{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T15:29:14Z","timestamp":1784042954617,"version":"3.55.0"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T00:00:00Z","timestamp":1555286400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007509","name":"Sociedad Espa\u00f1ola de Neumolog\u00eda y Cirug\u00eda Tor\u00e1cica","doi-asserted-by":"publisher","award":["171-2016"],"award-info":[{"award-number":["171-2016"]}],"id":[{"id":"10.13039\/501100007509","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0215322","type":"journal-article","created":{"date-parts":[[2019,4,15]],"date-time":"2019-04-15T17:31:06Z","timestamp":1555349466000},"page":"e0215322","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Tuberculosis incidence among infected contacts detected through contact tracing of smear-positive patients"],"prefix":"10.1371","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2221-5331","authenticated-orcid":true,"given":"Mario","family":"Martin-Sanchez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6439-0050","authenticated-orcid":true,"given":"Silvia","family":"Brugueras","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6980-2050","authenticated-orcid":true,"given":"Anna","family":"de Andr\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5057-7583","authenticated-orcid":true,"given":"Pere","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0419-0641","authenticated-orcid":true,"given":"Pilar","family":"Gorrindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3659-8222","authenticated-orcid":true,"given":"Miriam","family":"Ros","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Masdeu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0200-2459","authenticated-orcid":true,"given":"Joan-Pau","family":"Millet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-111X","authenticated-orcid":true,"given":"Joan A.","family":"Cayl\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c0ngels","family":"Orcau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Contact Tracing Group of the Tuberculosis Investigation Unit of Barcelona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,15]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1183\/09031936.00070812","article-title":"Contact investigation for tuberculosis: a systematic review and meta-analysis","volume":"41","author":"GJ Fox","year":"2013","journal-title":"Eur Respir J"},{"key":"ref2","first-page":"117","article-title":"The relationship between the risk of tuberculous infection and the risk of developing infectious tuberculosis","volume":"60","author":"K Styblo","year":"1985","journal-title":"Bull Int Union Tuberc Lung Dis"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1183\/09031936.00201609","article-title":"Tuberculosis contact investigation in low prevalence countries: A European consensus","volume":"36","author":"CGM Erkens","year":"2010","journal-title":"Eur Respir J"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1164\/rccm.201406-1159OC","article-title":"Risk of tuberculosis after recent exposure: A 10-year follow-up study of contacts in Amsterdam","volume":"190","author":"R Sloot","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.chest.2015.11.017","article-title":"Risk of active tuberculosis in the five years following infection \u22ef 15%?","volume":"149","author":"JM Trauer","year":"2016","journal-title":"Chest"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"828939","DOI":"10.1155\/2013\/828939","article-title":"Risk factors for tuberculosis","volume":"2013","author":"P Narasimhan","year":"2013","journal-title":"Pulmonary Medicine"},{"issue":"2","key":"ref7","first-page":"1","article-title":"Tuberculosis contact investigation in an intermediate burden setting: implications from a large tuberculosis contact cohort in Taiwan","volume":"50","author":"M-R Lee","year":"2017","journal-title":"Eur Respir J"},{"issue":"3","key":"ref8","first-page":"281","article-title":"Early and late tuberculosis risks among close contacts in Hong Kong","volume":"12","author":"MSN Lee","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"419","DOI":"10.7326\/M14-1019","article-title":"Treatment of latent tuberculosis infection a network meta-analysis","volume":"161","author":"HR Stagg","year":"2014","journal-title":"Annals of Internal Medicine"},{"issue":"23","key":"ref10","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1056\/NEJMoa1104875","article-title":"Three Months of Rifapentine and Isoniazid for Latent Tuberculosis Infection","volume":"365","author":"TR Sterling","year":"2011","journal-title":"N Engl J Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijid.2016.11.006","article-title":"Preventive therapy for latent tuberculosis infection\u2014the promise and the challenges. Vol. 56","volume":"56","author":"GJ Fox","year":"2017","journal-title":"International Journal of Infectious Diseases"},{"key":"ref12","first-page":"1","article-title":"Targeted tuberculin testing and treatment of latent tuberculosis infection","volume":"161","year":"2000","journal-title":"Am J Respir Crit Care Med"},{"key":"ref13","unstructured":"Orcau \u00c0, Cayl\u00e0 JA, Rius C. [Tuberculosis in Barcelona. Report 2016]. 2018. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.aspb.cat\/wp-content\/uploads\/2018\/10\/ASPB_Tuberculosi-Barcelona-Informe-2016-1.pdf\" xlink:type=\"simple\">http:\/\/www.aspb.cat\/wp-content\/uploads\/2018\/10\/ASPB_Tuberculosi-Barcelona-Informe-2016-1.pdf<\/ext-link>"},{"issue":"11","key":"ref14","first-page":"1235","article-title":"Adherence to treatment for latent tuberculosis infection: systematic review of studies in the US and Canada","volume":"12","author":"Y Hirsch-Moverman","year":"2008","journal-title":"Int J Tuberc Lung Dis"},{"issue":"4","key":"ref15","first-page":"555","article-title":"Efficacy of various durations of isoniazid preventive therapy for tuberculosis: Five years of follow-up in the IUAT trial. International union against tuberculosis committee on prophylaxis","volume":"60","year":"1982","journal-title":"Bull World Health Organ"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/1741-7015-9-127","article-title":"Control of tuberculosis in large cities in developed countries: An organizational problem","volume":"9","author":"JA Cayl\u00e0","year":"2011","journal-title":"BMC Medicine"},{"key":"ref17","article-title":"Recomanacions per a la realitzaci\u00f3 d\u2019estudis de contactes de malalts amb tuberculosi a Catalunya","author":"I Barrabeig-Fabregat","year":"2016"},{"issue":"RR-5","key":"ref18","first-page":"1","article-title":"Updated guidelines for using Interferon Gamma Release Assays to detect Mycobacterium tuberculosis infection\u2014United States, 2010","volume":"59","author":"TF Rutledge","year":"2010","journal-title":"MMWR Recomm reports Morb Mortal Wkly Rep Recomm reports \/ Centers Dis Control"},{"issue":"April","key":"ref19","first-page":"111","article-title":"Official American Thoracic Society\/Infectious Diseases Society of America\/Centers for Disease Control and Prevention Clinical Practice Guidelines: Diagnosis of Tuberculosis in Adults and Children","volume":"64","author":"DM Lewinsohn","year":"2016","journal-title":"Clin Infect Dis"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1093\/biomet\/67.1.145","article-title":"Chi-squared goodness-of-fit tests for the proportional hazards regression model","volume":"67","author":"D Schoenfeld","year":"1980","journal-title":"Biometrika"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1177\/1536867X1301300402","article-title":"Attributable and unattributable risks and fractions and other scenario comparisons","volume":"13","author":"RB Newson","year":"2013","journal-title":"Stata J"},{"issue":"9","key":"ref22","first-page":"1112","article-title":"Risk factors for developing tuberculosis: A 12-year follow-up of contacts of tuberculosis cases","volume":"14","author":"O Mor\u00e1n-Mendoza","year":"2010","journal-title":"Int J Tuberc Lung Dis"},{"issue":"1645","key":"ref23","doi-asserted-by":"crossref","first-page":"20130437","DOI":"10.1098\/rstb.2013.0437","article-title":"The ongoing challenge of latent tuberculosis","volume":"369","author":"H Esmail","year":"2014","journal-title":"Philos Trans R Soc B Biol Sci"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/oxfordjournals.aje.a121593","article-title":"The prognosis of a positive tuberculin reaction in childhood and adolescence","volume":"99","author":"GW Comstock","year":"1974","journal-title":"Am J Epidemiol"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000199","article-title":"Sexual inequality in tuberculosis","volume":"6","author":"O Neyrolles","year":"2009","journal-title":"PLoS Med"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1005374","article-title":"SeXX Matters in Infectious Disease Pathogenesis","volume":"12","author":"LG vom Steeg","year":"2016","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1525-1446.2010.00834.x","article-title":"The effect of a cultural intervention on adherence to latent tuberculosis infection therapy in latino immigrants","volume":"27","author":"RL Ailinger","year":"2010","journal-title":"Public Health Nurs"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1353\/hpu.2014.0109","article-title":"Successful Management of Latent Tuberculosis Infection in an Underserved Community by a Student-run Free Clinic","volume":"25","author":"MJ Peluso","year":"2014","journal-title":"J Health Care Poor Underserved"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4103\/1817-1737.44778","article-title":"Diagnosis of latent tuberculosis: Can we do better?","volume":"4","author":"IO Al-Orainey","year":"2009","journal-title":"Ann Thorac Med"},{"key":"ref30","unstructured":"WHO. Global Tuberculosis Report 2017 [Internet]. 2017. 1\u2013262 p. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/apps.who.int\/iris\/bitstream\/10665\/259366\/1\/9789241565516-eng.pdf?ua=1\" xlink:type=\"simple\">http:\/\/apps.who.int\/iris\/bitstream\/10665\/259366\/1\/9789241565516-eng.pdf?ua=1<\/ext-link>"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1146\/annurev-publhealth-031912-114431","article-title":"Prospects for Tuberculosis Elimination","volume":"34","author":"C Dye","year":"2013","journal-title":"Annu Rev Public Health"},{"issue":"15","key":"ref32","first-page":"1","article-title":"The End TB Strategy","volume":"6736","author":"M Uplekar","year":"2015","journal-title":"Lancet"},{"issue":"10","key":"ref33","doi-asserted-by":"crossref","first-page":"689","DOI":"10.7326\/M17-1150","article-title":"Self-administered versus directly observed once-weekly isoniazid and rifapentine treatment of latent tuberculosis infection","volume":"167","author":"R Belknap","year":"2017","journal-title":"Ann Intern Med"},{"key":"ref34","first-page":"32","article-title":"Latent tuberculosis infection: updated and consolidated guidelines for programmatic management","year":"2018"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"e0147744","DOI":"10.1371\/journal.pone.0147744","article-title":"Impact of community-based DOT on tuberculosis treatment outcomes: A systematic review and meta-analysis","volume":"11","author":"H Zhang","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1002\/hpm.2495","article-title":"Barriers to treatment adherence for individuals with latent tuberculosis infection: A systematic search and narrative synthesis of the literature","volume":"33","author":"Y Liu","year":"2018","journal-title":"Int J Health Plann Manage"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"1572","DOI":"10.5588\/ijtld.16.0147","article-title":"Tuberculosis clinical units improve contact tracing","volume":"20","author":"S Brugueras","year":"2016","journal-title":"Int J Tuberc Lung Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0215322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T04:52:37Z","timestamp":1588999957000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0215322"}},"subtitle":[],"editor":[{"given":"Lei","family":"Gao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,15]]},"references-count":37,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0215322","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,15]]}}}