{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T16:27:58Z","timestamp":1790440078625,"version":"4.1.0"},"reference-count":60,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T00:00:00Z","timestamp":1555545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK048373"],"award-info":[{"award-number":["DK048373"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute Of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"crossref","award":["DK104344"],"award-info":[{"award-number":["DK104344"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Regeneron Pharmaceuticals Inc"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0215132","type":"journal-article","created":{"date-parts":[[2019,4,18]],"date-time":"2019-04-18T17:35:48Z","timestamp":1555608948000},"page":"e0215132","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":49,"title":["RNA sequencing of intestinal mucosa reveals novel pathways functionally linked to celiac disease pathogenesis"],"prefix":"10.1371","volume":"14","author":[{"given":"Maureen M.","family":"Leonard","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Serena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kourtney P.","family":"Nickerson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Camhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig","family":"Sturgeon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Yan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria R.","family":"Fiorentino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aubrey","family":"Katz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Nath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Richter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Sleeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cagan","family":"Gurer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2134-0261","authenticated-orcid":true,"given":"Alessio","family":"Fasano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,18]]},"reference":[{"issue":"6","key":"ref1","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.cgh.2017.06.037","article-title":"Global prevalence of celiac disease: systematic review and meta-analysis","volume":"16","author":"P Singh","year":"2018","journal-title":"Clinical Gastroenterology and Hepatology"},{"issue":"7","key":"ref2","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1001\/jama.2017.9730","article-title":"Celiac Disease and Nonceliac Gluten Sensitivity: A Review","volume":"318","author":"MM Leonard","year":"2017","journal-title":"JAMA"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrgastro.2015.136","article-title":"Coeliac disease and autoimmune disease-genetic overlap and screening","volume":"12","author":"KE Lundin","year":"2015","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"7","key":"ref4","doi-asserted-by":"crossref","first-page":"530","DOI":"10.3109\/07853890.2010.514285","article-title":"Natural history of celiac disease autoimmunity in a USA cohort followed since 1974","volume":"42","author":"C Catassi","year":"2010","journal-title":"Ann Med"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/ng.3268","article-title":"Fine mapping in the MHC region accounts for 18% additional genetic risk for celiac disease","volume":"47","author":"J Gutierrez-Achury","year":"2015","journal-title":"Nat Genet"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1136\/gutjnl-2016-311713","article-title":"Heritability of non-HLA genetics in coeliac disease: a population-based study in 107 000 twins","volume":"65","author":"R Kuja-Halkola","year":"2016","journal-title":"Gut"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.bpg.2015.04.004","article-title":"Genetics of celiac disease","volume":"29","author":"I Ricano-Ponce","year":"2015","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jaut.2003.12.001","article-title":"cDNA microarray analysis of gene expression in coeliac disease jejunal biopsy samples","volume":"22","author":"K Juuti-Uusitalo","year":"2004","journal-title":"J Autoimmun"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"944","DOI":"10.1136\/gut.2003.018374","article-title":"A microarray screen for novel candidate genes in coeliac disease pathogenesis","volume":"53","author":"B Diosdado","year":"2004","journal-title":"Gut"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1186\/1471-2164-9-377","article-title":"Altered gene expression in highly purified enterocytes from patients with active coeliac disease","volume":"9","author":"S Bracken","year":"2008","journal-title":"BMC Genomics"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.3109\/08916930903225229","article-title":"Long-term and acute effects of gliadin on small intestine of patients on potentially pathogenic networks in celiac disease","volume":"43","author":"A Castellanos-Rubio","year":"2010","journal-title":"Autoimmunity"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1203\/PDR.0b013e318217ecec","article-title":"Gene expression profiling of duodenal biopsies discriminates celiac disease mucosa from normal mucosa","volume":"69","author":"H Bragde","year":"2011","journal-title":"Pediatr Res"},{"issue":"8","key":"ref13","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1038\/ejhg.2014.244","article-title":"Expression analysis in intestinal mucosa reveals complex relations among genes under the association peaks in celiac disease","volume":"23","author":"L Plaza-Izurieta","year":"2015","journal-title":"Eur J Hum Genet"},{"issue":"10","key":"ref14","doi-asserted-by":"crossref","first-page":"e0140049","DOI":"10.1371\/journal.pone.0140049","article-title":"Transcriptome Analysis of CD4+ T Cells in Coeliac Disease Reveals Imprint of BACH2 and IFNgamma Regulation","volume":"10","author":"EM Quinn","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1097\/MPG.0000000000000338","article-title":"Alteration of tight junction gene expression in celiac disease","volume":"58","author":"A Jauregi-Miguel","year":"2014","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0013066","article-title":"Ontology-based meta-analysis of global collections of high-throughput public data","volume":"5","author":"I Kupershmidt","year":"2010","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"ref17","doi-asserted-by":"crossref","first-page":"S27","DOI":"10.1097\/MPG.0b013e3181818fb9","article-title":"Celiac disease pathogenesis: the proinflammatory cytokine network","volume":"47","author":"JA Garrote","year":"2008","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"9","key":"ref18","doi-asserted-by":"crossref","first-page":"e0138338","DOI":"10.1371\/journal.pone.0138338","article-title":"Gliadin Induces Neutrophil Migration via Engagement of the Formyl Peptide Receptor, FPR1","volume":"10","author":"KM Lammers","year":"2015","journal-title":"PLoS One"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1016\/j.cgh.2006.11.014","article-title":"Neutrophil recruitment and barrier impairment in celiac disease: a genomic study","volume":"5","author":"B Diosdado","year":"2007","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1053\/j.gastro.2008.03.023","article-title":"Gliadin induces an increase in intestinal permeability and zonulin release by binding to the chemokine receptor CXCR3","volume":"135","author":"KM Lammers","year":"2008","journal-title":"Gastroenterology"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-2567.2010.03378.x","article-title":"Identification of a novel immunomodulatory gliadin peptide that causes interleukin-8 release in a chemokine receptor CXCR3-dependent manner only in patients with coeliac disease","volume":"132","author":"KM Lammers","year":"2011","journal-title":"Immunology"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.0105-2896.2005.00294.x","article-title":"Innate and adaptive immunity: the yin and yang of celiac disease","volume":"206","author":"B Jabri","year":"2005","journal-title":"Immunol Rev"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.2337\/diabetes.52.9.2287","article-title":"Immunologic activity in the small intestinal mucosa of pediatric patients with type 1 diabetes","volume":"52","author":"M Westerholm-Ormio","year":"2003","journal-title":"Diabetes"},{"issue":"4","key":"ref24","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1111\/j.1582-4934.2010.01066.x","article-title":"Gliadin fragments promote migration of dendritic cells","volume":"15","author":"B Chladkova","year":"2011","journal-title":"J Cell Mol Med"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"e33556","DOI":"10.1371\/journal.pone.0033556","article-title":"Rapid accumulation of CD14+CD11c+ dendritic cells in gut mucosa of celiac disease after in vivo gluten challenge","volume":"7","author":"AC Beitnes","year":"2012","journal-title":"PLoS One"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/jcp.40.3.307","article-title":"Expression of c-myc oncogene in coeliac disease","volume":"40","author":"PJ Ciclitira","year":"1987","journal-title":"J Clin Pathol"},{"issue":"6380","key":"ref27","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1126\/science.aan0814","article-title":"C1orf106 is a colitis risk gene that regulates stability of epithelial adherens junctions","volume":"359","author":"V Mohanan","year":"2018","journal-title":"Science"},{"issue":"37","key":"ref28","doi-asserted-by":"crossref","first-page":"35421","DOI":"10.1074\/jbc.M305387200","article-title":"Implications of nectin-like molecule-2\/IGSF4\/RA175\/SgIGSF\/TSLC1\/SynCAM1 in cell-cell adhesion and transmembrane protein localization in epithelial cells","volume":"278","author":"T Shingai","year":"2003","journal-title":"J Biol Chem"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1080\/08916930802350789","article-title":"TH17 (and TH1) signatures of intestinal biopsies of CD patients in response to gliadin","volume":"42","author":"A Castellanos-Rubio","year":"2009","journal-title":"Autoimmunity"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1159\/000260087","article-title":"Differential mucosal IL-17 expression in two gliadin-induced disorders: gluten sensitivity and the autoimmune enteropathy celiac disease","volume":"152","author":"A Sapone","year":"2010","journal-title":"Int Arch Allergy Immunol"},{"issue":"12","key":"ref31","doi-asserted-by":"crossref","first-page":"7234","DOI":"10.4049\/jimmunol.165.12.7234","article-title":"Up-regulation of the IL-12 receptor beta 2 chain in Crohn&apos;s disease","volume":"165","author":"T Parrello","year":"2000","journal-title":"J Immunol"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1111\/imr.12373","article-title":"The many faces of Mac-1 in autoimmune disease","volume":"269","author":"F Rosetti","year":"2016","journal-title":"Immunol Rev"},{"issue":"3","key":"ref33","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/cei.12911","article-title":"Proinflammatory cytokine interferon-gamma and microbiome-derived metabolites dictate epigenetic switch between forkhead box protein 3 isoforms in coeliac disease","volume":"187","author":"G Serena","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1016\/j.bbi.2018.07.007","article-title":"Microbiota affects the expression of genes involved in HPA axis regulation and local metabolism of glucocorticoids in chronic psychosocial stress","volume":"73","author":"M Vodicka","year":"2018","journal-title":"Brain Behav Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"205","DOI":"10.12688\/f1000research.13020.1","article-title":"Update on regulation and effector functions of Th17 cells","volume":"7","author":"I Sandquist","year":"2018","journal-title":"F1000Res"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/j.cell.2009.09.033","article-title":"Induction of intestinal Th17 cells by segmented filamentous bacteria","volume":"139","author":"II Ivanov","year":"2009","journal-title":"Cell"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"e0144634","DOI":"10.1371\/journal.pone.0144634","article-title":"Celiac Disease Histopathology Recapitulates Hedgehog Downregulation, Consistent with Wound Healing Processes Activation","volume":"10","author":"S Senger","year":"2015","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"127589","DOI":"10.1155\/2013\/127589","article-title":"Celiac disease and autoimmune-associated conditions","volume":"2013","author":"E Lauret","year":"2013","journal-title":"Biomed Res Int"},{"issue":"25","key":"ref39","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMcp1113994","article-title":"Clinical practice. Celiac disease","volume":"367","author":"A Fasano","year":"2012","journal-title":"N Engl J Med"},{"issue":"6","key":"ref40","article-title":"Retinoic Acid as a Modulator of T Cell Immunity","volume":"8","author":"MR Bono","year":"2016","journal-title":"Nutrients"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"137893","DOI":"10.1155\/2015\/137893","article-title":"Vitamin A Impairs the Reprogramming of Tregs into IL-17-Producing Cells during Intestinal Inflammation","volume":"2015","author":"G Tejon","year":"2015","journal-title":"Biomed Res Int"},{"issue":"8","key":"ref42","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/icb.2016.39","article-title":"Retinoic acid suppresses IL-17 production and pathogenic activity of gammadelta T cells in CNS autoimmunity","volume":"94","author":"M Raverdeau","year":"2016","journal-title":"Immunol Cell Biol"},{"issue":"3","key":"ref43","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s10067-016-3197-x","article-title":"Vitamin A improve Th17 and Treg regulation in systemic lupus erythematosus","volume":"35","author":"K Handono","year":"2016","journal-title":"Clin Rheumatol"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1111\/j.1365-3083.2010.02425.x","article-title":"Differentiation imbalance of Th1\/Th17 in peripheral blood mononuclear cells might contribute to pathogenesis of Hashimoto&apos;s thyroiditis","volume":"72","author":"Y Shi","year":"2010","journal-title":"Scand J Immunol"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","DOI":"10.4238\/gmr.15017522","article-title":"All-trans retinoic acid prevents the development of type 1 diabetes by affecting the levels of interferon gamma and interleukin 4 in streptozotocin-induced murine diabetes model","volume":"15","author":"Y Wang","year":"2016","journal-title":"Genet Mol Res"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/cei.12905","article-title":"RORgammat expression in Tregs promotes systemic lupus erythematosus via IL-17 secretion, alteration of Treg phenotype and suppression of Th2 responses","volume":"188","author":"MA Kluger","year":"2017","journal-title":"Clin Exp Immunol"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1053\/gast.1999.0029900297","article-title":"Duration of exposure to gluten and risk for autoimmune disorders in patients with celiac disease. SIGEP Study Group for Autoimmune Disorders in Celiac Disease","volume":"117","author":"A Ventura","year":"1999","journal-title":"Gastroenterology"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1067\/mpd.2000.107160","article-title":"Gluten-dependent diabetes-related and thyroid-related autoantibodies in patients with celiac disease","volume":"137","author":"A Ventura","year":"2000","journal-title":"J Pediatr"},{"issue":"7","key":"ref49","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.cgh.2007.12.022","article-title":"Incidence of autoimmune diseases in celiac disease: protective effect of the gluten-free diet","volume":"6","author":"J Cosnes","year":"2008","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"7","key":"ref50","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.2337\/diacare.25.7.1117","article-title":"A longitudinal study of the effects of a gluten-free diet on glycemic control and weight gain in subjects with type 1 diabetes and celiac disease","volume":"25","author":"R Amin","year":"2002","journal-title":"Diabetes Care"},{"issue":"11","key":"ref51","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.2337\/dc06-0990","article-title":"Clinical benefit of a gluten-free diet in type 1 diabetic children with screening-detected celiac disease: a population-based screening study with 2 years&apos; follow-up","volume":"29","author":"D Hansen","year":"2006","journal-title":"Diabetes Care"},{"issue":"3","key":"ref52","doi-asserted-by":"crossref","first-page":"e489","DOI":"10.1542\/peds.2008-2434","article-title":"Gastrointestinal symptoms in children with type 1 diabetes screened for celiac disease","volume":"124","author":"P Narula","year":"2009","journal-title":"Pediatrics"},{"key":"ref53","first-page":"297","article-title":"Update on celiac disease\u2014etiology, differential diagnosis, drug targets, and management advances","volume":"4","author":"SA Scanlon","year":"2011","journal-title":"Clin Exp Gastroenterol"},{"issue":"10","key":"ref54","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1097\/00042737-199910000-00019","article-title":"The histopathology of coeliac disease: time for a standardized report scheme for pathologists","volume":"11","author":"G Oberhuber","year":"1999","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"23204","DOI":"10.1038\/srep23204","article-title":"C9orf72 ablation causes immune dysregulation characterized by leukocyte expansion, autoantibody production, and glomerulonephropathy in mice","volume":"6","author":"A Atanasio","year":"2016","journal-title":"Sci Rep"},{"issue":"7","key":"ref56","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"CA Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"ref57","doi-asserted-by":"crossref","unstructured":"Shu J, Qiu G, Mohammad I, editors. A semi-automatic image analysis tool for biomarker detection in immunohistochemistry analysis. Image and Graphics (ICIG), 2013 Seventh International Conference on; 2013: IEEE.","DOI":"10.1109\/ICIG.2013.197"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/1471-2105-11-94","article-title":"Evaluation of statistical methods for normalization and differential expression in mRNA-Seq experiments","volume":"11","author":"JH Bullard","year":"2010","journal-title":"BMC Bioinformatics"},{"issue":"10","key":"ref59","doi-asserted-by":"crossref","first-page":"R106","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"S Anders","year":"2010","journal-title":"Genome Biol"},{"issue":"5","key":"ref60","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"clusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"G Yu","year":"2012","journal-title":"OMICS"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0215132","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,16]],"date-time":"2022-09-16T08:51:35Z","timestamp":1663318295000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0215132"}},"subtitle":[],"editor":[{"given":"Karol","family":"Sestak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,18]]},"references-count":60,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,18]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0215132","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,18]]}}}