follow-up] In spanish","volume":"29","author":"P Sobrino-Vegas","year":"2011","journal-title":"Enferm Infecc Microbiol Clin"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/1742-4690-6-27","article-title":"Spanish HIV BioBank. The Spanish HIV BioBank: a model of cooperative HIV research","volume":"6","author":"I Garc\u00eda-Merino","year":"2009","journal-title":"Retrovirology"},{"issue":"7571","key":"ref30","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"A Auton","year":"2015","journal-title":"Nature"},{"issue":"15","key":"ref31","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1093\/bioinformatics\/btl268","article-title":"SNPStats: a web tool for the analysis of association studies","volume":"22","author":"X Sol\u00e9","year":"2006","journal-title":"Bioinformatics"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1086\/423386","article-title":"CCR2 genotype and disease progression in a treated population of HIV type 1-infected women","volume":"39","author":"S Philpott","year":"2004","journal-title":"Clin Infect Dis"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.jcv.2004.05.021","article-title":"CCR2-64I and CXCL12 3&apos;A alleles confer a favorable prognosis to AIDS patients undergoing HAART therapy","volume":"34","author":"AM Passam","year":"2005","journal-title":"J Clin Virol"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"466","DOI":"10.2174\/157016208785861131","article-title":"Better CD4+ T cell recovery in Brazilian HIV-infected individuals under HAART due to cumulative carriage of SDF-1-3&apos;A, CCR2-V64I, CCR5-D32 and CCR5-promoter 59029A\/G polymorphisms","volume":"6","author":"PO Rigato","year":"2008","journal-title":"Curr HIV Res"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1128\/JVI.72.9.7450-7458.1998","article-title":"Influence of the CCR2-V64I polymorphism on human immunodeficiency virus type 1 coreceptor activity and on chemokine receptor function of CCR2b, CCR3, CCR5, and CXCR4","volume":"72","author":"B Lee","year":"1998","journal-title":"J Virol"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1038\/nm0398-350","article-title":"A chemokine receptor CCR2 allele delays HIV-1 disease progression and is associated with a CCR5 promoter mutation","volume":"4","author":"LG Kostrikis","year":"1998","journal-title":"Nat Med"},{"issue":"9","key":"ref37","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1086\/496893","article-title":"Stromal cell-derived factor-1 genotype, coreceptor tropism, and HIV type 1 disease progression","volume":"192","author":"ES Daar","year":"2005","journal-title":"J Infect Dis"},{"issue":"6594","key":"ref38","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/382833a0","article-title":"The CXC chemokine SDF-1 is the ligand for LESTR\/fusin and prevents infection by T-cell-line-adapted HIV-1","volume":"382","author":"E Oberlin","year":"1996","journal-title":"Nature"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s10238-012-0194-5","article-title":"CXCL12, CXCR4 and IFN\u03b3 genes expression: implications for proinflammatory microenvironment of breast cancer","volume":"13","author":"KB de Oliveira","year":"2013","journal-title":"Clin Exp Med"},{"issue":"7","key":"ref40","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1086\/343741","article-title":"Plasma stromal cell-derived factor (SDF)-1 levels, SDF1-3&apos;A genotype, and expression of CXCR4 on T lymphocytes: their impact on resistance to human immunodeficiency virus type 1 infection and its progression","volume":"186","author":"A Soriano","year":"2002","journal-title":"J Infect Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0214421","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,4]],"date-time":"2020-12-04T09:19:01Z","timestamp":1607073541000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0214421"}},"subtitle":[],"editor":[{"given":"Golo","family":"Ahlenstiel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":40,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0214421","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]}}}