{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T05:34:32Z","timestamp":1790400872049,"version":"4.1.0"},"reference-count":35,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T00:00:00Z","timestamp":1554681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"\u201cPrograma Nicolas Monarde\u201d, Consejeria de Salud, Junta de Andaluc\u00eda co- funded by the Fondo Europeo de Desarrollo Regional-FEDER","award":["C-0030-2018"],"award-info":[{"award-number":["C-0030-2018"]}]},{"name":"FPU from Ministerio de Educaci\u00f3n, Cultura y deporte, co-funded by Fondo Europeo de Desarrollo Regional-FEDER","award":["FPU13\/04211"],"award-info":[{"award-number":["FPU13\/04211"]}]},{"name":"\u201cEstancias breves FPU\u201d, Ministerio de Educaci\u00f3n, Cultura y Deporte co- funded by the Fondo Europeo de Desarrollo Regional-FEDER","award":["EST15\/00657"],"award-info":[{"award-number":["EST15\/00657"]}]},{"name":"\u2018\u2018Miguel Servet Type I\u2019\u2019 contract from the Instituto de Salud Carlos III co- funded by the Fondo Europeo de Desarrollo Regional-FEDER","award":["CP16\/00163"],"award-info":[{"award-number":["CP16\/00163"]}]},{"name":"\u201cPrograma Nicolas Monarde\u201d, Consejeria de Salud, Junta de Andaluc\u00eda co- funded by the Fondo Europeo de Desarrollo Regional-FEDER","award":["C-0032-2016"],"award-info":[{"award-number":["C-0032-2016"]}]},{"name":"\u2018\u2018Miguel Servet Type II\u2019\u2019 contract from the Instituto de Salud Carlos III co- funded by the Fondo Europeo de Desarrollo Regional-FEDER","award":["CPI18\/00003"],"award-info":[{"award-number":["CPI18\/00003"]}]},{"name":"FIS project from Instituto de Salud Carlos III co-founded by Fondo Europeo de Desarrollo Regional - FEDER","award":["PI11\/ 02518; PI14\/00082"],"award-info":[{"award-number":["PI11\/ 02518; PI14\/00082"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0215083","type":"journal-article","created":{"date-parts":[[2019,4,8]],"date-time":"2019-04-08T17:26:41Z","timestamp":1554744401000},"page":"e0215083","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":51,"title":["Human adipose tissue H3K4me3 histone mark in adipogenic, lipid metabolism and inflammatory genes is positively associated with BMI and HOMA-IR"],"prefix":"10.1371","volume":"14","author":[{"given":"Daniel","family":"Castellano-Castillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Damien","family":"Denechaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Fajas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6121-151X","authenticated-orcid":true,"given":"Isabel","family":"Moreno-Indias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilfredo","family":"Oliva-Olivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Tinahones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2867-0845","authenticated-orcid":true,"given":"Mar\u00eda Isabel","family":"Queipo-Ortu\u00f1o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Cardona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.3810\/pgm.2009.11.2074","article-title":"The Medical Risks of Obesity","volume":"121","author":"X Pi-sunyer","year":"2009","journal-title":"Postgrad Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/B978-0-12-408134-5.00014-7","article-title":"Adipose Tissue as an Endocrine Organ","volume":"89","author":"N Musi","year":"2014","journal-title":"Cell Endocrinol Heal Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1093\/eurheartj\/ehn387","article-title":"Adipose tissue dysfunction in obesity, diabetes, and vascular diseases","volume":"29","author":"GR Hajer","year":"2008","journal-title":"Eur Heart J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2346","DOI":"10.7150\/jca.16884","article-title":"Obesity and cancer: The role of adipose tissue and adipo-cytokines-induced chronic inflammation","volume":"7","author":"R Divella","year":"2016","journal-title":"J Cancer"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1055\/s-0029-1192044","article-title":"Adipose tissue dysfunction in obesity","volume":"117","author":"M Bl\u00fcher","year":"2009","journal-title":"Exp Clin Endocrinol Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/joim.12071","article-title":"Ectopic lipid storage and insulin resistance: A harmful relationship","volume":"274","author":"J Bor\u00e9n","year":"2013","journal-title":"J Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00412-015-0530-0","article-title":"Chromatin deregulation in disease","volume":"125","author":"AC Mirabella","year":"2016","journal-title":"Chromosoma"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"e0192314","DOI":"10.1371\/journal.pone.0192314","article-title":"Chromatin immunoprecipitation improvements for the processing of small frozen pieces of adipose tissue","volume":"13","author":"D Castellano-Castillo","year":"2018","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"e24783","DOI":"10.1371\/journal.pone.0024783","article-title":"Adipose tissue gene expression of factors related to lipid processing in obesity","volume":"6","author":"M Clemente-Postigo","year":"2011","journal-title":"PLoS One"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1161\/CIRCULATIONAHA.109.192644","article-title":"Harmonizing the Metabolic Syndrome: A Joint Interim Statement of the International Diabetes Federation Task Force on Epidemiology and Prevention; National Heart, Lung, and Blood Institute; American Heart Association; World Heart Federation; International","volume":"120","author":"KGMM Alberti","year":"2009","journal-title":"Circulation"},{"key":"ref11","first-page":"1229","article-title":"Hyperglycemia Induces a Dynamic Cooperativity of","volume":"58","author":"D Brasacchio","year":"2009","journal-title":"Hyperglycemia Induces a Dynamic Cooperativity of"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-11180-6","article-title":"Peroxisome Proliferator-Activated Receptor Gamma in Obesity and Colorectal Cancer: The Role of Epigenetics","volume":"7","author":"TK Motawi","year":"2017","journal-title":"Sci Rep"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"e264","DOI":"10.1038\/nutd.2017.15","article-title":"Human adipose tissue accumulation is associated with pro-inflammatory changes in subcutaneous rather than visceral adipose tissue","volume":"7","author":"IK Lesna","year":"2017","journal-title":"Nutr Diabetes."},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1538","DOI":"10.1172\/JCI96139","article-title":"Insulin resistance causes inflammation in adipose tissue","volume":"128","author":"M Shimobayashi","year":"2018","journal-title":"J Clin Invest"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.1210\/jc.2015-4125","article-title":"Adipose tissue hypoxia, inflammation, and fibrosis in obese insulin-sensitive and obese insulin-resistant subjects","volume":"101","author":"HM Lawler","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"ref16","first-page":"137","article-title":"E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis","volume":"126","author":"P Denechaud","year":"2016","journal-title":"E2F1 mediates sustained lipogenesis and contributes to hepatic steatosis"},{"key":"ref17","first-page":"1","article-title":"E2F1 inhibits circulating cholesterol clearance by regulating Pcsk9 expression in the liver","volume":"2","author":"Q Lai","year":"2017","journal-title":"JCI insight"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1021\/cb500846u","article-title":"Metabolic regulation of histone post-translational modifications","volume":"10","author":"J Fan","year":"2016","journal-title":"ACS Chem Biol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"20812","DOI":"10.1074\/jbc.M211813200","article-title":"The methyl donor S-Adenosylmethionine inhibits active demethylation of DNA. A candidate novel mechanism for the pharmacological effects of S-Adenosylmethionine","volume":"278","author":"N Detich","year":"2003","journal-title":"J Biol Chem"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/nutd.2015.44","article-title":"Serum S-adenosylmethionine, but not methionine, increases in response to overfeeding in humans","volume":"6","author":"AK Elshorbagy","year":"2016","journal-title":"Nutr Diabetes"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1073\/pnas.0409451102","article-title":"Glucose and fat metabolism in adipose tissue of acetyl-CoA carboxylase 2 knockout mice","volume":"102","author":"W Oh","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1096\/fasebj.28.1_supplement.269.2","article-title":"Fasting rapidly increases fatty acid oxidation in white adipose tissue (269.2)","volume":"28","author":"E Torchon","year":"2014","journal-title":"Faseb J"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1016\/j.tem.2012.06.004","article-title":"Mitochondrial dysfunction in white adipose tissue","volume":"23","author":"CM Kusminski","year":"2012","journal-title":"Trends Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"e0188324","DOI":"10.1371\/journal.pone.0188324","article-title":"Different response to hypoxia of adipose-derived multipotent cells from obese subjects with and without metabolic syndrome","volume":"12","author":"W Oliva-Olivera","year":"2017","journal-title":"PLoS One"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"4198","DOI":"10.1038\/emboj.2011.295","article-title":"H3K4 tri-methylation provides an epigenetic signature of active enhancers","volume":"30","author":"A Pekowska","year":"2011","journal-title":"EMBO J"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fendo.2017.00311","article-title":"E2F1, a novel regulator of metabolism","volume":"8","author":"PD Denechaud","year":"2017","journal-title":"Front Endocrinol (Lausanne)"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2074","DOI":"10.1080\/15548627.2015.1094597","article-title":"Elevated autophagy gene expression in adipose tissue of obese humans: A potential non-cell-cycle-dependent function of E2F1","volume":"11","author":"Y Haim","year":"2015","journal-title":"Autophagy"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"113","DOI":"10.2217\/epi.13.13","article-title":"The correlation between histone modifications and gene expression","volume":"5","author":"X Dong","year":"2013","journal-title":"Epigenomics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cell.2007.05.009","article-title":"High-Resolution Profiling of Histone Methylations in the Human Genome","volume":"129","author":"A Barski","year":"2007","journal-title":"Cell"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1955","DOI":"10.1038\/s41467-018-04426-y","article-title":"Methionine metabolism influences genomic architecture and gene expression through H3K4me3 peak width Ziwei","volume":"9","author":"Z Dai","year":"2018","journal-title":"Nat Commun"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1038\/s41467-018-03554-9","article-title":"Integration of human adipocyte chromosomal interactions with adipose gene expression prioritizes obesity-related genes from GWAS","volume":"9","author":"DZ Pan","year":"2018","journal-title":"Nat Commun"},{"key":"ref32","first-page":"1","article-title":"Novel insights into chromosomal conformations in cancer","volume":"16","author":"R Jia","year":"2017","journal-title":"Mol Cancer. Molecular Cancer"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"15048","DOI":"10.1073\/pnas.1615546113","article-title":"Normal chromosome conformation depends on subtelomeric facultative heterochromatin in <italic>Neurospora crassa<\/italic>","volume":"113","author":"AD Klocko","year":"2016","journal-title":"Proc Natl Acad Sci"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0144398","article-title":"The role of H3K4me3 in transcriptional regulation is altered in Huntington\u2019s disease","volume":"10","author":"X Dong","year":"2015","journal-title":"PLoS One"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"3853","DOI":"10.1038\/sj.onc.1206502","article-title":"Inhibition of histone deacetylase activity increases chromosomal instability by the aberrant regulation of mitotic checkpoint activation","volume":"22","author":"H-J Shin","year":"2003","journal-title":"Oncogene"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0215083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,15]],"date-time":"2022-09-15T13:58:52Z","timestamp":1663250332000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0215083"}},"subtitle":[],"editor":[{"given":"Susanne","family":"Kaser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,8]]},"references-count":35,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0215083","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,8]]}}}