{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T09:40:09Z","timestamp":1785577209191,"version":"3.56.0"},"reference-count":31,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T00:00:00Z","timestamp":1554249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0214877","type":"journal-article","created":{"date-parts":[[2019,4,3]],"date-time":"2019-04-03T17:30:23Z","timestamp":1554312623000},"page":"e0214877","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":28,"title":["Evaluation of the bacterial ocular surface microbiome in clinically normal horses before and after treatment with topical neomycin-polymyxin-bacitracin"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9702-7298","authenticated-orcid":true,"given":"Erin M.","family":"Scott","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn","family":"Arnold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9808-5115","authenticated-orcid":true,"given":"Samantha","family":"Dowell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan S.","family":"Suchodolski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,3]]},"reference":[{"key":"ref1","first-page":"600","article-title":"Bacterial and fungal isolates from Equidae with ulcerative keratitis","volume":"6","author":"CP Moore","year":"1983","journal-title":"J Am Vet Med Assoc"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0196-9846(17)30003-4","article-title":"Microbiology of the equine eye in health and disease","volume":"6","author":"RD Whitley","year":"1984","journal-title":"Vet Clin North Am Large Anim Pract"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2460\/javma.1995.207.07.0928","article-title":"Antibacterial susceptibility patterns for microbial isolates associated with infectious keratitis in horses: 63 cases (1986\u20131994)","volume":"7","author":"CP Moore","year":"1995","journal-title":"Am J Vet Med Assoc"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1046\/j.1463-5224.2003.00265.x","article-title":"Seasonal effects on the aerobic bacterial and fungal conjunctival flora of normal thoroughbred brood mares in Florida","volume":"6","author":"SE Andrew","year":"2003","journal-title":"Vet Ophthalmol"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.jtos.2016.04.004","article-title":"Impact of microbiome on ocular health","volume":"14","author":"A Kugadas","year":"2016","journal-title":"Ocul Surf"},{"key":"ref6","first-page":"325","article-title":"Human microbiota and ophthalmic disease","volume":"89","author":"LJ Lu","year":"2016","journal-title":"Yale J Biol Med"},{"key":"ref7","article-title":"The effects of antibiotics on the microbiome throughout development and alternative approaches for therapeutic modulation","author":"A Langdon","year":"2016","journal-title":"Genome Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.2042-3306.1983.tb04578.x","article-title":"Microbial isolates of the normal equine eye","volume":"2","author":"RD Whitley","year":"1983","journal-title":"Equine Vet J"},{"issue":"6","key":"ref9","first-page":"773","article-title":"Prevalence of ocular microorganisms in hospitalized and stabled horses","volume":"49","author":"CP Moore","year":"1988","journal-title":"Am J Vet Res"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"800","DOI":"10.2460\/ajvr.2005.66.800","article-title":"Changes in bacterial and fungal ocular flora of clinically normal horses following experimental application of topical antimicrobial or antimicrobial-corticosteroid ophthalmic preparations","volume":"66","author":"AJ Gemensky-Metzler","year":"2005","journal-title":"Am J Vet Res"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1463-5224.2010.00867.x","article-title":"Conjunctival bacterial and fungal flora in healthy horses in the UK","volume":"14","author":"IC Johns","year":"2001","journal-title":"Vet Ophthalmol"},{"key":"ref12","article-title":"Identification of bacterial and fungi samples from the conjunctival surface of normal horses in South-East Queensland, Australia","author":"ECGM Hampson","year":"2018","journal-title":"Vet Ophthalmol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.exer.2013.06.003","article-title":"Characterization of the normal microbiota of the ocular surface","volume":"117","author":"MDP Willcox","year":"2013","journal-title":"Exp Eye Res"},{"issue":"8","key":"ref14","doi-asserted-by":"crossref","first-page":"5408","DOI":"10.1167\/iovs.10-6939","article-title":"Diversity of bacteria at healthy human conjunctiva","volume":"52","author":"Q Dong","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"643.e7","DOI":"10.1016\/j.cmi.2016.04.008","article-title":"Defining the normal core microbiome of conjunctival microbial communities","volume":"22","author":"Y Huang","year":"2016","journal-title":"Clin Microbiol Infect"},{"issue":"13","key":"ref16","doi-asserted-by":"crossref","first-page":"5116","DOI":"10.1167\/iovs.16-19803","article-title":"Paucibacterial microbiome and resident DNA Virome of the healthy conjunctiva","volume":"57","author":"T Doan","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref17","article-title":"Temporal stability and composition of the ocular surface microbiome","author":"J Ozkan","year":"2017","journal-title":"Nature Sci Rep"},{"key":"ref18","article-title":"The oral and conjunctival microbiotas in cats with and without feline immunodeficiency virus infection","author":"SJ Weese","year":"2015","journal-title":"Vet Res"},{"key":"ref19","article-title":"Initial description of the core ocular surface microbiome in dogs: bacterial community diversity and composition in a defined canine population","author":"ML Leis","year":"2018","journal-title":"Vet Ophthalmol"},{"key":"ref20","article-title":"QIIME2: Reproducible, interactive, scalable, extensible microbiome data science","author":"E Bolyen","year":"2018","journal-title":"PeerJ Preprints"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: High-resolution sample inference from Illumina amplicon data","volume":"13","author":"BJ Callahan","year":"2016","journal-title":"Nat Methods"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"5069","DOI":"10.1128\/AEM.03006-05","article-title":"Greengenes, a chimera-checked 16S rRNA gene database and workbench compatible with ARB","volume":"72","author":"TZ DeSantis","year":"2006","journal-title":"Appl Environ Microbiol"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ismej.2011.139","article-title":"An improved Greengenes taxonomy with explicit ranks for ecological and evolutionary analyses of bacteria and archaea","volume":"6","author":"D McDonald","year":"2012","journal-title":"ISME J"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate\u2014a practical and powerful approach to multiple testing","volume":"57","author":"Y Benjamini","year":"1995","journal-title":"J Roy Stat Soc B Met"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2011-12-6-r60","article-title":"Metagenomic biomarker discovery and explanation","volume":"12","author":"N Segata","year":"2011","journal-title":"Genome Biol"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1093\/bioinformatics\/btw725","article-title":"Calypso: a user-friendly webserver for mining and visualizing microbiome-environment interactions","volume":"33","author":"M Zakrzewski","year":"2017","journal-title":"Bioinformatics"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.ajo.2014.06.014","article-title":"Considerations in understanding the ocular surface microbiome","volume":"158","author":"ME Zegans","year":"2014","journal-title":"Am J Ophthalmol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.exer.2013.07.014","article-title":"Antimicrobial compounds in tears","volume":"117","author":"AM McDermott","year":"2013","journal-title":"Exp Eye Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s10792-007-9068-3","article-title":"Retrospective analysis of etiopathogenesis of all cases of endophthalmitis in a large tertiary referral center","volume":"27","author":"H Karacal","year":"2007","journal-title":"Int Ophthalmol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2460\/ajvr.78.2.207","article-title":"Alterations in conjunctival bacterial and antimicrobial susceptibility during topical administration of ofloxacin after cataract surgery in dogs","volume":"78","author":"LS Sandmeyer","year":"2017","journal-title":"Am J Vet Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1038\/ajg.2014.73","article-title":"Analyzing the human microbiome: a \u201chow to\u201d guide for physicians","volume":"109","author":"AD Tyler","year":"2014","journal-title":"Am J Gastroenterol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0214877","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,16]],"date-time":"2024-07-16T15:26:33Z","timestamp":1721143593000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0214877"}},"subtitle":[],"editor":[{"given":"Christopher","family":"Staley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,3]]},"references-count":31,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,3]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0214877","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,3]]}}}