{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:37:51Z","timestamp":1791837471884,"version":"4.3.4"},"reference-count":52,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T00:00:00Z","timestamp":1553731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0214468","type":"journal-article","created":{"date-parts":[[2019,3,28]],"date-time":"2019-03-28T13:49:45Z","timestamp":1553780985000},"page":"e0214468","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":56,"title":["Low-grade inflammation is negatively associated with physical Health-Related Quality of Life in healthy individuals: Results from The Danish Blood Donor Study (DBDS)"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1881-5673","authenticated-orcid":true,"given":"Khoa Manh","family":"Dinh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrine Agerg\u00e5rd","family":"Kaspersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Mikkelsen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ole Birger","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkel Steen","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lise Wegner","family":"Th\u00f8rner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Hjalgrim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Rostgaard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Ullum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Erikstrup","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,3,28]]},"reference":[{"issue":"12","key":"ref1","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.1172\/JCI200318921","article-title":"C-reactive protein: a critical update","volume":"111","author":"MB Pepys","year":"2003","journal-title":"J Clin Invest"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1373\/49.4.666","article-title":"Population Distributions of C-reactive Protein in Ap- parently Healthy Men and Women in the United States: Implication for Clinical Interpretation","volume":"49","author":"N Rifai","year":"2003","journal-title":"Clin Chem"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1373\/49.4.669","article-title":"Distributions of C-reactive Protein Measured by High-Sensitivity Assays in Apparently Healthy Men and Women from Different Populations in Europe","volume":"49","author":"A Imhof","year":"2003","journal-title":"Clin Chem"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"155","DOI":"10.3109\/10408363.2011.599831","article-title":"Elevated C-reactive protein in the diagnosis, prognosis, and cause of cancer","volume":"48","author":"KH Allin","year":"2011","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/j.jacc.2007.06.012","article-title":"C-Reactive Protein Gene Polymorphisms, C-Reactive Protein Blood Levels, and Cardiovascular Disease Risk","volume":"50","author":"FG Hage","year":"2007","journal-title":"J Am Coll Cardiol"},{"issue":"9709","key":"ref6","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0140-6736(09)61717-7","article-title":"C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis","volume":"375","author":"S Kaptoge","year":"2010","journal-title":"Lancet"},{"issue":"8","key":"ref7","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1002\/art.20431","article-title":"Increased levels of C-reactive protein in serum from blood donors before the onset of rheumatoid arthritis","volume":"50","author":"MMJ Nielen","year":"2004","journal-title":"Arthritis Rheum"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1002\/ijc.23606","article-title":"C-reactive protein and colorectal cancer risk: a systematic review of prospective studies","volume":"123","author":"KK Tsilidis","year":"2008","journal-title":"Int J Cancer J Int Cancer"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.blre.2012.12.001","article-title":"C-reactive protein and atherothrombosis: Cause or effect?","volume":"27","author":"E Grad","year":"2013","journal-title":"Blood Rev"},{"issue":"14","key":"ref10","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1056\/NEJMoa1107477","article-title":"Fibrinogen, and Cardiovascular Disease Prediction","volume":"367","author":"C-Reactive Protein","year":"2012","journal-title":"N Engl J Med"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1080\/02813430903020446","article-title":"The impact of changes in self-rated general health on 28-year mortality among middle-aged Danes","volume":"27","author":"ABS Nielsen","year":"2009","journal-title":"Scand J Prim Health Care"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1288.e1","DOI":"10.1016\/j.jclinepi.2007.03.004","article-title":"The health-related quality-of-life impact of chronic conditions varied with age in general population","volume":"60","author":"SI Saarni","year":"2007","journal-title":"J Clin Epidemiol"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.psychres.2006.11.005","article-title":"Validity of the mental health component scale of the 12-item Short-Form Health Survey (MCS-12) as measure of common mental disorders in the general population","volume":"152","author":"SC Gill","year":"2007","journal-title":"Psychiatry Res"},{"issue":"03","key":"ref14","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1017\/thg.2013.21","article-title":"Heritability of Health-Related Quality of Life: SF-12 Summary Scores in a Population-Based Nationwide Twin Cohort","volume":"16","author":"T Steenstrup","year":"2013","journal-title":"Twin Res Hum Genet"},{"key":"ref15","article-title":"Health-related quality of life among general practice patients with differing chronic diseases in Germany: Cross sectional survey","author":"H-M Wang","year":"2008","journal-title":"BMC Public Health"},{"key":"ref16","first-page":"423","article-title":"Self rated health as a predictor of coronary heart disease in Copenhagen","volume":"50","author":"L M\u00f8ller","year":"1996"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1177\/1359105311435428","article-title":"Inflammation and positive affect are associated with subjective health in women of the general population","volume":"18","author":"AN Andreasson","year":"2013","journal-title":"J Health Psychol"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bbi.2005.01.001","article-title":"Self-rated health and vital exhaustion, but not depression, is related to inflammation in women with coronary heart disease","volume":"19","author":"I Janszky","year":"2005","journal-title":"Brain Behav Immun"},{"issue":"4","key":"ref19","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/01.psy.0000130491.95823.94","article-title":"Self-rated Health Is Related to Levels of Circulating Cytokines","volume":"66","author":"M Lekander","year":"2004","journal-title":"Psychosom Med"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1042\/CS20060128","article-title":"Inflammatory cytokines, behaviour and age as determinants of self-rated health in women","volume":"112","author":"A-L Und\u00e9n","year":"2007","journal-title":"Clin Sci"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1016\/j.psyneuen.2011.04.003","article-title":"Poorer self-rated health is associated with elevated inflammatory markers among older adults","volume":"36","author":"LM Christian","year":"2011","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"ref22","doi-asserted-by":"crossref","first-page":"M201","DOI":"10.1093\/gerona\/52A.4.M201","article-title":"The association of plasma IL-6 levels with functional disability in community-dwelling elderly","volume":"52","author":"HJ Cohen","year":"1997","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.jpsychores.2012.05.013","article-title":"Poor self-rated health is significantly associated with elevated C-reactive protein levels in women, but not in men, in the Japanese general population","volume":"73","author":"K Tanno","year":"2012","journal-title":"J Psychosom Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.bbi.2013.10.020","article-title":"Self-rated health and C-reactive protein in young adults","volume":"36","author":"L Shanahan","year":"2014","journal-title":"Brain Behav Immun"},{"issue":"4","key":"ref25","first-page":"213","article-title":"Self-rated health is associated with elevated C-reactive protein even among apparently healthy individuals","volume":"17","author":"E Leshem-Rubinow","year":"2015","journal-title":"Isr Med Assoc J IMAJ"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"e009440","DOI":"10.1136\/bmjopen-2015-009440","article-title":"Is poor self-rated health associated with low-grade inflammation in 43 110 late adolescent men of the general population? A cross-sectional study","volume":"6","author":"C Warnoff","year":"2016","journal-title":"BMJ Open"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"e88196","DOI":"10.1371\/journal.pone.0088196","article-title":"Combined Oral Contraception and Obesity Are Strong Predictors of Low-Grade Inflammation in Healthy Individuals: Results from the Danish Blood Donor Study (DBDS)","volume":"9","author":"CJ S\u00f8rensen","year":"2014","journal-title":"PLoS ONE"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1097\/EDE.0000000000000301","article-title":"Obesity and Risk of Infection: Results from the Danish Blood Donor Study","volume":"26","author":"KA Kaspersen","year":"2015","journal-title":"Epidemiology"},{"issue":"3 Pt 2","key":"ref29","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1111\/trf.12518","article-title":"Predictors of iron levels in 14,737 Danish blood donors: results from the Danish Blood Donor Study","volume":"54","author":"AS Rigas","year":"2014","journal-title":"Transfusion (Paris)"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1423-0410.2011.01553.x","article-title":"The Danish Blood Donor Study: a large, prospective cohort and biobank for medical research","volume":"102","author":"OB Pedersen","year":"2012","journal-title":"Vox Sang"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.jclinepi.2004.06.005","article-title":"A simple imputation algorithm reduced missing data in SF-12 health surveys","volume":"58","author":"TV Perneger","year":"2005","journal-title":"J Clin Epidemiol"},{"issue":"03","key":"ref32","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1017\/thg.2013.21","article-title":"Heritability of Health-Related Quality of Life: SF-12 Summary Scores in a Population-Based Nationwide Twin Cohort","volume":"16","author":"T Steenstrup","year":"2013","journal-title":"Twin Res Hum Genet"},{"key":"ref33","article-title":"Danish SF-36 manual\u2014a health status questionnaire","author":"JB Bj\u00f8rner","year":"2003"},{"issue":"11","key":"ref34","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1016\/S0895-4356(98)00109-7","article-title":"Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. International Quality of Life Assessment","volume":"51","author":"B Gandek","year":"1998","journal-title":"J Clin Epidemiol"},{"key":"ref35","unstructured":"SF-36\/SF-12 webpage: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sf-36.org\/tools\/sf12.shtml\" xlink:type=\"simple\">http:\/\/www.sf-36.org\/tools\/sf12.shtml<\/ext-link>."},{"issue":"10","key":"ref36","doi-asserted-by":"crossref","first-page":"e0164220","DOI":"10.1371\/journal.pone.0164220","article-title":"Low-Grade Inflammation Is Associated with Susceptibility to Infection in Healthy Men: Results from the Danish Blood Donor Study (DBDS)","volume":"11","author":"KA ard Kaspersen","year":"2016","journal-title":"PloS One"},{"issue":"4","key":"ref37","doi-asserted-by":"crossref","first-page":"e36062","DOI":"10.1371\/journal.pone.0036062","article-title":"Gender, Obesity and Repeated Elevation of C-Reactive Protein: Data from the CARDIA Cohort","volume":"7","author":"S Ishii","year":"2012","journal-title":"PLoS ONE"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1093\/aje\/kwr525","article-title":"A Simple Unified Approach for Estimating Natural Direct and Indirect Effects","volume":"176","author":"T Lange","year":"2012","journal-title":"Am J Epidemiol"},{"issue":"2","key":"ref39","doi-asserted-by":"crossref","first-page":"e88196","DOI":"10.1371\/journal.pone.0088196","article-title":"Combined Oral Contraception and Obesity Are Strong Predictors of Low-Grade Inflammation in Healthy Individuals: Results from the Danish Blood Donor Study (DBDS)","volume":"9","author":"CJ S\u00f8rensen","year":"2014","journal-title":"PLoS ONE"},{"issue":"5","key":"ref40","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1373\/clinchem.2012.201939","article-title":"Low Plasma 25-Hydroxyvitamin D and Risk of Tobacco-Related Cancer","volume":"59","author":"S Afzal","year":"2013","journal-title":"Clin Chem"},{"key":"ref41","unstructured":"MIT LIV\u2014MIN SUNDHED 2007\u20132009. Available: \/\/<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.laengelevekbh.kk.dk\/Sundhed\/~\/media\/folkesundhed\/Files\/Arbejdspladser\/Vaerktoejssamlingmitlivminsundhed.ashx\" xlink:type=\"simple\">www.laengelevekbh.kk.dk\/Sundhed\/~\/media\/folkesundhed\/Files\/Arbejdspladser\/Vaerktoejssamlingmitlivminsundhed.ashx<\/ext-link>. Accessed November 2009."},{"key":"ref42","unstructured":"F\u00f8devarestyrelsen. Tips om fisk. Ministeriet for familie- og forbrugeranliggender. F\u00f8devarestyrelsen. Available <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.foedevarestyrelsen.dk\/Publikationer\/Alle%20publikationer\/2005208.pdf\" xlink:type=\"simple\">http:\/\/www.foedevarestyrelsen.dk\/Publikationer\/Alle%20publikationer\/2005208.pdf<\/ext-link>. Accessed February 2005."},{"issue":"11","key":"ref43","doi-asserted-by":"crossref","first-page":"2751","DOI":"10.1161\/01.STR.31.11.2751","article-title":"AHA Dietary Guidelines: revision 2000: A statement for healthcare professionals from the Nutrition Committee of the American Heart Association","volume":"31","author":"RM Krauss","year":"2000","journal-title":"Stroke J Cereb Circ"},{"issue":"9","key":"ref44","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1016\/j.rmed.2009.04.003","article-title":"Elevated ACE activity is not associated with asthma, COPD, and COPD co-morbidity","volume":"103","author":"J Lee","year":"2009","journal-title":"Respir Med"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1111\/trf.13085","article-title":"No association between iron status and self-reported health-related quality of life in 16,375 Danish blood donors: results from the Danish Blood Donor Study","volume":"55","author":"AS Rigas","year":"2015","journal-title":"Transfusion (Paris)"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"b2393","DOI":"10.1136\/bmj.b2393","article-title":"Multiple imputation for missing data in epidemiological and clinical research: potential and pitfalls","volume":"338","author":"JAC Sterne","year":"2009","journal-title":"BMJ"},{"issue":"14","key":"ref47","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1056\/NEJMsr1203730","article-title":"The prevention and treatment of missing data in clinical trials","volume":"367","author":"RJ Little","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"ref48","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1348\/1359107042304533","article-title":"Subjective health and fibrinogen in a healthy Chinese cohort","volume":"9","author":"R Fielding","year":"2004","journal-title":"Br J Health Psychol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1093\/eurpub\/ckl070","article-title":"Socioeconomic conditions, lifestyle factors, and self-rated health among men and women in Sweden","volume":"17","author":"A Molarius","year":"2007","journal-title":"Eur J Public Health"},{"issue":"2","key":"ref50","doi-asserted-by":"crossref","first-page":"318","DOI":"10.2105\/AJPH.93.2.318","article-title":"Relation of dietary quality, physical activity, and smoking habits to 10-year changes in health status in older Europeans in the SENECA study","volume":"93","author":"A Haveman-Nies","year":"2003","journal-title":"Am J Public Health"},{"issue":"8","key":"ref51","first-page":"1019","article-title":"Paradoxical Trend for Improvement in Mental Health With Aging: A Community-Based Study of 1,546 Adults Aged 21\u2013100 Years","volume":"77","author":"ML Thomas","year":"2016"},{"issue":"16","key":"ref52","doi-asserted-by":"crossref","first-page":"7246","DOI":"10.1073\/pnas.1001715107","article-title":"Reasoning about social conflicts improves into old age","volume":"107","author":"I Grossmann","year":"2010","journal-title":"Proc Natl Acad Sci"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0216339","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2019,5,28]],"date-time":"2019-05-28T00:00:00Z","timestamp":1559001600000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0214468","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T09:24:01Z","timestamp":1589016241000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0214468"}},"subtitle":[],"editor":[{"given":"Pedro","family":"Tauler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,3,28]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0214468","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,3,28]]}}}