{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:31:57Z","timestamp":1792099917590,"version":"4.4.0"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T00:00:00Z","timestamp":1555891200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI16\/01627"],"award-info":[{"award-number":["PI16\/01627"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["PI17\/01925"],"award-info":[{"award-number":["PI17\/01925"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"name":"European Regional Development Fund (FEDER) and Centro de Investigaci\u00f3n Biom\u00e9dica en Red, M. P.","award":["CB16\/11\/00261"],"award-info":[{"award-number":["CB16\/11\/00261"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0215818","type":"journal-article","created":{"date-parts":[[2019,4,22]],"date-time":"2019-04-22T13:35:47Z","timestamp":1555940147000},"page":"e0215818","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":22,"title":["The altered expression of autophagy-related genes participates in heart failure: NRBP2 and CALCOCO2 are associated with left ventricular dysfunction parameters in human dilated cardiomyopathy"],"prefix":"10.1371","volume":"14","author":[{"given":"Carolina","family":"Gil-Cayuela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Mart\u00ednez-Dolz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Ram\u00f3n","family":"Gonz\u00e1lez-Juanatey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisca","family":"Lago","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Rosell\u00f3-Llet\u00ed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Rivera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4415-7160","authenticated-orcid":true,"given":"Manuel","family":"Portol\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2019,4,22]]},"reference":[{"key":"ref1","first-page":"841","article-title":"Report of the 1995 World Health Organization\/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies","volume":"93","author":"P Richardson","year":"1996"},{"key":"ref2","first-page":"1867","article-title":"Incidence, causes, and outcomes of dilated cardiomyopathy in children","volume":"296","author":"JA Towbin","year":"2006"},{"key":"ref3","first-page":"1265","article-title":"RNA sequencing analysis identifies new human collagen genes involved in cardiac remodeling","volume":"65","author":"C Gil-Cayuela","year":"2015"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"e0168130","DOI":"10.1371\/journal.pone.0168130","article-title":"New Altered Non-Fibrillar Collagens in Human Dilated Cardiomyopathy: Role in the Remodeling Process","volume":"11","author":"C Gil-Cayuela","year":"2016","journal-title":"PloS One"},{"key":"ref5","first-page":"e107635","article-title":"Endoplasmic reticulum stress induces different molecular structural alterations in human dilated and ischemic cardiomyopathy","volume":"9","author":"A Ortega","year":"2014"},{"key":"ref6","first-page":"280","article-title":"Changes in human Golgi apparatus reflect new left ventricular dimensions and function in dilated cardiomyopathy patients","volume":"19","author":"E Tarazon","year":"2017"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"549","DOI":"10.4161\/auto.28448","article-title":"Autophagosomes, phagosomes, autolysosomes, phagolysosomes, autophagolysosomes \u2026 wait, I'm confused","volume":"10","author":"DJ Klionsky","year":"2014","journal-title":"Autophagy"},{"key":"ref8","first-page":"421","article-title":"Autophagosome formation in mammalian cells","volume":"27","author":"N Mizushima","year":"2002"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"950","DOI":"10.4161\/auto.6.7.13009","article-title":"The Golgi as a potential membrane source for autophagy","volume":"6","author":"J Geng","year":"2010","journal-title":"Autophagy"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.4161\/auto.25969","article-title":"Cardiovascular autophagy: concepts, controversies, and perspectives","volume":"9","author":"S Lavandero","year":"2013","journal-title":"Autophagy"},{"key":"ref11","first-page":"1115","article-title":"Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): The Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology","volume":"26","author":"K Swedberg","year":"2005"},{"key":"ref12","first-page":"176","article-title":"The Council for International Organizations and Medical Sciences (CIOMS) guidelines on ethics of clinical trials","volume":"4","author":"DJ Macrae","year":"2007"},{"key":"ref13","first-page":"e0190987","article-title":"Myocardium of patients with dilated cardiomyopathy presents altered expression of genes involved in thyroid hormone biosynthesis","volume":"13","author":"C Gil-Cayuela","year":"2018"},{"key":"ref14","first-page":"43","article-title":"Modification of the Lowry assay to measure proteins and phenols in covalently bound complexes","volume":"346","author":"AL Winters","year":"2005"},{"key":"ref15","first-page":"59","article-title":"Quantification of structures and gold labeling in transmission electron microscopy","volume":"88","author":"J Lucocq","year":"2008"},{"key":"ref16","first-page":"1069","article-title":"Autophagy fights disease through cellular self-digestion","volume":"451","author":"N Mizushima","year":"2008"},{"key":"ref17","first-page":"654","article-title":"Recycle or die: the role of autophagy in cardioprotection","volume":"44","author":"AB Gustafsson","year":"2008"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"305","DOI":"10.4161\/auto.2946","article-title":"Protective effect of autophagy in anoxia-reoxygenation of isolated cardiomyocyte?","volume":"2","author":"VE Dosenko","year":"2006","journal-title":"Autophagy"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aau0462","article-title":"Cardioprotective effects of autophagy: Eat your heart out, heart failure!","volume":"10","author":"G Santulli","year":"2018","journal-title":"Sci Transl Med"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3389\/fphar.2018.01292","article-title":"Activating Cannabinoid Receptor 2 Protects Against Diabetic Cardiomyopathy Through Autophagy Induction","volume":"9","author":"A Wu","year":"2018","journal-title":"Front Pharmacol"},{"key":"ref21","first-page":"914","article-title":"Distinct roles of autophagy in the heart during ischemia and reperfusion: roles of AMP-activated protein kinase and Beclin 1 in mediating autophagy","volume":"100","author":"Y Matsui","year":"2007"},{"key":"ref22","first-page":"1782","article-title":"Cardiac autophagy is a maladaptive response to hemodynamic stress","volume":"117","author":"H Zhu","year":"2007"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/15548627.2016.1212788","article-title":"Spatiotemporal dynamics of autophagy receptors in selective mitophagy","volume":"12","author":"AS Moore","year":"2016","journal-title":"Autophagy"},{"key":"ref24","first-page":"329","article-title":"LC3C, bound selectively by a noncanonical LIR motif in NDP52, is required for antibacterial autophagy","volume":"48","author":"N von Muhlinen","year":"2012"},{"key":"ref25","first-page":"3040","article-title":"C9orf72 binds SMCR8, localizes to lysosomes, and regulates mTORC1 signaling","volume":"27","author":"J Amick","year":"2016"},{"key":"ref26","article-title":"Multiplex image-based autophagy RNAi screening identifies SMCR8 as ULK1 kinase activity and gene expression regulator","volume":"6","author":"J Jung","year":"2017"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"e7099","DOI":"10.1371\/journal.pone.0007099","article-title":"Lysosomal-associated protein multispanning transmembrane 5 gene (LAPTM5) is associated with spontaneous regression of neuroblastomas","volume":"4","author":"J Inoue","year":"2009","journal-title":"PloS One"},{"key":"ref28","first-page":"1004","article-title":"UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in beta-cells: evidence of interplay between the ubiquitin\/proteasome system and autophagy","volume":"10","author":"S Costes","year":"2014"},{"key":"ref29","first-page":"650","article-title":"Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages","volume":"6","author":"K Wex","year":"2015","journal-title":"Front Immunol"},{"key":"ref30","first-page":"7059","article-title":"NRBP2 Overexpression Increases the Chemosensitivity of Hepatocellular Carcinoma Cells via Akt Signaling","volume":"76","author":"L Zhang","year":"2016"},{"key":"ref31","first-page":"2486","article-title":"Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation","volume":"31","author":"CH Wilson","year":"2012"},{"key":"ref32","first-page":"1","article-title":"Relationship between the proteasomal system and autophagy","volume":"4","author":"A Lilienbaum","year":"2013"},{"key":"ref33","first-page":"691","article-title":"Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection","volume":"1782","author":"NB Nedelsky","year":"2008"},{"key":"ref34","first-page":"503","article-title":"Maturation of autophagosomes and endosomes: a key role for Rab7","volume":"1833","author":"JM Hyttinen","year":"2013"},{"key":"ref35","first-page":"499","article-title":"Lipids regulate P2X7-receptor-dependent actin assembly by phagosomes via ADP translocation and ATP synthesis in the phagosome lumen","volume":"122","author":"MP Kuehnel","year":"2009"},{"key":"ref36","first-page":"2051","article-title":"The activation of P2X7 receptor impairs lysosomal functions and stimulates the release of autophagolysosomes in microglial cells","volume":"182","author":"T Takenouchi","year":"2009"},{"key":"ref37","first-page":"1101","article-title":"TMEM175 Is an Organelle K(+) Channel Regulating Lysosomal Function","volume":"162","author":"C Cang","year":"2015"},{"key":"ref38","first-page":"3309","article-title":"A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity","volume":"114","author":"JD Matute","year":"2009"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.4161\/auto.28638","article-title":"Deficient autophagy unravels the ROS paradox in chronic granulomatous disease","volume":"10","author":"FL van de Veerdonk","year":"2014","journal-title":"Autophagy"},{"key":"ref40","first-page":"579","article-title":"Autophagic vacuoles in cardiomyocytes of dilated cardiomyopathy with initially decompensated heart failure predict improved prognosis","volume":"12","author":"T Saito","year":"2016"},{"key":"ref41","first-page":"965","article-title":"Autophagic degeneration as a possible mechanism of myocardial cell death in dilated cardiomyopathy","volume":"65","author":"H Shimomura","year":"2001"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0215818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:50:01Z","timestamp":1588971001000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0215818"}},"subtitle":[],"editor":[{"given":"John Lynn","family":"Jefferies","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2019,4,22]]},"references-count":41,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2019,4,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0215818","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,4,22]]}}}