{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:16:36Z","timestamp":1770815796633,"version":"3.50.1"},"reference-count":32,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T00:00:00Z","timestamp":1553472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0214437","type":"journal-article","created":{"date-parts":[[2019,3,25]],"date-time":"2019-03-25T17:39:26Z","timestamp":1553535566000},"page":"e0214437","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":7,"title":["NLRX1 does not play a role in diabetes nor the development of diabetic nephropathy induced by multiple low doses of streptozotocin"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9303-6042","authenticated-orcid":true,"given":"Angelique M. L.","family":"Scantlebery","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa","family":"Uil","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loes M.","family":"Butter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ren\u00e9e","family":"Poelman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nike","family":"Claessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen E.","family":"Girardin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandrine","family":"Florquin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joris J. T. H.","family":"Roelofs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaklien C.","family":"Leemans","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2019,3,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.diabres.2008.08.024","article-title":"Progression of diabetic nephropathy in type 1 diabetic patients","volume":"83","author":"B Najafian","year":"2009","journal-title":"Diabetes Res Clin Pract"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1007\/s00125-003-1194-5","article-title":"Diabetic nephropathy is associated with low-grade inflammation in Type 1 diabetic patients","volume":"46","author":"M Saraheimo","year":"2003","journal-title":"Diabetologia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2174\/1389450115666140321120635","article-title":"Oxidative stress: meeting multiple targets in pathogenesis of diabetic nephropathy","volume":"15","author":"MK Arora","year":"2014","journal-title":"Curr Drug Targets"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2174\/1871529X11202020106","article-title":"Mitochondrial dysfunction, oxidative stress and diabetic cardiovascular disorders","volume":"12","author":"GX Shen","year":"2012","journal-title":"Cardiovasc Hematol Disord Drug Targets"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s10157-013-0898-1","article-title":"Treatment and impact of dyslipidemia in diabetic nephropathy","volume":"18","author":"T Toyama","year":"2014","journal-title":"Clin Exp Nephrol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"193757","DOI":"10.1155\/2013\/193757","article-title":"The role of autophagy in the pathogenesis of diabetic nephropathy","volume":"2013","author":"K Yamahara","year":"2013","journal-title":"J Diabetes Res"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1159\/000320749","article-title":"Rapid progression of diabetic nephropathy is linked to inflammation and episodes of acute renal failure","volume":"32","author":"KJ Kelly","year":"2010","journal-title":"Am J Nephrol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.1093\/ndt\/gfh207","article-title":"NF-kappaB activation and overexpression of regulated genes in human diabetic nephropathy","volume":"19","author":"S Mezzano","year":"2004","journal-title":"Nephrol Dial Transplant"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1038\/nrneph.2014.91","article-title":"Pattern recognition receptors and the inflammasome in kidney disease","volume":"10","author":"JC Leemans","year":"2014","journal-title":"Nat Rev Nephrol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1681\/ASN.2010111210","article-title":"Toll-like receptor 4 promotes tubular inflammation in diabetic nephropathy","volume":"23","author":"M Lin","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/1755-1536-3-23","article-title":"Toll-like receptor 2 agonists inhibit human fibrocyte differentiation","volume":"3","author":"AS Maharjan","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0168-8227(99)00044-3","article-title":"Pathogenesis of diabetic nephropathy: the role of oxidative stress and protein kinase C","volume":"45","author":"H Ha","year":"1999","journal-title":"Diabetes Res Clin Pract"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4256","DOI":"10.2174\/092986710793348581","article-title":"Oxidative stress in diabetic nephropathy","volume":"17","author":"N Kashihara","year":"2010","journal-title":"Curr Med Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1242\/jcs.051193","article-title":"An N-terminal addressing sequence targets NLRX1 to the mitochondrial matrix","volume":"122","author":"D Arnoult","year":"2009","journal-title":"J Cell Sci"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nature06501","article-title":"NLRX1 is a regulator of mitochondrial antiviral immunity","volume":"451","author":"CB Moore","year":"2008","journal-title":"Nature"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.embor.7401161","article-title":"NLRX1 is a mitochondrial NOD-like receptor that amplifies NF-kappaB and JNK pathways by inducing reactive oxygen species production","volume":"9","author":"I Tattoli","year":"2008","journal-title":"EMBO Rep"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1084\/jem.20161031","article-title":"NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity","volume":"214","author":"G Stokman","year":"2017","journal-title":"J Exp Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1177\/1753425912467383","article-title":"NLRX1 does not inhibit MAVS-dependent antiviral signalling","volume":"19","author":"F Soares","year":"2013","journal-title":"Innate Immun"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"36","DOI":"10.4239\/wjd.v1.i2.36","article-title":"Surrogate markers of insulin resistance: A review","volume":"1","author":"B Singh","year":"2010","journal-title":"World J Diabetes"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0304-3940(02)01423-4","article-title":"Assumption-free analysis of quantitative real-time polymerase chain reaction (PCR) data","volume":"339","author":"C Ramakers","year":"2003","journal-title":"Neurosci Lett. Elsevier"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1042\/CS20130267","article-title":"Role of Toll-like receptors in diabetic nephropathy","volume":"126","author":"H Mudaliar","year":"2014","journal-title":"Clin Sci (Lond)"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1681\/ASN.2009070721","article-title":"Mouse Models of Diabetic Nephropathy","volume":"20","author":"FC Brosius","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"5542","DOI":"10.1038\/s41598-018-23839-9","article-title":"Combining streptozotocin and unilateral nephrectomy is an effective method for inducing experimental diabetic nephropathy in the \u201cresistant\u201d C57Bl\/6J mouse strain","volume":"8","author":"M Uil","year":"2018","journal-title":"Sci Rep"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1900","DOI":"10.1093\/ndt\/15.12.1900","article-title":"Nephropathy of type 1 and type 2 diabetes: diverse pathophysiology, same treatment?","volume":"15","author":"P Ruggenenti","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.bbadis.2018.03.003","article-title":"Deletion of NLRX1 increases fatty acid metabolism and prevents diet-induced hepatic steatosis and metabolic syndrome","volume":"1864","author":"L Kors","year":"2018","journal-title":"Biochim Biophys Acta"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1210\/js.2017-00360","article-title":"Male Mice Lacking NLRX1 Are Partially Protected From High-Fat Diet\u2013Induced Hyperglycemia","volume":"2","author":"SR Costford","year":"2018","journal-title":"J Endocr Soc"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1084\/jem.180.3.995","article-title":"Effect of tumor necrosis factor alpha on insulin-dependent diabetes mellitus in NOD mice. I. The early development of autoimmunity and the diabetogenic process","volume":"180","author":"XD Yang","year":"1994","journal-title":"J Exp Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"15995","DOI":"10.1073\/pnas.0508122102","article-title":"The role of TNF- in the pathogenesis of type 1 diabetes in the nonobese diabetic mouse: Analysis of dendritic cell maturation","volume":"102","author":"L-F Lee","year":"2005","journal-title":"Proc Natl Acad Sci"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.2174\/156802606778194217","article-title":"Anti-TNF-alpha antibody therapies in autoimmune diseases","volume":"6","author":"K Chatzantoni","year":"2006","journal-title":"Curr Top Med Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/eji.201445427","article-title":"Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal","volume":"46","author":"EL Mills","year":"2016","journal-title":"Eur J Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/j.celrep.2016.09.085","article-title":"A Metabolic Roadblock in Inflammatory Macrophages","volume":"17","author":"LAJ O\u2019Neill","year":"2016","journal-title":"Cell Rep"},{"key":"ref32","article-title":"The molecular machinery of Keilin\u2019s respiratory chain An historical perspective","author":"PR Rich","year":"2003","journal-title":"The molecular machinery of Keilin\u2019s respiratory chain An historical perspective"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0214437","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:19:21Z","timestamp":1589001561000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0214437"}},"subtitle":[],"editor":[{"given":"Partha","family":"Mukhopadhyay","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,25]]},"references-count":32,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0214437","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,25]]}}}