{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:52:44Z","timestamp":1792788764623,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T00:00:00Z","timestamp":1561507200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"A second collaborative program to improve the health research capacity of western medical universities in China and Prince of Songkla University"},{"name":"Guizhou innovative talent foundation","award":["2016-4015"],"award-info":[{"award-number":["2016-4015"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0214779","type":"journal-article","created":{"date-parts":[[2019,6,26]],"date-time":"2019-06-26T13:29:14Z","timestamp":1561555754000},"page":"e0214779","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":86,"title":["Clinical pattern of antibiotic overuse and misuse in primary healthcare hospitals in the southwest of China"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7411-2441","authenticated-orcid":true,"given":"Yue","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarunyou","family":"Chusri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rassamee","family":"Sangthong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward","family":"McNeil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingying","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanni","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-4463","authenticated-orcid":true,"given":"Virasakdi","family":"Chongsuvivatwong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,6,26]]},"reference":[{"key":"ref1","unstructured":"World Health Organization. Antibiotic prescribing and resistance: Views from low- and middle-income prescribing and dispensing professionals. 2017. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.who.int\/antimicrobial-resistance\/LSHTM-Antibiotic-Prescribing-LMIC-Prescribing-and-Dispensing-2017.pdf\" xlink:type=\"simple\">https:\/\/www.who.int\/antimicrobial-resistance\/LSHTM-Antibiotic-Prescribing-LMIC-Prescribing-and-Dispensing-2017.pdf<\/ext-link>"},{"key":"ref2","unstructured":"Center for Disease Dynamics. Economics &amp; Policy, State of the World\u2019s Antibiotics. 2015. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/cddep.org\/publications\/state_worlds_antibiotics_2015\/\" xlink:type=\"simple\">https:\/\/cddep.org\/publications\/state_worlds_antibiotics_2015\/<\/ext-link>"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"e0196668","DOI":"10.1371\/journal.pone.0196668","article-title":"Consumption of antibiotics in Chinese public general tertiary hospitals (2011\u20132014): Trends, pattern changes and regional differences","volume":"13","author":"Q Xiaoyuan","year":"2018","journal-title":"PloS One"},{"issue":"8","key":"ref4","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1016\/S1473-3099(14)70780-7","article-title":"Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data","volume":"14","author":"TP Van Boeckel","year":"2014","journal-title":"Lancet Infection Diseases"},{"issue":"5","key":"ref5","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1377\/hlthaff.2010.0965","article-title":"Overprescribing In China, Driven By Financial Incentives, Results In Very High Use Of Antibiotics, Injections, And Corticosteroids","volume":"31","author":"L Yongbin","year":"2012","journal-title":"Health Affairs"},{"issue":"1999","key":"ref6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0168-8510(99)00026-3","article-title":"Association between health insurance and antibiotics prescribing in four counties in rural China","volume":"48","author":"H Dong","year":"1999","journal-title":"Health Policy"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ijantimicag.2016.06.017","article-title":"Retrospective survey of the efficacy of mandatory implementation of the Essential Medicine Policy in the primary healthcare setting in China: failure to promote the rational use of antibiotics in clinics","volume":"48","author":"YH Xiao","year":"2016","journal-title":"International Journal of Antimicrobial Agents"},{"key":"ref8","first-page":"2015","article-title":"China Health and Family Planning Statistics Yearbook, 2015\u20132017"},{"issue":"12","key":"ref9","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1001\/jamainternmed.2014.5214","article-title":"Use and prescription of antibiotics in primary health care settings in China","volume":"174","author":"J Wang","year":"2014","journal-title":"JAMA Internal Medicine"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2199","DOI":"10.2147\/IDR.S170349","article-title":"Antibiotic prescriptions to adults with acute respiratory tract infections by Italian general practitioners","volume":"11","author":"A Bianco","year":"2018","journal-title":"Infection Drug Resistance"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1111\/idj.12287","article-title":"Worldwide pattern of antibiotic prescription in endodontic infections","volume":"67","author":"JJ Segura-Egea","year":"2017","journal-title":"International Dental Journal"},{"issue":"26","key":"ref12","first-page":"454","article-title":"Outpatient Antibiotic Prescription","volume":"113","author":"J Batzing-Feigenbaum","year":"2016","journal-title":"Deutsches Arzteblatt International"},{"key":"ref13","unstructured":"World Health Organization, International Statistical Classification of Diseases and Related Health Problems 10th Revision (ICD-10)-2014-WHO Version for 2014. Geneva, Switzerland: WHO. 2014. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/classifications\/icd10\/\" xlink:type=\"simple\">http:\/\/apps.who.int\/classifications\/icd10\/<\/ext-link> browse\/2014\/en#\/X; [accessed 13.04.15]."},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1016\/j.ijantimicag.2016.09.008","article-title":"Antimicrobial prescribing patterns in a large tertiary hospital in Shanghai, China","volume":"48","author":"YY Wang","year":"2016","journal-title":"International Journal of Antimicrobial Agents"},{"key":"ref15","unstructured":"Centers for Disease Control and Prevention. Antibiotic Prescribing and Use in Doctor\u2019s Offices. 2017. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cdc.gov\/antibiotic-use\/community\/for-hcp\/outpatient-hcp\/adult-treatment-rec.html\" xlink:type=\"simple\">https:\/\/www.cdc.gov\/antibiotic-use\/community\/for-hcp\/outpatient-hcp\/adult-treatment-rec.html<\/ext-link>."},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1017\/ice.2018.26","article-title":"Outpatient Antibiotic Prescription Trends in the United States: A National Cohort Study","volume":"39","author":"MJ Durkin","year":"2018","journal-title":"Infection Control and Hospital Epidemiology"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1371\/journal.pone.0181957","article-title":"Antibiotic prescriptions for outpatient acute rhinosinusitis in Canada, 2007\u20132013","volume":"12","author":"P Sharma","year":"2017","journal-title":"PLoS One"},{"issue":"2017","key":"ref18","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.ijid.2016.12.004","article-title":"Antibiotic prescription patterns for upper respiratory tract infections in the outpatient Qatari population in the private sector","volume":"55","author":"AA Butt","year":"2017","journal-title":"Intional Journal of Infectious Diseases"},{"issue":"6","key":"ref19","article-title":"Overuse of antibiotics for the common cold\u2014attitudes and behaviors among doctors in rural areas of Shandong Province, China. Bmc Pharmacology &amp;","volume":"16","author":"Q Sun","year":"2015","journal-title":"Toxicology"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1080\/02813432.2017.1333301","article-title":"Antibiotic prescribing for acute respiratory tract infections in Norwegian primary care out-of-hours service","volume":"35","author":"BH Lindberg","year":"2017","journal-title":"Scandinavian Journal of Primary Health Care"},{"key":"ref21","unstructured":"Centers for Disease Control and Prevention. Antibiotic Prescribing and Use. 2018. URL <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/www.cdc.gov\/antibiotic-use\/index.html\" xlink:type=\"simple\">https:\/\/www.cdc.gov\/antibiotic-use\/index.html<\/ext-link>."},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"e0117710","DOI":"10.1371\/journal.pone.0117710","article-title":"Systematic Review on Irrational Use of Medicines in China and Vietnam","volume":"10","author":"W Mao","year":"2015","journal-title":"PLOS ONE"},{"issue":"1","key":"ref23","first-page":"55","article-title":"Pattern of prescribing practices in the Madhya Pradesh, India","volume":"6","author":"SS Bhartiy","year":"2008","journal-title":"Kathmandu University Medical Journal"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"120","DOI":"10.3346\/jkms.2012.27.2.120","article-title":"Factors Affecting the Prescribing Patterns of Antibiotics and Injections","volume":"27","author":"KH Choi","year":"2012","journal-title":"Journal of Korean Medical Science"},{"issue":"10","key":"ref25","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/S1473-3099(04)01145-4","article-title":"How antibiotics can make us sick: the less obvious adverse effects of antimicrobial chemotherapy","volume":"4","author":"SJ Dancer","year":"2004","journal-title":"Lancet Infectious Diseases"},{"issue":"7","key":"ref26","first-page":"1420","article-title":"Changes in Antibiotic Resistance Patterns of Conjunctival Flora Due to Repeated Use of Topical Antibiotics after Intravitreal Injection","volume":"119","author":"E Milder","year":"2012","journal-title":"Antibiotic Resistance Patterns of Conjunctival Flora"},{"issue":"12","key":"ref27","doi-asserted-by":"crossref","first-page":"e84177","DOI":"10.1371\/journal.pone.0084177","article-title":"Public Knowledge, Attitudes, and Experience Regarding the Use of Antibiotics in Italy","volume":"8","author":"F Napolitano","year":"2013","journal-title":"PloS One"},{"issue":"23","key":"ref28","article-title":"Exploring Patient Awareness and Perceptions of the Appropriate Use of Antibiotics: A Mixed-Methods Study","volume":"6","author":"ME Davis","year":"2017","journal-title":"Antibiotics-Basel"},{"issue":"111","key":"ref29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ijmedinf.2017.12.005","article-title":"Internet and social media use for antibiotic-related information seeking: Findings from a survey among adult population in Italy","author":"R Zucco","year":"2018","journal-title":"International Journal of Medical Informatics"},{"issue":"10","key":"ref30","doi-asserted-by":"crossref","first-page":"e0204878","DOI":"10.1371\/journal.pone.0204878","article-title":"Online health information and public knowledge, attitudes, and behaviours regarding antibiotics in the UK: Multiple regression analysis of Wellcome Monitor and Eurobarometer Data","volume":"13","author":"A. Anderson","year":"2018","journal-title":"Plos One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0214779","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,11]],"date-time":"2020-05-11T11:36:57Z","timestamp":1589197017000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0214779"}},"subtitle":[],"editor":[{"given":"Italo Francesco","family":"Angelillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,6,26]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2019,6,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0214779","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/585257","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,6,26]]}}}